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Grants since Jan 2018
Coalition [23,521]
ALP [21,424]
LIBS [12,003]
LNP [7,080]
NATS [4,438]
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655 grants worth $544,578,413 have been awarded to organisations matching MONASH UNIVERSITY or ABN 12377614012 since January 2018

MONASH UNIVERSITY
Hotham  $31,990,410
Address MONASH UNIVERSITY 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency Department of Health
Program Health Workforce
Component Rural Health Multidisciplinary Training Programme
CategoryPublic Health Services Closed Non-Competitive
PurposeThe Rural Health Multidisciplinary Training Programme aims to increase the rural health workforce by supporting universities to deliver quality medical, multidisciplinary and dental training in rural communities and promote/encourage rural careers
ActivityRural Health Multidisciplinary Training Programme
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
31 May 201818 Jan 201910 Jan 201931 Dec 2020 2018-19
MONASH UNIVERSITY
Melbourne  $1,733,327
Address MELBOURNE 3004 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency Department of Health
Program Health policy Research and Analysis
Component CT Grant Activity - Low Survival Cancers
CategoryMedical Research
PurposeCT Grant Activity - Low Survival Cancers
ActivityCT Grant Activity - Low Survival Cancers
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
31 Aug 201808 Feb 201903 Jan 201915 May 2024 2018-19
MONASH UNIVERSITY
Melbourne  $1,084,852
Address MELBOURNE 3004 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency Department of Health
Program Health policy Research and Analysis
Component CT Grant Activity - Low Survival Cancers
CategoryMedical Research
PurposeCT Grant Activity - Low Survival Cancers
ActivityCT Grant Activity - Low Survival Cancers
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
31 Aug 201808 Feb 201903 Jan 201915 Feb 2024 2018-19
MONASH UNIVERSITY
Melbourne  $1,682,836
Address MELBOURNE 3004 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency Department of Health
Program Health policy Research and Analysis
Component CT Grant Activity - Low Survival Cancers
CategoryMedical Research
PurposeCT Grant Activity - Low Survival Cancers
ActivityCT Grant Activity - Low Survival Cancers
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
31 Aug 201808 Feb 201903 Jan 201915 Feb 2024 2018-19
MONASH UNIVERSITY
Hotham  $24,200
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Foreign Affairs and Trade
Agency Department of Foreign Affairs and Trade
Program Public Diplomacy including IRGP grants
Component Australia-Indonesia Institute (AII)
CategoryPublic Diplomacy Open Competitive
PurposeThis project advances cross-cultural understanding and engagement through the development a documentary film, corresponding screening events, and website that explores the similarities, differences, challenges, and educational successes of two Islamic schools, one in Melbourne, Australia and another in Semarang, Indonesia.
ActivityIslamic Schooling in Australia and Indonesia: A Collaborative Documentary Film
Delivery Area Multiple VIC, Overseas AUSTRALIA, INDONESIA
ApprovedPublishedStartEndBudget
30 Jul 201930 Aug 201927 Aug 201901 Aug 2021 2019-20
MONASH UNIVERSITY
Hotham  $19,800
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Foreign Affairs and Trade
Agency Department of Foreign Affairs and Trade
Program Public Diplomacy including IRGP grants
Component Australia-Indonesia Institute (AII)
CategoryPublic Diplomacy Open Competitive
PurposeThe economic and social wellbeing of disabled citizens in Makassar will be enhanced through the design, development and piloting of a scalable model of micro-volunteering in which mainstream communication platforms are leveraged to give access to personalised advice and support.
ActivityCo-production micro-volunteering support for disabled citizens
Delivery Area Multiple VIC, Overseas AUSTRALIA, INDONESIA
ApprovedPublishedStartEndBudget
30 Jul 201930 Aug 201923 Aug 201927 Nov 2020 2019-20
MONASH UNIVERSITY
Hotham  $125,355
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency Department of Health
Program Health and Medical Research
Component 2018 MRFF Rare Cancers Rare Diseases, Unmet Need commencing 2018
CategoryMedical Research Targeted or Restricted Competitive
PurposeSurvival for children with relapsed and recurrent brain tumours is poor, and there have been few new treatment options. However, recent research shows that these tumours have a general change in their DNA (methylation), and altering methylation may stop the tumours. This international trial will test the safety of treating children with ependymoma with a methylation inhibitor (azacitidine) and a standard chemotherapy drug (carboplatin), in the first step of exploring this new treatment option.
ActivityMRF1170019 | COZMOS: Phase I/Ib trial of COmbined 5'-aZacitidine and carboplatin for recurrent/refractory paediatric brain and solid tuMOurs
Delivery Area Multiple NSW, VIC, SA, WA, QLD AUSTRALIA
ApprovedPublishedStartEndBudget
29 Mar 201926 Apr 201901 Apr 201931 Mar 2022 2018-19
MONASH UNIVERSITY
Hotham  $226,284
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency Department of Health
Program Health and Medical Research
Component 2018 MRFF Rare Cancers Rare Diseases, Unmet Need commencing 2018
CategoryMedical Research Targeted or Restricted Competitive
PurposeSJELiOT is a phase 1 clinical trial that explores the combination of a new drug called LY2606368 with other chemotherapy drugs used to treat the childhood brain cancer medulloblastoma. We will determine the maximum dose that is safe to use in children in whom the disease has come back or does not respond to treatment. Also, a small group of patients will receive the identified safe combination dose to detect a preliminary signal that this new combination is effective at treating the disease.
ActivityMRF1170110 | SJ-ELiOT: St Jude - Phase 1 Evaluation of LY2606368, Molecularly-Targeted CHK1/2i Therapy, in Combination with Cyclophosphamide or Gemcitabine for Children and Adolescents with Refractory or Recurrent Medulloblastoma Brain Tumours
Delivery Area Multiple VIC, WA, QLD, Overseas AUSTRALIA, GERMANY, UNITED STATES
ApprovedPublishedStartEndBudget
29 Mar 201926 Apr 201901 Apr 201931 Mar 2024 2018-19
MONASH UNIVERSITY
Hotham  $3,509,303
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency Department of Health
Program Health and Medical Research
Component 2018 MRFF Rare Cancers Rare Diseases, Unmet Need commencing 2018
CategoryMedical Research Targeted or Restricted Competitive
PurposeThere is an unmet need to reduce the mortality and disablity of the most severely injured trauma patients. Erythropoietin (EPO), a hormone which controls the production of red blood cells, also plays a key role in regulating our bodies response to injury and trauma. Previous work strongly suggests that EPO may decrease death and disability of critically ill trauma patients. We will perform the highest quality clinical trial to determine if EPO improves the lives of those critically injured.
ActivityMRF1170001 | ErythroPOietin alfa to prevent mortality and reduce severe disability in critically ill TRAUMA patients: a multicentre, stratified, double blind, placebo randomised controlled trial. (The EPO-TRAUMA trial)
Delivery Area Multiple ACT, NSW, VIC, SA, WA, QLD, NT, TAS AUSTRALIA
ApprovedPublishedStartEndBudget
29 Mar 201926 Apr 201901 Apr 201931 Mar 2024 2018-19
MONASH UNIVERSITY
Hotham  $1,604,184
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency Department of Health
Program Health and Medical Research
Component 2018 MRFF Rare Cancers Rare Diseases, Unmet Need commencing 2018
CategoryMedical Research Targeted or Restricted Competitive
PurposeBehavioural variant Frontotemporal Dementia (bvFTD) affects younger people aged 45-65 years old. Personality changes and memory loss can be distressing to both patients and family. There is no cure and no approved disease modifying therapies currently available. This clinical trial will test the effectiveness of sodium selenate as a new treatment to reduce the progression of bvFTD in patients and potentially reduce economic costs, e.g. a reduction in healthcare use, residential and formal care.
ActivityMRF1170276 | Evaluating the effectiveness and safety of sodium selenate as a disease modifying treatment for patients with behavioural variant Frontotemporal Dementia (bvFTD)
Delivery Area Multiple NSW, VIC AUSTRALIA
ApprovedPublishedStartEndBudget
29 Mar 201926 Apr 201901 Apr 201931 Mar 2024 2018-19
MONASH UNIVERSITY
Hotham  $1,380,298
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency Department of Health
Program Health and Medical Research
Component 2018 MRFF Rare Cancers Rare Diseases, Unmet Need commencing 2018
CategoryMedical Research Targeted or Restricted Competitive
PurposeAcute myeloid leukaemia (AML) is a rare blood cancer with poor outcomes in older patients. We will conduct a nationwide trial to introduce novel breakthrough combinations targeting cell survival pathways in leukaemia. Collaborative partnerships between academic groups, industry and clinical networks will study molecular dynamics, artificial intelligence-augmented data collection methods (www.fungalAi.com), quality of life/fatigue and dynamics of immune fitness in older patients with AML.
ActivityMRF1169950 | NOVEL VENETOCLAX COMBINATIONS TO IMPROVE OUTCOMES IN UNFIT OLDER PATIENTS WITH ACUTE MYELOID LEUKAEMIA
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
29 Mar 201926 Apr 201901 Apr 201931 Mar 2024 2018-19
MONASH UNIVERSITY
Hotham  $1,353,514
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency Department of Health
Program Health and Medical Research
Component 2018 MRFF Rare Cancers Rare Diseases, Unmet Need commencing 2018
CategoryMedical Research Targeted or Restricted Competitive
PurposePatients diagnosed with rhabdomyosarcoma (RMS) are treated with chemotherapy, radiotherapy and surgery, but many do not survive. Our U.K. and European colleagues have developed a new trial, the FaR-RMS study, which includes optimising current treatments, as well as testing the latest promising agents. This study is designed to answer a number of questions within the one trial, and new drugs can be rapidly added. Opening this trial in Australia gives new hope to all patients battling RMS.
ActivityMRF1170254 | FaR-RMS: Frontline And Relapse study in RhabdoMyoSarcoma
Delivery Area Multiple NSW, VIC, SA, WA, QLD AUSTRALIA
ApprovedPublishedStartEndBudget
29 Mar 201926 Apr 201901 Apr 201931 Mar 2024 2018-19
MONASH UNIVERSITY ACTING FOR AND ON BEHALF OF THE AUSTRALIAN AND NEW ZEALAND CHILDREN'S HAEMATOLOGY/ONCOLOGY GROUP
Hotham  $1,500,000
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency Cancer Australia
Program Improved cancer control
Component Support for Cancer Clinical Trials Program
CategoryCancer Targeted or Restricted Competitive
PurposeClinical trials benefit the community by improving the survival of people affected by cancer, and contribute to a reduction in premature death and disability. Clinical trials are fundamental to establishing if new cancer treatments, diagnostic tests or preventive interventions are effective and they help generate evidence for best-practice cancer care.
ActivityThe development of industry-independent cancer clinical trial protocols.
Delivery Area Multiple National AUSTRALIA
ApprovedPublishedStartEndBudget
29 Jun 201805 Jul 201801 Jul 201801 Sep 2021 2018-19
MONASH UNIVERSITY
Hotham  $50,000
Address CLAYTON 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Growing Business Investment and Improving Business Capability
Component Entrepreneurs' Programme - Innovation Connections
CategoryIndustry Innovation Demand Driven
PurposeInnovation Connections promotes collaboration between small and medium sized Australian businesses and the research sector to develop new ideas with commercial potential.
ActivityInnovation Connections
Delivery Area 3061 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
28 May 201917 Jun 201917 Jun 201930 Jul 2020 2018-19
MONASH UNIVERSITY
Hotham  $14,000
Address CLAYTON 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Supporting Science and Commercialisation
Component Science for Australia's Future - Inspiring Australia
CategoryScientific Research Open Competitive
PurposeAll Australians deserve the opportunity to participate in science activities including people with disabilities. This project will develop and deliver modified maker activities that meet the requirements of people with different abilities. Maker workshops provide opportunities for engagement with scientific principles in a creative and hands on manner. The activities will be custom designed to engage participants that have sensory disabilities, significant motor disabilities and/or cognitive disabilities. The focus will be on engaging participants in the scientific activities focused on what they are able to achieve rather than any limitations.
ActivityMaker workshops for all: including people with disabilities
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
28 Mar 201904 Apr 201901 Apr 201929 Apr 2020 2018-19
MONASH UNIVERSITY
Hotham  $50,000
Address CLAYTON 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Growing Business Investment and Improving Business Capability
Component Entrepreneurs' Programme - Innovation Connections
CategoryIndustry Innovation Demand Driven
PurposeInnovation Connections promotes collaboration between small and medium sized Australian businesses and the research sector to develop new ideas with commercial potential.
ActivityInnovation Connections
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
28 Mar 201906 May 201906 May 201905 May 2020 2018-19
MONASH UNIVERSITY
Hotham  $239,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to construct measures of credit reallocation from regulatory bank-level data for Australia and other countries. The project intends to develop empirical models able to evaluate the role of credit reallocation on aggregate output and a theoretical model with search and match frictions to evaluate quantitatively the role of bank credit in explaining macroeconomic outcomes. The project expects to provide significant benefits for policymakers for assessing the interplay between monetary and credit policy, formulating macroeconomic and macro prudential policies, and shedding light on the causes of productivity dynamics in Australia, boosting its comparative advantage.
ActivityGross credit flows, credit reallocation, and the macroeconomy
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Oct 201930 Sep 2022 2018-19
MONASH UNIVERSITY
Hotham  $445,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to examine the relationship between cuticle (skin) properties, water balance, and fitness in springtails, key players in soil systems. Springtail cuticles are diverse, responsive, and extremely resistant to wetting by water, alcohol and other substances. Their Australian diversity has not been well explored for biomimetic new materials. This project expects to explore options for new applications in materials science and engineering by generalising the cuticle structure-function relationship. Expected outcomes are new information to harness for industry the diversity of nature's self-cleaning, water repellent surfaces. Significant benefits lie in potential new biomimetic manufacturing options.
ActivitySkin in the game: biomimetics, fitness and the springtail cuticle
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $370,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to transform understandings of Australian families across the past century through a comprehensive history of Australian fatherhood. Fathers are central to pressing concerns in contemporary Australia. Through analysis of oral history and documentary archives, the project seeks to illuminate factors shaping men's experience of fatherhood and how fathers from diverse backgrounds, including migrant and indigenous dads, have negotiated their role in changing circumstances. The outcomes will extend and enrich Australian and international scholarship in histories of the family, emotions and cultural memory. Project findings are anticipated to impact contemporary Australian family policy and education.
ActivityA history of Australian fatherhood 1919-2019
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $408,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop new algorithms that automatically generate explanations for the results produced by complex computational models. In recent times, these models have become increasingly accurate, and hence pervasive. However, the reasoning of Deep Neural Networks and Bayesian Networks, and of complex Regression models and Decision Trees is often unclear, impairing effective decision making by practitioners who use the results of these models or investigate the decisions made by the systems. Practical benefits of clear decision making reasoning by complex computational models include reduced risk, increased productivity and revenue, appropriate adoption of technologies including improved education for practitioners, and improved outcomes for end users. Significant benefits will be demonstrated through the evaluations with practitioners in the areas of healthcare and energy.
ActivityExplaining the outcomes of complex computational models
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $500,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to capture conditions responsible for the generation of the coherent structures that are formed in wall-bounded turbulent flows, through the use of variational data assimilation and adjoint-based optimisation techniques. The project is expected to provide knowledge and intellectual property that is essential for the accurate modelling and prediction of the interaction between the ground-level activities like pollutant emissions and the atmosphere and the flow over vehicles through pipes, turbines and compressors. This project will provide benefits such as reducing the risk in environmental and commercial design and decision making and will facilitate new opportunities for the commercial development of devices to reduce drag and enhance mixing and heat transfer via the direct manipulation of coherent structures.
ActivityGenesis and evolution of coherent structures in wall-bounded turbulence
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $480,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to uncover the reengineering potential of the biosynthetic machinery that produces glycopeptide antibiotics by advancing our understanding of how the core peptide production line functions. Natural product biosynthesis often produces complex peptide structures, with one important example being the glycopeptide antibiotics. This project expects to generate new knowledge about enzymatic peptide biosynthesis using a highly interdisciplinary approach and previously developed tools. The anticipated outcomes of this project will be an enhanced understanding of how such complex peptide biosynthesis is performed, which is knowledge vital for future efforts to reengineer such biosynthetic peptide assembly lines as a series of modular LEGO blocks to produce new bioactive peptides.
ActivityBiosynthetic LEGO: enzymatic redesign to produce new vancomycin analogues
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $680,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to study the process of branching morphogenesis which drives the development of the kidney. Previous studies group have demonstrated, in general terms, how branching progresses during gestation. However, little is known about the fundamental cellular events which trigger or characterise this basic developmental process. This project expects to provide deep insights into the cellular basis of tissue and organ development. In studying this process the project should provide critical insights into how cells act, individually and collectively, to build tissues.
ActivityThe cellular basis of branching morphogenesis during kidney development
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Oct 201930 Sep 2022 2018-19
MONASH UNIVERSITY
Hotham  $241,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to develop a new and more inclusive philosophical conception of dignity. It expects to generate an alternative to the exclusionary view that dignity is inherent since not all human beings possess the relevant inherent traits. The project will develop a conception of dignity as something conferred, and expects to show that such dignity can and should be conferred on all human beings. The expected outcome is a new understanding of the importance of dignity in human rights law and in health care services. The intended benefits are better appreciation of the role of dignity in human rights, and guidance for health and aged care services on how they can promote the dignity of all of their clients.
ActivityConferring dignity in law and health care
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $345,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to uncover how a ubiquitous agricultural endocrine disruptor affects development, survival and reproduction in frogs. Widespread pollution by endocrine disrupting chemicals poses a serious threat to wildlife, human health, and the environment. This project will integrate laboratory- and field-based experiments to provide insights into how aquatic contamination by endocrine disruptors can affect vulnerable early life stages and, in turn, adult performance and reproduction. The findings will add significantly to understanding the impact of chemical pollution on wildlife responses to human altered environments.
ActivityWildlife responses to endocrine disruptors
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $376,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to decipher how the boundaries between the different organs are established in the developing embryo. The project aims to identify the components of the gene regulatory network that controls lateral plate mesoderm formation, develop a mathematical model that can explain how the domains are formed within this region, and validate novel interactions in vivo in zebrafish. The expected outcome of the project is to reveal how the progenitors of our body parts are instructed to be positioned at the right time and at the right place in the embryo. This project should provide significant benefit such as the expansion of Australia's knowledge base and research capability in cross-disciplinary science.
ActivityFormation of boundaries in the developing embryo
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $493,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to determine the mechanisms by which arrays of high speed jets interact. The project will combine experiments at multiple specialist facilities with analytical approaches to unlock the physics behind both steady and transient behaviour in high'speed multijets. Understanding multijet interaction mechanisms is crucial in the development of more efficient power-generation turbines, and the operation of high'speed flight vehicles. Expected outcomes of the project include deep insight into the characteristics of multijet arrays, and the forging of strong links with multiple international research centres. As well as fundamental knowledge, the project will facilitate improved efficiency in gas turbine systems, using pulsed-detonation combustion.
ActivityThe art of controlling multijet resonance in jet noise and power generation
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $0
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to uncover the origins of extremely bright supernovae called superluminous supernovae. How and why massive stars end their lives as superluminous supernovae is unknown. Based on their shapes and similarities to other peculiar supernovae, this project should clarify the mechanisms that lead massive stars to explode as superluminous supernovae. The project also aims to develop superluminous supernovae as a tool to investigate the distant universe. By observing superluminous supernovae in the distant universe, this project should address the properties of the first generation stars in the universe and advance our understanding of stellar evolution, supernovae, and the early universe.
ActivityUncovering the enigmatic origins of the brightest supernovae
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201901 Jan 2019 2018-19
MONASH UNIVERSITY
Hotham  $520,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims at a step-change in functional, porous microparticle manufacture. To achieve this, the project will use precision flow chemistry techniques that will integrate emulsion preparation, microparticle production and chemical functionalisation in one continuous process. The expected outcome of the project is a process for the manufacture of a suite of designer porous polymer microparticles. Expected benefits are disruptive advances in a number of key technological sectors, including biomedicine, pharmacy, energy and bioprocessing. Platform technology for cartilage tissue engineering has been chosen as an exemplar of the power of precision microparticles.
ActivityPrecision porous polymer microparticles via integrated flow processes
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $0
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to generate new understandings of how science and biomedicine are co-producing and shaping healthcare. This will be achieved by combining hospital and laboratory ethnography to examine how genomic data is produced, circulated and applied in clinical settings. The project aims to build a theoretical framework and conceptual understanding of genomic medicine that may be used by practitioners and may inform policy. This project should provide significant benefits such as minimising costs by helping identify and streamline decision-making processes, and by showing how public engagement practices shape patients' and practitioners' approaches to genomics.
ActivityHow genomics is shaping healthcare: an ethnographic study
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201802 Sep 201902 Sep 2019 2018-19
MONASH UNIVERSITY
Hotham  $420,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to elucidate fundamental principles of alternative splicing, a basic mechanism that plays a vital role in several biological processes across all organisms. Plants are highly effective in adapting to varied environmental, seasonal and climatic conditions and this project aims to uncover how alternative splicing contributes to regulation of gene expression in response to developmental and environmental cues. Uncovering the underlying mechanisms of alternative splicing will not only advance fundamental knowledge, but also has the potential to provide tools and technologies through which sensitivities of plants to environmental stress can be potentially manipulated to benefit agriculture.
ActivityEvolution and specificity of alternative splicing in plants
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $386,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to examine the genetic mechanisms that generate limb diversity, using wing reduction in the emu as a model. A hot topic in biology at present is evolutionary developmental biology, or how genes control morphological diversity. This project will explore the functions of two novel genes implicated in wing reduction. The project expects to expand knowledge in the area of developmental biology, and limb morphogenesis specifically. It will bear upon the phylogeny of flightlessness among birds. It also has potential implications for studying human limb deformities. Overall, the project will enhance our understanding of how genes control the great diversity that we see in nature.
ActivityGenetic regulation of wing reduction in the emu
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Oct 201930 Sep 2022 2018-19
MONASH UNIVERSITY
Hotham  $456,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate the complex regulation of labour disputes in Indonesia, the Philippines and Vietnam. Effective rules and institutions for the resolution of collective labour disputes are integral features of a sound industrial relations system. Yet in many developing countries, formal channels for the resolution of such disputes are largely ineffective. This heightens the risk of industrial disruption and encourages reliance on informal modes of regulation. The project will provide an empirical analysis of existing models of labour regulation, and inform policy development and the activities of agencies involved in labour dispute resolution in the region. It will better equip researchers, legal practitioners, policy makers and NGOs engaging transnationally in the Asia Pacific region.
ActivityThe regulation of labour disputes in Southeast Asia
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $445,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate how polycomb-like proteins regulate polycomb group (PcG) proteins and recruit them to their target genes. During the development of all multicellular organisms, PcG proteins are essential for keeping thousands of genes in a repressed state. PcG proteins are recruited to their target genes with the aid of their Polycomb-like protein cofactors, in a process that is poorly understood mechanistically. This project will determine the mechanism that underpins the recruitment and regulation of PcG proteins by polycomb-like proteins. Outcomes will have relevance for most development processes of multicellular organisms.
ActivityRegulation of histone methylation by polycomb-like proteins
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $330,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate the history of meritocratic ideas in West Germany, Singapore and Japan. The project will generate new knowledge on the ways in which democratic societies built political legitimacy after World War II by analysing the history of education reforms. Expected outcomes include a deeper understanding of the historical conditions which promote social cohesion in modern societies. This project should provide significant benefits by fostering social and educational policy-making which enhances the political legitimacy and stability of parliamentarian democracies in Australia and around the world.
ActivityThe meritocratic moment in West Germany, Singapore, and Japan
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $348,500
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate the macroeconomic consequences of disruptions in financial markets and heightened uncertainty about the future. Key components of the project include new measures of uncertainty and development of new tools to estimate flexible empirical and structural models of uncertainty and financial frictions. The project expects to provide policymakers with tools to design effective policies to counteract the effects of heightened uncertainty and financial disruptions. The results of this project are expected to put Australia at the frontier of the international scientific research on the macroeconomic effects of uncertainty and financial frictions.
ActivityUncertainty, financial frictions, and the Australian business cycle
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Oct 201930 Sep 2022 2018-19
MONASH UNIVERSITY
Hotham  $414,864
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to improve our understanding of the complex regulatory mechanisms that increase genetic and phenotypic robustness. Survival of organisms depends on their ability to cope with genetic variation. A novel process of genetic compensation has recently been identified, producing a normal phenotype in a homozygous mutant, that would be expected to have deleterious effects. This project will reveal how compensation is achieved by examining the molecular pathways that are activated following genetic mutation. This project is expected to strengthen Australian reputation in evolutionary genetics, and in turn enhance our understanding of how organisms adapt to changing environments.
ActivityElucidating a novel mechanism for coping with harmful mutations
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $326,066
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to advance knowledge of an important class of Lie algebras, for which recent work has shown that a deeper mathematical theory, and better computational tools are required. Lie theory is a mathematical area with rich applications in the physical sciences. Expected outcomes from this project include the first systematic treatment of these algebras, new powerful algorithms to compute with them, and explicit nilpotent orbit classifications that will solve open problems in black hole theory. This should significantly enhance fundamental mathematical research and the Lie functionality of leading computer algebra systems, and is expected to strengthen international linkages.
ActivityComputing with Lie groups and algebras: nilpotent orbits and applications
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $386,660
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to better understand where the elements in the periodic table come from, by investigating spectacular but poorly understood nuclear-burning events that occur in stars. The project aims to understand the inner workings of stars by calculating detailed three-dimensional simulations using Australia's largest supercomputers, and to combine this with telescope surveys that are recording the chemical make-up of millions of stars. The project expects to create new knowledge in the areas of stellar physics and nucleosynthesis. Many branches of astronomy rely on stellar models so the impact would extend far beyond the immediate field, ultimately expanding our understanding of the Universe.
ActivityNucleosynthetic signatures of convective-reactive events in stars
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $450,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop new chemical-biology tools and approaches for selectively targeting signalling pathways mediated by G protein-coupled receptors (GPCR). GPCRs are an important family of cell surface signalling proteins that are responsible for the regulation of numerous vital physiological functions. The A1 adenosine receptor is an important model and therapeutically relevant GPCR that will be the focus of this project. Compounds known as bitopic ligands, which can interact with distinct binding sites (termed orthosteric and allosteric sites), will be explored as pathway selective agents capable of activating the signalling pathways mediating the desired effect in preference to those producing adverse effects. Longer-term benefits include the identification of bioactive compounds with more selective modes of action and improved safety profiles.
ActivityChemical-biology approaches to pathway selective adenosine receptor ligands
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jul 201930 Jun 2022 2018-19
MONASH UNIVERSITY
Hotham  $380,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to develop a systematic approach to accommodating religious values and practices in healthcare. Current approaches are ad hoc and discriminatory, and in an increasingly religiously diverse contemporary Australia, a systematic approach is needed. This project will consider and provide policy advice on how healthcare could be reformed so that the issue of accommodation of religious values and practices is treated in a consistent and ethical manner. The benefit of the project will be a better, cost effective, model for healthcare management that reduces disparities for disadvantaged and vulnerable groups.
ActivityReligion, pluralism, and healthcare practice: a philosophical assessment
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $558,824
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to examine the relative contributions of multiple biological clock and sleep factors that may be linked to cognitive function and sleepiness in adolescents. Over 70 per cent of adolescents in Australia experience insufficient sleep. Cross'sectional studies have shown that insufficient sleep and mistimed sleep lead to reduced cognitive function. The project intends to identify specific sleep and circadian markers that are linked to academic performance, and generate innovative algorithms that predict these associations. The project will provide new knowledge to drive prevention and early intervention programs that use sleep-wake and light exposure information to improve sleep quality.
ActivityAssessment of circadian and light interactions in adolescent sleepiness
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Oct 201930 Sep 2023 2018-19
MONASH UNIVERSITY
Hotham  $210,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to identify policies in which the fostering of non-cognitive skills (NCS) can break the persistence of economic disadvantage. The project seeks to investigate the mechanisms behind differential development, intergenerational transmission of NCS between "rich and poor," how exposure to economic stress inhibits NCS development and the role of schooling in boosting NCS of disadvantaged children. Expected outcomes include evidence-based policy advice on how human capital investments in NCS can be beneficial for health, educational and labour market success, and how NCS can survive despite economic stress. Intended benefits include new cost-effective policies to reduce inequality and maximise the welfare of society.
ActivityEconomic stress, non-cognitive skill development and life outcomes
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $740,948
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component Linkage Infrastructure, Equipment and Facilities
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to establish a new national capability for airborne-radar remote'sensing to provide unprecedented detail on environmental variables including soil moisture, salinity, vegetation and terrain height. This instrument, together with existing radar and radiometer capability, will yield the first airborne satellite simulator of its type in the world, providing Australian and overseas researchers with a unique and affordable tool for world-class pioneering research. This novel combination of sensors is expected to yield a level of detail that cannot be achieved with any one sensor alone. Applications include increased capability for monitoring of important environmental data, such as information on soil moisture status required for efficient and sustainable water use.
ActivityHigh resolution airborne P-band radar for environmental research
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2019 2018-19
MONASH UNIVERSITY
Hotham  $416,670
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to test how mitochondrial DNA variation drives molecular, physiological, and behavioural differences between genders and among populations. This project, through the testing of a new hypothesis, expects to generate new knowledge to understand why males and females differ consistently in key health-related traits like longevity. The expected outcomes of this project will provide new discoveries that deliver fundamental insights into the genetics of gender differences, with benefits that extend into the biomedical sciences. The project is also expected to enhance the international profile of Australian science through cutting-edge research in evolutionary genetics.
ActivityThe effects of mitochondrial genetic variation on physiology and behaviour
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $309,828
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate how documentary film, television and online media have transformed our sense of the Australian environment since the 1950s. The project will produce a historicised account of how media has fashioned contemporary environmental consciousness. Expected outcomes include environmental knowledge and social action, collaborations between media producers, scientists and educators, and attention to the role of Indigenous knowledge practices in relation to the environment. The project will enhance understanding of the significance of environmental documentaries in shaping practical and imaginative responses to a world undergoing transformation.
ActivityRemaking the Australian environment through documentary film and television
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $440,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to determine the interplay of micro/nanostructures on stem cell mechanotransduction and to control the cellular environment. It is expected that this will expand our knowledge on how to control stem cell fate. Expected outcomes are novel scalable technologies for micro/nanostructures and smart surfaces, controlled stem-cell expansion and differentiation, and the creation of a library of protein expression based on the cell interactions. These outcomes will provide critical information required for the future development of instructive biomaterials to drive stem cell expansion and tissue-regeneration. Those materials should benefit the future development of efficient and cost-effective regenerative medicine solutions.
ActivityMicro/nano smart surfaces to unlock the potential of multipotent stem cells
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $440,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to address urban congestion by utilising people's travel plans to coordinate journeys. The project expects to generate new knowledge in scalable optimisation, based on innovative modelling of urban transport, and tested on historical data from Melbourne. The expected outcomes of the project are an active transport database and optimised mode choice and routing system, with predicted reductions in congestion based on simulation of its use. This project aims to design an urban trip advisory system that could be followed by automated vehicles as well as human drivers, to reduce the financial and environmental cost of current urban congestion.
ActivityPersonalised public transport
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $470,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop stronger zinc alloys for a new class of biodegradable metallic stents. A key challenge for biodegradable stent technology is to make stents as thin as possible while also being strong. This project will develop ultra-high strength zinc alloys that can be used to fabricate thinner biodegradable stents for easier surgical operation. The project outcomes should be a major step in the design and development of a new generation of biodegradable stents that will avoid the risks associated with existing products and potentially create a better life for millions of patients worldwide.
ActivityStronger zinc alloys for more flexible biodegradable stents
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $329,480
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to attack unsolved problems at the intersection of extremal and structural graph theory, two of the most significant branches of graph theory. Graph theory, which is the mathematics of networks, models many real-world problems and is a key component of modern mathematics. This project expects to develop a theory that synthesises the latest developments in the two fields. It is expected that the tools developed will be widely applicable, for example, in algorithms for network optimisation. The project will build collaborations between Australian researchers and world-leading international mathematicians, and will provide advanced training for talented young researchers.
ActivityNew directions in extremal and structural graph theory
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $215,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to expand understanding of the history of thinking about injustice, by connecting medieval political theory to an earlier tradition of identifying injustices in society that is inspired by biblical prophets. Employing digital analysis of an overlooked group of writings about the body politic, the project seeks to identify the forces shaping notions of injustice, and the process by which complaints were transformed into political advice. The project will make historical texts available in modern translations, expanding the accessibility of the medieval past beyond those with specialist technical skills.
ActivityAddressing injustice in the medieval political theory
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $409,805
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to resolve how entire ecological communities respond to global warming and identify the mechanisms that underpin these responses. Combining manipulations of marine invertebrate communities with assays of energy use, the project expects to reveal emergent effects that cannot be predicted from responses of individual species. The expected outcome is a mechanistic understanding of how warming affects resource use of entire communities that will increase our capacity to predict the consequences of climate change on food-web stability and productivity. These findings should reveal how species interactions alter energy use and invasion risk which is vital to manage ecosystems in a warmer world.
ActivityUnravelling the impacts of global warming on whole ecological communities
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $393,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to build state-of-the-art deep learning models to predict future actions in videos. The project expects to produce the next great step for machine intelligence, the potential to explore a handful of labelled examples to better understand, interpret and infer human actions. Expected outcomes of this project lay theoretical foundations for learning future action prediction in the wild scenario and build the next generation of intelligent systems to accommodate limited supervision. This should benefit science, society, and the economy nationally through the applications of autonomous vehicles, sensor technologies, and cybersecurity.
ActivityTowards data-efficient future action prediction in the wild
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $404,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop novel perovskite-based catalysts with high catalytic activity and long-term stability for the practical application of alkaline water splitting. A new family of overall water'splitting materials in alkaline media based on low-cost and earth-abundant perovskite oxides will be developed, which offer a viable alternative to the benchmark noble metal-based catalysts. Clean hydrogen energy generated by these efficient perovskite catalysts will not only reduce carbon dioxide emissions and alleviate air pollution, but also create opportunities for Australian industries, such as the widespread use of renewable solar and wind energy and fuel cell vehicles.
ActivityPerovskite-based electrocatalysts for water electrolysis
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $220,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project investigates a variety of collective action problems that confront communities that aim to produce knowledge and information, such as academic communities and the media. This project is expected to generate insights into the role of governance institutions in science, social media, and journalism, using techniques of agent-based modelling, economics, and philosophical analysis. Expected outcomes of the project include enhanced capacity to build epistemic networks to maximise the production and dissemination of knowledge, improved understanding of the role of knowledge networks in a just democratic society.
ActivityGoverning the knowledge commons
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Oct 201930 Sep 2022 2018-19
MONASH UNIVERSITY
Hotham  $165,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to show that the history of women's rights is much longer and richer than previously thought. There is a common perception that the notion of women's rights first emerged in the late eighteenth century. This project expects to generate a new understanding of feminist history by investigating texts calling for the recognition of women's dignity, worth, nobility, and excellence (cognate concepts to rights) in England and Europe from 1600 to 1750, against the backdrop of the rise of Cartesianism. The anticipated outcome is greater awareness of an enduring feminist tradition within the history of philosophy. The expected social benefits include a shift in public thinking about feminist history and women in philosophy.
ActivityThe philosophical foundations of women-s rights: a new history, 1600-1750
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $695,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to apply recently developed culturing methods to archive and phenotype bacterial species found in the human gut in a representative sample from metropolitan, rural and indigenous Australians. This project expects to isolate, genome sequence, classify, characterize and permanently archive 1500 bacterial species. Expected outcomes of this project include detailed knowledge of previously undiscovered bacterial species, improved methods to measure the bacterial species that inhabit the human gut and a detailed understanding of the gut microbiota of Australians. This project should significantly enhance our knowledge of bacterial diversity and evolution and provide detailed insights into bacterial transmission.
ActivityBacterial communities in metropolitan, rural and indigenous Australians
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $401,651
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate the cellular and circuit mechanisms of itch transmission in the spinal cord by defining the activation and propagation of itch'specific signals. This project expects to generate new knowledge in the area of neuronal signalling and circuitry using novel electrophysiological approaches that target and manipulate specific nerves and cellular components. The project will characterise signalling within specific spinal subcircuits in order to understand the mechanisms of receptor activation and signalling, and investigate how circuit activity is regulated. This project expects to advance fundamental understanding of itch signalling in the nervous system and provide avenues for future therapeutics.
ActivityMechanisms of itch - from endosomal signalling to neural circuits
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Oct 201930 Sep 2023 2018-19
MONASH UNIVERSITY
Hotham  $500,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to determine the molecular structure of the interface between novel peptide self-assemblies and cell membranes through x-ray diffraction and molecular simulation. The project will generate knowledge to enable atomic scale engineering of peptide nanomaterials, and exploitation of these materials to modulate cell responses. Expected outcomes include designed peptide nanostructures with specific chemical and physical cues to promote sustainable growth of desired cells, whilst inhibiting undesirable responses. These outcomes should provide benefits in terms of a practical toolkit for tailoring structure and function of peptide nanostructures and open up a new era in molecular design of smart biomaterials.-This easily scalable, new materials platform will contribute to emerging high-value manufacturing industries in Australia.
ActivityAtomic scale precision engineering of cell-material interfaces
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $440,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop a flexible mathematical framework for internet resource allocation among competing demands by exploiting application context to allocate resources more efficiently. The project will extend an existing framework which allocates resources independently at each time period, by considering benefits over periods of time relevant to users. The expected outcome of this project is a systematic method for designing next-generation congestion-avoidance protocols that anticipate and accommodate different types of demand. This project will provide significant benefits including better provision of internet services and new ways to help combat traffic congestion, bringing benefits to both the environment and society.
ActivityEfficient and fair context-aware resource allocation in networks
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $809,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component Linkage Infrastructure, Equipment and Facilities
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to establish the most advanced all-in-one multi-functional 3D imaging system in the world. The facility is expected to combine broadband pulse lasers, optical and electronic measurement modules and electrochemical workstations with confocal Raman microscopy to realise 3D imaging and mapping of micro and nanoscale devices. The facility will offer optical tools for in'situ studying of how these micro and nanoscale devices are affected by interactions with external stimuli such as light, heat and stress. The facility will build capacity in Australia for research into advanced functional devices, and develop the workforce for device industries of the future.
ActivityMulti-functional 3D imaging system for micro and nanoscale devices
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201813 Jun 201913 Jun 2020 2018-19
MONASH UNIVERSITY
Hotham  $898,450
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component Linkage Infrastructure, Equipment and Facilities
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to establish the first Magnetic Particle Imaging (MPI) facility in Australia. MPI is a technique that detects the magnetic properties of iron-oxide nanoparticles to produce 3D images. MPI is a high'speed and high'sensitivity breakthrough technology with applications in the disciplines of cell tracking, material science and biotechnology. The facility will be critical for the generation of new knowledge in the industrial biosciences research sector and provide unique benefits to the national research community. It will also significantly enhance Australia's leadership in nanotechnology and molecular imaging, strengthen Australia's research and innovation reputation in biotechnology, and unlock opportunities for the Australian biotechnology industry.
ActivityA national Magnetic Particle Imaging facility
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2019 2018-19
MONASH UNIVERSITY
Hotham  $335,700
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project investigates the phenomenon of children who cross over from statutory child protection systems into youth justice systems. The analysis will be draw data from Children's Court files and international policy. It expects to generate new knowledge regarding the characteristics and trajectories of crossover children, and to improve understandings of how this group differs from children only involved with child protection or youth justice systems. The findings will inform novel and effective approaches to preventing and responding to the drift of children from child protection into youth justice systems which will improve social and economic outcomes for young people and the broader community.
ActivityDual child protection and youth justice clients: expanding the evidence base
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $325,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to determine how the frequency of intense tropical and subtropical thunderstorms will change as a result of future global warming. Climate models project that the energy available to such storms will increase in the future, but the reasons for this increase in available energy, and the implications for thunderstorm activity, remain uncertain. Using observations and high-resolution models, the project expects to generate new knowledge of the mechanisms driving changes in intense thunderstorm activity under climate change, and to provide more accurate projections of the frequency of intense thunderstorms in a warmer climate. This project should deliver benefits to sectors of the economy such as agriculture and transportation, which are significantly exposed to such hazards.
ActivityIntense thunderstorms in the tropics and subtropics under global warming
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $399,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate how young people present professional identities on social media when preparing for employment, and how employers use social media in recruitment. This project will provide insights into the positive and negative impacts of young people's social media use on employability, providing an evidence base and guide for schools and educators to prepare young people for employment. This project will contribute to an understanding of how young people can effectively manage their social media use to enhance their career prospects. This knowledge will be translated into educational materials to inform and guide young people preparing for employment.
ActivityThe impact of social media on the employment prospects of young Australians
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $364,259
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to explain the origin of stars with a chemical composition that is so peculiar that they cannot be explained by any theory of how stars evolve or how elements are created. Their very existence represents fundamental problems in astrophysics. This project proposes a novel method to distinguish peculiarity of up to 20 million stars, mostly observed from Australia. Expected outcomes include new theories to explain two of the most puzzling kinds of peculiar stars, discoveries of new kinds of anomalous stars, and discoveries of ancient or metal-free stars that should not exist. The project is expected to generate social benefit, as well as long-term economic benefits by inspiring and training the next generation of data analysts, programmers, engineers, teachers, and scientists. It may also generate economic benefits from a generalised method for outlier detection in high-dimensional datasets.
ActivityThe stars that should not exist
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201827 Aug 201926 Aug 2022 2018-19
MONASH UNIVERSITY
Hotham  $377,829
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to create efficient, effective techniques that provide accurate forecasts for heterogeneous sets of time series of varying sizes. Exploiting similarities between time series means using many related series, not larger series when building forecasts. The expected outcomes should be innovative methods that improve accuracy and allow forecasting with shorter time series. The project addresses the need to exploit properties of big data accurately in a short time frame, which is transforming many industries. This should enable more accurate and reliable forecasts across industries as diverse as retail, food manufacturing, transport, mining, tourism, energy, and technology.
ActivityEfficient and effective analytics for real-world time series forecasting
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $460,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to reveal the biophysics of sperm motion at surfaces, using 3D imaging, advanced mathematical modelling, and microfluidics. This interdisciplinary project expects to generate new knowledge of sperm flagellar activity, using an innovative microfluidic approach to measure full dynamics of sperm motion in 3D and compare experimental observations with computational results. The project is expected to reveal the intraflagellar mechanisms that trigger the switch between 3D and 2D flagellar waveforms near surfaces. This should provide significant benefits, such as important insights into the biophysics of mammalian reproduction and the origin of flagellar motility in eukaryotes.
ActivityUnderstanding sperm motion at surfaces
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $450,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to improve our understanding of the role of fluids in controlling exchanges between the deep Earth, shallow rocks, and atmosphere. The project expects to investigate some of the key weaknesses in the thermodynamic models that are used to predict the behaviour of sulphur, carbon and metals in fluids at high pressure and temperature by using recent advances in computational and experimental (geo)chemistry. Integrated in large'scale geodynamic models, the more reliable predictions will provide a more realistic assessment of the role of sulphur in controlling metal endowment and atmospheric chemistry through geological times. This should provide a useful guide for mineral exploration and planetary science.
ActivityAqueous fluids in the deep earth
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Oct 201930 Sep 2022 2018-19
MONASH UNIVERSITY
Hotham  $352,351
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate the use of digital data in schools to identify ways to improve its capture and use. Masses of digital data are generated within schools every day, but despite its potential, this data remains poorly used and understood. The project intends to work with school communities in order to develop innovative data tools and techniques that make more effective use of the data. The project will provide new insights into the technical, informatics, organisational and social issues surrounding the (re)use of digital data in schools and the development of digital data -best practice- models. This project should provide benefits in terms of improved teaching and learning, parent engagement and use of infrastructure investment.
ActivityData-smart schools: enhancing the use of digital data in secondary schools
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $530,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to provide key new insights into cell resistance to stress centred on subcellular transport in stress. Environmental stress in its various forms results in the breakdown of cellular functions such as conventional transport into and out of the host cell nucleus. This project will examine a nuclear transporter that has the ability to remain active in stress. Results will establish a platform for stress biology research by the evaluation of nuclear transport in stress in cellular and in-vivo models, and its impact on cell fate. These outcomes will have broad-reaching benefits for enacting climate change responses as well as enhancing Australia's international collaborative network and providing research training opportunities.
ActivityNuclear transport in stress
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $344,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to produce a deeper understanding of factors affecting the aerodynamic forces and detailed flow dynamics of a flapping insect-like wing over a multi-dimensional parameter space with an initial focus on micro-air vehicles. The project will determine the effects of oncoming flow uniformities and environmental factors on flight performance, and how to correct for these factors to stabilise flight using feedback control. The project will use advanced computational and experimental modelling and analysis to provide specific design guidance and strategies for very'small and highly functional micro air vehicles for wide ranging applications in areas including transport, marine engineering and sport.
ActivityUnderstanding flapping aerodynamics in non-optimal environments
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $560,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to discover what exactly happens to brain cells (neurons) when transcranial Direct Current Stimulation (tDCS) is administered. Direct current stimulation of prefrontal cortex has gained much attention as an easy to use and self-administered brain stimulation technique for improving learning and performance in tests, and even for management of conditions such as overeating and gambling. Despite the widespread use of tDCS the neural basis of its effects remain unknown. By applying tDCS in animals performing cognitive tasks, this projects aims to address fundamental unanswered questions about 'where' and 'how' the tDCS influences neural information encoding and behaviour using cellular- and neural circuit-level evidence.
ActivityThe neural basis of the cognitive effects of prefrontal cortex stimulation
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $440,700
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to define the sporulation process in the bacterium Clostridium difficile, and advance our understanding of a link between antibiotic use and sporulation. To survive in hostile environments, some bacteria produce a dormant and resilient cell form called a spore which can survive for many years in unfavourable environments, but our understanding of how this process occurs is limited. This project will provide a deeper understanding of the sporulation process and the long-lasting detrimental impact of antibiotic use. The project expects to provide economic benefits, reduce environmental microbial contamination and contribute to better health of animals and humans.
ActivityA link between antibiotic resistance and bacterial sporulation
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $401,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop a multifunctional smart window which combines thermal regulation of the indoor environment with solar energy harvesting by regulating thermal and light transmittance through the window while harvesting solar energy. This project expects to generate a low-energy building fabric for green building construction. The new product is expected to lead to a reduction in heating and cooling energy consumption in building and industrial applications, a reduction in carbon emissions and electricity generation for indoor lighting. This will provide significant benefits by expanding fundamental knowledge of material science and advanced manufacturing, and enhancing Australia's research capacity by promoting high quality research opportunities for early career researchers.
ActivityNanotechnology-based multifunctional smart window development
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $376,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate the emergence of a political movement promoting Hong Kong nationalism, transforming a seemingly depoliticised trade port into one of the most politically charged cities in the world. The project will use an ethnographic approach of close engagement with activists and their experiences to build on macro-level analyses of Hong Kong's relationship with China and generate new knowledge of the personal aspirations and anxieties driving these tensions. By observing processes of ethnogenesis in real time, the project will provide innovative insights on the ongoing global debates about the origins, appeal, and implications of nationalism today. The results of the project will help build Australia's ability to engage with both Hong Kong and China.
ActivityThe newest nationalism: constructing a Hong Kong national identity
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201821 Jan 201920 Jan 2022 2018-19
MONASH UNIVERSITY
Hotham  $385,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to decipher the chemical complexity required to mimic the digestive behaviour of milk fats and to identify their influence on lipophilic nutrient activity during transit through the gut. The link between milk's complex fat composition and its nutrient delivery properties are unknown because the digestive colloidal structures that drive fat'soluble nutrient absorption are poorly understood. The project expects to identify which milk lipids are essential to milk's role as nature's nutrient delivery vehicle. It will also identify a universally-available nutrient delivery platform for resource-poor communities, and enhanced knowledge of lipid physical chemistry. The findings will promote greater interaction between the dairy and pharmaceutical industries, adding value to their respective products.
ActivityMilk mimicry: Self-assembly in complex lipid mixtures during digestion
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $416,092
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to combine structural, biophysical and functional studies to characterise how ubiquitin enzymes are regulated. Ubiquitination controls essential cellular pathways in all eukaryotes and this project expects to generate new knowledge regarding the vital regulation of this process. This project expects to develop broadly applicable techniques for investigating protein conformation and self-association as a means of controlling catalytic activity. The project should significantly increase understanding of several modes of regulation of ubiquitin ligase catalytic activity, and how this controls a myriad of cellular processes. The project will lay the foundation for applied research anti-viral compounds, plant anti-fungals and cancer therapies.
ActivityUnderstanding intramolecular regulation of ubiquitin enzymes
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $500,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to determine the molecular code (genes and their products) responsible for the expansion of the nonhuman primate visual cortex, which underpins the formation of discrete functional and anatomical areas. The project will detail all the genes expressed at key stages of brain development and how interfering with their expression inhibits the normal formation of areas. The expected outcomes are a chronological and functional map of the molecular code that underpins the formation of the complex primate visual cortex. This will contribute to defining the mechanisms leading to the evolution of the complex primate visual brain and complement the numerous brain connectome studies being undertaken globally.
ActivityFrom gene to duty: the emergence of the complex brain
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $390,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop a foundation for understanding how microscopic topology and intermolecular interactions control the flow behaviour of supramolecular polymer networks. Brownian dynamics algorithms will be developed to unravel the complex dynamics of the network and calibrated by comparison with carefully designed experiments. The expected outcome of the project is a quantitative framework for connecting the molecular structure and energy landscape with resulting macroscopic properties. This project should yield significant benefit in the rational design of supramolecular systems in which the thermorheological properties can be tuned over a wide range of force/time scales with applications spanning from enhanced oil recovery to injectable hydrogels.
ActivityLinking topology and rheology for designing supramolecular polymer networks
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $455,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate how neurons maintain their identity, without reverting back to less specialised cells. Stable fate maintenance is essential because when it fails, cells lose their ability to perform their ascribed function, which impedes organism fitness. This project aims to define how two proteins work in partnership to maintain the identity of brain neurons. We intend our discoveries to stimulate new research, for example to test whether the human counterparts of the Drosophila proteins studied here, function similarly. Benefits will be provided in the form of job creation, and new knowledge in fundamental aspects of life, including brain development and cell fate maintenance.
ActivityHow neurons maintain their fate
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $440,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop low-power technologies for programming and tuning photonic integrated circuits (PICs). By replacing thermal tuning, the project will reduce power consumption from watts to milliwatts, which also eliminates the thermal crosstalk that limits the complexity of today's PICs. The expected outcome will be the basis for a generic field-programmable photonic chip, which can be used to rapidly prototype designs for production as full custom chips as part of a new Australian industry capability. The expected benefits will be a faster innovation cycle, greater adoption of photonic technologies, and support of research into, for example, neuromorphic optical processing, and advanced communications and sensing systems.
ActivityLow-energy electro-photonics: novel materials, devices and systems
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Oct 201930 Sep 2022 2018-19
MONASH UNIVERSITY
Hotham  $390,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to quantify the amount of precipitation over the Southern Ocean and identify the key dynamical and microphysical processes that lead to its development. Large uncertainties exist in the frequency and intensity of precipitation, which limits the ability to model the coupled Southern Ocean climate system. Observations from the RV Investigator, an Australian marine research vessel, have revealed heavy precipitation events within the shallow convection commonly found between fronts that have not been captured by either satellite observations or numerical models. This project will improve weather forecasts, including precipitation, and climate projections over the Southern Ocean and the adjoining Antarctic and the southern part of Australia.
ActivityPrecipitation in shallow convection over the Southern Ocean
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Oct 201930 Sep 2022 2018-19
MONASH UNIVERSITY
Hotham  $339,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to develop new econometric methods that can measure distributional policy effects by accounting for heterogeneous policy impacts among observationally equivalent individuals. The project expects to develop quantile regression methods under a difference-in-differences framework that accommodates issues of censoring and sample selection. The outcomes of this project are expected to substantially broaden the scope of the standard mean difference-in-differences approach and have significant contributions to empirical studies in the future. The project intends to provide statistically valid inferential procedures and conduct simulation exercise and empirical studies relevant to policy evaluation for the benefit of Australia and other jurisdictions.
ActivityEconometric methods for distributional policy effects
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $400,747
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to clarify the role of syndecan-mediated calcium in stem cell development using Caenorhabditis elegans. Stem cells have great potential for regenerative studies. While stem cells cultures are widely used, we do not fully understand how stem cells develop within an organism. This project expects to uncover the mechanisms underpinning calcium regulation by syndecan in stem cells. The expected outcomes include the optimisation of C. elegans stem cell methods to screen calcium regulating compounds and the creation of an in vivo calcium sensor. The project should advance knowledge of the role of syndecans in stem cells and provide the first analysis of in vivo calcium kinetics in stem cells.
ActivityCalcium-mediated regulation of stem cell development
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $387,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to enable security researchers to detect critical vulnerabilities in large software systems with maximal efficiency, cost-effectively, and with known statistical accuracy. The aim is to develop advanced high-performance fuzzers that effectively thwart malware attacks, ransomware epidemics, and cyber terrorism by exposing security flaws before they can commence. The project will employ a well-established statistical framework utilised in ecology research to provide fundamental insights to boosting the efficiency of software vulnerability discovery, and on the trade-off between investing more resources and gaining better cyber security guarantees. As our reliance on new technologies is ever growing, this project equips Australia to curb cyber crime cost-effectively.
ActivityFortifying our digital economy: advanced automated vulnerability discovery
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $400,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop new membranes for use as separators in lithium'sulphur batteries. Currently diffusion of polysulphides within these batteries reduces battery power and lifetime. The new membranes are intended to block polysulphide diffusion over an extended lifetime, while transporting the other ions needed for the battery to function. The project is expected to generate new membrane materials and further knowledge about the design, synthesis and larger'scale production of membranes for electrochemical applications. This project will provide significant benefits by producing potentially lighter, longer-lasting and cheaper batteries than existing lithium-ion technologies, with the potential to accelerate the adoption of electric cars.
ActivityAdvanced separators for lithium-sulphur batteries
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Oct 201930 Sep 2022 2018-19
MONASH UNIVERSITY
Hotham  $245,600
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to advance understanding of the evolution of human dentition using an innovative approach that integrates sophisticated 3D digital modelling with engineering tools. Neanderthals are our closest extinct human relatives that inhabited Eurasia from about 230,000 to 28,000 years ago. However, their protruding faces, large noses and big anterior teeth, raise questions about why these people look so different from us. This project aims to fill this gap in human knowledge about our evolutionary history, and to enhance the international visibility of Australian research in palaeoanthropology and dental biomechanics.
ActivityA real-time biomechanical study of Neanderthal anterior dentition
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Sep 201931 Aug 2022 2018-19
MONASH UNIVERSITY
Hotham  $315,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop target-agnostic analytics, creating models of data that can be queried about any variable or feature without having to be relearned. Government and business collect vast quantities of data, but these are wasted if we cannot use them to predict the future from the past. Presently, big-data analytics is effective at predicting a single pre-defined target variable, yet in many applications, what we know about a system and what we want to find out are far more complex. This project expects to yield novel target-agnostic technologies with associated publications and open'source software. The project will expand the capabilities of machine learning, providing better use of the massive data assets collected across most public, commercial and industry sectors.
ActivityTarget-agnostic analytics: building agile predictive models for big data
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $405,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to define and characterise the protein machines that give mitochondria their characteristic shape in different cellular tissues. Innovative approaches involving gene editing and quantitative proteomics with molecular cell biology will be employed. This project expects to generate new knowledge in protein-mediated membrane shaping and mechanisms by which signaling occurs across multiple membranes. The project outcomes should include enhanced capacity for fundamental cell biology research in Australia. The project anticipates the contribution of new tools for structural biology, benefiting therapeutic and biotechnology applications and the training of young researchers in frontier technologies.
ActivityMachineries that maintain mitochondrial architecture
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $475,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate a new critical step in the autophagy pathway, autophagic lysosome reformation, a fundamental, evolutionarily conserved mechanism for cellular homeostasis. By combining gene function studies with advanced cellular imaging techniques, this project will investigate the dynamic membrane changes that drive this lysosome recycling pathway and how it is regulated by a hierarchical succession of specific enzymes. The expected outcome will be to re-define the archetypical autophagy pathway and characterise novel mechanisms by which it is controlled. This project will reveal new fundamental biological processes, and act as a framework for developing new imaging modalities and tools for studying autophagy.
ActivityPhosphoinositide regulation of lysosome reformation during autophagy
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $479,606
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to map the burden of work disability in Australia through geographic, socioeconomic, demographic and occupational factors. The project intends to determine the impact of state and territory workers' compensation practice on work disability and identify target groups for intervention. Expected outcomes include new insights which nation's workers- compensation systems can use in order to implement policy practices that will reduce the burden of work disability in Australia. This outcome would, in turn, improve national productivity and lead to flow-on benefits for the Australian economy and social protection systems such as social security and healthcare.
ActivityThe impact of policy, demography and geography on work disability
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $300,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to advance knowledge on magma transport mechanisms through the Earth's lithosphere, and boost predictive capacity to discover new ore deposits. Using field surveys, three-dimensional reflection seismic data, laboratory experiments and rock fracture mechanics, this project will investigate where, how and why, narrow finger-like conduits form in lithosphere'scale magma plumbing systems. The project expects to generate new knowledge on the formation and location of highly valuable ore deposits of nickel, copper, cobalt and platinum group elements, which are preferentially trapped in poorly understood, finger-like magma conduits. Anticipated outcomes of the project include fundamental insights into how magma transport dynamics control traps for magmatic sulfide ores as well as equipping mineral explorers in targeting their search for these important, but hard to find, ore deposits, benefitting society through future discoveries of economically strategic, new commodities.
ActivityMagma dynamics and ore deposits
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Oct 201930 Sep 2022 2018-19
MONASH UNIVERSITY
Hotham  $380,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate the developmental basis of vertebrate appendage diversity and how during evolution limbs became fins. The project expects to determine how specific populations of cells that regulate fin formation arise during development, the genetic basis of their function, and how their role in development has evolved in lineages with divergent appendage anatomy. Expected outcomes include understanding the molecular basis of the fin-limb transition and the origin of divergent appendage patterning systems. This should provide significant benefits by advancing our knowledge of the relationship between evolution and development, and understanding limb defects, which are amongst the most common of human congenital malformations.
ActivityHow limbs evolved from fins: the role of somite cells
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $0
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to address back electrode material, a bottleneck functional material in state-of-the-art perovskite solar cells (PSCs). By engineering printable and conductive materials based on carbon and gold nanowires, the project expects to enable highly-efficient and scalable PSCs while reducing cost of materials and production. These expected outcomes are to be implemented in PSCs and their impact rigorously tested in research cells to large-area PSCs modules produced through industry-relevant, scalable, and low-cost printing and coating methods. This will provide significant benefits to Australian industry, from small to medium enterprises to larger utility power companies, while creating economic opportunities and enabling sustainable societies.
ActivityPrinted back electrodes enabling low-cost perovskite solar cells
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201822 Jul 201922 Jul 2019 2018-19
MONASH UNIVERSITY
Hotham  $326,150
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to quantify the relationship and interdependencies between risk factors and service utilisation among family homicide victims and offenders. These will be identified from an analysis of criminal justice and Coroners- data on family homicide using Bayesian networks. This innovative approach will produce a model to predict the probability of a lethal outcome, and enable resources to be targeted for interventions to parties identified as high risk prior to escalation that could lead to death. The knowledge from this project will help save the lives of victims, change the life course of offenders and reduce exposure to violence by other family members to break intergenerational patterns of family violence.
ActivityBreaking patterns of violence to prevent family homicide
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $372,959
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to establish how Baleen whales, the largest animals on Earth and major ecosystem engineers, evolved their signature filter-feeding strategy. Unlike other mammals, whales are toothless, and instead use a keratinous, comb-like sieve to filter vast amounts of small prey from seawater. Various approaches, including biomechanics, three-dimensional imaging, geochemistry and quantitative palaeobiology will unravel how and when filter feeding emerged, how it diversified over time, and whether its evolution correlated with past environmental change. The project is expected to reveal clues on how whales became one of the greatest ecological actors in the sea, and will benefit conservation by providing a glimpse into their future.
ActivityAll you can eat: evolution of feeding in the largest animals on Earth
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jul 201930 Jun 2022 2018-19
MONASH UNIVERSITY
Hotham  $409,286
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to respond to the erosion of Australia's revenue sources by addressing the future of the Goods and Services Tax (GST). The GST taxes less than half of consumer spending and up to $4.5 billion is lost to avoidance and evasion each year. This project expects to generate new knowledge in tax law and policy by using an innovative approach to assess whether possible reform options are viable, sustainable and equitable. Expected outcomes of this project include the formulation of achievable and defensible options that offer a clear path forward on GST reform. This should provide significant benefits to the community by contributing to a fairer and more sustainable tax system capable of meeting the needs of all Australians.
ActivityReforming the Goods and Services Tax
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201802 Dec 201901 Dec 2024 2018-19
MONASH UNIVERSITY
Hotham  $408,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to resolve the shortfall in the fundamental understanding of the coupling between gas flow and geosynthetic liner systems by developing practical and new modelling techniques. The project expects to underpin the development of an experimentally validated theory to predict gas leakage rates through geosynthetics composite liner systems. Expected outcomes of the project are the establishment of a new conceptual framework and improved integrated design tools for the mitigation of gas escape through geosynthetics liner systems. These outcomes are expected to benefit the waste industry by providing the necessary scientific advances to enable a better estimate of gas emissions from landfills.
ActivityLandfill gas leakages in geosynthetic lining systems: closing missing gaps
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $486,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to determine how cells utilise scaffold-type signalling proteins to orchestrate, over time, diverse cellular responses critical for normal development and physiology. The project expects to generate fundamental new knowledge in cell and synthetic biology with broad relevance that will foster establishment of new international linkages and networks. This research should benefit the biotechnology sector by identifying strategies for engineering scaffolds with desired biological outputs, with applications in areas such as large'scale cell production, immunotherapy, wound healing and regenerative medicine.
ActivityDynamic regulation of cell signalling scaffolds
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $531,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims at fostering novel approaches to selectively target vital receptors in the human body, the muscarinic acetylcholine receptors (mAChRs). By harnessing the design of receptor mutations, compounds synthesis and fluorescent imaging, the project expects to develop new pharmacological tools for a family of receptors essential for the life of all vertebrates. By enriching our understanding of this family of receptor, the project expects to provide significant benefits to the research field by impacting on future drug discovery efforts, not only at mAChRs, but at other structurally related receptors.
ActivityDiscovering novel allosteric probes of muscarinic acetylcholine receptors
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $325,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to further the understanding of internal soil erosion across different spatial and temporal scales. Internal soil erosion is the most frequent cause of failures of water retaining structures. An approach combining advanced X-ray techniques with particle based methods will be developed to observe, analyse and link different material properties and external conditions governing the erosion process. This will lead to better criteria for soil erosion and numerical tools for field scale failure analysis and risk assessments. The expected outcomes of this project include enhanced capability to assess the integrity and stability of earth structures and better design criteria against erosion.
ActivityInternal soil erosion: from grain-scale insights to large-scale predictions
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jul 201930 Jun 2022 2018-19
MONASH UNIVERSITY
Hotham  $370,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to exploit the behaviour of semiconducting polymer chains in solution to realise high-performance polymer electronics. This project will be achieved through a combination of simulation, theory, and X-ray measurements of solution-phase chain conformation and device studies. The project expects to create new predictive understanding of how the self organisation of semiconducting polymer chains determines thin-film microstructure and thus charge transport in thin-film devices. Expected outcomes include new materials and processes for high-performance polymer transistors and enhanced interdisciplinary research partnerships. This approach should hasten the development of new technologies based on lightweight flexible electronic devices.
ActivityAggregation control for high-performance polymer electronics
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Oct 201930 Sep 2022 2018-19
MONASH UNIVERSITY
Hotham  $405,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to use a new neural marker to discover and conceptualise how the brain integrates perception with thought. Combining approaches from cognitive neuroscience and the philosophy of cognitive science, the project intends to show how cognitive performance in healthy individuals depends on the degree of integration of top-down and bottom-up signals in the brain. The expected outcome is new empirical and philosophical understanding of the conditions for optimal integration of perception and thought, as well as enhanced interdisciplinary capacity and cross-institutional collaboration. The anticipated benefit is an accessible neuroimaging tool for cognitive assessment.
ActivityThe integration of perception and thought
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201830 Jun 201929 Jun 2022 2018-19
MONASH UNIVERSITY
Hotham  $335,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to resolve the complex interactions affecting the long-term performance of geosynthetic liner systems under harsh environmental conditions for preventing groundwater contamination. Failures of waste containment lining systems result in millions of dollars remedial costs and high societal costs. The project expects to underpin the development of an experimentally-validated theory to predict the performance of geosynthetic liner systems at high temperatures. Expected outcomes of the project are the establishment of a new conceptual framework and providing new guidelines for the design of geosynthetic liner systems for environmental protection. These outcomes are expected to benefit the waste and mining industries by informing planning, decision makers, consultants and construction engineers with science-based information on new lining systems for landfills and mining and industry waste containment.
ActivityThermo-hydro-mechanics of geosynthetic liners: from processes to prediction
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Oct 201930 Sep 2022 2018-19
MONASH UNIVERSITY
Hotham  $416,134
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to reveal how the claustrum coordinates information flow across other brain areas. The project will test the hypothesis that the Claustrum, a structure in the brain's temporal lobe, coordinates the brains resting state networks. The project expects to characterise how the claustrum interacts with different networks, using a combination of anatomical, physiological and mathematical analysis techniques. The project expects to advance knowledge about the function of one of the least understood parts of the brain. This will provide benefits that include new analysis techniques for integrative brain function, and may form the basis of future biotechnologies for modulating brain activity using neuroengineering or pharmacological approaches.
ActivityInvolvement of the claustrum in coordinating brain circuits
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Oct 201930 Sep 2022 2018-19
MONASH UNIVERSITY
Hotham  $419,113
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate how warming and alien species invasions impact on Australia's alpine ecosystems. Using a combination of methods from across the natural and physical sciences, this project endeavours to generate new knowledge on alpine biodiversity and the ability of native and alien species to cope with the pressures of climate warming and decreasing snow fall. Expected outcomes of this project include improved accuracy and precision in predicting the impacts of environmental change providing benefits to conservation planning and protection of the Australian Alps.
ActivityAliens in the alps: predicting invasions and protecting native species
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $390,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component Linkage Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop advanced, cost-competitive catalysts based on scrap tyre char, an otherwise low-value by-product. These catalysts will be optimised for use in upgrading bio-oil derived from the pyrolysis of woody eucalyptus, an abundant biomass resource across Australia. The project is expected to promote the commercialisation of bio-oil production and enhance the valorisation of scrap tyre char. This is expected to reduce the carbon footprint from Australian industry, and promote the recycling and reuse of waste scrap tyres.
ActivityIn-situ catalytic upgrading of bio-oil using scrap tyre char
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201830 Apr 201930 Sep 201930 Sep 2022 2018-19
MONASH UNIVERSITY
Hotham  $249,421
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component Linkage Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate the contribution that informal sports participation makes to wellbeing amongst diverse young people, and ways in which governments, sport and health agencies can effectively support this participation. The project expects to generate new knowledge of how informal sports are self-organised and sustained, factors enabling and inhibiting participation, and will provide a detailed evidence base for the economic and social impact of informal participation. Expected outcomes include the provision of coherent guidance for government, sport and health agencies who will be better equipped to support informal sports opportunities for diverse young people that delivers an enhanced health outcome.
ActivityInformal sport as a health and social resource for diverse young people
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201830 Apr 201901 Jan 201931 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $480,015
Address MONASH UNIVERSITY 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency Department of Health
Program Health policy Research and Analysis
Component Accelerated Research
CategoryMedical Research Open Competitive
PurposeAccelerated Research
ActivityAccelerated Research
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
27 Feb 201808 May 201924 Apr 201930 Jun 2023 2018-19
MONASH UNIVERSITY
Hotham  $494,220
Address Clayton 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Blood Authority
Program National Blood Agreement Management
Component National Blood Sector Research and Development Program
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis study aims to conduct a cohort study of immunoglobulin (Ig) use and patient outcomes in chronic lymphocytic leukaemia (CLL) and non-Hodgkin lymphoma (NHL).
ActivityImmunoglobulin Project Grant: Immunoglobulin use in Chronic lymphocytic leukaemia And Non-Hodgkin lymphoma - the ICAN study
Delivery Area Multiple National AUSTRALIA
ApprovedPublishedStartEndBudget
26 Oct 201820 Feb 201919 Dec 201831 Dec 2021 2018-19
MONASH UNIVERSITY
Hotham  $27,000
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Infrastructure and Regional Development
Agency Department of Infrastructure and Regional Development
Program Department of Infrastructure and Regional Development
Component Used Car Safety Ratings Update 2018
CategoryTransport
PurposeContribution to the Monash University Accident Research Centre's Vehicle Safety Research group research program (Used Car Safety Ratings update and related research)
ActivityUsed Car Safety Ratings Update 2018
Delivery Area 3800 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
26 Mar 201828 Mar 201826 Mar 201830 Jun 2018 2017-18
MONASH UNIVERSITY
Hotham  $350,000
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component Linkage Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop innovative techniques to produce advanced tungsten oxide/metal oxide/mica composites for paint applications. The findings will be used to develop pearlescent paints for diverse applications in a range of industries, with the potential for huge benefits in improving the value of metal oxides and mica. The findings will be useful in the development of other new materials and provide a foundation for new applications such as photochromic and self-cleaning paints. This will generate opportunities to develop and apply advanced knowledge to solve significant problems in industry, leading to national economic growth by adding high values of mineral resources in Australia.
ActivityDevelopment and application of WO3-Mica Multifunctional Nanocomposites
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
26 Feb 201806 Mar 201806 Mar 201905 Mar 2022 2017-18
MONASH UNIVERSITY
Hotham  $223,507
Address CLAYTON 3168 VIC AUSTRALIA ABN: 12377614012
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component Linkage Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate the possible benefits of 3D printing for production of accessible materials for vision-impaired people. Currently tactile graphics are used to provide severely vision-impaired adults and children with access to graphical content used in education and in orientation and mobility training. This project is expected to clarify the kinds of graphics for which 3D prints are better suited than tactile graphics, and to build capacity within the national accessible format provision sector for the production and use of 3D prints. Benefits will include increased educational opportunities and quality of life for Australians with severe vision impairment, through improved access to graphic materials used in education and orientation and mobility training.
ActivityUsing 3D printing to improve access to graphics by vision-impaired people
Delivery Area 3168 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
26 Feb 201806 Mar 201804 Sep 201804 Sep 2021 2017-18
MONASH UNIVERSITY
Hotham  $2,500,000
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency Cancer Australia
Program Health System Policy, Design and Innovation
Component Medical Research Future Fund: Australian Brain Cancer Mission
CategoryMedical Research
PurposeThe purpose is to improve treatments and outcomes for children with brain cancer through increasing access to high quality international cancer clinical trials.
ActivityExpand the capacity of the Australian and New Zealand Children's Haematology/Oncology Group
Delivery Area Multiple National AUSTRALIA
ApprovedPublishedStartEndBudget
25 Sep 201826 Oct 201825 Sep 201828 Sep 2023 2018-19
MONASH UNIVERSITY
Hotham  $498,545
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component International Joint Calls
CategoryMedical Research Targeted or Restricted Competitive
PurposeThere are no national policies or programs for adolescent mental health in Vietnam, despite high prevalence of mental health problems. We aim to improve the mental health of Vietnamese adolescents by establishing whether a cultural adaptation of the Resourceful Adolescent Program, an evidence-based intervention, is effective in preventing symptoms of depression and suicidal behaviours. This adaptation will provide essential evidence for integration of RAP into school-based programs in Vietnam.
ActivityGNT1158429 | Addressing an unrecognised public health problem in Vietnam: a clustered randomised controlled trial of the culturally adapted Resourceful Adolescent Program (RAP-V) to improve adolescent mental health
Delivery Area Multiple VIC, QLD, Overseas AUSTRALIA, VIET NAM
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $128,225
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeTriage is an essential component of Emergency Department care. It aims to sort patients based on the urgency of their condition such that the highest acuity patients are prioritised for treatment. This research proposal aims to review Australian and international triage scales to assess their effectiveness. In particular, it will investigate whether the Australasian Triage Scale remains fit for purpose, and evaluate the recently devised World Health Organization Triage Scale.
ActivityGNT1169298 | Triage systems for emergency care: a contemporary evaluation
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $99,842
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeLupus (SLE) is a chronic autoimmune disease affecting many parts of the body including the brain. Lupus brain fog, or trouble with thinking, concentration and memory, is common, but little is known about why it occurs and what can be done about it. This study aims to improve tools to measure Lupus brain fog, and examine for any predictors, including new biological markers or imaging findings that can identify patients at risk. Effects on patient's function and well-being will also be measured.
ActivityGNT1168941 | Cognitive dysfunction in SLE: diagnostic tools, biological correlates and patient impact
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201930 Apr 2021 2017-18
MONASH UNIVERSITY
Hotham  $128,225
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeKnowledge gaps exist regarding osteoporosis within the community and clinicians in regional/rural Victoria. These knowledge gaps contribute to sub-optimal health related behaviours and clinical management. We will develop, implement and evaluate a co-designed innovative model of care, addressing both consumer and clinician factors, that will lead to improved OP outcomes for rural / regional Victorians, and which may be used to guide practice in other chronic conditions.
ActivityGNT1169192 | Osteo-improve: Development and evaluation of a co-designed, innovative health service delivery and community education initiative to improve regional and remote consumer and clinician osteoporosis understanding and management.
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $128,225
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeAntimicrobial resistance (AMR) threatens to undo decades of medical progress, via infections that are challenging or impossible to treat with antibiotics. Little is known about AMR in developing countries. Our proposed research will occur at Fiji's largest hospital. We will initially identify baseline rates of antimicrobial use and resistant organisms, then assess attitudes of key stakeholders towards antimicrobial stewardship, and finally design a tailored series of intervention to reduce AMR
ActivityGNT1169220 | Ways of Halting Antimicrobial resisTance In Fiji (WHAT-IF)
Delivery Area Multiple VIC, Overseas AUSTRALIA, FIJI
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $111,974
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeOur planet needs to produce enough food to feed a growing population. To protect our natural resources, individuals must change the way they eat. Local governments can support people to eat a more environmentally sustainable diet by investing in effective policy interventions. This research will describe existing policy options, explore the ways that these policies are created and finally, work with stakeholders to co-create guidelines for effective future policy work.
ActivityGNT1169213 | Protecting our planet and our population: the local government policy response to support an environmentally sustainable diet
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $128,225
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeHypertension affects millions of Australians. Some of these cases are caused by primary aldosteronism (PA), a condition of excessive aldosterone production by the adrenal gland. This project aims to establish the prevalence of PA in primary care; and to identify early clinical features and novel cellular markers that may help distinguish PA from other causes of hypertension. Findings from this project may influence guidelines on hypertension management in Australia.
ActivityGNT1168132 | Primary Aldosteronism: Prevalence, Clinical Features, and Biomarkers
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $128,225
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeWhen people are around birds, molds and dust, they may inhale small particles which can permanently damage their lungs. In some cases this leads to a disease called chronic hypersensitivity pneumonitis. It is not clear how much, over how long, and what types of exposure lead to this disease, and what protection might help. This project aims to develop a systematic tool to help doctors diagnose, treat and educate patients using rigorous evidence based methods.
ActivityGNT1169204 | Clinical and biological approaches to improving diagnostic confidence of Chronic Hypersensitivity Pneumonitis
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $114,033
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeBy 2050, a large proportion of the Australian population will be over 65. Traditional healthcare settings are unlikely to cope with the increased monitoring and treatment demands of this aged population. Most patients would prefer to maintain autonomy and independence without sacrificing the security that exists in the hospital. This PhD aims to explore new modalities that enable the advanced monitoring that exist in the Intensive Care, in nontraditional settings such as home, or nursing homes.
ActivityGNT1168809 | Advances in Contactless Patient Monitoring in the Inpatient Setting
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Aug 2021 2017-18
MONASH UNIVERSITY
Hotham  $872,196
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Partnership Projects
CategoryMedical Research Targeted or Restricted Competitive
PurposeGeneral practitioners (GPs) play a key role in the care of patients with work related mental health conditions but find this area of practice very difficult. Our study aims to improve the care GPs provide to patients with these conditions and patient health and return to work outcomes by implementing a national evidence based guideline on diagnosing and managing work-related mental health conditions in general practice.
ActivityGNT1160223 | IMPRovE: Implementing work-related Mental health guidelines in general PRacticE
Delivery Area Multiple NSW, VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Dec 201830 Nov 2022 2017-18
MONASH UNIVERSITY
Hotham  $181,066
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component TRIP Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeCancer patients are frequently malnourished prior to treatment, with prevalence as high as 90 percent for people with cancer of the gastrointestinal tract. Malnutrition reduces the patient's ability to respond to treatment and quality of life. Individualised nutrition care commencing prior to cancer treatment is best-practice, yet Health services lack affordable resources to deliver this service. In this proposal a mechanism to implement this much needed service will be developed.
ActivityGNT1168483 | Implementation of earlier evidence-based nutrition for people with upper gastrointestinal cancer.
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $181,066
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component TRIP Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeRetail food environments are an effective and critical target to improve population diet quality. This project will accelerate the uptake of initiatives in remote communities to improve the store food supply. It will support public health nutritionists to engage with remote retailers in the co-development and monitoring and evaluation of strategies that are contextually relevant and economically viable for retailers, while also effective in improving population diet.
ActivityGNT1168333 | Reducing the burden of disease and inequity through building a food system that supports healthy eating in remote Indigenous Australian communities
Delivery Area Multiple VIC, NT AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $181,066
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component TRIP Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeKnee pain, a common health problem lacking of effective therapy, is a predictor of future knee pain, disability, and adverse joint and health outcomes. There is an urgent unmet need for a sustainable, low-intensity preventive intervention for early knee pain. I propose to adapt and implement the HeLP-her in men and women of low socioeconomic status and rural regions who are overweight/obese or have early knee pain, applying new delivery modes, to reduce the burden of knee pain in the community.
ActivityGNT1168185 | HeLP-knee (Healthy Lifestyle Program for knee pain prevention) - a sustainable low-intensity self-management lifestyle intervention for reducing the burden of knee pain in the community
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $181,066
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component TRIP Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis fellowship project addresses the important problem of overuse of arthroscopic surgery for knee osteoarthritis. High quality evidence shows arthroscopy is ineffective and potentially harmful. Despite this, over 30,000 Australians undergo this surgery annually at a cost of greater than$32 million to Medicare. I propose to evaluate whether a patient decision aid is effective in improving patients- knowledge and risk perceptions about knee arthroscopy and reduces referrals for knee arthroscopy.
ActivityGNT1168749 | Reducing low-value knee arthroscopy in Australia
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $181,066
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component TRIP Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeThere is a major evidence-practice gap in the management of carotid stenosis (main brain artery narrowing). Globally many billions of dollars are wasted annually on unnecessary carotid procedures. This inappropriate industry is driven by all identified guidelines. I will lead experts in creating the world's first -evidence-true- guideline for carotid stenosis and determine how to best prevent arterial disease complications in these and other patients using only lifestyle coaching and medication.
ActivityGNT1168295 | Improving Prevention of Stroke and Other Arterial Disease Complications by Closing Evidence-Practice Gaps
Delivery Area Multiple NSW, VIC, WA, Overseas AUSTRALIA, AUSTRIA, GREECE, ITALY, UNITED KINGDOM, UNITED STATES
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $1,023,119
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeHow do antidepressants impact epilepsy development- This is a basic science proposal to seek to understand the interaction between antidepressant medications and epilepsy.
ActivityGNT1157353 | Antidepressants in epilepsy
Delivery Area Multiple VIC, Overseas AUSTRALIA, FINLAND
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $799,120
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeAlthough a number of organs can repair themselves from mild injury, when subjected to ongoing/persistent injury, they fail to properly do so. As a result, they undergo organ scarring (fibrosis) and a progressive loss of function. As currently available therapies fail to effectively stop this scarring process, we aim to combine an anti-fibrotic agent (serelaxin) with bone marrow-derived stem cells to effectively block fibrosis and further improve tissue repair and function.
ActivityGNT1156446 | Enhancing the anti-fibrotic and regenerative capacity of bone marrow-derived stem cells
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $796,802
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeChagas disease is a terrible parasitic disease and is described as the most burdensome neglected tropical disease in Latin American countries. An estimated 6 - 7 million people are infected worldwide with approximately 25 million people living at risk of infection. We have small molecules that inhibit the causative parasite, Trypanosoma cruzi. In this project we will improve potency and metabolic stability to furnish a therapeutic candidate for Chagas disease.
ActivityGNT1156436 | New Treatments for Chagas Disease
Delivery Area Multiple VIC, Overseas AUSTRALIA, BRAZIL, UNITED KINGDOM
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $1,392,005
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeWhen the immune system malfunctions it can cause the body to lose tolerance one or more of its own proteins, leading to autoimmune diseases that affect more than 5 percent of the population. This project uses autoimmune kidney disease to study why we lose tolerance to ourselves. Understanding this process is not only fundamental to defining the basis of autoimmune diseases but also a key step in the development of more effective, more targeted and less toxic therapies in the future.
ActivityGNT1162384 | Defining key determinants of HLA mediated T cell tolerance and autoimmunity
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $820,985
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis proposal aims to shed light on the molecular mechanisms underpinning the health-promoting effects of exercise. This proposal will focus on defining how reactive oxygen species contribute to exercise-induced adaptive responses in muscle that promote metabolic health and prevent the age-related decline in muscle function. Our studies will shed light on mechanisms that help prevent disease in our increasingly sedentary and ageing populations.
ActivityGNT1162798 | The role of NOX4 in muscle antioxidant defence and mitochondrial biogenesis
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $1,195,066
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeWe identified patients who are susceptible to specific infections (influenza, herpes, etc.) due to deficiency in components of the interferon signaling pathway. Interferons are long known to protect from infections, but each component was thought to contribute broad protection not to specific pathogens. We will use cells from these patients to characterise new specific functions of interferon components and pathways to generate new biomarkers of disease, patient response and new therapies.
ActivityGNT1159713 | Unravelling the role of type I Interferon family in human infectious and inflammatory diseases
Delivery Area Multiple VIC, Overseas AUSTRALIA, UNITED STATES
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $692,599
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeParkinson's disease (PD) is a degenerative disorder of the central nervous system in which the underlying cause is, in most cases, unknown. To pave the way to a better understanding of what goes wrong, and how to fix it, this study will investigate the function of cellular repair pathways that break down in PD. The results of this study can be used to explore the potential of new therapeutic targets and small molecules to treat disease.
ActivityGNT1160315 | Understanding how mitochondrial quality control pathways cooperate to maintain mitochondrial health
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $669,790
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeMany women suffer from either failed fertilisation or their embryos arrest during early development. This often results because their eggs have too few copies of mitochondrial DNA otherwise known as mitochondrial DNA deficiency. We will show how supplementation with autologous populations of mitochondrial DNA induce changes in the genes that an embryo expresses to promote the transition from a metabolically poor fate to a metabolically healthier fate.
ActivityGNT1160106 | Understanding how mitochondrial DNA contributes to embryo development.
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $766,585
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeMany bacterial 'superbugs- can increase their mutation rate, i.e. become hypermutable, and rapidly become resistant to many antibiotics. A near worst-case scenario are multidrug-resistant hypermutable bacteria that cause increased ill-health and death in patients and current treatments do not work well. We will develop improved treatments, using combinations of available antibiotics, that can effectively kill the pathogens and minimise resistance.
ActivityGNT1159579 | Overcoming multidrug-resistant hypermutable Pseudomonas aeruginosa via antibiotic combinations
Delivery Area Multiple VIC, Overseas AUSTRALIA, SPAIN
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $722,284
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeMitochondria are the powerhouses of our cells that produce the chemical ATP for functions such as muscle contraction and triggering of nerves. Mitochondrial Complex I is a molecular motor that helps to make this ATP. -Mitochondrial disease- is often seen when Complex I is defective resulting in early childhood death. In this project we will study the structural importance of components of Complex I and investigate the hypothesis that they also have additional functions in mitochondria.
ActivityGNT1164459 | Dissecting the functions of accessory subunits in mitochondrial complex I
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $574,323
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeAchilles tendinopathy is a painful condition that restricts weight bearing activity. Exercise treatments are first choice but often fail. Injections and surgery may then be offered but do not work well. Our studies suggest that high volume injections may improve Achilles tendinopathy symptoms, but require further testing. We will, for the first time, test this injection on Achilles tendinopathy symptoms over a year.
ActivityGNT1164268 | Efficacy of high volume injections compared to placebo following failure of conservative therapy for Achilles tendinopathy
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $542,521
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe major objective of this research is to elucidate new mechanisms that control stem cell development. The biochemical pathways under study are potentially druggable with small molecules. Therefore, this project has the potential to identify processes and pathways that are directly relevant to health and disease.
ActivityGNT1161439 | Controlling Stem Cell Development Through Calcium-Mediated Transcription
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $884,384
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeT cells are a critical component of the immune system that can recognise infected host cells. However, there remains many facets of T cell function that we do not understand. This project aims to investigate a major aspect of T cell-mediated immunity that is poorly understood, namely, T cell immunity to metabolites. Specifically, using a multi-disciplinary approach, this project will unearth the molecular correlates of metabolite-based immunity in humans.
ActivityGNT1159932 | Investigating diversity within the MR1-restricted T cell repertoire in humans
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $631,653
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeMPO-ANCA associated glomerulonephritis and acute kidney injury are important causes of inflammatory kidney disease. In these diseases, specialised white blood cells called mast cells (MCs) enhance injurious inflammation by releasing packages of inflammatory proteins, a process called degranulation. This pre-clinical study will re-purpose an anti-allergy drug, disodium cromoglycate to prevent and or treat inflammatory kidney diseases.
ActivityGNT1159361 | Immunomodulatory Mast Cells as Therapeutic Agents in Chronic Autoimmune and Acute Inflammatory Kidney Disease
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $747,518
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeType 2 diabetes (T2D) results in 3.7 million deaths each year. T2D is characterised by impaired blood sugar control (glucose homeostasis) due to defective insulin signalling. Insulin is secreted after a meal by the pancreas to instruct the muscle/fat to uptake glucose from the blood. Insulin also signals to the brain but the significance of this remains unclear. We aim to determine where and how insulin is integrated into the brain and determine its contribution to glucose homeostasis and T2D.
ActivityGNT1160043 | Insulin on the Brain: Determining how insulin signalling in the brain coordinates glucose homeostasis
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $950,184
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeStem cells are essential for maintenance and repair of many adult tissues including testis. Within a given tissue, different populations of stem cells can play contrasting roles in tissue maintenance and regeneration. We have identified a group of stem cells within the testis marked by a unique set of genes critical during embryo development. Our studies will assess the role of this new cell population in male fertility and testis repair and define genes required for its function.
ActivityGNT1164019 | Regulatory networks defining stem cell populations in the adult male germline
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $881,568
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis project will determine how a class of weightloss drugs (melanocortin agonists) increases blood pressure. This may pave the way for better drugs with fewer side effects, and also better understanding of the neural mechanisms that control blood pressure.
ActivityGNT1163341 | Can we engage weight loss circuits in the brain without causing hypertension-
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $645,788
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeAdvanced medical treatments come with a high risk of life-threatening microbial infections, and rising antimicrobial drug resistance demands innovative therapeutic strategies. In this project, we will characterize metabolic regulation as a novel therapeutic target in infection, focusing on the human fungal pathogen Candida albicans that causes hospital infections with 40 percent mortality. Our outcomes will be broadly relevant to designing improved therapies against infectious diseases.
ActivityGNT1158678 | An investigation into metabolic competition between host and pathogen in infection
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $654,920
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeTo cause disease, viruses enter host cells and build new progeny virions, that spread and cause further infections. Critical to this is the ability of viruses to transform host cells into virus factories by -reprograming- the cellular machinery. Using highly lethal pathogens, we identified a new strategy by which viruses mimic normal cellular responses to change the cellular synthetic machinery. By elucidating these mechanisms, this work should identify new potential targets for therapies.
ActivityGNT1160838 | Viral hijacking of the nucleolar DNA damage response machinery: novel mechanisms to regulate host cell biology
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $5,815,766
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe Statins in Reducing Events in the Elderly (STAREE) is a large scale primary prevention trial based in Australian general practice that is examining whether statin therapy prolongs independent living and reduces cardiovascular events in older adults (-70 years) without established vascular disease or diabetes.This application seeks support to complete participant follow-up and collection of clinical data essential to confirm study outcomes.
ActivityGNT1161503 | Statins in Reducing Events in the Elderly trial
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $570,888
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe body needs to react if blood sugar levels become abnormally low in order to prevent harmful life-threatening consequences. While hormonal cues from the periphery inform the brain about blood sugar levels, the brain is the main player to initiate counterregulation. The neuronal circuit how the brain senses glucose and initiates regulatory responses is unknown and will be the topic of this proposal.
ActivityGNT1160065 | How does the brain sense low glucose levels and switch on corrective actions-
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $936,759
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeVascular disease is a major cause of mortality in diabetes. Current treatments are inadequate as cardiovascular disease still represents more than 70 percent of mortality in people with diabetes. Our exciting new data demonstrate that a novel endogenous small molecule (Lipoxin A4) has protective effects against the pathological processes within vascular cells that drive atherosclerosis. This represents a promising approach to combat diabetic complications such as diabetes-associated atherosclerosis.
ActivityGNT1159460 | Lipoxins protect against diabetes associated atherosclerosis
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $1,397,337
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposePelvic organ prolapse is a hidden, debilitating gynaecological disorder affecting 25 percent of women causing sexual, bladder and bowel dysfunction. Prolapse is the herniation of the uterus, bladder, or bowel into the vagina as a result of childbirth injury. Surgical treatment often fails and the use of vaginal mesh has been banned due to unacceptable side effects. We are developing a cell-based therapy using a woman's own endometrial stem cells to repair the damaged tissue.
ActivityGNT1159677 | Cells and Nanobiomaterials to Treat and Prevent Pelvic Organ Prolapse
Delivery Area Multiple VIC, Overseas AUSTRALIA, UNITED KINGDOM
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $1,162,535
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe calcitonin-family receptor are physiologically important receptors that have been implicated in treatment of osteoporosis, migraine and cardiovascular diseases. Therapeutic development targeting at these receptors remains challenging due to lack of mechanistic understanding in how these GPCRs are activated. This proposal will explore the structure and function of the calcitonin-family receptors at a molecular level, enabling improved discovery and development of novel therapeutics.
ActivityGNT1159006 | A structural understanding of calcitonin gene-related peptide and adrenomedullin function
Delivery Area Multiple VIC, Overseas AUSTRALIA, NEW ZEALAND
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $672,521
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeShutdown of ovarian function at menopause depletes the female body of circulating oestrogen and inhibins. Whilst it is known that oestrogen deprivation is bad for bone health, little is known about the impact of inhibin loss. I have made a mouse that lacks functional inhibins, so that we can understand the body wide consequences of inhibin loss at menopause. Additionally, I have found a way to mass produce inhibins, allowing us to explore the potential of inhibin replacement therapies.
ActivityGNT1157680 | Defining the Physiology and Therapeutic Potential of Inhibin
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $1,242,532
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe glucagon-like peptide-1 receptor is a major drug target for treatment of type 2 diabetes and obesity. Different drugs acting at this receptor are capable of producing distinct physiological outputs, but a detailed understanding of the profile of receptor response that provides optimal clinical effectiveness is lacking. This project addresses this critical knowledge gap and will lead to improved for strategies to screen and develop new and better medicines.
ActivityGNT1157539 | The physiological and pathophysiological relevance of glucagon-like-peptide-1 receptor biased agonism
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $1,413,033
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeShift workers, as a result of their work schedules, are more likely to be overweight. Eating at night contributes to this increased risk. Effective strategies for weight loss are needed for this population and intermittent fasting (IF) and time restricted eating are two flexible approaches that may suit. We will investigate weight loss effectiveness of three diets: standard energy restriction; IF (day time fast) and IF (night time fast) in shift workers who are overweight.
ActivityGNT1159762 | Shifting Weight using Intermittent Fasting (the SWIFt study): A novel weight loss intervention in shift workers with obesity
Delivery Area Multiple VIC, SA AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $625,788
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeFungal infections cause 1.5 million deaths annually. Current antifungal drugs are insufficient, and the mortality from systemic fungal infections surpasses mortality from bacterial infections. This project aims to characterize how gene regulation by a short chain fatty acid inhibits disease-related processes in a major fungal pathogen. The outcomes will lay the foundation for developing improved antifungal therapies.
ActivityGNT1158687 | Control of host-pathogen interactions and fungal virulence by short chain fatty acids
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $1,256,312
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeFetal growth restriction (FGR) is a common but devastating pregnancy condition where the fetus fails to thrive, and brain development is particularly vulnerable. We have shown that the brain injury present in FGR offspring is complex, altering basic cell morphology, and cell communications. This project will examine and compare the neuroprotective benefits of 2 treatments in our ovine model of FGR, to inform the future clinical care for FGR and reduce neurodevelopmental brain injury.
ActivityGNT1160393 | Optimising neurodevelopmental outcomes for fetal growth restriction
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $989,384
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeMuscle stem cells repair muscle during injury and diseases such as muscular dystrophy. How they are activated and replace copies of themselves for activation during future repair is largely unknown. The immune system appears to help coordinate this process and we are looking at cell and signals that coordinate muscle stem cell repair.
ActivityGNT1159278 | Defining the molecular basis of macrophage-mediated muscle stem cell activation
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $1,371,900
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis project aimed to improve outcome of patients with acute ischaemic stroke by improving the safety of current treatments. This project also aims to develop a new test to predict the outcome of current clot-busting treatments to better identify patients for thrombolysis and to minimise risk.
ActivityGNT1156506 | Improving the safety and predictable efficacy of thrombolytic therapy in acute ischaemic stroke
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $643,734
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeFor almost 80 years, the main way to treat advanced prostate cancer has been to cut off the supply of male hormones. Unfortunately, this is only temporarily effective and compromises patients- quality of life. New clinical trials show that the reverse approach - over'supplying hormones to the tumour - is effective and improves quality of life. This project will use novel models of prostate cancer to identify which patients will get the most benefit from this new treatment strategy.
ActivityGNT1156570 | Giving prostate cancer enough rope with bipolar androgen therapy
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $817,063
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeEmbryo implantation is a critical step in establishing pregnancy and a major hurdle in IVF treatment to overcome infertility. The uterus must remodel considerably to become -receptive- for an embryo to implant. However, how the human uterus develops this receptivity is not well understood and this knowledge gap severely hampers IVF treatment. This project will investigate a novel uterine shield controlling human uterine receptivity and its clinical application in improving IVF success rates.
ActivityGNT1156666 | The magic shield of the human uterus and fate of embryo implantation
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $667,521
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis proposal will investigate how the bacterium Staphylococcus aureus causes life-threatening infections. We will identify that bacterial toxins kill immune cells by hijacking host factors. The study will determine alternative therapeutic options to prevent lethal infections with antibiotic-resistant bacteria.
ActivityGNT1163556 | Pore-forming toxins of Staphylococcus aureus: imaging assembly, pore formation and killing
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $2,703,830
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeSevere traumatic brain injury is a leading cause of death and disability in Australia. Intensive care in this setting focuses on ensuring adequate delivery of oxygen to the injured brain, albeit current management may not always achieve this. We will randomly allocate 860 severely brain injured patients to either standard care, or a novel management protocol informed by early brain tissue oxygen monitoring. This strategy will hopefully lead to improved functional outcomes and major savings.
ActivityGNT1156636 | Brain Oxygen Neuromonitoring In Australia And New Zealand Assessment (BONANZA) Trial
Delivery Area Multiple ACT, NSW, VIC, SA, WA, QLD, Overseas AUSTRALIA, NEW ZEALAND
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $561,171
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe bacterial type VI secretion system is a molecular syringe that allows bacteria to deliver effector proteins, such as toxins, directly into other bacteria. This project will determine how these effector proteins are selected for delivery, how they interact with the secretion system structural proteins and how specific 'prey' bacteria are selected and targeted. This information will allow us to engineer novel toxic proteins and deliver these into the specific bacteria that we wish to control.
ActivityGNT1165036 | Co-opting bacterial weaponry: Manipulation of the Acinetobacter type VI secretion system for targeted killing of bacteria
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $978,979
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeCerebral palsy is a devastating life-long condition. A large proportion of cases are associated with exposure to inflammation at the time of preterm birth. There is no effective treatment. Our studies will examine how inflammation impairs brain development and function in preterm infants and test whether blocking a key inflammatory protein in the blood, called tumour necrosis factor, improves brain development. We will generate critical knowledge towards reducing disability in preterm infants.
ActivityGNT1164954 | Preventing inflammation-induced brain injury in preterm infants: targeting systemic tumour necrosis factor
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $623,386
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis project will increase the understanding of how the energy sensing kinase gene family enables cells to link information about nutrient status with their growth. As this gene family is conserved between flies and humans our studies are highly relevant to human biology. This research has long term benefits in manipulating the relationship between diet and animal growth for treatment of obesity, as well as in development of SIK3-directed therapeutics in cancer.
ActivityGNT1158335 | Deciphering the role of SIK3 in development and disease
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $1,825,648
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeCryopreservation extends platelet shelf-life from 5 days to 2 years. However, evidence is insufficient for widespread use. Our recent 121-patient pilot trial found encouraging results. We now propose an 808-patient definitive trial in bleeding surgical patients, measuring blood loss, transfusion requirement, complications, and cost. Even if cryopreserved platelets are only equivalent to liquid'stored platelets, their longer shelf-life would justify rapid change in clinical practice worldwide.
ActivityGNT1156641 | A phase III multicentre blinded randomised controlled clinical non-inferiority trial of cryopreserved platelets vs. conventional liquid-stored platelets for the management of post-surgical bleeding.
Delivery Area Multiple ACT, NSW, VIC, QLD, TAS AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $646,890
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeObesity-induced type 2 diabetes is a growing worldwide epidemic caused by excess consumption of saturated fat and processed carbohydrate. Central to disease development is inflammation-induced insulin resistance that is driven by inflammatory factor, interleukin-1- (IL-1-). This proposal seeks to define whether dietary stress triggers programmed cell death to induce IL-1 activation. This research may reveal novel strategies to treat type 2 diabetes and associated diseases (e.g. atherosclerosis).
ActivityGNT1162765 | Role of programmed cell death in NLRP3 inflammasome activation and Metabolic Syndrome
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $711,032
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeIschaemic stroke, resulting from an obstructive clot, comprised approximately 85 percent of all strokes. There are several new therapies including the clot-busting drug, and clot retrieval (ECR) for large clots . However, only a small subset of patients are eligible for these therapies. We have demonstrated that human amnionic stem cell can reduce stroke size in animal experiments. We thus propose a Phase 1 dose escalation trial to assess the safety of allogeneic stem cell in stroke patients.
ActivityGNT1163282 | I-ACT: Phase I trial of Amnion Cell Therapy for Ischaemic Stroke to establish the maximum tolerable dose
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $1,202,978
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeBariatric surgery and more particularly vertical sleeve gastrectomy (VSG) are widely performed to combat morbid obesity. To improve surgery and to ultimately replace it, it is necessary to understand how it works. Our preliminary data from an animal model shows that increased energy expenditure and improved glucose regulation in brown adipose tissue are essential to surgical success. This project will uncover what are the interactions between the gut and the brain that allow this to happen.
ActivityGNT1163039 | The vagus nerve and gut - brain interactions: the underpinnings of successful weight loss surgery through recruitment of Brown Adipose Tissue
Delivery Area Multiple VIC, Overseas AUSTRALIA, UNITED STATES
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $814,384
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeT cells are a critical component of the immune system, however, there remains many facets of T cell function that we do not understand. This project aims to investigate a major aspect of T cell-mediated immunity that is poorly understood, namely, T cell mediated autoimmunity. Specifically, using a multi-disciplinary approach, this project will unearth the molecular correlates of aberrant lipid-mediated that manifests notably in skin-mediated autoimmune disorders in humans.
ActivityGNT1161883 | An investigation into aberrant T cell reactivity towards lipids
Delivery Area Multiple VIC, Overseas AUSTRALIA, UNITED STATES
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $656,155
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe PATCH-2 trial is clinical trial of a drug known as tranexamic acid. This is a relatively inexpensive drug that is currently used in the hospital in patients undergoing cardiac surgery or in patients who have bleeding after delivery. The use of this drug in patients with severe trauma has not been tested in the pre-hospital setting. The PATCH-2 trial will test whether tranexamic acid given in the prehospital setting improves patient outcomes by decreasing the amount of bleeding after trauma.
ActivityGNT1165275 | Pre-hospital anti-fibrinolytics for traumatic coagulopathy and haemorrhage-2 (The PATCH2 Study)
Delivery Area Multiple NSW, VIC, SA, QLD, NT, TAS, Overseas AUSTRALIA, NEW ZEALAND
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $550,157
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeCurrent asthma treatment does not always overcome breathing difficulties during an asthma attack and does not target long-term structural changes such as fibrosis that making the airways stiffer and harder to relax. We propose that serelaxin - a synthetic form of a natural hormone - could treat both excessive airway contraction and fibrosis. By showing its dual actions overcome the limitations of current therapies, we will be able to progress this new treatment towards clinical use for asthma.
ActivityGNT1165690 | Simultaneously targeting airway contraction and fibrosis as a new therapeutic strategy for asthma
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $922,284
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis application examines how the immune response can be diversified to include peptide targets that have been reconstructed during their normal degradation. As such novel targets of immunity can be generated that cannot be predicted from the genome of the pathogen or the host. We will explore the mechanism of generation and immune consequences of these antigens constitutively and during influenza infection.
ActivityGNT1165490 | Diversification of immune responses through unanticipated proteolytic mechanisms
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $955,024
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposePatients with diabetes or chronic kidney disease are at high risk of severe kidney injury following cardiopulmonary bypass surgery in which the kidney suffers a loss of blood supply (ischaemia). We have identified two independent pathways by which ischaemia induces kidney failure. Inhibitors of these pathways will be tested in models of kidney ischaemia in animals with diabetes or chronic kidney disease. Positive findings can be rapidly translated into clinical trials in this common procedure.
ActivityGNT1156982 | New treatments to prevent acute kidney injury in high risk patients.
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $1,289,423
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposePerinatal asphyxia causes severe oxygen deficit (hypoxia) to the fetus/newborn before or during birth. Perinatal asphyxia causes an estimated 1 million deaths worldwide annually, with most deaths occurring within the first hours of life. Those that survive have a high risk of brain injury. This application aims to reduce the devastating consequences of asphyxia by improving the way infants are cared for in the delivery room.
ActivityGNT1158494 | Improving cardiopulmonary resuscitation of infants in the delivery room.
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $470,079
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe effect of pregnancy on the long-term health outcomes of women with Multiple Sclerosis (MS) is not well understood, and information about the impact of MS-therapies on neonatal outcomes is scarce. We will use statistical methods to assess how pregnancy and therapy use affect the health of women with MS and their babies. This will assist doctors and nurses in counseling women about family planning, and will allow pregnancy decisions to be made with the best medical evidence available.
ActivityGNT1156519 | Multiple Sclerosis: Pregnancy and Prognosis
Delivery Area Multiple NSW, VIC, SA, QLD, TAS, Overseas AUSTRALIA, GERMANY
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $341,339
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe clinical assessment of people with drug, alcohol or other behavioural addictions (e.g. gambling) has traditionally relied on measuring the frequency and severity of the behaviour itself, and not the underlying brain-based processes that lead to these problems. This study will test a neurocognitive framework for addictions - derived from a panel of world leading experts in the field - to establish a unifying, scientifically-informed understanding of the core processes driving addictions.
ActivityGNT1162031 | MonCOG: Validating a neurocognitive framework and developing a purpose-built assessment tool for addictions
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2020 2017-18
MONASH UNIVERSITY
Hotham  $860,028
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis project investigates the way in which the viruses are able to replicate themselves in host cells. We focus on the picornavirus family that cause illnesses with important health and economic consequences including serious heart infections such as myocarditis and pericarditis as well as the 'common cold'. Through detailed study of the molecular interactions involved in virus infection we will reveal new possible avenues of antiviral development.
ActivityGNT1161916 | Structural basis for ribosomal docking on a picornavirus type I IRES
Delivery Area Multiple VIC, Overseas AUSTRALIA, UNITED STATES
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $1,769,409
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeOver 50,000 new strokes occur annually. Transition to home after stroke is poorly managed within the health system with only half of patients receiving a care plan or prevention education at the time of hospital discharge. We propose a randomised controlled trial in 890 survivors of stroke to assess the effectiveness and value of a new discharge support intervention with 12 weeks of tailored electronic self-management support to reduce readmissions and improve self-efficacy within 90 days.
ActivityGNT1162596 | Recovery-focused Community support to Avoid readmissions and improve Participation after Stroke (ReCAPS)
Delivery Area Multiple NSW, VIC, Overseas AUSTRALIA, UNITED KINGDOM
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $877,192
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeMitochondria are important organelles that play roles in ATP generation, metabolism cell death. Recent evidence suggests that mitochondria can also cause long lasting effects on gene expression. We will investigate this possibility in oocytes by manipulating mitochondrial function and examining the impact on subsequent embryo development.
ActivityGNT1165627 | Mitochondrial metabolism and its role in the maternal epigenome
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $727,087
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeCure rates for acute leukemia have not improved over the last 20 years. One explanation for this lack of progress is the existence of cells within the leukemia that escape chemotherapy. Using genetically modified mice that can identify these cells, this project will examine the ways that these cells escape chemotherapy. This work will identify new ways to eliminate the cells that escape chemotherapy and lead to recurrence of the disease in most people.
ActivityGNT1165840 | Targeted therapies for chemo-resistant leukaemia cells
Delivery Area Multiple VIC, Overseas AUSTRALIA, SWITZERLAND
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $1,470,583
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeElderly people are at great risk of irregular heart rhythms and heart failure. Statin therapy may be beneficial but may also cause side effects among older people. Understanding the balance of benefits and risks of statin therapy is essential to guide doctors, patients and policy makers in how we should best approach keeping older people healthy.
ActivityGNT1165440 | The STAREE Heart Study
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $595,788
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeDisorders of the mitochondrial respiratory chain represent the most common inborn errors of metabolism in humans. Of these deficiencies, many are due to defects in the action of Complex IV. By understanding how different proteins come together to build Complex IV, we will understand their importance to mitochondrial disease pathogenesis.
ActivityGNT1165217 | Defining molecular pathways for COX2 maturation in mitochondrial Complex IV
Delivery Area Multiple NSW, VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $579,920
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe rapid emergence of antibiotic resistant bacteria is occurring worldwide. Research efforts to pursue alternative treatments are urgently needed. Bacteriophages (phages) are specialist viruses that infect and kill bacteria. The clinical use of phages to treat bacterial infections is termed -phage therapy-. We are investigating the use of phages to re'sensitise antibiotic-resistant bacterial infection to conventional antibiotics, allowing a novel combination treatment strategy.
ActivityGNT1156588 | Bacteriophage therapy increases antibiotic sensitivities in multiply antibiotic resistant Acinetobacter baumannii
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $409,717
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis project will describe the connections formed between hospitals by patient referral networks and use this information to propose innovative approaches to combat the spread of antimicrobial resistance.
ActivityGNT1156742 | Understanding Patient Movement Networks To Better Prevent Dissemination of Antimicrobial Resistance
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $657,521
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeOur aim is better understand the function of a host cell protein that is required for the replication of HIV-1, hepatitis C, Japanese encephalitis virus, West Nile virus and dengue virus. This host cell protein is a proven druggable target to limit viral infection, and yet we understand little of how it works. Our results will inform the development of novel broad'spectrum antiviral therapeutics.
ActivityGNT1157053 | Functional dissection of a unique DEAD-box helicase; target for antivirals
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $1,210,400
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis project will assess the impact of the Victorian Voluntary Assisted Dying Act (2017), which enables individuals with terminal illnesses to obtain a medicine to take their own lives. It will document the experiences of patients, families and health professionals, develop a framework for ongoing evaluation of VAD, and help ensure adequate protections for those who are most vulnerable. Thereby, it will contribute to the enhancement of end of life care both in Victoria and around the world.
ActivityGNT1161502 | A new direction in end of life care- Assessing the impact and outcomes of the Victorian Voluntary Assisted Dying Act
Delivery Area Multiple NSW, VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $671,653
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeGenes in all human cells are switched 'on' and 'off' in a process that is affected by specific proteins. The immediate product of genes, a molecule termed RNA, can change the way proteins affect gene expression. In this study, we aim to understand how RNA regulate the function of specific proteins, that normally maintain thousands of genes in an 'off' state. We will determine how these proteins are altered during disease, when they can no longer be affected by RNA.
ActivityGNT1162921 | RNA-mediated regulation of the histone methyltransferase PRC2: a new link to disease-associated and causing mutations.
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $633,058
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeMesenchymal stromal cells (MSCs) have stem cell-like features and can modify immune responses. MSC therapy is being investigated in different diseases, but it remains unclear how MSCs work, as the cells do not survive after injection into the body. We will use a range of unique technologies to resolve how short-lived MSCs modulate immune responses to produce broad therapeutic effects. Our discoveries will enable more effective and safer cell therapies for a wide range of diseases.
ActivityGNT1162499 | Dying stem cells as a mechanism of mesenchymal stromal cell therapy
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $767,521
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeMalaria is a disease with a globally significant burden and distribution, including a presence in Australia's northern neighbours East Timor, Indonesia and Papua New Guinea. Resistance to all major classes of antimalarial drugs has emerged in Asia in the last decade, meaning new antimalarials with unique mechanisms of action are urgently needed. This project seeks to identify the novel mechanism of action responsible for the activity of a new class of aminobenzimidazole antimalarials.
ActivityGNT1163235 | New aminobenzimidazole antimalarial agents with a novel mechanism of action
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $642,013
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis basic science study will investigate the neural mechanisms underlying cognitive deficits caused by blockade of specific ion channels in the brain, establishing fundamental knowledge in this burgeoning field. This ultimately will have important implications for our understanding of the pathophysiology of schizophrenia, a psychiatric condition associated with loss of these same ion channels.
ActivityGNT1156733 | Functional disconnections in schizophrenia
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $737,521
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeIn this project we will develop inhibitors of GSTO1-1, an enzyme that is thought to play an important and exacerbating role in acute and life-threatening inflammatory responses such as those involved in sepsis. We will test our novel and improved compounds in vitro, determine pharmacokinetic properties, profile their selectivity, and test them for in vivo efficacy as potential anti-inflammatory candidates for the future treatment of sepsis..
ActivityGNT1156455 | Small molecule Inhibitors of glutathione transferase omega 1-1 (GSTO1-1) for the treatment of inflammatory disease
Delivery Area Multiple ACT, NSW, VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $555,788
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe hallmark of degenerative diseases such as Huntington's and Parkinson's is the accumulation of toxic protein aggregates. We have identified a gene called mir-1 that protects animals against protein aggregation. Using genetic and biochemical approaches we will decipher how mir-1 is able to protect animals and mammalian cells from protein aggregation to potentially enable therapeutic strategies in the future.
ActivityGNT1156481 | MIR-1: A Conserved Gatekeeper of Protein Aggregation
Delivery Area Multiple VIC, Overseas AUSTRALIA, UNITED KINGDOM
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $878,108
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeAntimicrobial resistance (AMR) is emerging at an alarming level, rendering some bacterial infections untreatable and increasing dependence on last line antibiotics. This project will seek to characterise antimicrobial resistance within the naturally occurring gut bacteria to inform clinical antibiotic selection and minimise the emergence and spread of antibiotic resistance within the hospital and community setting.
ActivityGNT1156333 | Characterisation of mobile antimicrobial resistance in the human gastrointestinal microbiota
Delivery Area Multiple VIC, SA, Overseas AUSTRALIA, UNITED KINGDOM
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $691,653
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeOur CRISPR-Cas9 mediated loss-of-function genetic screen identifies two new candidate epigenetic regulators- TAF5L and TAF6L- for maintenance of the mouse ESC state. In this proposed research, we will aim- 1) to dissect the detail molecular functions of TAF5L and TAF6L in mouse ESCs; 2) to examine the role of TAF5L and TAF6L in induced pluripotent stem cells (iPSCs) generation, and 3) to investigate the role of TAF5L and TAF6L in neurodevelopment.
ActivityGNT1159461 | Dissecting TAF5L and TAF6L functions in embryonic stem cells, reprogramming and neurodevelopment
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $890,314
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeDrug-resistance threatens our ability to treat deadly malaria infections, and resistance has now emerged against artemisinins, the last-line medicines for malaria. This work will use modern analytical and computational techniques to measure the molecules present in parasites, and blood, that are associated with artemisinin resistance. Understanding these factors will allow development of new strategies to monitor, and manage, the spread of resistance to this essential drug.
ActivityGNT1160705 | Host and pathogen contributors to artemisinin resistance
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $993,742
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThere is currently no cure for blood vessel damage leading to heart attacks and death. We postulate that a novel factor mediating oxidative stress, called Nox5, is the major culprit in this process. We will investigate this using unique animal models including mice and rabbits, as well as in human cells and tissues. These studies will lead to better and more effective treatments to prevent and cure heart attacks, stroke and amputations.
ActivityGNT1163233 | Targeting Nox5 to prevent atherosclerosis and aneurysm formation
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $1,233,369
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeBALANCE is a clinical trial comparing a shorter and longer duration (7 and 14 days) of antibiotic treatment. The study is focused critically ill patients in Intensive Care Units with blood stream infection. If 7 days of antibiotics is equally as good as 14 days of antibiotics this will have significant benefit for patients and the broader community. The benefits may include reduced antibiotic resistance, a shorter stay in hospital and lower costs for the community.
ActivityGNT1161936 | Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): A Randomized Controlled Clinical Trial
Delivery Area Multiple VIC, QLD, Overseas AUSTRALIA, CANADA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2023 2017-18
MONASH UNIVERSITY
Hotham  $1,416,603
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeAcquired genetic mutations normally associated with blood cancers like leukaemia can be detected in the blood or bone marrow long before any disease appears. Known as CHIP (clonal haematopoiesis of indeterminate potential), it is more common in older age, and has been associated with other health problems common in the elderly, like heart disease and stroke. We will study how common CHIP is, and its health consequences, in a large clinical trial of otherwise healthy people aged 70 or older.
ActivityGNT1163002 | Clonal haematopoiesis of indeterminate potential (CHIP) and its consequences for blood cancers, cardiovascular disease and stroke - the ASPREE-CHIP sub-study
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
MONASH UNIVERSITY
Hotham  $859,702
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeAntibodies are crucial for health, protecting us from pathogens and their toxic products, often for the duration of our lives. The biology of plasma cells, which make antibodies, is poorly understood but it could allow us to control antibody production for better outcomes in vaccines and better treatments for diseases caused by antibodies. We propose to use a new mouse model to finally understand the basis of plasma cell survival and how to make it longer or shorter to improved health outcomes.
ActivityGNT1163053 | The Dynamics and Determinants of Plasma Cell Survival
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $1,071,166
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe majority of patients with AML are elderly and unfit for intensive chemotherapy. Standard low-intensity therapy is generally unsuccessful and survival short-lived. We have recently led ground-breaking studies showing that targeting the cell'survival machinery with the BCL-2 inhibitor venetoclax in combination with chemotherapy is an exciting therapeutic prospect. We have now identified two non-overlapping mechanisms of resistance to this regimen amendable to combination with novel inhibitors.
ActivityGNT1162809 | Transforming the treatment landscape in elderly Acute Myeloid Leukaemia
Delivery Area Multiple VIC, Overseas AUSTRALIA, NEW ZEALAND, UNITED STATES
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
MONASH UNIVERSITY
Hotham  $94,406
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeMy aim is to assess disparities in stroke occurrence, services utilised and outcomes between Aboriginal and Torres Strait Islander (hereafter referred to as Aboriginal) and non-Aboriginal people in SA, NT and WA, and determine barriers to care. This project will provide an evidence base to assist in identifying the services that should be targeted for improvement, in order to -close the gap- in outcomes between Aboriginal and non-Aboriginal people with stroke.
ActivityGNT1169269 | Aboriginal and Torres Strait Islander stroke incidence, mortality and disability study.
Delivery Area Multiple VIC, SA, WA AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201810 Jan 201901 Jan 201928 Feb 2021 2017-18
MONASH UNIVERSITY
Hotham  $90,794
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeMany people develop epilepsy following a traumatic brain injury (TBI) which may prolong rehabilitation and lead to lifelong disability and early mortality, although the mechanisms are unknown and there are no specific treatments to prevent seizures from occurring. This research aims to investigate the causes of epilepsy following TBI, to utilise a novel technique to detect seizures in hospital in the early vulnerable days following TBI, and to aid in future clinical drug trials.
ActivityGNT1169386 | The development and management of post traumatic epilepsy
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201810 Jan 201901 Jan 201931 Jan 2021 2017-18
MONASH UNIVERSITY
Hotham  $72,735
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeAntibiotic resistance in bacteria is a major global health problem. Polymyxins are antibiotics used to treat bacterial infections to all other classes. Bacteria resistant to polymyxins are increasingly noted but little is known about this form of antibiotic resistance. In this project, we will carry out genetic sequencing of bacteria resistant to polymyxins to learn about how resistance develops and to understand whether these bacteria are being transmitted between patients in hospitals.
ActivityGNT1169514 | Genomic approaches for understanding resistance to polymyxins in carbapenem-resistant Enterobacteriaceae
Delivery Area Multiple VIC, Overseas AUSTRALIA, UNITED STATES
ApprovedPublishedStartEndBudget
25 Oct 201817 Jan 201901 Jan 201931 Aug 2020 2017-18
MONASH UNIVERSITY
Hotham  $55,000
Address CLAYTON 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Growing Business Investment and Improving Business Capability
Component Entrepreneurs' Programme - Innovation Connections
CategoryIndustry Innovation Demand Driven
PurposeInnovation Connections promotes collaboration between small and medium sized Australian businesses and the research sector to develop new ideas with commercial potential.
ActivityInnovation Connections
Delivery Area 3000 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201715 Jan 201808 Jan 201808 Jan 2019 2017-18
MONASH UNIVERSITY
Hotham  $29,954
Address CLAYTON 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Foreign Affairs and Trade
Agency Department of Foreign Affairs and Trade
Program Public Diplomacy including IRGP grants
Component COALAR 2019-20
CategorySocial Justice Open Competitive
PurposeBrazil is recognised as a leader in family violence prevention, particularly policies and laws addressing femicide (the gendered killing of women, most commonly intimate partner homicide). Family violence is receiving unprecedented funding and policy attention in Australia. Victoria's Royal Commission into Family Violence led to a program of transformative change designed to end gendered and family violence. This project will bring Brazilian government, non-government, academic and justice'sector professionals to Australia to establish a research network focused on public policy innovation to prevent family and gender-based violence in Brazil and Australia. Subsequently, the research network will promote deeper understandings of domestic violence research, policy and practice in both countries.
ActivityBrazil-Australia Partnership on Preventing Domestic and Gender-based Violence
Delivery Area 3800 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
24 Oct 201924 Oct 201908 Dec 201915 Dec 2019 2019-20
MONASH UNIVERSITY
Hotham  $88,503
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeInflammatory bowel disease (IBD) is common exerting a large personal and societal burden to the Australian population. Current medications used to treat IBD are expensive, have many side effects and at times require hospitalisation for their administration. We aim to develop the non invasive and inexpensive technique of vagal nerve stimulation as a novel treatment strategy for IBD.
ActivityGNT1151453 | Vagal nerve stimulation as a novel therapy in inflammatory bowel disease
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
24 Oct 201730 Jan 201801 Jan 201831 Dec 2020 2016-17
MONASH UNIVERSITY
Hotham  $88,553
Address Clayton 3800 VIC AUSTRALIA ABN: 12377614012
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeOver 50 percent of people with osteoarthritis (OA) will fall. Resources exist to assist clinicians in the management of OA, but give little or no attention to falls.The association between OA and falls supports the need to incorporate falls prevention strategies into routine OA care. This project aims to reduce falls and fall-related harm in people with OA by creating a list of recommendations for preventing falls that can be incorporated into current OA resources and routine OA care.
ActivityGNT1151089 | Reducing falls by improving knowledge translation: A mixed-methods study to incorporate falls prevention best-practice evidence into osteoarthritis care
Delivery Area VIC AUSTRALIA
ApprovedPublishedStartEndBudget
24 Oct 201730 Jan 201801 Jan 201831 Dec 2020 2016-17