#AusGovInfo Research Community

Grants since Jan 2018
Coalition [24,636]
ALP [22,504]
LIBS [12,591]
LNP [7,416]
NATS [4,629]
GREENS [2,362]
IND [1,341]
KATTER [792]
CA [392]
OVERSEAS [147]
NONE [130]

About this Project

With new Ministers announced regularly, this Commonwealth Grants project maps each Minister against the grants made during their tenure in any given position. A new Minister (or occasionally an entire Ministry) has been published on average every eight weeks since the beginning of the 2017-18 financial year (mid 2017). I've created a new dataset with these positions and dates to map both budget data (which operates on a financial year) and Commonwealth the grants that each agency claims are coming out of annual budget appropriations.

Portfolios are the administrative lines drawn between specific agencies and responsible Ministers. Each Portfolio administers specific agencies and those agencies can only spend funding appropriated through Parliament and documented in the Portfolio Budget Statements published on budget night or the MYEFO updates each December or Portfolio Additional Estimate Statements published in February.

Portfolio names change when Administrative Arragement Orders are made by the presiding government. This can change the portfolio to which an agency is attributed or the Minister responsible. The Prime Minister, Scott Morrison announced significant changes to the Portfolios and agencies they administed which came into effect on 1, February 2020.

At launch, only grants published since GrantsConnect went live in January 2018 are included in the data. This means that only one full financial year is covered in the data, with the 2019-20 financial year still unfolding at this point. Commonwealth grants data contains agency and program names as per the budget documents published in budget night. I have integrated these datasets despite the challenges posed by Administrative Arrangement Orders made after budget night. Given the intention of this project is to link grant decisions with resposnible Ministers, queries are based on the approval date in each grant notice as opposed to the publication date.

Publication date is based on start date of the grant and can vary substantially from the approval date. Grants are republished at a later date where variations have been made. If there is a significant time difference between grant approval and variation, different Ministers and governments can be responsible for those variations.

Commonwealth grants data has been published at GrantsConnect since Jan 2018 under the CC By 3.0 licence.

There are several dates in Commonwealth grants data: approval date, publication date, start-end dates and the budget/financial year from which each grant is appropriated. According to Department of Finance media, publication is required by the approving agency on GrantConnect 'no later than twenty-one calendar days after the grant agreement takes effect '.

The date of effect [start date] will depend on the particular arrangement. It can be the date on which a grant agreement is executed or a specified starting date. Where there is no grant agreement, the date of effect can be for example, the date of first payment or the announcement of a successful grantee.
The approval date for reporting purposes is the date that the decision-maker makes a decision to award a grant. Where, for example, negotiating a grant agreement takes some time, there may be a delay between the approval date and the date that the grant award information is published.

Where approval, publication and budget years vary significantly this is likely due to the grant being republished in a later year with a variation or delays in the start of the grant. Variation status and reason is not included in GrantConnect download data but is published at the source (GrantConnect) if you click on the button in the Grants tab.

In order to match with budget data, drill-down at this site is based on the financial year (year of budget appropriations) from which the grant was taken, not the year of grant publication. Budget year can vary from approval and publication years.

Example grant result

GREAT BARRIER REEF FOUNDATION
Brisbane  $487,633,300
Address Brisbane 4000 QLD AUSTRALIA ABN: 82090616443
Portfolio Environment and Energy
Agency Department of the Environment and Energy
Program Sustainable Management of Natural Resources and the Environment
Component Reef Trust
CategoryNatural Resources - Conservation and Protection
PurposeThe project will deliver activities which are consistent with the purposes of the Reef Trust Special Account Determination to achieve the Reef Trust Objectives and assist to protect the Great Barrier Reef World Heritage Area.
ActivityReef Trust grant to the Great Barrier Reef Foundation
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
20 Jun 201812 Jul 201827 Jun 201830 Jun 2024 2017-18
Senators for Victoria
Official portrait of Bridget McKenzie
Bridget McKenzie The Nationals
Official portrait of David Van
David Van Liberal Party of Australia
Official portrait of James Paterson
James Paterson Liberal Party of Australia
Official portrait of Jane Hume
Jane Hume Liberal Party of Australia
Official portrait of Janet Rice
Janet Rice Australian Greens
Official portrait of Jess Walsh
Jess Walsh Australian Labor Party
Official portrait of Kim Carr
Kim Carr Australian Labor Party
Official portrait of Kimberley Kitching
Kimberley Kitching Australian Labor Party
Official portrait of Raff Ciccone
Raff Ciccone Australian Labor Party
Official portrait of Richard Di Natale
Richard Di Natale Australian Greens
Official portrait of Sarah Henderson
Sarah Henderson Liberal Party of Australia
Official portrait of Scott Ryan
Scott Ryan Liberal Party of Australia
Past Members for HOTHAM
Official portrait of Clare O'Neil
Former Member Clare O'Neil
45th Parliament
Australian Labor Party
Clare O'Neil 45th Parliament 23 Interests

The ABS summarises SEIFA scores as measuring people's access to material and social resources, and their ability to participate in society. SEIFA deciles for postcodes in HOTHAM range between 6 and 9 with an average of:
8.17
PostcodeSEIFA Decile
GLEN WAVERLEY 3150 9
MCKINNON 3204 9
BENTLEIGH EAST 3165 9
MULGRAVE 3170 8
HUNTINGDALE 3166 8
NOTTING HILL 3168 6

SuburbPostcodeGrantsNumber
1CLAYTON3800$327,774,142329
2CLAYTON3168$287,850,636360
3MULGRAVE3170$21,165,64531
4BENTLEIGH3204$16,509,39117
5CLAYTON3103$12,669,52013
6OAKLEIGH3166$10,149,96332
7GLEN WAVERLEY3150$8,691,71138
8BENTLEIGH EAST3165$2,154,71819
9DINGLEY3172$293,94810
10MULGRAVE3122$39,6441
11MULGRAVE3180$26,4001
12WEST CHATSWOOD1515$14,5461

ABS employment data by electorate

12.3% 25.9% 11.9% 9.4% 14.1% 10.2% 5.3% 9.0%
Managers Professionals Technicians/Trades Community/Personal Service Clerical/Admin Sales Machinery Ops/Drivers Labourers

Individual Tax data for postcodes within HOTHAM

Tax data taken from ATO Taxation statistics 2016–17, Table 6B, 'Selected items, by taxable status, state/territory, postcode and taxable income range'. Housing data from ABS.

*Franking credits for individuals + franking credits for shares in partnerships
Centrelink Recipients $ Income/Returns $ Income B4 Tax $ Income After Tax $ HELP Repaid $ Franking Credit* $ Net Rent % Owned % Mortgaged % Rented
38,087 59,923 4.3226 B 4.1519 B 12.916 M 51.471 M -17.913 M 36.5 30.1 29.6

The electorate of HOTHAM has been given 852 grants worth $687,340,264 across 32 Categories

CategoryValueNumber
1 MEDICAL RESEARCH $297,577,327 217
2 SCIENCE, TECHNOLOGY, ENGINEERING AND MATHEMATICS (STEM) RESEARCH $137,311,995 246
3 HEALTH AND MEDICAL RESEARCH $80,216,522 72
4 HUMANITIES, ARTS AND SOCIAL SCIENCES (HASS) RESEARCH $39,451,573 87
5 PUBLIC HEALTH SERVICES $37,688,410 2
6 AGED CARE $29,096,156 53
7 SERVICES FOR PEOPLE WITH DISABILITIES $22,001,574 10
8 INDIGENOUS EDUCATION $16,324,000 1
9 HIGHER EDUCATION $7,907,006 3
10 REGIONAL DEVELOPMENT $4,198,318 25
11 TRANSPORT $3,998,366 4
12 INDUSTRY INNOVATION $3,279,122 45
13 PUBLIC HEALTH AND SAFETY $2,113,276 1
14 MENTAL HEALTH $1,650,000 1
15 CANCER $1,620,000 2
16 COMMUNITY DEVELOPMENT $519,364 36
17 BUSINESS DEVELOPMENT $394,399 2
18 ADDICTION AND SUBSTANCE ABUSE $357,500 1
19 SCIENTIFIC RESEARCH $352,261 10
20 NATURAL RESOURCES - CONSERVATION AND PROTECTION $270,642 4
21 MULTICULTURALISM $210,182 4
22 FARMING $206,800 1
23 SCIENCE $170,500 3
24 PUBLIC DIPLOMACY $139,216 6
25 HUMANITIES $88,000 1
26 COMMEMORATIVE $49,148 7
27 COMMUNITY SAFETY $48,354 1
28 CLIMATE CHANGE $35,149 1
29 SOCIAL JUSTICE $29,954 1
30 NATIONAL SECURITY $21,400 1
31 VETERANS $12,850 3
32 INDIGENOUS ARTS AND CULTURE $900 1

109 organisations in the electorate of HOTHAM have been awarded Commonwealth grants

1MONASH UNIVERSITY$534,081,322 662
2MTP?IIGC $63,497,500 6
3LINK HEALTH AND COMMUNITY $18,707,569 9
4STARS FOUNDATION $16,324,000 1
5MONASH HEALTH$12,669,520 13
6MONASH CITY COUNCIL$7,706,650 12
7THE JEAN HAILES FOUNDATION$6,248,000 2
8OC CONNECTIONS $4,968,513 3
9AUSTRALIAN AUTOMOTIVE AFTERMARKET ASSOCIATION LIMITED$3,941,666 2
10FUSION AUSTRALIA $3,482,319 7
11MECRUS $3,300,000 1
12AUSTSWIM $2,113,276 1
13BENTLEIGH BAYSIDE COMMUNITY HEALTH $2,032,263 7
14AUSTRALIAN ADHD PROFESSIONALS ASSOCIATION $1,650,000 1
15M RIEWOLDT HOLDINGS LIMITED$1,000,000 1
16CYLITE $865,013 3
17SOUTH EAST VOLUNTEERS $689,626 3
18WHATEVER SUPPORT WHENEVER $494,098 1
19POLISH COMMUNITY CARE SERVICES $380,495 2
20CARECHOICE AUST AS TRUSTEE FOR CARECHOICE BUSINESS TRUST$302,848 1
21WATCH DISABILITY SERVICES$259,130 1
22POLISH COMMUNITY COUNCIL OF VICTORIA$222,212 6
23GRASSLAND SOCIETY OF SOUTHERN AUSTRALIA$206,800 1
24GYDER SURGICAL $201,899 1
25KESEM HEALTH$192,500 1
26HAWTHORN FOOTBALL CLUB $187,000 1
27MONASH UNIVERSITY$132,210 5
28COMMUNITY ABUNDANCE $114,768 1
29INYER POCKET SOFTWARE $88,000 1
30CHILD AND FAMILY CARE NETWORK$84,150 2
31WAVECARE $65,192 3
32TASKFORCE COMMUNITY AGENCY$60,500 2
33DIXON HOUSE NEIGHBOURHOOD CENTRE$55,000 2
34AUROSCIENCE $55,000 1
35HUDSON INSTITUTE OF MEDICAL RESEARCH$49,210 1
36THE TRUSTEE FOR SELIGMANN--TRUST$48,354 1
37WAVLINK$47,055 2
38UNCLE CHARLIES $44,000 2
39SWINBURNE UNIVERSITY OF TECHNOLOGY$39,644 1
40COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION CSIRO$37,000 2
41DELTA ENERGY SYSTEMS AUSTRALIA $33,000 1
42OPTISCAN $33,000 1
43EASTERN INNOVATION BUSINESS CENTRE $26,400 1
44HRL TECHNOLOGY GROUP $22,000 1
45IDENTIFIBRE $22,000 1
46THE TRUSTEE FOR RAKUMBA TRUST$22,000 2
47ECO RECYCLERS $22,000 1
48IMPLANT SOLUTIONS $22,000 1
49R AND I INSTRUMENT AND GEAR CO AUST $22,000 1
50FLINDERS ISLAND MEAT $22,000 1
51MITCHELL LAMINATES $21,450 2
52DR JACQUI TRUE$21,400 1
53MACKIE CRICKET CLUB$20,000 1
54CRANBOURNE FRIENDS ROYAL BOTANIC GARDENS VICTORIA$20,000 1
55CENTENARY PARK TENNIS CLUBORPORATED$17,474 1
56DINGLEY VILLAGE NEIGHBOURHOOD CENTRE$17,248 1
57ORMOND JUNIOR FOOTBAL CLUB$16,796 1
58PONY CLUB ASSOCIATION OF VICTORIA$16,500 1
59OAKLEIGH-CARNEGIE RSL SUB-BRANCH$16,288 2
60CHATSWOOD RSL CLUB $14,546 1
61WAVERLEY CITY ARCHERS$14,000 1
62ORMOND TENNIS CLUB $12,500 1
63AUSTRALIAN REHABILITATION AND ASSISTIVE TECHNOLOGY ASSOCIATIONO$11,000 1
64ROBOCUP JUNIOR (AUSTRALIA)$11,000 1
65WHEELERS HILL TENNIS CLUB$10,358 1
66TEMPLE SOCIETY AUSTRALIA$10,111 3
67TAMIL SENIOR CITIZENS FELLOWSHIP VIC $9,215 1
68INDIAN SENIOR CITIZENS ASSOCIATION OF VICTORIA, AUSTRALIA$9,167 1
69WESLEY COLLEGE MELBOURNE $9,091 1
70MAKE A DIFFERENCE DINGLEY VILLAGE$9,075 2
71CEYLONESE WELFARE ORGANISATION $8,754 1
72BORTHWICK FOODS ? RETAIL $8,239 1
73BENTLEIGH ANA CRICKET CLUB$8,081 2
74GLENDAL PRIMARY SCHOOL$6,210 1
75GLEN WAVERLEY BOWLS CLUB$5,500 1
76SOS HEALTH FOUNDATION$5,500 2
77KILVINGTON GRAMMAR SCHOOL $5,478 1
78BRENTWOOD SECONDARY COLLEGE$5,000 1
79BAYSIDE HOCKEY CLUB$5,000 1
80TAMIL COMMUNITY EMPOWERMENT COUNCIL AUSTRALIA$5,000 1
81BENTLEIGH FOOTBALL NETBALL CLUB $5,000 1
82COOK ISLANDS WOMEN'S FEDERATION OF VICTORIA$5,000 1
83BENTLEIGH CRICKET CLUB$5,000 1
84MRS CHRISTINE MARLOW$5,000 1
85SAINT ELIZABETH CENTRE FOR SOCIAL ASSISTANCE$5,000 1
86SOUTH SPRINGVALE SOCCER CLUB$5,000 1
87U3A WHEELERS HILL$4,850 1
88OLYMPOS GREEK SENIOR CITIZENS CLUB$4,700 1
89WHEELERS HILL PRIMARY SCHOOL$4,524 1
90ROTARY CLUB OF MT WAVERLEY$4,503 1
91BENTLEIGH RECREATION TENNIS CLUB $4,250 1
92CARRINGTON PARK LEISURE CENTRE MANAGEMENT ASSOCIATION$3,800 1
93MOORABBIN AREA TOY LIBRARY$3,400 1
94WAVERLEY SOFTBALL ASSOCIATION$3,300 1
95GOLDEN FLOWER CHINESE FRIENDSHIP ASSOCIATION $3,200 1
96MONASH CHINESE FRIENDSHIP ASSOCIATION$3,150 1
97A TREE FOR GALLIPOLI - MOVE THE HOUSE$3,000 1
98WHEELERS HILL SECONDARY COLLEGE$2,925 1
99COOKIE CONCEPTS $2,750 1
100OAKLEIGH OCCASIONAL CARE CO-OPERATIVE LIMITED$2,750 1
101ALBANY RISE PRIMARY SCHOOL$2,735 1
102MONASH OAKLEIGH COMMUNITY SUPPORT AND INFORMATION SERVICE$2,600 1
103OAKLEIGH BOWLING CLUB $2,500 1
104CLAYTON MANDARIN FRIENDSHIP ASSOCIATION$2,500 1
105SOUTH EASTERN MULTIPLE BIRTH ASSOCIATION VICTORIA$2,448 1
106I MATTER FOUNDATION $2,000 1
107DINGLEY VILLAGE HISTORICAL SOCIETY$1,375 1
108CIRCOLO PENSIONATI "DON BOSCO"$1,321 1
109U3A MOORLEIGH$1,000 1
2016-17
[5] $561,781
2017-18
[259] $158,207,084
2018-19
[341] $360,266,071
2019-20
[247] $168,305,328

2017-18 HOTHAM grants

SOUTH EAST VOLUNTEERS
Hotham  $365,750
Address GLEN WAVERLEY 3150 VIC AUSTRALIA ABN: 66484048216
Portfolio Social Services
Agency Department of Social Services
Program Families and Communities
Component Volunteer Management Activity
CategoryCommunity Development Targeted or Restricted Competitive
PurposeVolunteer Management supports the delivery of volunteer support services and one-off innovation and collaboration projects to encourage, support and increase participation in volunteering.
ActivityVolunteer Management
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
29 Nov 201721 Feb 201801 Jan 201830 Jun 2021 2017-18
WESLEY COLLEGE MELBOURNE
Hotham  $9,091
Address Glen Waverley 3150 VIC AUSTRALIA ABN: 55611238530
Portfolio Defence
Agency Department of Veterans Affairs
Program Commemorative Activities
Component Armistice Centenary Grants Program
CategoryCommemorative Closed Non-Competitive
PurposeWrite a book on the service of former Wesley College students in the First World War.
ActivityBook on the Service of Former Wesley College Students in First World War Project
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
29 Jun 201831 Jul 201818 Jul 201828 Feb 2019 2017-18
MITCHELL LAMINATES
Hotham  $5,500
Address DINGLEY 3172 VIC AUSTRALIA ABN: 51056527907
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Growing Business Investment and Improving Business Capability
Component Entrepreneurs' Programme - Business Management
CategoryIndustry Innovation Demand Driven
PurposeA Business Growth Grant has been awarded to undertake strategic business activities.
ActivityBusiness Growth Grant
Delivery Area 3172 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
28 Mar 201811 Apr 201803 Apr 201830 Aug 2018 2017-18
HUDSON INSTITUTE OF MEDICAL RESEARCH
Hotham  $49,210
Address CLAYTON 3168 VIC AUSTRALIA ABN: 48132025024
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Supporting Science and Commercialisation
Component Science for Australia's Future - Inspiring Australia
CategoryScientific Research Open Competitive
PurposeHudson Institute of Medical Researchs 'Inspiring Future Women Leaders in STEM' program offers a laboratory experience for female secondary school students from the Institutes local community, in the south-eastern suburbs of Melbourne. The aim is to encourage more young women to consider a career in science. Over two years (2018-19), a total of 24 female students from Year 10 and 11 will work with leading female scientists in research and daily activities at the institute. Ten students will participate each year, with an additional two opportunities for female indigenous students. The two week immersion program includes exploring a scientific research project in the laboratory, seminars, events, exposure to bio'scientific technologies and forums to seek career advice from scientists and postgraduate students. The project will culminate in an event for teachers and families where students will present their research projects and experiences.
ActivityInspiring Future Women Leaders in STEM
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
28 Mar 201812 Jun 201808 Jun 201823 Mar 2021 2017-18
AUSTRALIAN AUTOMOTIVE AFTERMARKET ASSOCIATION LIMITED
Hotham  $641,666
Address CLAYTON 3168 VIC AUSTRALIA ABN: 23002271454
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Growing Business Investment and Improving Business Capability
Component Encouraging Innovation in Advanced Manufacturing
CategoryTransport
PurposeTo set up an automotive aftermarket innovation lab which will increase the capabilities of Australian businesses and aid in the development of new automotive aftermarket products for local and export markets.
ActivityEstablishment of automotive aftermarket product testing facility
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Jun 201816 Jul 201828 Jun 201830 Jun 2019 2017-18
MONASH UNIVERSITY
Hotham  $27,000
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Infrastructure and Regional Development
Agency Department of Infrastructure and Regional Development
Program Department of Infrastructure and Regional Development
Component Used Car Safety Ratings Update 2018
CategoryTransport
PurposeContribution to the Monash University Accident Research Centre's Vehicle Safety Research group research program (Used Car Safety Ratings update and related research)
ActivityUsed Car Safety Ratings Update 2018
Delivery Area 3800 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
26 Mar 201828 Mar 201826 Mar 201830 Jun 2018 2017-18
MTPCONNECT
Hotham  $143,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 53608571277
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Growing Business Investment and Improving Business Capability
Component Industry Growth Centres
CategoryIndustry Innovation
PurposeTo undertake an analysis in determining the feasibility of employing an adaptive regulatory framework in the Australian digital health industry. Also to undertake preparatory activities for organising a showcase in demonstrating the outputs of the work
ActivityIndustry Growth Initiative
Delivery Area 2008 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
26 Jun 201805 Jul 201828 Jun 201830 Jun 2019 2017-18
MONASH UNIVERSITY
Hotham  $350,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component Linkage Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop innovative techniques to produce advanced tungsten oxide/metal oxide/mica composites for paint applications. The findings will be used to develop pearlescent paints for diverse applications in a range of industries, with the potential for huge benefits in improving the value of metal oxides and mica. The findings will be useful in the development of other new materials and provide a foundation for new applications such as photochromic and self-cleaning paints. This will generate opportunities to develop and apply advanced knowledge to solve significant problems in industry, leading to national economic growth by adding high values of mineral resources in Australia.
ActivityDevelopment and application of WO3-Mica Multifunctional Nanocomposites
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
26 Feb 201806 Mar 201806 Mar 201905 Mar 2022 2017-18
MONASH UNIVERSITY
Hotham  $223,507
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component Linkage Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate the possible benefits of 3D printing for production of accessible materials for vision-impaired people. Currently tactile graphics are used to provide severely vision-impaired adults and children with access to graphical content used in education and in orientation and mobility training. This project is expected to clarify the kinds of graphics for which 3D prints are better suited than tactile graphics, and to build capacity within the national accessible format provision sector for the production and use of 3D prints. Benefits will include increased educational opportunities and quality of life for Australians with severe vision impairment, through improved access to graphic materials used in education and orientation and mobility training.
ActivityUsing 3D printing to improve access to graphics by vision-impaired people
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
26 Feb 201806 Mar 201804 Sep 201804 Sep 2021 2017-18
MONASH UNIVERSITY
Hotham  $498,545
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component International Joint Calls
CategoryMedical Research Targeted or Restricted Competitive
PurposeThere are no national policies or programs for adolescent mental health in Vietnam, despite high prevalence of mental health problems. We aim to improve the mental health of Vietnamese adolescents by establishing whether a cultural adaptation of the Resourceful Adolescent Program, an evidence-based intervention, is effective in preventing symptoms of depression and suicidal behaviours. This adaptation will provide essential evidence for integration of RAP into school-based programs in Vietnam.
ActivityGNT1158429 | Addressing an unrecognised public health problem in Vietnam: a clustered randomised controlled trial of the culturally adapted Resourceful Adolescent Program (RAP-V) to improve adolescent mental health
Delivery Area Multiple VIC, QLD, Overseas AUSTRALIA, VIET NAM
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $128,225
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeTriage is an essential component of Emergency Department care. It aims to sort patients based on the urgency of their condition such that the highest acuity patients are prioritised for treatment. This research proposal aims to review Australian and international triage scales to assess their effectiveness. In particular, it will investigate whether the Australasian Triage Scale remains fit for purpose, and evaluate the recently devised World Health Organization Triage Scale.
ActivityGNT1169298 | Triage systems for emergency care: a contemporary evaluation
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $99,842
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeLupus (SLE) is a chronic autoimmune disease affecting many parts of the body including the brain. Lupus brain fog, or trouble with thinking, concentration and memory, is common, but little is known about why it occurs and what can be done about it. This study aims to improve tools to measure Lupus brain fog, and examine for any predictors, including new biological markers or imaging findings that can identify patients at risk. Effects on patient's function and well-being will also be measured.
ActivityGNT1168941 | Cognitive dysfunction in SLE: diagnostic tools, biological correlates and patient impact
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201930 Apr 2021 2017-18
MONASH UNIVERSITY
Hotham  $128,225
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeKnowledge gaps exist regarding osteoporosis within the community and clinicians in regional/rural Victoria. These knowledge gaps contribute to sub-optimal health related behaviours and clinical management. We will develop, implement and evaluate a co-designed innovative model of care, addressing both consumer and clinician factors, that will lead to improved OP outcomes for rural / regional Victorians, and which may be used to guide practice in other chronic conditions.
ActivityGNT1169192 | Osteo-improve: Development and evaluation of a co-designed, innovative health service delivery and community education initiative to improve regional and remote consumer and clinician osteoporosis understanding and management.
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $128,225
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeAntimicrobial resistance (AMR) threatens to undo decades of medical progress, via infections that are challenging or impossible to treat with antibiotics. Little is known about AMR in developing countries. Our proposed research will occur at Fiji's largest hospital. We will initially identify baseline rates of antimicrobial use and resistant organisms, then assess attitudes of key stakeholders towards antimicrobial stewardship, and finally design a tailored series of intervention to reduce AMR
ActivityGNT1169220 | Ways of Halting Antimicrobial resisTance In Fiji (WHAT-IF)
Delivery Area Multiple VIC, Overseas AUSTRALIA, FIJI
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $111,974
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeOur planet needs to produce enough food to feed a growing population. To protect our natural resources, individuals must change the way they eat. Local governments can support people to eat a more environmentally sustainable diet by investing in effective policy interventions. This research will describe existing policy options, explore the ways that these policies are created and finally, work with stakeholders to co-create guidelines for effective future policy work.
ActivityGNT1169213 | Protecting our planet and our population: the local government policy response to support an environmentally sustainable diet
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $128,225
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeHypertension affects millions of Australians. Some of these cases are caused by primary aldosteronism (PA), a condition of excessive aldosterone production by the adrenal gland. This project aims to establish the prevalence of PA in primary care; and to identify early clinical features and novel cellular markers that may help distinguish PA from other causes of hypertension. Findings from this project may influence guidelines on hypertension management in Australia.
ActivityGNT1168132 | Primary Aldosteronism: Prevalence, Clinical Features, and Biomarkers
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $128,225
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeWhen people are around birds, molds and dust, they may inhale small particles which can permanently damage their lungs. In some cases this leads to a disease called chronic hypersensitivity pneumonitis. It is not clear how much, over how long, and what types of exposure lead to this disease, and what protection might help. This project aims to develop a systematic tool to help doctors diagnose, treat and educate patients using rigorous evidence based methods.
ActivityGNT1169204 | Clinical and biological approaches to improving diagnostic confidence of Chronic Hypersensitivity Pneumonitis
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $114,033
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeBy 2050, a large proportion of the Australian population will be over 65. Traditional healthcare settings are unlikely to cope with the increased monitoring and treatment demands of this aged population. Most patients would prefer to maintain autonomy and independence without sacrificing the security that exists in the hospital. This PhD aims to explore new modalities that enable the advanced monitoring that exist in the Intensive Care, in nontraditional settings such as home, or nursing homes.
ActivityGNT1168809 | Advances in Contactless Patient Monitoring in the Inpatient Setting
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Aug 2021 2017-18
MONASH UNIVERSITY
Hotham  $872,196
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Partnership Projects
CategoryMedical Research Targeted or Restricted Competitive
PurposeGeneral practitioners (GPs) play a key role in the care of patients with work related mental health conditions but find this area of practice very difficult. Our study aims to improve the care GPs provide to patients with these conditions and patient health and return to work outcomes by implementing a national evidence based guideline on diagnosing and managing work-related mental health conditions in general practice.
ActivityGNT1160223 | IMPRovE: Implementing work-related Mental health guidelines in general PRacticE
Delivery Area Multiple NSW, VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Dec 201830 Nov 2022 2017-18
MONASH UNIVERSITY
Hotham  $181,066
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component TRIP Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeCancer patients are frequently malnourished prior to treatment, with prevalence as high as 90 percent for people with cancer of the gastrointestinal tract. Malnutrition reduces the patient's ability to respond to treatment and quality of life. Individualised nutrition care commencing prior to cancer treatment is best-practice, yet Health services lack affordable resources to deliver this service. In this proposal a mechanism to implement this much needed service will be developed.
ActivityGNT1168483 | Implementation of earlier evidence-based nutrition for people with upper gastrointestinal cancer.
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $181,066
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component TRIP Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeRetail food environments are an effective and critical target to improve population diet quality. This project will accelerate the uptake of initiatives in remote communities to improve the store food supply. It will support public health nutritionists to engage with remote retailers in the co-development and monitoring and evaluation of strategies that are contextually relevant and economically viable for retailers, while also effective in improving population diet.
ActivityGNT1168333 | Reducing the burden of disease and inequity through building a food system that supports healthy eating in remote Indigenous Australian communities
Delivery Area Multiple VIC, NT AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $181,066
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component TRIP Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeKnee pain, a common health problem lacking of effective therapy, is a predictor of future knee pain, disability, and adverse joint and health outcomes. There is an urgent unmet need for a sustainable, low-intensity preventive intervention for early knee pain. I propose to adapt and implement the HeLP-her in men and women of low socioeconomic status and rural regions who are overweight/obese or have early knee pain, applying new delivery modes, to reduce the burden of knee pain in the community.
ActivityGNT1168185 | HeLP-knee (Healthy Lifestyle Program for knee pain prevention) - a sustainable low-intensity self-management lifestyle intervention for reducing the burden of knee pain in the community
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $181,066
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component TRIP Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis fellowship project addresses the important problem of overuse of arthroscopic surgery for knee osteoarthritis. High quality evidence shows arthroscopy is ineffective and potentially harmful. Despite this, over 30,000 Australians undergo this surgery annually at a cost of greater than$32 million to Medicare. I propose to evaluate whether a patient decision aid is effective in improving patients- knowledge and risk perceptions about knee arthroscopy and reduces referrals for knee arthroscopy.
ActivityGNT1168749 | Reducing low-value knee arthroscopy in Australia
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $181,066
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component TRIP Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeThere is a major evidence-practice gap in the management of carotid stenosis (main brain artery narrowing). Globally many billions of dollars are wasted annually on unnecessary carotid procedures. This inappropriate industry is driven by all identified guidelines. I will lead experts in creating the world's first -evidence-true- guideline for carotid stenosis and determine how to best prevent arterial disease complications in these and other patients using only lifestyle coaching and medication.
ActivityGNT1168295 | Improving Prevention of Stroke and Other Arterial Disease Complications by Closing Evidence-Practice Gaps
Delivery Area Multiple NSW, VIC, WA, Overseas AUSTRALIA, AUSTRIA, GREECE, ITALY, UNITED KINGDOM, UNITED STATES
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $1,023,119
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeHow do antidepressants impact epilepsy development- This is a basic science proposal to seek to understand the interaction between antidepressant medications and epilepsy.
ActivityGNT1157353 | Antidepressants in epilepsy
Delivery Area Multiple VIC, Overseas AUSTRALIA, FINLAND
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $799,120
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeAlthough a number of organs can repair themselves from mild injury, when subjected to ongoing/persistent injury, they fail to properly do so. As a result, they undergo organ scarring (fibrosis) and a progressive loss of function. As currently available therapies fail to effectively stop this scarring process, we aim to combine an anti-fibrotic agent (serelaxin) with bone marrow-derived stem cells to effectively block fibrosis and further improve tissue repair and function.
ActivityGNT1156446 | Enhancing the anti-fibrotic and regenerative capacity of bone marrow-derived stem cells
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $796,802
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeChagas disease is a terrible parasitic disease and is described as the most burdensome neglected tropical disease in Latin American countries. An estimated 6 - 7 million people are infected worldwide with approximately 25 million people living at risk of infection. We have small molecules that inhibit the causative parasite, Trypanosoma cruzi. In this project we will improve potency and metabolic stability to furnish a therapeutic candidate for Chagas disease.
ActivityGNT1156436 | New Treatments for Chagas Disease
Delivery Area Multiple VIC, Overseas AUSTRALIA, BRAZIL, UNITED KINGDOM
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $1,392,005
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeWhen the immune system malfunctions it can cause the body to lose tolerance one or more of its own proteins, leading to autoimmune diseases that affect more than 5 percent of the population. This project uses autoimmune kidney disease to study why we lose tolerance to ourselves. Understanding this process is not only fundamental to defining the basis of autoimmune diseases but also a key step in the development of more effective, more targeted and less toxic therapies in the future.
ActivityGNT1162384 | Defining key determinants of HLA mediated T cell tolerance and autoimmunity
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $820,985
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis proposal aims to shed light on the molecular mechanisms underpinning the health-promoting effects of exercise. This proposal will focus on defining how reactive oxygen species contribute to exercise-induced adaptive responses in muscle that promote metabolic health and prevent the age-related decline in muscle function. Our studies will shed light on mechanisms that help prevent disease in our increasingly sedentary and ageing populations.
ActivityGNT1162798 | The role of NOX4 in muscle antioxidant defence and mitochondrial biogenesis
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $1,195,066
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeWe identified patients who are susceptible to specific infections (influenza, herpes, etc.) due to deficiency in components of the interferon signaling pathway. Interferons are long known to protect from infections, but each component was thought to contribute broad protection not to specific pathogens. We will use cells from these patients to characterise new specific functions of interferon components and pathways to generate new biomarkers of disease, patient response and new therapies.
ActivityGNT1159713 | Unravelling the role of type I Interferon family in human infectious and inflammatory diseases
Delivery Area Multiple VIC, Overseas AUSTRALIA, UNITED STATES
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $692,599
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeParkinson's disease (PD) is a degenerative disorder of the central nervous system in which the underlying cause is, in most cases, unknown. To pave the way to a better understanding of what goes wrong, and how to fix it, this study will investigate the function of cellular repair pathways that break down in PD. The results of this study can be used to explore the potential of new therapeutic targets and small molecules to treat disease.
ActivityGNT1160315 | Understanding how mitochondrial quality control pathways cooperate to maintain mitochondrial health
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $669,790
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeMany women suffer from either failed fertilisation or their embryos arrest during early development. This often results because their eggs have too few copies of mitochondrial DNA otherwise known as mitochondrial DNA deficiency. We will show how supplementation with autologous populations of mitochondrial DNA induce changes in the genes that an embryo expresses to promote the transition from a metabolically poor fate to a metabolically healthier fate.
ActivityGNT1160106 | Understanding how mitochondrial DNA contributes to embryo development.
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $766,585
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeMany bacterial 'superbugs- can increase their mutation rate, i.e. become hypermutable, and rapidly become resistant to many antibiotics. A near worst-case scenario are multidrug-resistant hypermutable bacteria that cause increased ill-health and death in patients and current treatments do not work well. We will develop improved treatments, using combinations of available antibiotics, that can effectively kill the pathogens and minimise resistance.
ActivityGNT1159579 | Overcoming multidrug-resistant hypermutable Pseudomonas aeruginosa via antibiotic combinations
Delivery Area Multiple VIC, Overseas AUSTRALIA, SPAIN
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $722,284
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeMitochondria are the powerhouses of our cells that produce the chemical ATP for functions such as muscle contraction and triggering of nerves. Mitochondrial Complex I is a molecular motor that helps to make this ATP. -Mitochondrial disease- is often seen when Complex I is defective resulting in early childhood death. In this project we will study the structural importance of components of Complex I and investigate the hypothesis that they also have additional functions in mitochondria.
ActivityGNT1164459 | Dissecting the functions of accessory subunits in mitochondrial complex I
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $574,323
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeAchilles tendinopathy is a painful condition that restricts weight bearing activity. Exercise treatments are first choice but often fail. Injections and surgery may then be offered but do not work well. Our studies suggest that high volume injections may improve Achilles tendinopathy symptoms, but require further testing. We will, for the first time, test this injection on Achilles tendinopathy symptoms over a year.
ActivityGNT1164268 | Efficacy of high volume injections compared to placebo following failure of conservative therapy for Achilles tendinopathy
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $542,521
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe major objective of this research is to elucidate new mechanisms that control stem cell development. The biochemical pathways under study are potentially druggable with small molecules. Therefore, this project has the potential to identify processes and pathways that are directly relevant to health and disease.
ActivityGNT1161439 | Controlling Stem Cell Development Through Calcium-Mediated Transcription
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $884,384
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeT cells are a critical component of the immune system that can recognise infected host cells. However, there remains many facets of T cell function that we do not understand. This project aims to investigate a major aspect of T cell-mediated immunity that is poorly understood, namely, T cell immunity to metabolites. Specifically, using a multi-disciplinary approach, this project will unearth the molecular correlates of metabolite-based immunity in humans.
ActivityGNT1159932 | Investigating diversity within the MR1-restricted T cell repertoire in humans
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $631,653
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeMPO-ANCA associated glomerulonephritis and acute kidney injury are important causes of inflammatory kidney disease. In these diseases, specialised white blood cells called mast cells (MCs) enhance injurious inflammation by releasing packages of inflammatory proteins, a process called degranulation. This pre-clinical study will re-purpose an anti-allergy drug, disodium cromoglycate to prevent and or treat inflammatory kidney diseases.
ActivityGNT1159361 | Immunomodulatory Mast Cells as Therapeutic Agents in Chronic Autoimmune and Acute Inflammatory Kidney Disease
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $747,518
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeType 2 diabetes (T2D) results in 3.7 million deaths each year. T2D is characterised by impaired blood sugar control (glucose homeostasis) due to defective insulin signalling. Insulin is secreted after a meal by the pancreas to instruct the muscle/fat to uptake glucose from the blood. Insulin also signals to the brain but the significance of this remains unclear. We aim to determine where and how insulin is integrated into the brain and determine its contribution to glucose homeostasis and T2D.
ActivityGNT1160043 | Insulin on the Brain: Determining how insulin signalling in the brain coordinates glucose homeostasis
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $950,184
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeStem cells are essential for maintenance and repair of many adult tissues including testis. Within a given tissue, different populations of stem cells can play contrasting roles in tissue maintenance and regeneration. We have identified a group of stem cells within the testis marked by a unique set of genes critical during embryo development. Our studies will assess the role of this new cell population in male fertility and testis repair and define genes required for its function.
ActivityGNT1164019 | Regulatory networks defining stem cell populations in the adult male germline
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $881,568
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis project will determine how a class of weightloss drugs (melanocortin agonists) increases blood pressure. This may pave the way for better drugs with fewer side effects, and also better understanding of the neural mechanisms that control blood pressure.
ActivityGNT1163341 | Can we engage weight loss circuits in the brain without causing hypertension-
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $645,788
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeAdvanced medical treatments come with a high risk of life-threatening microbial infections, and rising antimicrobial drug resistance demands innovative therapeutic strategies. In this project, we will characterize metabolic regulation as a novel therapeutic target in infection, focusing on the human fungal pathogen Candida albicans that causes hospital infections with 40 percent mortality. Our outcomes will be broadly relevant to designing improved therapies against infectious diseases.
ActivityGNT1158678 | An investigation into metabolic competition between host and pathogen in infection
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $654,920
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeTo cause disease, viruses enter host cells and build new progeny virions, that spread and cause further infections. Critical to this is the ability of viruses to transform host cells into virus factories by -reprograming- the cellular machinery. Using highly lethal pathogens, we identified a new strategy by which viruses mimic normal cellular responses to change the cellular synthetic machinery. By elucidating these mechanisms, this work should identify new potential targets for therapies.
ActivityGNT1160838 | Viral hijacking of the nucleolar DNA damage response machinery: novel mechanisms to regulate host cell biology
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $5,815,766
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe Statins in Reducing Events in the Elderly (STAREE) is a large scale primary prevention trial based in Australian general practice that is examining whether statin therapy prolongs independent living and reduces cardiovascular events in older adults (-70 years) without established vascular disease or diabetes.This application seeks support to complete participant follow-up and collection of clinical data essential to confirm study outcomes.
ActivityGNT1161503 | Statins in Reducing Events in the Elderly trial
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $570,888
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe body needs to react if blood sugar levels become abnormally low in order to prevent harmful life-threatening consequences. While hormonal cues from the periphery inform the brain about blood sugar levels, the brain is the main player to initiate counterregulation. The neuronal circuit how the brain senses glucose and initiates regulatory responses is unknown and will be the topic of this proposal.
ActivityGNT1160065 | How does the brain sense low glucose levels and switch on corrective actions-
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $936,759
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeVascular disease is a major cause of mortality in diabetes. Current treatments are inadequate as cardiovascular disease still represents more than 70 percent of mortality in people with diabetes. Our exciting new data demonstrate that a novel endogenous small molecule (Lipoxin A4) has protective effects against the pathological processes within vascular cells that drive atherosclerosis. This represents a promising approach to combat diabetic complications such as diabetes-associated atherosclerosis.
ActivityGNT1159460 | Lipoxins protect against diabetes associated atherosclerosis
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $1,397,337
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposePelvic organ prolapse is a hidden, debilitating gynaecological disorder affecting 25 percent of women causing sexual, bladder and bowel dysfunction. Prolapse is the herniation of the uterus, bladder, or bowel into the vagina as a result of childbirth injury. Surgical treatment often fails and the use of vaginal mesh has been banned due to unacceptable side effects. We are developing a cell-based therapy using a woman's own endometrial stem cells to repair the damaged tissue.
ActivityGNT1159677 | Cells and Nanobiomaterials to Treat and Prevent Pelvic Organ Prolapse
Delivery Area Multiple VIC, Overseas AUSTRALIA, UNITED KINGDOM
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $1,162,535
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe calcitonin-family receptor are physiologically important receptors that have been implicated in treatment of osteoporosis, migraine and cardiovascular diseases. Therapeutic development targeting at these receptors remains challenging due to lack of mechanistic understanding in how these GPCRs are activated. This proposal will explore the structure and function of the calcitonin-family receptors at a molecular level, enabling improved discovery and development of novel therapeutics.
ActivityGNT1159006 | A structural understanding of calcitonin gene-related peptide and adrenomedullin function
Delivery Area Multiple VIC, Overseas AUSTRALIA, NEW ZEALAND
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $672,521
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeShutdown of ovarian function at menopause depletes the female body of circulating oestrogen and inhibins. Whilst it is known that oestrogen deprivation is bad for bone health, little is known about the impact of inhibin loss. I have made a mouse that lacks functional inhibins, so that we can understand the body wide consequences of inhibin loss at menopause. Additionally, I have found a way to mass produce inhibins, allowing us to explore the potential of inhibin replacement therapies.
ActivityGNT1157680 | Defining the Physiology and Therapeutic Potential of Inhibin
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $1,242,532
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe glucagon-like peptide-1 receptor is a major drug target for treatment of type 2 diabetes and obesity. Different drugs acting at this receptor are capable of producing distinct physiological outputs, but a detailed understanding of the profile of receptor response that provides optimal clinical effectiveness is lacking. This project addresses this critical knowledge gap and will lead to improved for strategies to screen and develop new and better medicines.
ActivityGNT1157539 | The physiological and pathophysiological relevance of glucagon-like-peptide-1 receptor biased agonism
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $1,413,033
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeShift workers, as a result of their work schedules, are more likely to be overweight. Eating at night contributes to this increased risk. Effective strategies for weight loss are needed for this population and intermittent fasting (IF) and time restricted eating are two flexible approaches that may suit. We will investigate weight loss effectiveness of three diets: standard energy restriction; IF (day time fast) and IF (night time fast) in shift workers who are overweight.
ActivityGNT1159762 | Shifting Weight using Intermittent Fasting (the SWIFt study): A novel weight loss intervention in shift workers with obesity
Delivery Area Multiple VIC, SA AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $625,788
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeFungal infections cause 1.5 million deaths annually. Current antifungal drugs are insufficient, and the mortality from systemic fungal infections surpasses mortality from bacterial infections. This project aims to characterize how gene regulation by a short chain fatty acid inhibits disease-related processes in a major fungal pathogen. The outcomes will lay the foundation for developing improved antifungal therapies.
ActivityGNT1158687 | Control of host-pathogen interactions and fungal virulence by short chain fatty acids
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $1,256,312
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeFetal growth restriction (FGR) is a common but devastating pregnancy condition where the fetus fails to thrive, and brain development is particularly vulnerable. We have shown that the brain injury present in FGR offspring is complex, altering basic cell morphology, and cell communications. This project will examine and compare the neuroprotective benefits of 2 treatments in our ovine model of FGR, to inform the future clinical care for FGR and reduce neurodevelopmental brain injury.
ActivityGNT1160393 | Optimising neurodevelopmental outcomes for fetal growth restriction
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $989,384
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeMuscle stem cells repair muscle during injury and diseases such as muscular dystrophy. How they are activated and replace copies of themselves for activation during future repair is largely unknown. The immune system appears to help coordinate this process and we are looking at cell and signals that coordinate muscle stem cell repair.
ActivityGNT1159278 | Defining the molecular basis of macrophage-mediated muscle stem cell activation
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $1,371,900
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis project aimed to improve outcome of patients with acute ischaemic stroke by improving the safety of current treatments. This project also aims to develop a new test to predict the outcome of current clot-busting treatments to better identify patients for thrombolysis and to minimise risk.
ActivityGNT1156506 | Improving the safety and predictable efficacy of thrombolytic therapy in acute ischaemic stroke
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $643,734
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeFor almost 80 years, the main way to treat advanced prostate cancer has been to cut off the supply of male hormones. Unfortunately, this is only temporarily effective and compromises patients- quality of life. New clinical trials show that the reverse approach - over'supplying hormones to the tumour - is effective and improves quality of life. This project will use novel models of prostate cancer to identify which patients will get the most benefit from this new treatment strategy.
ActivityGNT1156570 | Giving prostate cancer enough rope with bipolar androgen therapy
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $817,063
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeEmbryo implantation is a critical step in establishing pregnancy and a major hurdle in IVF treatment to overcome infertility. The uterus must remodel considerably to become -receptive- for an embryo to implant. However, how the human uterus develops this receptivity is not well understood and this knowledge gap severely hampers IVF treatment. This project will investigate a novel uterine shield controlling human uterine receptivity and its clinical application in improving IVF success rates.
ActivityGNT1156666 | The magic shield of the human uterus and fate of embryo implantation
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $667,521
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis proposal will investigate how the bacterium Staphylococcus aureus causes life-threatening infections. We will identify that bacterial toxins kill immune cells by hijacking host factors. The study will determine alternative therapeutic options to prevent lethal infections with antibiotic-resistant bacteria.
ActivityGNT1163556 | Pore-forming toxins of Staphylococcus aureus: imaging assembly, pore formation and killing
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $2,703,830
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeSevere traumatic brain injury is a leading cause of death and disability in Australia. Intensive care in this setting focuses on ensuring adequate delivery of oxygen to the injured brain, albeit current management may not always achieve this. We will randomly allocate 860 severely brain injured patients to either standard care, or a novel management protocol informed by early brain tissue oxygen monitoring. This strategy will hopefully lead to improved functional outcomes and major savings.
ActivityGNT1156636 | Brain Oxygen Neuromonitoring In Australia And New Zealand Assessment (BONANZA) Trial
Delivery Area Multiple ACT, NSW, VIC, SA, WA, QLD, Overseas AUSTRALIA, NEW ZEALAND
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $561,171
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe bacterial type VI secretion system is a molecular syringe that allows bacteria to deliver effector proteins, such as toxins, directly into other bacteria. This project will determine how these effector proteins are selected for delivery, how they interact with the secretion system structural proteins and how specific 'prey' bacteria are selected and targeted. This information will allow us to engineer novel toxic proteins and deliver these into the specific bacteria that we wish to control.
ActivityGNT1165036 | Co-opting bacterial weaponry: Manipulation of the Acinetobacter type VI secretion system for targeted killing of bacteria
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $978,979
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeCerebral palsy is a devastating life-long condition. A large proportion of cases are associated with exposure to inflammation at the time of preterm birth. There is no effective treatment. Our studies will examine how inflammation impairs brain development and function in preterm infants and test whether blocking a key inflammatory protein in the blood, called tumour necrosis factor, improves brain development. We will generate critical knowledge towards reducing disability in preterm infants.
ActivityGNT1164954 | Preventing inflammation-induced brain injury in preterm infants: targeting systemic tumour necrosis factor
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $623,386
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis project will increase the understanding of how the energy sensing kinase gene family enables cells to link information about nutrient status with their growth. As this gene family is conserved between flies and humans our studies are highly relevant to human biology. This research has long term benefits in manipulating the relationship between diet and animal growth for treatment of obesity, as well as in development of SIK3-directed therapeutics in cancer.
ActivityGNT1158335 | Deciphering the role of SIK3 in development and disease
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $1,825,648
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeCryopreservation extends platelet shelf-life from 5 days to 2 years. However, evidence is insufficient for widespread use. Our recent 121-patient pilot trial found encouraging results. We now propose an 808-patient definitive trial in bleeding surgical patients, measuring blood loss, transfusion requirement, complications, and cost. Even if cryopreserved platelets are only equivalent to liquid'stored platelets, their longer shelf-life would justify rapid change in clinical practice worldwide.
ActivityGNT1156641 | A phase III multicentre blinded randomised controlled clinical non-inferiority trial of cryopreserved platelets vs. conventional liquid-stored platelets for the management of post-surgical bleeding.
Delivery Area Multiple ACT, NSW, VIC, QLD, TAS AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $646,890
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeObesity-induced type 2 diabetes is a growing worldwide epidemic caused by excess consumption of saturated fat and processed carbohydrate. Central to disease development is inflammation-induced insulin resistance that is driven by inflammatory factor, interleukin-1- (IL-1-). This proposal seeks to define whether dietary stress triggers programmed cell death to induce IL-1 activation. This research may reveal novel strategies to treat type 2 diabetes and associated diseases (e.g. atherosclerosis).
ActivityGNT1162765 | Role of programmed cell death in NLRP3 inflammasome activation and Metabolic Syndrome
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $711,032
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeIschaemic stroke, resulting from an obstructive clot, comprised approximately 85 percent of all strokes. There are several new therapies including the clot-busting drug, and clot retrieval (ECR) for large clots . However, only a small subset of patients are eligible for these therapies. We have demonstrated that human amnionic stem cell can reduce stroke size in animal experiments. We thus propose a Phase 1 dose escalation trial to assess the safety of allogeneic stem cell in stroke patients.
ActivityGNT1163282 | I-ACT: Phase I trial of Amnion Cell Therapy for Ischaemic Stroke to establish the maximum tolerable dose
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $1,202,978
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeBariatric surgery and more particularly vertical sleeve gastrectomy (VSG) are widely performed to combat morbid obesity. To improve surgery and to ultimately replace it, it is necessary to understand how it works. Our preliminary data from an animal model shows that increased energy expenditure and improved glucose regulation in brown adipose tissue are essential to surgical success. This project will uncover what are the interactions between the gut and the brain that allow this to happen.
ActivityGNT1163039 | The vagus nerve and gut - brain interactions: the underpinnings of successful weight loss surgery through recruitment of Brown Adipose Tissue
Delivery Area Multiple VIC, Overseas AUSTRALIA, UNITED STATES
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $814,384
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeT cells are a critical component of the immune system, however, there remains many facets of T cell function that we do not understand. This project aims to investigate a major aspect of T cell-mediated immunity that is poorly understood, namely, T cell mediated autoimmunity. Specifically, using a multi-disciplinary approach, this project will unearth the molecular correlates of aberrant lipid-mediated that manifests notably in skin-mediated autoimmune disorders in humans.
ActivityGNT1161883 | An investigation into aberrant T cell reactivity towards lipids
Delivery Area Multiple VIC, Overseas AUSTRALIA, UNITED STATES
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $656,155
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe PATCH-2 trial is clinical trial of a drug known as tranexamic acid. This is a relatively inexpensive drug that is currently used in the hospital in patients undergoing cardiac surgery or in patients who have bleeding after delivery. The use of this drug in patients with severe trauma has not been tested in the pre-hospital setting. The PATCH-2 trial will test whether tranexamic acid given in the prehospital setting improves patient outcomes by decreasing the amount of bleeding after trauma.
ActivityGNT1165275 | Pre-hospital anti-fibrinolytics for traumatic coagulopathy and haemorrhage-2 (The PATCH2 Study)
Delivery Area Multiple NSW, VIC, SA, QLD, NT, TAS, Overseas AUSTRALIA, NEW ZEALAND
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $550,157
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeCurrent asthma treatment does not always overcome breathing difficulties during an asthma attack and does not target long-term structural changes such as fibrosis that making the airways stiffer and harder to relax. We propose that serelaxin - a synthetic form of a natural hormone - could treat both excessive airway contraction and fibrosis. By showing its dual actions overcome the limitations of current therapies, we will be able to progress this new treatment towards clinical use for asthma.
ActivityGNT1165690 | Simultaneously targeting airway contraction and fibrosis as a new therapeutic strategy for asthma
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $922,284
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis application examines how the immune response can be diversified to include peptide targets that have been reconstructed during their normal degradation. As such novel targets of immunity can be generated that cannot be predicted from the genome of the pathogen or the host. We will explore the mechanism of generation and immune consequences of these antigens constitutively and during influenza infection.
ActivityGNT1165490 | Diversification of immune responses through unanticipated proteolytic mechanisms
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $955,024
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposePatients with diabetes or chronic kidney disease are at high risk of severe kidney injury following cardiopulmonary bypass surgery in which the kidney suffers a loss of blood supply (ischaemia). We have identified two independent pathways by which ischaemia induces kidney failure. Inhibitors of these pathways will be tested in models of kidney ischaemia in animals with diabetes or chronic kidney disease. Positive findings can be rapidly translated into clinical trials in this common procedure.
ActivityGNT1156982 | New treatments to prevent acute kidney injury in high risk patients.
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $1,289,423
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposePerinatal asphyxia causes severe oxygen deficit (hypoxia) to the fetus/newborn before or during birth. Perinatal asphyxia causes an estimated 1 million deaths worldwide annually, with most deaths occurring within the first hours of life. Those that survive have a high risk of brain injury. This application aims to reduce the devastating consequences of asphyxia by improving the way infants are cared for in the delivery room.
ActivityGNT1158494 | Improving cardiopulmonary resuscitation of infants in the delivery room.
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $470,079
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe effect of pregnancy on the long-term health outcomes of women with Multiple Sclerosis (MS) is not well understood, and information about the impact of MS-therapies on neonatal outcomes is scarce. We will use statistical methods to assess how pregnancy and therapy use affect the health of women with MS and their babies. This will assist doctors and nurses in counseling women about family planning, and will allow pregnancy decisions to be made with the best medical evidence available.
ActivityGNT1156519 | Multiple Sclerosis: Pregnancy and Prognosis
Delivery Area Multiple NSW, VIC, SA, QLD, TAS, Overseas AUSTRALIA, GERMANY
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $341,339
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe clinical assessment of people with drug, alcohol or other behavioural addictions (e.g. gambling) has traditionally relied on measuring the frequency and severity of the behaviour itself, and not the underlying brain-based processes that lead to these problems. This study will test a neurocognitive framework for addictions - derived from a panel of world leading experts in the field - to establish a unifying, scientifically-informed understanding of the core processes driving addictions.
ActivityGNT1162031 | MonCOG: Validating a neurocognitive framework and developing a purpose-built assessment tool for addictions
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $860,028
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis project investigates the way in which the viruses are able to replicate themselves in host cells. We focus on the picornavirus family that cause illnesses with important health and economic consequences including serious heart infections such as myocarditis and pericarditis as well as the 'common cold'. Through detailed study of the molecular interactions involved in virus infection we will reveal new possible avenues of antiviral development.
ActivityGNT1161916 | Structural basis for ribosomal docking on a picornavirus type I IRES
Delivery Area Multiple VIC, Overseas AUSTRALIA, UNITED STATES
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $1,769,409
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeOver 50,000 new strokes occur annually. Transition to home after stroke is poorly managed within the health system with only half of patients receiving a care plan or prevention education at the time of hospital discharge. We propose a randomised controlled trial in 890 survivors of stroke to assess the effectiveness and value of a new discharge support intervention with 12 weeks of tailored electronic self-management support to reduce readmissions and improve self-efficacy within 90 days.
ActivityGNT1162596 | Recovery-focused Community support to Avoid readmissions and improve Participation after Stroke (ReCAPS)
Delivery Area Multiple NSW, VIC, Overseas AUSTRALIA, UNITED KINGDOM
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $877,192
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeMitochondria are important organelles that play roles in ATP generation, metabolism cell death. Recent evidence suggests that mitochondria can also cause long lasting effects on gene expression. We will investigate this possibility in oocytes by manipulating mitochondrial function and examining the impact on subsequent embryo development.
ActivityGNT1165627 | Mitochondrial metabolism and its role in the maternal epigenome
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $727,087
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeCure rates for acute leukemia have not improved over the last 20 years. One explanation for this lack of progress is the existence of cells within the leukemia that escape chemotherapy. Using genetically modified mice that can identify these cells, this project will examine the ways that these cells escape chemotherapy. This work will identify new ways to eliminate the cells that escape chemotherapy and lead to recurrence of the disease in most people.
ActivityGNT1165840 | Targeted therapies for chemo-resistant leukaemia cells
Delivery Area Multiple VIC, Overseas AUSTRALIA, SWITZERLAND
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $1,470,583
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeElderly people are at great risk of irregular heart rhythms and heart failure. Statin therapy may be beneficial but may also cause side effects among older people. Understanding the balance of benefits and risks of statin therapy is essential to guide doctors, patients and policy makers in how we should best approach keeping older people healthy.
ActivityGNT1165440 | The STAREE Heart Study
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $595,788
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeDisorders of the mitochondrial respiratory chain represent the most common inborn errors of metabolism in humans. Of these deficiencies, many are due to defects in the action of Complex IV. By understanding how different proteins come together to build Complex IV, we will understand their importance to mitochondrial disease pathogenesis.
ActivityGNT1165217 | Defining molecular pathways for COX2 maturation in mitochondrial Complex IV
Delivery Area Multiple NSW, VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $579,920
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe rapid emergence of antibiotic resistant bacteria is occurring worldwide. Research efforts to pursue alternative treatments are urgently needed. Bacteriophages (phages) are specialist viruses that infect and kill bacteria. The clinical use of phages to treat bacterial infections is termed -phage therapy-. We are investigating the use of phages to re'sensitise antibiotic-resistant bacterial infection to conventional antibiotics, allowing a novel combination treatment strategy.
ActivityGNT1156588 | Bacteriophage therapy increases antibiotic sensitivities in multiply antibiotic resistant Acinetobacter baumannii
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $409,717
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis project will describe the connections formed between hospitals by patient referral networks and use this information to propose innovative approaches to combat the spread of antimicrobial resistance.
ActivityGNT1156742 | Understanding Patient Movement Networks To Better Prevent Dissemination of Antimicrobial Resistance
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $657,521
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeOur aim is better understand the function of a host cell protein that is required for the replication of HIV-1, hepatitis C, Japanese encephalitis virus, West Nile virus and dengue virus. This host cell protein is a proven druggable target to limit viral infection, and yet we understand little of how it works. Our results will inform the development of novel broad'spectrum antiviral therapeutics.
ActivityGNT1157053 | Functional dissection of a unique DEAD-box helicase; target for antivirals
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $1,210,400
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis project will assess the impact of the Victorian Voluntary Assisted Dying Act (2017), which enables individuals with terminal illnesses to obtain a medicine to take their own lives. It will document the experiences of patients, families and health professionals, develop a framework for ongoing evaluation of VAD, and help ensure adequate protections for those who are most vulnerable. Thereby, it will contribute to the enhancement of end of life care both in Victoria and around the world.
ActivityGNT1161502 | A new direction in end of life care- Assessing the impact and outcomes of the Victorian Voluntary Assisted Dying Act
Delivery Area Multiple NSW, VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $671,653
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeGenes in all human cells are switched 'on' and 'off' in a process that is affected by specific proteins. The immediate product of genes, a molecule termed RNA, can change the way proteins affect gene expression. In this study, we aim to understand how RNA regulate the function of specific proteins, that normally maintain thousands of genes in an 'off' state. We will determine how these proteins are altered during disease, when they can no longer be affected by RNA.
ActivityGNT1162921 | RNA-mediated regulation of the histone methyltransferase PRC2: a new link to disease-associated and causing mutations.
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $633,058
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeMesenchymal stromal cells (MSCs) have stem cell-like features and can modify immune responses. MSC therapy is being investigated in different diseases, but it remains unclear how MSCs work, as the cells do not survive after injection into the body. We will use a range of unique technologies to resolve how short-lived MSCs modulate immune responses to produce broad therapeutic effects. Our discoveries will enable more effective and safer cell therapies for a wide range of diseases.
ActivityGNT1162499 | Dying stem cells as a mechanism of mesenchymal stromal cell therapy
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $767,521
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeMalaria is a disease with a globally significant burden and distribution, including a presence in Australia's northern neighbours East Timor, Indonesia and Papua New Guinea. Resistance to all major classes of antimalarial drugs has emerged in Asia in the last decade, meaning new antimalarials with unique mechanisms of action are urgently needed. This project seeks to identify the novel mechanism of action responsible for the activity of a new class of aminobenzimidazole antimalarials.
ActivityGNT1163235 | New aminobenzimidazole antimalarial agents with a novel mechanism of action
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $642,013
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis basic science study will investigate the neural mechanisms underlying cognitive deficits caused by blockade of specific ion channels in the brain, establishing fundamental knowledge in this burgeoning field. This ultimately will have important implications for our understanding of the pathophysiology of schizophrenia, a psychiatric condition associated with loss of these same ion channels.
ActivityGNT1156733 | Functional disconnections in schizophrenia
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $737,521
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeIn this project we will develop inhibitors of GSTO1-1, an enzyme that is thought to play an important and exacerbating role in acute and life-threatening inflammatory responses such as those involved in sepsis. We will test our novel and improved compounds in vitro, determine pharmacokinetic properties, profile their selectivity, and test them for in vivo efficacy as potential anti-inflammatory candidates for the future treatment of sepsis..
ActivityGNT1156455 | Small molecule Inhibitors of glutathione transferase omega 1-1 (GSTO1-1) for the treatment of inflammatory disease
Delivery Area Multiple ACT, NSW, VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $555,788
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe hallmark of degenerative diseases such as Huntington's and Parkinson's is the accumulation of toxic protein aggregates. We have identified a gene called mir-1 that protects animals against protein aggregation. Using genetic and biochemical approaches we will decipher how mir-1 is able to protect animals and mammalian cells from protein aggregation to potentially enable therapeutic strategies in the future.
ActivityGNT1156481 | MIR-1: A Conserved Gatekeeper of Protein Aggregation
Delivery Area Multiple VIC, Overseas AUSTRALIA, UNITED KINGDOM
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $878,108
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeAntimicrobial resistance (AMR) is emerging at an alarming level, rendering some bacterial infections untreatable and increasing dependence on last line antibiotics. This project will seek to characterise antimicrobial resistance within the naturally occurring gut bacteria to inform clinical antibiotic selection and minimise the emergence and spread of antibiotic resistance within the hospital and community setting.
ActivityGNT1156333 | Characterisation of mobile antimicrobial resistance in the human gastrointestinal microbiota
Delivery Area Multiple VIC, SA, Overseas AUSTRALIA, UNITED KINGDOM
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $691,653
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeOur CRISPR-Cas9 mediated loss-of-function genetic screen identifies two new candidate epigenetic regulators- TAF5L and TAF6L- for maintenance of the mouse ESC state. In this proposed research, we will aim- 1) to dissect the detail molecular functions of TAF5L and TAF6L in mouse ESCs; 2) to examine the role of TAF5L and TAF6L in induced pluripotent stem cells (iPSCs) generation, and 3) to investigate the role of TAF5L and TAF6L in neurodevelopment.
ActivityGNT1159461 | Dissecting TAF5L and TAF6L functions in embryonic stem cells, reprogramming and neurodevelopment
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $890,314
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeDrug-resistance threatens our ability to treat deadly malaria infections, and resistance has now emerged against artemisinins, the last-line medicines for malaria. This work will use modern analytical and computational techniques to measure the molecules present in parasites, and blood, that are associated with artemisinin resistance. Understanding these factors will allow development of new strategies to monitor, and manage, the spread of resistance to this essential drug.
ActivityGNT1160705 | Host and pathogen contributors to artemisinin resistance
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $993,742
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThere is currently no cure for blood vessel damage leading to heart attacks and death. We postulate that a novel factor mediating oxidative stress, called Nox5, is the major culprit in this process. We will investigate this using unique animal models including mice and rabbits, as well as in human cells and tissues. These studies will lead to better and more effective treatments to prevent and cure heart attacks, stroke and amputations.
ActivityGNT1163233 | Targeting Nox5 to prevent atherosclerosis and aneurysm formation
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $1,233,369
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeBALANCE is a clinical trial comparing a shorter and longer duration (7 and 14 days) of antibiotic treatment. The study is focused critically ill patients in Intensive Care Units with blood stream infection. If 7 days of antibiotics is equally as good as 14 days of antibiotics this will have significant benefit for patients and the broader community. The benefits may include reduced antibiotic resistance, a shorter stay in hospital and lower costs for the community.
ActivityGNT1161936 | Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): A Randomized Controlled Clinical Trial
Delivery Area Multiple VIC, QLD, Overseas AUSTRALIA, CANADA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $1,416,603
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeAcquired genetic mutations normally associated with blood cancers like leukaemia can be detected in the blood or bone marrow long before any disease appears. Known as CHIP (clonal haematopoiesis of indeterminate potential), it is more common in older age, and has been associated with other health problems common in the elderly, like heart disease and stroke. We will study how common CHIP is, and its health consequences, in a large clinical trial of otherwise healthy people aged 70 or older.
ActivityGNT1163002 | Clonal haematopoiesis of indeterminate potential (CHIP) and its consequences for blood cancers, cardiovascular disease and stroke - the ASPREE-CHIP sub-study
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $859,702
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeAntibodies are crucial for health, protecting us from pathogens and their toxic products, often for the duration of our lives. The biology of plasma cells, which make antibodies, is poorly understood but it could allow us to control antibody production for better outcomes in vaccines and better treatments for diseases caused by antibodies. We propose to use a new mouse model to finally understand the basis of plasma cell survival and how to make it longer or shorter to improved health outcomes.
ActivityGNT1163053 | The Dynamics and Determinants of Plasma Cell Survival
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $1,071,166
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe majority of patients with AML are elderly and unfit for intensive chemotherapy. Standard low-intensity therapy is generally unsuccessful and survival short-lived. We have recently led ground-breaking studies showing that targeting the cell'survival machinery with the BCL-2 inhibitor venetoclax in combination with chemotherapy is an exciting therapeutic prospect. We have now identified two non-overlapping mechanisms of resistance to this regimen amendable to combination with novel inhibitors.
ActivityGNT1162809 | Transforming the treatment landscape in elderly Acute Myeloid Leukaemia
Delivery Area Multiple VIC, Overseas AUSTRALIA, NEW ZEALAND, UNITED STATES
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $94,406
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeMy aim is to assess disparities in stroke occurrence, services utilised and outcomes between Aboriginal and Torres Strait Islander (hereafter referred to as Aboriginal) and non-Aboriginal people in SA, NT and WA, and determine barriers to care. This project will provide an evidence base to assist in identifying the services that should be targeted for improvement, in order to -close the gap- in outcomes between Aboriginal and non-Aboriginal people with stroke.
ActivityGNT1169269 | Aboriginal and Torres Strait Islander stroke incidence, mortality and disability study.
Delivery Area Multiple VIC, SA, WA AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201810 Jan 201901 Jan 201928 Feb 2021 2017-18
MONASH UNIVERSITY
Hotham  $90,794
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeMany people develop epilepsy following a traumatic brain injury (TBI) which may prolong rehabilitation and lead to lifelong disability and early mortality, although the mechanisms are unknown and there are no specific treatments to prevent seizures from occurring. This research aims to investigate the causes of epilepsy following TBI, to utilise a novel technique to detect seizures in hospital in the early vulnerable days following TBI, and to aid in future clinical drug trials.
ActivityGNT1169386 | The development and management of post traumatic epilepsy
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201810 Jan 201901 Jan 201931 Jan 2021 2017-18
MONASH UNIVERSITY
Hotham  $72,735
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeAntibiotic resistance in bacteria is a major global health problem. Polymyxins are antibiotics used to treat bacterial infections to all other classes. Bacteria resistant to polymyxins are increasingly noted but little is known about this form of antibiotic resistance. In this project, we will carry out genetic sequencing of bacteria resistant to polymyxins to learn about how resistance develops and to understand whether these bacteria are being transmitted between patients in hospitals.
ActivityGNT1169514 | Genomic approaches for understanding resistance to polymyxins in carbapenem-resistant Enterobacteriaceae
Delivery Area Multiple VIC, Overseas AUSTRALIA, UNITED STATES
ApprovedPublishedStartEndBudget
25 Oct 201817 Jan 201901 Jan 201931 Aug 2020 2017-18
MONASH UNIVERSITY
Hotham  $55,000
Address CLAYTON 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Growing Business Investment and Improving Business Capability
Component Entrepreneurs' Programme - Innovation Connections
CategoryIndustry Innovation Demand Driven
PurposeInnovation Connections promotes collaboration between small and medium sized Australian businesses and the research sector to develop new ideas with commercial potential.
ActivityInnovation Connections
Delivery Area 3000 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201715 Jan 201808 Jan 201808 Jan 2019 2017-18
ROTARY CLUB OF MT WAVERLEY
Hotham  $4,503
Address Glen Waverley 3150 VIC AUSTRALIA ABN: 56404492665
Portfolio Defence
Agency Department of Veterans Affairs
Program Commemorative Activities
Component Armistice Centenary Grants Program
CategoryCommemorative Closed Non-Competitive
PurposeEnhance an existing memorial walkway by adding a plaque dedicated to the Armistice of the First World War and produce a booklet outlining all plaques and their significance in the existing walkway.
ActivityAnzac Centenary Walkway Plaque Project
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Jul 201817 Sep 201806 Sep 201828 Feb 2019 2017-18
MONASH UNIVERSITY
Hotham  $365,608
Address CLAYTON 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component Linkage Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop a new approach, based on remote sensing and computational modelling, to assess and manage the structural health of large floating covers used for odour control and biogas harvesting to prevent unexpected failures. The project has potential benefits for high-value-added manufacturing and maintenance of these floating covers by Australian industry.
ActivityQuantitative structural health assessment of large membrane-like structures
Delivery Area 3800 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
24 Jul 201720 Feb 201828 Jun 201827 Jun 2021 2017-18
MONASH UNIVERSITY
Hotham  $692,657
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Partnership Projects
CategoryMedical Research Targeted or Restricted Competitive
PurposePatients with severe heart failure and cardiac arrest sometimes need an external machine to oxygenate and pump their blood, which is called extracorporeal membrane oxygenation (ECMO). ECMO is extremely expensive, and the use of ECMO across Australia has doubled in five years without key information about the risks and benefits. This partnership will bring together experts in heart failure, clinical trials, registries and evidence translation to systematically improve outcomes for these patients.
ActivityGNT1152793 | The EXCEL Project: A collaborative approach to improve outcomes of Australian patients with acute heart failure and cardiac arrest requiring extracorporeal life support
Delivery Area Multiple NSW, VIC, WA, QLD AUSTRALIA
ApprovedPublishedStartEndBudget
24 Apr 201805 Jun 201801 Jun 201831 May 2021 2017-18
MONASH UNIVERSITY
Hotham  $675,881
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Partnership Projects
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis Partnership Project will provide new national clinical practice guidelines for menopause and midlife women's health care, identify limitations to the delivery of comprehensive midlife care from the perspective of both general practitioners and women, and evaluate the utility of pre-consultation assessment to ensure midlife women's health care delivery is comprehensive and individualised.
ActivityGNT1152778 | Optimising the health of women at midlife to minimise immediate and long-term morbidity.
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
24 Apr 201805 Jun 201801 Jun 201831 May 2022 2017-18
WHEELERS HILL SECONDARY COLLEGE
Hotham  $2,925
Address Wheelers Hill 3150 VIC AUSTRALIA ABN: 57228472434
Portfolio Defence
Agency Department of Veterans Affairs
Program Commemorative Activities
Component Armistice Centenary Grants Program
CategoryCommemorative Closed Non-Competitive
PurposeConstruct a new memorial wall with a commemorative plaque honouring those who served during the First World War.
ActivityArmistice Centenary Memorial Project
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
23 Aug 201820 Sep 201810 Sep 201828 Feb 2019 2017-18
AUROSCIENCE
Hotham  $55,000
Address NOTTING HILL 3168 VIC AUSTRALIA ABN: 71629018177
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Growing Business Investment and Improving Business Capability
Component Entrepreneurs' Programme - Innovation Connections
CategoryIndustry Innovation Demand Driven
PurposeInnovation Connections promotes collaboration between small and medium sized Australian businesses and the research sector to develop new ideas with commercial potential.
ActivityInnovation Connections
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
22 Nov 201709 Jan 201804 Jan 201828 Jul 2019 2017-18
MONASH UNIVERSITY
Hotham  $33,000
Address CLAYTON 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Growing Business Investment and Improving Business Capability
Component Entrepreneurs' Programme - Innovation Connections
CategoryIndustry Innovation Demand Driven
PurposeInnovation Connections promotes collaboration between small and medium sized Australian businesses and the research sector to develop new ideas with commercial potential.
ActivityInnovation Connections
Delivery Area 3121 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
22 Jan 201821 Feb 201815 Feb 201819 Dec 2018 2017-18
MONASH UNIVERSITY
Hotham  $2,750
Address Scenic Blvd & Wellington Road 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Environment and Energy
Agency Great Barrier Reef Marine Park Authority
Program Departmental Outcome 1
Component Reef Guardians Research Grants 2018
CategoryScientific Research Open Competitive
PurposeThe purpose of the Grant is to provide post-graduate students (studying towards a doctorate or master's degree at an Australian university/institution) with funding to support research projects that are directly relevant to the planning and management of the Great Barrier Reef Marine Park and World Heritage Area.
ActivityReef Guardians Research Grants 2018
Delivery Area 4810 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
21 Nov 201708 Jun 201821 Nov 201731 Jan 2019 2017-18
CYLITE
Hotham  $30,113
Address NOTTINGHILL 3168 VIC AUSTRALIA ABN: 47098027877
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Growing Business Investment and Improving Business Capability
Component Entrepreneurs' Programme - Innovation Connections
CategoryIndustry Innovation Demand Driven
PurposeInnovation Connections promotes collaboration between small and medium sized Australian businesses and the research sector to develop new ideas with commercial potential.
ActivityInnovation Connections
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
21 Mar 201803 Apr 201828 Mar 201802 May 2019 2017-18
MONASH UNIVERSITY
Hotham  $20,000
Address CLAYTON 3170 VIC AUSTRALIA ABN: 12377614012
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Supporting Science and Commercialisation
Component Science for Australia's Future - Inspiring Australia
CategoryScientific Research Open Competitive
PurposeNASA scientists are headed to Australia, bringing Saturn to Sydney, new planets to Perth, and more. In September, NASA's Cassini, which has been in orbit around Saturn, met its fateful end while the Kepler Space Telescope, which has been discovering planets around other stars, will run out of fuel by mid-2018. Audiences will hear from NASA scientists from the Cassini and Kepler missions at a series of events hosted by Mt Stromlo Observatory astrophysicist Dr Brad Tucker. With the announcement of Australia's very own space agency, it's a timely look at the international context of our contribution to furthering humanity's understanding of the Universe.
ActivityA New View of Life - Celebrating the end of Kepler and Cassini
Delivery Area 2611 ACT AUSTRALIA
ApprovedPublishedStartEndBudget
19 Dec 201709 Mar 201801 Mar 201823 Apr 2019 2017-18
MONASH UNIVERSITY
Hotham  $5,550
Address CLAYTON 3170 VIC AUSTRALIA ABN: 12377614012
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Supporting Science and Commercialisation
Component Science for Australia's Future - Inspiring Australia
CategoryScientific Research Open Competitive
PurposeCome inside BrainPark, the world's first research facility to offer lifestyle and technology-based interventions for addictive and compulsive behaviours. At BrainPark, we will use science, technology, lifestyle and art to harness the power of brain plasticity. People with addictions or compulsions are immersed in a positive, interactive and evidence-based environment to help them conquer their compulsions and establish healthy habits for life. Visitors will receive an exclusive behind the scenes tour of virtual reality, physical exercise, cognitive training, meditation, and non-invasive brain stimulation activities, and experience how the Monash Institute of Cognitive and Clinical Neurosciences is working to bring transformational changes to how addictions and compulsions are experienced, diagnosed and treated.
ActivityBrainPark: Revealing a new approach to a ddiction and OCD
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
19 Dec 201709 Mar 201828 Feb 201820 Apr 2019 2017-18
OAKLEIGH-CARNEGIE RSL SUB-BRANCH
Hotham  $9,138
Address Oakleigh 3166 VIC AUSTRALIA ABN: 95473757479
Portfolio Defence
Agency Department of Veterans Affairs
Program Commemorative Activities
Component Armistice Centenary Grants Program
CategoryCommemorative Closed Non-Competitive
PurposeReplace two flagpoles, commission a mural and hold a commemorative event at the Sub-Branch on Armistice Day.
ActivityRemembrance and Dedication to the Past and Future Project
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
18 Sep 201817 Oct 201808 Oct 201828 Feb 2019 2017-18
MONASH UNIVERSITY
Hotham  $229,749
Address CLAYTON 3170 VIC AUSTRALIA ABN: 12377614012
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Supporting Science and Commercialisation
Component Science for Australia's Future - Inspiring Australia
CategoryScientific Research Open Competitive
PurposeMonash University will partner with Monash Tech School, Victorian Space and Science Education Centre, Micro:Bit, Tech Girls Movement, Hacker Exchange and Monash Generator to tailor a program to develop an entrepreneurial mindset in the next generation. 500 secondary school girls and 25 female IT students as mentors will work in teams on ideas based on the Internet of Things (the network of physical devices embedded with electronics which enables these objects to connect and exchange data). Girls will develop a project idea, prototype it, and build a viable business concept around it. The teams will receive entrepreneurship training to help further develop their ideas and the two best ideas teams will go forward to the Silicon valley-based Hacker Exchange for intensive training.
ActivityDriving social change: Women, Entreprene urship, IoT
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
18 Apr 201818 Jun 201806 Jun 201807 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $25,857
Address CLAYTON 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Growing Business Investment and Improving Business Capability
Component Entrepreneurs' Programme - Innovation Connections
CategoryIndustry Innovation Demand Driven
PurposeInnovation Connections promotes collaboration between small and medium sized Australian businesses and the research sector to develop new ideas with commercial potential.
ActivityInnovation Connections
Delivery Area 5106 SA AUSTRALIA
ApprovedPublishedStartEndBudget
18 Apr 201820 Jun 201819 Jun 201823 Sep 2018 2017-18
MONASH UNIVERSITY
Hotham  $2,499,270
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Centres of Research Excellence
CategoryMedical Research Targeted or Restricted Competitive
PurposeDespite high standards of health care and the existence of a universal health care system in Australia, women continue to have poor sexual and reproductive health, particularly in relation to abortion, contraception, and preconception care. The aim of SPHERE is to improve the quality, safety, and capacity of primary health care services to achieve better outcomes in women's sexual and reproductive health.
ActivityGNT1153592 | SPHERE - The Centre of Research Excellence in Sexual and Reproductive Health for Women: Achieving Better Outcomes through Primary Care
Delivery Area Multiple NSW, VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201828 Aug 201801 Nov 201831 Oct 2023 2017-18
MONASH UNIVERSITY
Hotham  $437,036
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Career Development Fellowship
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis fellowship aims to (1) prevent hepatitis C infection by interrupting transmission in key populations integrating high-quality evidence from clinical trials into real-world settings; (2) prevent long harm and costs from hepatitis C for both individuals and populations; and (3) use clinical and implementation science to inform policy and modelling for Australia that will have global implications.
ActivityGNT1166499 | Improving delivery of hepatitis C treatment to achieve and sustain elimination
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $327,192
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Early Career Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeTemporal lobe epilepsy is often resistant to treatment. The seizures and the associated psychiatric disorders associated with acquired epilepsy seriously affect the quality of life of patients. This study investigates a novel treatment target that could improve the symptoms of the disease to a point that no further therapy may be required.
ActivityGNT1166170 | Sodium selenate reverses drug resistant temporal lobe epilepsy
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $327,192
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Early Career Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposePreterm babies exposed to inflammation during pregnancy have a high incidence of breathing difficulties and brain injury, which often lead to Cerebral Palsy. My research aims to investigate whether inflammation injures the fetal brainstem - a life'sustaining brain region which controls our breathing, and whether anti-inflammatory treatments can protect against this injury. Outcomes of this work will guide clinical trials focused on reducing the burden of preterm brain injury.
ActivityGNT1165935 | Improving breathing of preterm newborns exposed to inflammation during pregnancy
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $417,192
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Early Career Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeMood instability is a psychiatric syndrome characterised by debilitating mood swings and mood states such as mania and depression. While mood itself has a clear biological basis, it is not currently understood how the brain circuits underlying mood are disrupted in mood instability. This project will test a new neurocomputational model of mood instability, leading to a biologically founded understanding of this syndrome, and to advances in its diagnosis and treatment across disorders.
ActivityGNT1165010 | Towards a neurocomputational model of mood instability in psychiatric illness
Delivery Area Multiple VIC, Overseas AUSTRALIA, UNITED STATES
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $327,192
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Early Career Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeAdvanced Glycation Endproducts (AGEs) are formed when sugars and proteins stick together, resulting in the brown colour, caramel flavour and sticky surface of heated foods. AGEs in food can be absorbed into our bodies and damage body tissues. Obese women who struggle to become pregnant have an increased build-up of AGEs in their uterus, which inhibits their ability to conceive. I will investigate whether a low-AGE diet can improve fertility outcomes in obese women who are unable to get pregnant.
ActivityGNT1164771 | Dark, sticky and treacherous: targeting dietary advanced glycation end-products (AGEs) in female infertility
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $232,315
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Early Career Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeFocal epilepsies are the most common forms of epilepsy. In most people with these epilepsies, no cause for the seizures can be identified with routine investigations. This study will evaluate how many of these people in fact have a type of epilepsy which runs in families, and how many have genes causing their epilepsy. Finding a genetic cause for a person's epilepsy is important for selecting the most appropriate treatment, and can also lead to development of novel personalised therapies.
ActivityGNT1163708 | Investigating the genetic contribution to the focal epilepsies
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $483,404
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Career Development Fellowship
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis fellowship project will answer key questions in assessment of environmental health risks, including: 1) how to improve the exposure assessment through new technology and advanced statistical models- 2) whether health impacts of air pollution are recoverable- and 3) whether health impacts of extreme weathers have changed over time- The findings will provide strategies and supportive evidence for policy decisions on mitigating the health impacts of extreme weathers and air pollution.
ActivityGNT1163693 | Improving the assessment of environmental health risks with new technology and novel approaches
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $327,192
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Early Career Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeOver 20,000 Australian women develop gestational diabetes (GDM) annually, increasing their risk of pregnancy complications, as well as diabetes and heart disease later in life. Lipids are a key source of energy for cells and often change during pregnancy, yet their role in GDM is unknown. Using novel techniques, I will measure hundreds of lipids to examine whether certain lipid species contribute to GDM development and whether these lipids are altered by diet, lifestyle, and/or drug therapies.
ActivityGNT1161871 | Plasma lipidomic signatures for risk prediction and prevention of gestational diabetes
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $327,192
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Early Career Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeMitochondria (the organelles inside cells that generate energy) contain DNA (mtDNA) which, if it escapes outside the mitochondria, sends danger signals to our immune systems. mtDNA escape has been reported in many human diseases, but how it occurs and how it drives disease is unknown. This project will use cutting-edge microscopy to visualize the mechanism of mtDNA release, the understanding of which, could impact a wide range of diseases, including autoimmune diseases and viral infections.
ActivityGNT1161352 | mtDNA release and novel applications for caspase inhibition
Delivery Area Multiple VIC, Overseas AUSTRALIA, UNITED STATES
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $193,596
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Early Career Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeHeart disease remains a major concern despite advances in health promotion and treatment options. A major challenge faced by cardiologists is identifying patients that are at highest risk of disease progression or heart attacks. This proposal involves collaboration between cardiologists and engineers, aiming to assess whether mechanical stress induced by blood flow can be reliably calculated from heart scans and if this can be used clinically to improve prediction of clinical events.
ActivityGNT1161089 | Validation and Effect of Low Endothelial Shear Stress on Coronary Atherosclerosis
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $193,596
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Early Career Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis project will identify variations in diagnostic accuracy and early management of melanoma in different clinical settings and identify areas where improvements could be made in clinical care pathways to both improve patient outcomes and reduce costs to the health care system.
ActivityGNT1160757 | Melanoma diagnosis and early management: evaluating and improving patient outcomes through a clinical quality registry
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $483,404
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Career Development Fellowship
CategoryMedical Research Targeted or Restricted Competitive
PurposeInfection is a common and fatal complication of stroke. With the escalating problem of antibiotic-resistance, new therapeutic approaches are urgently needed. Research from my laboratory shows that stroke not only damages the brain, but also weakens host antibacterial defence. I will use innovative methods to identify signalling pathways that underlie immune dysfunction. The results will allow us to develop novel strategies for strengthening host immunity and improve stroke outcomes.
ActivityGNT1160693 | Novel strategies to improve stroke outcome
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $327,192
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Early Career Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeIn 20 percent of pregnancies women have to have their baby very early because the woman herself becomes extremely sick due to a condition called preeclampsia. Our current treatments for preeclampsia don-t work sufficiently well in everyone. Through my research, I aim to develop new and better treatments that will allow women with even the worst preeclampsia to continue their pregnancy so that their baby can be born better grown and more healthy.
ActivityGNT1160684 | Developing New Treatments for Severe Preeclampsia
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $417,192
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Early Career Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeWhen we move, our brains are bombarded with moving visual stimulation from the outside world. We must collect all this information and piece it together to form coherent picture in order to navigate our way around. To understand how this integration occurs, this project aims to unravel a neural circuit that links our visual and spatial perceptual systems. This will have important implications for understanding Alzheimer's disease, which affects these brain regions.
ActivityGNT1159764 | Unravelling the neural circuits that mediate visuospatial integration
Delivery Area Multiple VIC, Overseas AUSTRALIA, UNITED KINGDOM
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $347,035
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Development Grants
CategoryMedical Research Targeted or Restricted Competitive
PurposeContrary to popular belief many women using in vitro fertilization (IVF) will remain childless. High costs of IVF and limited access to financial assistance has generated a socio-economic divide in accessing treatment. We will collect blood from women at three sites and measure six proteins in the blood to predict if the mother's body is ready to accept and nurture an embryo, establishing pregnancy and continuing to a live birth. Successful outcome would reduce the failure rate.
ActivityGNT1159714 | Validation of a Prognostic Assay for Embryo Transfer Outcome
Delivery Area Multiple VIC, Overseas AUSTRALIA, SINGAPORE
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $483,404
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Career Development Fellowship
CategoryMedical Research Targeted or Restricted Competitive
PurposeMild traumatic brain injuries (mTBI), such as concussions, affect millions of people worldwide. Of particular concern are those at high risk of suffering repeated mTBIs, because they are associated with lasting neurological impairments and neurodegenerative disease. There are also no interventions known to prevent the effects of mTBI. My overarching research goal is to better understand mTBIs and to identify means to improve their diagnosis, management, and ultimately their clinical management.
ActivityGNT1159645 | A translational research approach to study mild traumatic brain injury
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $483,404
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Career Development Fellowship
CategoryMedical Research Targeted or Restricted Competitive
PurposeI have established an accessible form of cell therapy that is safe even in premature babies with chronic lung disease. I will extend on my research by working with key industry partners to develop processes for the manufacture of regenerative medicines at a low cost and highly efficient manner. This will expedite patient access to potentially life'saving treatments. These cells will be used in five clinical trials in adults and extremely premature babies across three Australian hospitals.
ActivityGNT1159277 | Increasing Accessibility of Regenerative Medicine Through Innovative Solutions
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $649,175
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Research Fellowship
CategoryMedical Research Targeted or Restricted Competitive
PurposeInfluenza and HIV are major global health challenges. My research will identify why certain individuals (e.g., Indigenous Australians) are at high risk of viral infections and their associated complications, whereas others can combat and control the infection effectively. Understanding the strengths and weaknesses of the immune system towards viral infection will provide astounding opportunities to design new therapies to control (reprogram or boost) the immune system to fight off infection.
ActivityGNT1159272 | T cell-mediated responses to influenza and Human Immunodeficiency virus (HIV) infection
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $437,036
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Career Development Fellowship
CategoryMedical Research Targeted or Restricted Competitive
PurposeInflammatory bowel disease (IBD) is becoming a major public health concern worldwide, and the incidence is increasing. The underlying causes of IBD are complex where much remains unknown and current treatments are only successful in some people. Gut bacteria play an important role in maintaining a healthy gut, therefore I will study the effect of gut bacteria on immune responses in those with IBD to understand the most critical contributing factors to IBD, and to refine new treatments.
ActivityGNT1159230 | Understanding immune disorders of the gut
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $327,192
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Early Career Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis project aims to address the urgent global health issue of antimicrobial resistance through the discovery and development of innovative new drug technology that restores the activity of our existing antibiotics drugs, that bacterial 'superbugs- have developed resistance against. This drug technology will shut down bacterial resistance mechanisms at the genetic level, making antibiotic drugs effective again.
ActivityGNT1158171 | Targeting pan-drug resistant (PDR) Gram-negative pathogens with novel antisense drug technology
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $785,385
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Research Fellowship
CategoryMedical Research Targeted or Restricted Competitive
PurposeAntibiotic-resistant 'superbugs- are a significant global medical challenge. Polymyxins are the only effective antibiotics against Gram-negative bacteria, although limited pharmacological data are available for their optimal use. In the next 5 years, I will re-develop polymyxins and discover novel antibiotics against high-priority pathogens. My research targets the -Bad Bugs, No Drugs- unmet medical need highlighted by the World Health Organization and The Infectious Diseases Society of America.
ActivityGNT1157909 | A systems approach to combat the significant antibiotic resistance challenge: Novel therapeutic strategies, mechanistic discoveries, and drug development
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $163,596
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Early Career Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeSafe medicines use is a major health issue for older people. Medicine related harm is a significant factor for older people that leads to hospital admissions even if the medicine is prescribed for a valid evidence based reason. It remains unclear if a severe adverse drug effect that leads to a hospital admission should mean a medicine is stopped or continued. This research will use big data to examine the clinical effects of continuing and withdrawing medicines in older people.
ActivityGNT1156892 | Clinical outcomes in older people of continuing or deprescribing medicines that caused a hospital admission
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $327,192
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Early Career Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe project aims to identify the main risk factors associated with the antiepileptic drug treatment responses, development of adverse effects and drug-resistant epilepsy. It will create algorithm and scoring system to predict dynamic long-term treatment responses and to be evaluated in real-world clinical practice. The scoring system can have broad application and be used as basis for modelling dynamic outcomes of other non-communicable chronic diseases.
ActivityGNT1156444 | Dynamic Modelling of Long-term Prognosis in Epilepsy
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $261,754
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Early Career Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeOlder people receiving community and residential aged care services often take multiple medicines. When used appropriately, medicines can improve health outcomes, but sometimes medicines can cause unintended harm. This project will analyse Australian and international -Big Data- for the purpose of developing services that maximise the benefits and reduce the risks relating to medicines use among older people receiving community or residential aged care services.
ActivityGNT1156439 | Are they thriving- Lowering risk and improving safety of medicines use in older Australians receiving community and residential aged care services
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $677,127
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Development Grants
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe leading cause of death worldwide, accounting for 30 percent of all global deaths, is cardiovascular disease. This figure has heart attack and associated changes heart oxygen levels as a major injury-causing component. We have discovered a potential treatment that is limited by its solubility properties. In this RandD plan we will develop soluble preclinical progression drug candidates for the treatment of oxygen-related heart attack injury.
ActivityGNT1155527 | Prodrug Development of Biased N-Alkylpyridazinones for the Acute Intravenous Treatment of Myocardial Ischaemia-Reperfusion Injury
Delivery Area Multiple NSW, VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $649,175
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Research Fellowship
CategoryMedical Research Targeted or Restricted Competitive
PurposeColorectal cancer (CRC) is the third leading cause of cancer mortality in Australia. My laboratory's work has utilised sophisticated functional genomic approaches to identify new therapeutic targets and biomarkers that are entering clinic testing. In the next five years, we will use biochemical, genetic and genomic tools to understand the importance of these pathways in normal development and cancer and progress preclinical development of targeted agents in clinically relevant cancer models.
ActivityGNT1155354 | Therapeutic targeting of the colorectal epigenome
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $717,275
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Research Fellowship
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe glucagon family of G protein-coupled receptors are involved the control of blood glucose levels and are attractive drug targets for the treatment of type 2 diabetes and obesity. However, the development of novel therapies is often coupled with a high failure rate due to a lack of fundamental understanding of how these receptors work. This fellowship will define these fundamental mechanisms and will identify strategies to design better medicines to treat major health burdens.
ActivityGNT1155302 | Novel targeting of the glucagon family of G protein-coupled receptors
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $649,175
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Research Fellowship
CategoryMedical Research Targeted or Restricted Competitive
PurposeThrough this Fellowship, and my leadership roles within the rapidly evolving international activities in this domain, I will generate the knowledge required to inform the evolution of a new breast and prostate cancer management paradigm to substantially improve health outcomes for all Australians.
ActivityGNT1155163 | Precision Medicine for Prostate and Breast Cancer
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $649,175
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Research Fellowship
CategoryMedical Research Targeted or Restricted Competitive
PurposeHunger does more than just make us want to eat. The proposal examines how and why hunger can also influence our mood, motivation and memory. This is important because inability of the brain to process hunger correctly can significantly affect behaviours that underlie anorexia and bulimia nervosa or food addiction and binge eating disorders leading to obesity.
ActivityGNT1154974 | Hunger-sensitive neural pathways influence appetite and behaviour
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $888,270
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Research Fellowship
CategoryMedical Research Targeted or Restricted Competitive
PurposeBirth is one of the greatest physiological challenges that we will ever experience and so it is not surprising that it is a period of high risk of death or permanent injury. Despite the risk, our understanding of how infants transition from fetal to newborn life is limited. My research is focused on improving our understanding of how infants make the transition to newborn life and reducing the risks for these most vulnerable of humans.
ActivityGNT1154914 | Optimizing neonatal resuscitation in the delivery room
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $792,275
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Research Fellowship
CategoryMedical Research Targeted or Restricted Competitive
PurposeWhether we are born male or female affects our sense of social place, behaviour, gender identity, reproductive options, and disease susceptibility. I am a molecular geneticist investigating the biology of gender. I identify the genetic causes of -intersex- and transsex conditions and the mechanisms underpinning sexual development, towards improved clinical management. I study how the levels of male genes contribute to male bias in Parkinson's disease and towards developing a gene therapy.
ActivityGNT1154870 | Molecular Genetics of Human Sexual Differentiation
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $680,825
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Development Grants
CategoryMedical Research Targeted or Restricted Competitive
PurposeFibrotic disease is characterised by excessive scarring and tissue hardening leading to organ failure and accounts for approximately 43 percent of deaths from disease in the developed world, representing a major unmet medical need. Our group has identified a novel biological target and associated drug molecules for the treatment of fibrosis. In this project we will provide a preclinical proof-of-concept concept in animal models for our drug molecules to attract ongoing commercial support.
ActivityGNT1154749 | Dihydroceramide Desaturase-1 (Des1) Inhibitors for the Treatment of Fibrotic Disease
Delivery Area Multiple VIC, SA AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $649,175
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Research Fellowship
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe regulation of gene expression patterns is critical to normal human development and disease. The central theme of my laboratory under this fellowship is to define the transcriptional mechanisms by which regulatory complexes that participate in gene activation and gene suppression in metabolic disease.
ActivityGNT1154650 | New models of gene regulation in diabetic complications
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $888,270
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Research Fellowship
CategoryMedical Research Targeted or Restricted Competitive
PurposeMany drugs act on a family of proteins in our body called G protein-coupled receptors (GPCRs). However, despite some notable successes, most of the attempts to make drugs that act on GPCRs have failed. Focusing on neuropsychiatric and metabolic disease, through establishment of world leading capability and a multi-disciplinary team of expert collaborators, my research will ask, what are the molecular features that make effective drugs that act on GPCRs-
ActivityGNT1154434 | Improving translational understanding of the most abundant therapeutic target class
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $717,275
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Research Fellowship
CategoryMedical Research Targeted or Restricted Competitive
PurposeAttention deficit hyperactivity disorder (ADHD) is the most prevalent mental condition of childhood and is marked by inattention, hyperactivity and /or impulsivity. We know that ADHD runs in families and thus has a genetic basis, but we are just beginning to unlock the genetic code for ADHD. Understanding how genes give rise to the symptoms of ADHD via their effects across multiple systems - cellular, brain, cognitive or symptoms, will impact diagnosis and personalised treatment approaches.
ActivityGNT1154378 | Systems Neuroscience of Attention Deficit Hyperactivity Disorder (ADHD)
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $717,275
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Research Fellowship
CategoryMedical Research Targeted or Restricted Competitive
PurposeRespiratory diseases are one of the most significant burdens on human health with more than 1 billion people suffering from respiratory conditions worldwide, and 4 million deaths each year. Our body surfaces are colonized by bacteria, fungi and viruses even when we are healthy. These microbes, collectively called the microbiome, can influence our susceptibility to respiratory diseases. We aim to discover how we can use the microbiome to prevent and treat respiratory diseases.
ActivityGNT1154344 | Harnessing the microbiome to protect against chronic lung diseases
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $649,175
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Research Fellowship
CategoryMedical Research Targeted or Restricted Competitive
PurposeUncontrolled regulation of the immune system promotes inflammation-associated pancreatic, stomach and lung cancers, which are among the most common cancers worldwide. The high death rate of these cancers is largely due to late detection at advanced stages, along with the ineffectiveness of current therapies. My project aims to identify key regulators of the immune system as novel molecular biomarkers (e.g. for early detection) and targets for personalised treatments in these diseases.
ActivityGNT1154279 | Targeting key regulators of innate immunity in inflammation-associated cancer
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $792,275
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Research Fellowship
CategoryMedical Research Targeted or Restricted Competitive
PurposeI am a successful leader backed by a strong interdisciplinary team who has major national and international collaborations to ensure better care and outcomes for people who experience stroke. My innovative program for this Fellowship comprises three parallel, inter-linked and well-funded streams to transform how care is cost-effectively and equitably delivered to reduce the population impact of stroke (i.e. fewer deaths and disability). Health economics training will fill a skills shortage.
ActivityGNT1154273 | Improving the cost-effectiveness of care and outcomes of stroke through innovation, capacity building and leveraging data platforms.
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $724,175
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Research Fellowship
CategoryMedical Research Targeted or Restricted Competitive
PurposeMy work has a strong translational focus on developing novel concepts, methods and agents that can reduce suffering and death from the most serious diseases worldwide. The outcome of my research will make a major difference in the prevention and treatment of blood clotting, plaque build-up in vessels, inflammation, tissue scarring and diabetes.
ActivityGNT1154270 | Smart targeted nanoparticles for diagnosis and therapy
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201819 Sep 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $327,192
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Early Career Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeI will develop a point-of-care test for the diagnosis and management of chronic kidney disease (CKD). This test will target novel CKD biomarkers that are present at early stages, facilitating early intervention and reducing the burden of CKD on the Australian healthcare system. When combined with in-home dialysis and health informatics this device has the potential to revolutionise the experience of CKD patients from remote areas by reducing travel time for testing and appointments.
ActivityGNT1161573 | Point of care microRNA detection for the diagnosis and management of kidney disease in rural and remote areas
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201816 Oct 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $193,596
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Early Career Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeFor patients with paracetamol overdose, the most common pharmaceutical overdose in the world, this research will help refine the use of novel tests and promote individualised therapy (precision medicine). Implications will include whether a novel antidote regimen can decrease mortality/morbidity. We will also investigate shorter treatments with implications of decreasing time in hospital and need for prolonged treatment. We will be able to calculate potential cost'savings to health services.
ActivityGNT1159907 | Improving the management and risk assessment of paracetamol overdose
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201822 Oct 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $437,036
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Career Development Fellowship
CategoryMedical Research Targeted or Restricted Competitive
PurposeWe now know that the bacteria found throughout our bodies play important, though poorly understood, roles in both disease and maintenance of health. In the human gut, we have identified novel bacteria, present in healthy individuals, that can drive inflammation in certain circumstances. As an emerging leader in microbiome, bioinformatics and innate immunity. I will identify novel therapeutic interventions to target these bacteria and block the inflammation for the treatment of diseases.
ActivityGNT1159239 | Phenotypic, genomic and informatic characterization of host-microbiota interactions to develop disease therapies
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201822 Oct 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $483,404
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Career Development Fellowship
CategoryMedical Research Targeted or Restricted Competitive
PurposeOpioid prescribing and related mortality is increasing. Abundant research describes harm, yet there is a lack studies that test the implementation of strategies to reduce this harm, and evaluate regulatory responses intended to reduce harm in real-world settings. This Fellowship, led by an academic and clinical pharmacist, will address this gap by implementation studies of scalable interventions designed for use in pharmacy and primary care settings, and evaluating recent regulatory changes.
ActivityGNT1163961 | Implementation research to treat and prevent opioid-related harms
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201822 Oct 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $649,175
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Research Fellowship
CategoryMedical Research Targeted or Restricted Competitive
PurposeExposure to contaminated environments in areas with poor water and sanitation management often leads to poor gastrointestinal health. This impacts on child health in slum settings, and on internationally mobile populations visiting areas with inadequate sanitation. Via funded collaborative projects, I will perform research among these 2 population groups, together providing better understanding of how environmental exposures impact on the function of the intestine and disrupt human health.
ActivityGNT1155005 | Environment and host interactions: impact on the burden of gastrointestinal infections
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201822 Oct 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $327,192
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Early Career Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeWe all need to sleep and, yet, not everyone sleeps well. The reasons why some sleep well and others do not is largely unknown, despite the far-reaching consequences of insomnia. We propose one reason some people report poor sleep is due to the brain abnormally monitoring the internal and external world during sleep. By focusing on understanding the mechanisms underlying insomnia, I hope to take a crucial step in devising more efficient individualised therapeutic approaches.
ActivityGNT1161498 | Fathoming sleep depth: a novel approach to the understanding and assessing of sleep-state misperception in insomnia
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
16 Jul 201806 Nov 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $711,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component Linkage Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop technologies to mitigate three dimensional (3D) geological risk in resources management. This project expects to create new knowledge and methods in the field of 3D geological modelling through the innovative application of mathematical methods, structural geology concepts and probabilistic programming. The expected outcomes are an enhanced capability to model the subsurface, characterise model uncertainty and test multiple geological scenarios. This enhanced capability is important for the future of Australia's subsurface management, including urban geology and our continuously growing sustainable resources industry.
ActivityEnabling three dimensional stochastic geological modelling
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
15 Jun 201819 Jun 201812 Nov 201812 Nov 2021 2017-18
MONASH UNIVERSITY
Hotham  $168,356
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component Linkage Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to examine the effectiveness of an innovative government program, which seeks to enhance the safety and rehabilitative culture of juvenile detention centres by increasing staff interpersonal skills through specialist training, coaching and supervision. The project is expected to identify best practice principles, allowing government departments to focus efforts on training and staff support to provide a higher quality work force. An evidence based framework will be developed in consultation with juvenile justice agencies across Australia. This will potentially improve outcomes for young people in custody and the wider community.
ActivityTowards an effective practice model for youth detention
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
15 Jun 201819 Jun 201818 Sep 201818 Sep 2020 2017-18
MTPCONNECT
Hotham  $77,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 53608571277
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Not Applicable
Component Departmental Programmes
CategoryScience
PurposeAd hoc grant to support Australian Pavilion at the 2018 Biotechnology Innovation Organisation International Convention (BIO) in Boston, USA during 4-7 June 2018.
Activity2018 Biotechnology Innovation Organisation International Convention
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
14 May 201822 May 201814 May 201831 Oct 2018 2017-18
STARS FOUNDATION
Hotham  $16,324,000
Address BENTLEIGH 3204 VIC AUSTRALIA ABN: 68604680088
Portfolio Prime Minister and Cabinet
Agency Department of the Prime Minister and Cabinet
Program Children and Schooling
Component Children and Schooling
CategoryIndigenous Education Closed Non-Competitive
PurposeStrategic activities that focus on getting children to school, improving education outcomes and improving access to further education as well as supporting families to give children a good start in life.
ActivityStars Foundation School-based Mentoring Program for Aboriginal and Torres Strait Islander Girls
Delivery Area Multiple VIC, NT AUSTRALIA
ApprovedPublishedStartEndBudget
13 Nov 201719 Jan 201801 Jan 201831 Dec 2021 2017-18
GLENDAL PRIMARY SCHOOL
Hotham  $6,210
Address Glen Waverley 3150 VIC AUSTRALIA ABN: 82446237315
Portfolio Defence
Agency Department of Veterans Affairs
Program Commemorative Activities
Component Armistice Centenary Grants Program
CategoryCommemorative Closed Non-Competitive
PurposeCreate a memorial garden, with a plaque, for use during commemorative services.
ActivityMemorial Garden Project
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
13 Jul 201807 Aug 201831 Jul 201828 Feb 2019 2017-18
ALBANY RISE PRIMARY SCHOOL
Hotham  $2,735
Address Mulgrave 3170 VIC AUSTRALIA ABN: 13548109436
Portfolio Defence
Agency Department of Veterans Affairs
Program Commemorative Activities
Component Armistice Centenary Grants Program
CategoryCommemorative Closed Non-Competitive
PurposeConstruct new flagpoles, a garden bed area and install a commemorative plaque.
ActivityInclusive Commemoration Project
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
13 Jul 201814 Aug 201803 Aug 201828 Feb 2019 2017-18
MONASH UNIVERSITY
Hotham  $25,000
Address Building 3A, Wellington Road 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Department of Education and Training
Program Higher Education Support
Component 2.3 Higher Education Support
CategoryHigher Education Closed Non-Competitive
PurposeThis grant is to assist universities with the cost of systems changes associated with implementing the Government's tranparency in higher education expenditure data collection
ActivityTransparency in higher education expenditure - contribution towards university systems change costs
Delivery Area 3800 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
12 Feb 201825 Jun 201805 Jun 201830 Jun 2018 2017-18
BORTHWICK FOODS ? RETAIL
Hotham  $8,239
Address MULGRAVE 3170 VIC AUSTRALIA ABN: 50104036357
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Growing Business Investment and Improving Business Capability
Component Entrepreneurs' Programme - Business Management
CategoryIndustry Innovation Demand Driven
PurposeA Business Growth Grant has been awarded to undertake product and service development activities.
ActivityBusiness Growth Grant
Delivery Area 3150 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
12 Feb 201826 Feb 201815 Feb 201801 May 2018 2017-18
CYLITE
Hotham  $812,900
Address NOTTINGHILL 3168 VIC AUSTRALIA ABN: 47098027877
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Growing Business Investment and Improving Business Capability
Component Advanced Manufacturing Growth Fund
CategoryIndustry Innovation Open Competitive
PurposeCylite has developed key technology enabling the next generation of ophthalmic diagnostics with applications in Myopia and Cataract treatment. The project will establish the equipment and infrastructure necessary to manufacture their first release of instrument in their Victorian facility The program comprises two stages: 1. Development of manufacturing equipment and processes, the development of tooling required, and initial prototype manufacturing 2. Evaluation of processes and improvement to provide high production yield and device performance and expansion of line through automation and additional workstations to meet projected capacity.
ActivityAnterior Insight Manufacturing Ramp
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
11 Oct 201717 Jan 201815 Jan 201830 Sep 2019 2017-18
MONASH UNIVERSITY
Hotham  $255,120
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component Linkage Infrastructure, Equipment and Facilities
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to establish a three-dimensional (3D) cryo-correlative light and electron microscopy facility. The facility will integrate light microscopy with high resolution cryo-electron tomography and 3D slice-and-view focused ion beam scanning electron microscopy. The open access facility should create new capabilities for Australian researchers to tag biological events and structures with fluorescence markers and image them using the currently highest resolution 3D imaging techniques for biological matter. The facility expects to reveal fundamental insights into cell and structural biology, and help drive innovation in agriculture, pharmaceutics, and biomaterials.
ActivityThree-dimensional cryo correlative light and electron microscopy facility
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201801 Jan 201831 Dec 2019 2017-18
MONASH UNIVERSITY
Hotham  $299,105
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component Linkage Infrastructure, Equipment and Facilities
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to provide researchers with an integrated capability for separation, isolation, and precise structural identification of volatile compounds. It expects to deliver a systematic solution using unprecedented, automated multidimensional gas chromatographic separation, isolating pure compounds for off-line characterisation using appropriate spectroscopic tools, for example nuclear magnetic resonance. This will provide significant benefits, such as permitting traceability of (bio)'synthetic pathways, better characterise chemical signalling in plants, accelerate identification of advanced intermediates required for total synthesis of alkaloids, improve detection of metabolites, and determine interactions between small allergens and proteins.
ActivityGas chromatography: separating inseparables, identifiying unidentifiables
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201801 Jan 201830 Jun 2019 2017-18
MONASH UNIVERSITY
Hotham  $637,800
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component Linkage Infrastructure, Equipment and Facilities
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to enhance understanding of multi'scale fluid flows in engineering, geophysics and biomedicine by delivering a facility for high temporal and spatial resolution, three-dimensional velocity measurements. The four-dimensional, coherent imaging velocimetry facility for fluid mechanics research is aimed at addressing limitations of commercially available imaging systems. It is expected to provide unprecedented measurement capabilities with significant benefit to the design, control and modelling of complex fluid flows found in many areas. Applications include the jets used for heating, cooling, mixing, and drug delivery in engineering and pharmacy to the kinematics of sperm and micro-organisms in bio-medicine, and wave-particle flows in geo-physics.
ActivityFour-dimensional coherent imaging velocimetry facility for fluid mechanics research
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201828 Mar 201831 Dec 2019 2017-18
MONASH UNIVERSITY
Hotham  $659,060
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component Linkage Infrastructure, Equipment and Facilities
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to establish an earth systems monitoring facility, using unmanned aerial vehicles and world-leading sensor technology. It will have the capability to measure the natural and built environment at millimetre to centimetre scales and to monitor rapid changes. The ensuing data and interpretations will be useful for decision-making and policy development amongst government agencies and the agricultural, environmental, civil infrastructure and mining industries.
ActivityUnmanned aerial vehicle sensing and data discovery for a changing planet
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201801 Jan 201820 Dec 2018 2017-18
MONASH UNIVERSITY
Hotham  $824,080
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component Linkage Infrastructure, Equipment and Facilities
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to establish a readily accessible facility for measurement of electric and magnetic properties of materials under extreme temperature, magnetic field, and sensitivity conditions. The expected outcome is to build capacity for and support world-leading research into novel topological materials, atomically thin materials, materials with strong light-matter interactions and magnetic materials. The benefits to society are new devices for efficient generation, storage, transmission and switching of energy.
ActivityFacility for electric and magnetic probes of materials at extreme conditions
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201801 Jan 201830 Jun 2019 2017-18
MONASH UNIVERSITY
Hotham  $365,058
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to increase knowledge of how evolutionary innovations affect biodiversity. This project will focus on a classic example of evolutionary innovation, the specialized throat jaws found in many fish groups, including damselfishes, wrasses, and cichlids. These unique jaws may explain why these fish groups contain so many species and are such successful invasive species in Australia and elsewhere. This project proposes an integrative combination of methods and functional experiments to reveal the biodiversity consequences of evolutionary innovation. It will also enhance Australian biosecurity through the production of new ways to assess invasion risk from aquaculture and aquarium trade species.
ActivityThe biodiversity consequences of evolutionary innovation
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201808 Mar 201807 Mar 2021 2017-18
MONASH UNIVERSITY
Hotham  $319,446
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop a novel wireless communication technique by utilising the human body as an antenna to connect wearable electronic devices to nearby external devices. This project expects to generate a new knowledge in the area of wireless body area network using the innovative approach of applying the near-field electromagnetic energy around the human body as a wireless channel. Expected outcomes of this project include a wireless channel model that will enable the design of ultra-low-power and reliable off-body wireless link for wearable devices. This should provide significant benefits, such as, cost-effective and innovative technology of personal wireless communication in healthcare, entertainment, military, and sports.
ActivityThe human body as an antenna for a novel wireless communication technique
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201801 Jan 201831 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $365,058
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate mechanisms underlying ligand binding and signal transduction at G protein-coupled receptors (GPCRs) by utilising the adenosine receptor family as a model system. This interdisciplinary project will use structural biology, pharmacology and biochemistry. The expected outcomes include understanding ligand selectivity across the four adenosine receptor family members. This should provide significant benefits, such as advancement of fundamental knowledge that could also lead to therapeutic development.
ActivityStructural insights into adenosine receptors
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201801 Jan 201831 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $365,058
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThe project aims to test when, where and how exotic plant populations become invasive through the rapid evolution of chemical compounds that inhibit native plant species. Using an innovative quantitative genetics framework, the intended outcome is to determine how the chemicals are selected, and whether there is sufficient heritable variation for the chemicals to evolve across heterogeneous landscapes characteristic of introduced ranges. The project will deliver key insights into the ecological and genetic mechanisms of adaptive evolution in invasive species, and predict evolutionary dynamics of biological invasions that inform their effective management. The project's expected outcomes will be useful to policy makers, weed managers and farming communities.
ActivityEvolution of chemical warfare in invasive plants
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201801 Jan 201831 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $368,446
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop communication schemes that can enable wireless devices to simultaneously receive and transmit on the same frequency. Over the last century wireless devices have been operating inefficiently by using different frequencies for reception and transmission. The project aims to make wireless devices frequency efficient, and is expected to double the data rates of every wireless device in the world, and thereby contribute to significant improvement of the capacity of future mobile networks.
ActivityFull-duplex wireless communication
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201801 Jan 201831 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $358,551
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop a powerful analysis tool to measure gas transport and mixing within lungs. This project will study the mechanical workings of the lungs, using an innovative approach for analysis of lung images. The expected outcome of this project is a novel platform for investigation and understanding of lung function. It is anticipated that application of the project outcomes to medical challenges in the long-term will lead to improved diagnostics and treatments for lung diseases.
ActivityLinking structure and function: a new approach for understanding the lung
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201828 Apr 201825 Jun 2021 2017-18
MONASH UNIVERSITY
Hotham  $356,761
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to integrate evolutionary theory into conservation science to ensure management promotes the long-term resilience of biodiversity. The management of evolutionary risks and benefits is routinely left out of decision tools that identify optimal management strategies. By developing tools that integrate evolutionary theory into key conservation problems, this project is expected to significantly advance conservation science. It should provide managers with essential tools to support the persistence of biodiversity and thus long-term success of biodiversity conservation.
ActivityAn evidence-based approach to integrate evolutionary theory in conservation
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201801 Jan 201831 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $336,128
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to advance knowledge on the prevention of road traffic crashes that result in serious injury or death. Road traffic injuries are the second leading cause of hospitalised injury and injury-related deaths in Australia, and are estimated to cost the economy $27 billion annually. This project will establish a data collection system that will evaluate existing and novel countermeasures to serious road traffic crashes. The outcome of this project will inform road safety policies and cost-effective countermeasures. Insights from the project can contribute to road safety improvements in Australia and a substantial reduction in the burden of fatal and non-fatal road traffic injury.
ActivityEvaluating interventions to prevent serious road traffic crashes
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201808 Mar 201808 Mar 2021 2017-18
MONASH UNIVERSITY
Hotham  $28,196
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate the role of few-body correlations in quantum matter by using recently developed theoretical approaches to incorporate correlations beyond the scope of traditional theories. The project expects to gain fundamental insight into quantum few-body correlations in materials by investigating single impurity particles immersed in quantum media, such as highly controllable atomic gases and semiconductors. The significant benefits include the development of novel theoretical approaches and the generation of knowledge that could potentially underpin a new generation of quantum devices.
ActivityStrong few-body correlations from controllable impurities in quantum matter
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201801 Jan 201801 Apr 2018 2017-18
MONASH UNIVERSITY
Hotham  $342,996
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate the links between the molecular mechanisms underlying brain plasticity and the effects of non-invasive brain stimulation. It will use a novel approach that integrates genetics, electrophysiology and biological modelling. Plasticity underpins all learning, memory and aging. Brain stimulation can drive plasticity in humans, but these effects are extremely difficult to harness and vary widely between people. Expected outcomes include a critical understanding of the fundamental mechanisms governing plasticity. This will provide significant benefits such as the development of individually optimised brain stimulation protocols, enabling tailored, reliable approaches to address brain function and cognition.
ActivityHarnessing neural plasticity with brain stimulation
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201808 Jan 201831 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $357,996
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to provide detailed investigations into the relative importance of key life domains, for example health and relationships, at different life stages and their links with the subjective wellbeing of Australians. It will use nationally representative survey data and innovative choice experiments to generate new knowledge to the rapidly expanding economics literature on subjective wellbeing measures and individual and societal welfare. This evidence will help prioritise those policies which maximise the wellbeing of Australians.
ActivityWhat do Australians really care about- New survey and experimental evidence
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201801 Sep 201831 Aug 2021 2017-18
MONASH UNIVERSITY
Hotham  $402,996
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to understand time investment decisions of children and adolescents. There is a need for more robust evidence on the combination of time investments that improve early cognitive skills and well being. Using advanced econometric techniques and longitudinal data, this project expects to generate new knowledge on how children and adolescents spend their time, and how such time investments affect their health and cognitive development. Expected outcomes of this project include a greater understanding of the early determinants of health and economic inequalities. This will contribute to the development of effective policies for improving educational outcomes, preventing harmful behaviours and promoting health and well being.
ActivityChildren's time investments, cognitive development and health
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201801 Sep 201813 Jul 2022 2017-18
MONASH UNIVERSITY
Hotham  $366,603
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to characterise the neurobiology of motivation by combining cutting-edge techniques in psychology, economics, computational modelling and neuroimaging. This project will provide novel mechanistic insights into the brain processes underlying motivation. It will form the basis for international collaborations that significantly advance the frontier field of decision neuroscience, and lay the foundation for future interventions to improve motivation. The results from this project will therefore have wide-ranging translational implications for improving health and socioeconomic outcomes, including workplace productivity and quality of life.
ActivityEffort for reward - neural processes underlying human motivation
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201801 Jan 201831 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $411,113
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThe aim of this project is to discover how cells in the brain combine different types of information to allow decisions to be made. This project will focus on the part of the brain that integrates multiple sources of information to guide choices to accomplish behavioural goals. Using novel electrophysiological and engineering techniques, this project intends to measure the influence of sensory and cognitive information relayed by other brain areas, and to determine how this correlates with behaviour. The intended outcome of this project is a new understanding of how information is processed in brain cells. This should benefit the development of neural engineering devices.
ActivityNeural integration of feedforward and feedback circuits for decision-making
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201801 Jan 201818 Sep 2021 2017-18
MONASH UNIVERSITY
Hotham  $367,446
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop an innovative interface model and a comprehensive understanding of the interfacial behaviours between granular materials using advanced numerical, experimental and theoretical approaches. This project expects to generate new knowledge of mixing and segregation in particle science and technology and a practical guide to applications. Expected outcomes of this project include the enhanced competitiveness of Australia and energy efficiency in its important industries such as minerals, metallurgical, chemical, energy and pharmaceutical. These outcomes should provide significant benefits such as mitigated emissions and global warming in a carbon and resource constrained world.
ActivityGranular interfaces for sustainable processing of raw materials
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201801 Jan 201831 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $343,551
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to determine how the histone methyltransferase Polycomb repressive complex 2 (PRC2) is regulated. The project expects to generate new knowledge in transcription regulation and epigenetics. The intended outcome is to enhance the national capabilities in two important fields, Polycomb biology and cryo-electron microscopy (cryo-EM). This should provide significant benefits, including strengthening of the epigenetic community through the development of innovative research program in Polycomb biology and the establishment of a national world-class cryo-EM community.
ActivityMolecular mechanism for the regulation of Polycomb repressive complex 2
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201801 Jan 201831 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $367,446
Address CLAYTON 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop next-generation nanomaterials that have a special worm-like shape and can intelligently respond to environmental signals. The project is expected to generate new knowledge in the area of advanced manufacturing utilising innovative approaches in nanotechnology and polymer chemistry. The anticipated outcome is an environmentally friendly technology for industrial production of high value-added nanomaterials that may ultimately have a variety of applications including, but not limited to, early diagnosis and efficient therapy of cancer. This should provide benefits to the Australian economy, environment and society.
ActivityScalable synthesis of smart nanoworms with tailored properties
Delivery Area 3800 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201821 Jan 201809 Nov 2023 2017-18
MONASH UNIVERSITY
Hotham  $339,446
Address CLAYTON 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to create a framework which allows authoring, reading and storing of tactile electronic books for people with vision impairment by using multi-touch, audio, and tactile technologies. The project expects to generate new knowledge in the areas of human computer interaction and information visualisation utilising new techniques to present visual information in the form of audio and tactile. Expected outcomes of the project are to reduce the cost of authoring accessible textual and graphical content, and to provide a practical and intuitive reading experience. This should provide benefits to people with vision impairment while accessing information in a more effective and efficient way.
ActivityCreating tactile electronic books for people with vision impairment
Delivery Area 3800 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201825 Jun 201824 Jun 2021 2017-18
MONASH UNIVERSITY
Hotham  $369,365
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to provide a theoretical interpretation for recent observations of protoplanetary discs. Recent first images from the Atacama Large Millimetre Array (ALMA) telescope in Chile and the Very Large Telescope (VLT) have provided a snapshot of planets forming around young stars. This project will use three-dimensional simulations to understand how newborn planets can carve structures such as 'gaps' and 'holes' seen by telescopes. The project aims to develop an algorithm, capable of simulating a mixture of gas and multiple types of solid particles, which is applicable in astronomy and engineering.
ActivityGaps, rings and holes in protoplanetary discs
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201830 May 201830 May 2021 2017-18
MONASH UNIVERSITY
Hotham  $397,872
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to integrate existing data on the genetic mechanisms of lifespan evolution in model systems with a novel combination of whole genome sequencing and comparative phylogenomics to reveal the common genomic signatures of lifespan evolution in vertebrates. Expected outcomes include a perspective on the evolution of lifespan, a topic of major health interest for Australia and the rest of the developed world. This will provide significant benefits, such as long-term implications for aging research, with possible business applications. It will also increase Australia's visibility and competitiveness in the developing field of bioinformatics.
ActivityUncovering vertebrate lifespan biodiversity with whole genome sequencing
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201801 Jan 201831 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $392,893
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop novel approaches for analysis of single biological cells at atomic scale. The project will first develop an approach by utilising nanoscale ion beam to interact with the frozen cells in a controllable manner, followed by performing nanoscale dissection and analyses. By introducing engineered two-dimensional materials, namely graphene, atomic resolution three-dimensional imaging of the cellular chemistry will become feasible, which will shed light on various fundamental mechanisms inside the cells. This will provide significant benefits upon success, and will impact a wide spectrum of fields from understanding cellular functions to developing effective drugs.
ActivityEngineering approaches towards atomic imaging of bacterial cells
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201801 Jan 201831 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $379,489
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to understand why so few biological traits scale proportionally with body size. In contrast to previous mechanistic studies of this longstanding question, the problem will be approached from an evolutionary viewpoint, using artificial selection to engineer animals in which biological scaling laws are either broken or enhanced. By measuring the consequences of this for fitness, the project will provide a new understanding of how organismal size and physiology evolve in nature. The approach should provide significant benefits to our understanding of the role of genetic constraints in hindering or facilitating biological adaptation, furthering our understanding of the capacity of animals to respond to environmental change.
ActivityThe evolution of biological scaling
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201801 Jan 201831 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $402,934
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to study the fundamental issues in robotic-assisted minimally invasive thermal ablation, an important therapy for patients with cancer. It aims to establish advanced characterisation and modelling methodologies for thermomechanical behaviours of soft tissues, together with automatic planning and precise manipulation control techniques for robotic thermal ablation therapies. The project will establish new knowledge and instrumentation for robotic-assisted thermal ablation and minimally invasive surgery. The outcomes of this project will produce important benefits to medicine, healthcare and medical technology industry, and further consolidate Australia's position in innovative technologies and research and development of advanced healthcare systems and instruments.
ActivityCharacterization, modelling and control for robotic thermal ablation
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201801 Apr 201801 Apr 2021 2017-18
MONASH UNIVERSITY
Hotham  $294,720
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop a framework for accurately predicting species responses to environmental change. Future environments will involve shifts in many environmental factors, and species will evolve. Yet we lack understanding of how multiple environmental factors affect the ability of species to evolve and adapt to environmental change. The intended outcome is a tool for predicting the impact of environmental change on the distribution and abundance of organisms. The benefits include improved conservation outcomes and better pest/disease vector control.
ActivityMultiple stressors and vulnerability to global change
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201801 Jan 201831 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $388,975
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to study a fundamental property of random graphs, by further developing a recently introduced approach to the problem of enumerating graphs with given degrees. Using this new method, the project expects to generate new knowledge on the number of connections that each node has with other nodes in a random graph, and to develop new strategies for counting the graphs or networks with a given property. The project expects to produce new theoretical results as well as enhanced capabilities of mathematical research. Potential benefits arise through the uses of these theoretical combinatorial objects to study naturally occurring networks such as social networks, the network of the world wide web, and chemical compounds.
ActivityEnumeration and properties of large discrete structures
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201801 May 201801 May 2021 2017-18
MONASH UNIVERSITY
Hotham  $501,024
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop new technology to enhance the transport of nucleic acids (DNA or RNA) across biological membranes, and to facilitate the delivery of nucleic acids into mammalian cells. Elaborate transport mechanisms have emerged by evolution of viruses but the use of viruses for therapeutic purposes presents safety challenges. This project aims to enhance the efficiency of synthetic nucleic acid delivery systems, making use of novel biocompatible materials which assemble into controlled three-dimensional structures, offering more control over membrane interactions. The project is expected to provide a new platform of smart materials which could be developed for biomedical applications in the future.
ActivityFine control of nucleic acid transport using cyclic peptide nanotubes
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201801 Jan 201831 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $649,632
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate drug resistance in microbial agents. With the emergence of "super bugs" there is a need to understand the biochemistry of antimicrobial resistance. Combining vibrational spectroscopic approaches and metabolomic techniques, the project will investigate cell populations, single cells and subcellular structures in search of biomarkers for drug resistance. The discovery of such biomarkers could lead to improved disease management and eradication programs through identification and treatment of drug resistant pathogens in individuals that have the potential to re-infect the community.
ActivityProbing antimicrobial drug resistance by multimodal molecular analysis
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201801 Jan 201831 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $323,415
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to improve Australia's capacity to predict shoreline position with sea level rise, identify the role of vegetation in foreshore stabilisation and determine thresholds for shoreline retreat by quantifying the links between biological, geomorphological and sedimentary processes and shoreline position. Sea level rise and potential increases in storminess are predicted to lead to severe impacts and there is an immediate and critical need to understand and accurately predict the functioning, dynamics, and distribution of Australia's coastal zones. Expected outcomes of this interdisciplinary project include an integrated modelling framework crucial for planning and management of sea level rise responses in Australia.
ActivityThe role of vegetated foreshores in stabilising Australia's shorelines
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
10 Nov 201720 Feb 201801 Aug 201830 Jul 2021 2017-18
MONASH UNIVERSITY
Hotham  $238,048
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio