bckgound
Articles
Meetings
Interests
Donations
Tenders
Charities
Grants
Grants since Jan 2018
Coalition [23,521]
ALP [21,424]
LIBS [12,003]
LNP [7,080]
NATS [4,438]
GREENS [2,241]
IND [1,279]
KATTER [771]
CA [380]
OVERSEAS [147]
NONE [100]

Who gets government grants?

Please note that settings that return over 1,000 grants may lag when you move between tabs.

Enter a name keyword eg Catholic, church, climate, animal, red cross




558 grants worth $473,449,256 have been awarded to organisations matching THE UNIVERSITY OF QUEENSLAND or ABN 63942912684 since January 2018

THE UNIVERSITY OF QUEENSLAND
Ryan  $30,953,453
Address ST LUCIA, BRISBANE 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency Department of Health
Program Health Workforce
Component Rural Health Multidisciplinary Training Programme
CategoryPublic Health Services Closed Non-Competitive
PurposeThe Rural Health Multidisciplinary Training Programme aims to increase the rural health workforce by supporting universities to deliver quality medical, multidisciplinary and dental training in rural communities and promote/encourage rural careers
ActivityRural Health Multidisciplinary Training Programme
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
31 May 201826 Feb 201915 Jan 201931 Dec 2020 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $11,165
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Foreign Affairs and Trade
Agency Department of Foreign Affairs and Trade
Program Public Diplomacy including IRGP grants
Component Australia-Japan Foundation
CategoryPublic Diplomacy Open Competitive
PurposeThe University of Queensland (UQ) and the University of Tsukuba (UT) will collaborate on a world-class sports coaching program for Japanese sport coaches by leveraging UQ's strengths and the shared interests in sport coaching of both institutions.
ActivityHigh performance coach development: Harnessing cross cultural advantages
Delivery Area 4072 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
31 Jul 201914 Aug 201902 Sep 201902 Sep 2020 2019-20
THE UNIVERSITY OF QUEENSLAND
Brisbane  $49,916
Address BRISBANE 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Growing Business Investment and Improving Business Capability
Component Entrepreneurs' Programme - Innovation Connections
CategoryIndustry Innovation Demand Driven
PurposeInnovation Connections promotes collaboration between small and medium sized Australian businesses and the research sector to develop new ideas with commercial potential.
ActivityInnovation Connections
Delivery Area 4108 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
30 Oct 201904 Dec 201929 Nov 201931 Dec 2020 2019-20
THE UNIVERSITY OF QUEENSLAND
Ryan  $1,864,500
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Department of Education and Training
Program International Education Support
Component Destination Australia Program
CategoryScholarships Open Competitive
PurposeDestination Australia will support both Australian and international students to study in Regional Australia
ActivityDestination Australia Program
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
30 Oct 201902 Jan 202023 Dec 201931 Dec 2023 2019-20
UNIVERSITY OF QUEENSLAND
Ryan  $21,960
Address ST LUCIA 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Agriculture and Water Resources
Agency Department of Agriculture
Program Dept Agricultural Resources
Component Science and Innovation Awards for Young People in Agriculture, Fisheries and Forestry
CategoryRural Development Open Competitive
PurposeSupport Science and Innovation Awards for Young People in Agriculture, Fisheries and Forestry
ActivityNatural resistance to avian influenza: a novel approach for improving biosecurity.
Delivery Area Multiple National AUSTRALIA
ApprovedPublishedStartEndBudget
30 Nov 201703 Jul 201827 Apr 201827 Apr 2019 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $43,900
Address ST LUCIA 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Agriculture and Water Resources
Agency Department of Agriculture
Program Dept Agricultural Resources
Component Science and Innovation Awards for Young People in Agriculture, Fisheries and Forestry
CategoryRural Development Open Competitive
PurposeSupport Science and Innovation Awards for Young People in Agriculture, Fisheries and Forestry
ActivityDeveloping low-cost organic waste agglomeration methodology for high-efficiency fertillisers, a circular nutrient economy and increased grower returns.
Delivery Area Multiple National AUSTRALIA
ApprovedPublishedStartEndBudget
30 Nov 201703 Jul 201817 May 201817 May 2019 2017-18
THE UNIVERSITY OF QUEENSLAND
Ryan  $33,000
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Foreign Affairs and Trade
Agency Department of Foreign Affairs and Trade
Program Public Diplomacy including IRGP grants
Component Australia-Indonesia Institute (AII)
CategoryPublic Diplomacy Open Competitive
PurposeThis project will work with Australian and Indonesian experts and local HIV networks to develop and implement a 5 day training and education program for men and women customary leaders in West Papua province.
ActivityEngaging adat leaders to support HIV prevention and care
Delivery Area Multiple QLD, Overseas AUSTRALIA, INDONESIA
ApprovedPublishedStartEndBudget
30 Jul 201930 Aug 201923 Aug 201931 Dec 2020 2019-20
THE UNIVERSITY OF QUEENSLAND
Ryan  $35,000,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component ARC Centres of Excellence
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThe ARC CoE for Plant Success in Nature and Agriculture will discover the adaptive strategies underpinning productivity and resilience in diverse plants and deepen knowledge of the genetic and physiological networks driving key traits. Using novel quantitative and computational approaches, the Centre will link gene networks with traits across biological levels, giving breeders an unparalleled predictive capacity. The Centre will accelerate technologies to transfer successful networks into crops and build legal frameworks to secure this knowledge. With a uniquely multidisciplinary team, the Centre will deliver new strategies to address the problems of food security and climate change, establishing Australia as a global leader in these areas.
ActivityARC Centre of Excellence for Plant Success in Nature and Agriculture
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
29 Nov 201905 Dec 201901 Jan 202031 Dec 2026 2019-20
THE UNIVERSITY OF QUEENSLAND
Ryan  $32,137,007
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component ARC Centres of Excellence
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThe 2020 ARC Centre of Excellence for Children and Families over the Life Course (LCC2020) aims to deliver transformative research and translation to break the cycle of deep and persistent disadvantage for Australians. Critically, LCC2020 will tackle disadvantage in specific context to understand how people negotiate it daily in real places, and how best to design policies and programs that support improved life pathways. By understanding life course contexts much more finely and using new methods and better data to personalise responses to disadvantage, LCC2020 will deliver the evidence, infrastructure, capacity and partnerships to reduce disadvantage and better equip Australian children and families for emerging challenges.
ActivityARC Centre of Excellence for Children and Families over the Life Course
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
29 Nov 201905 Dec 201901 Jan 202031 Dec 2026 2019-20
THE UNIVERSITY OF QUEENSLAND
Ryan  $35,000,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component ARC Centres of Excellence
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThe ARC Centre of Excellence for Innovations in Peptide and Protein Science (CIPPS) strives to build a critical understanding of peptides and proteins in order to unleash the potential of these biomolecules for human benefit. We will discover nature's untapped reservoir of peptides and proteins, decode their structures and functions, anddevelop enhanced synthetic technologies to address biology's next grand challenge—the design of peptides and proteins for targeted scientific, agricultural, biotechnology, animal health and pharmaceutical applications. CIPPS will assemble leading researchers from diverse disciplines to create a sustainable national entity that will drive new Australian industries and train next generation researchers.
ActivityARC Centre of Excellence for Innovations in Peptide and Protein Science
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
29 Nov 201905 Dec 201901 Jan 202031 Dec 2026 2019-20
UNIVERSITY OF QUEENSLAND
Ryan  $1,500
Address Brisbane City 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Environment and Energy
Agency Great Barrier Reef Marine Park Authority
Program Portfolio Budget Statements
Component Reef Guardian Research Grants
CategoryScientific Research Open Competitive
PurposeRGRG1900017: Identifying Warming Refuges on the Great Barrier Reef (GBR); Spatial patterns of Stratification and Mixing into the 21st Century.
ActivityIdentifying Warming Refuges on the GBR
Delivery Area 4072 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
29 Nov 201824 Jun 201904 Jun 201931 Jan 2020 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $14,000
Address BRISBANE 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Growing Business Investment and Improving Business Capability
Component Entrepreneurs' Programme - Innovation Connections
CategoryIndustry Innovation Demand Driven
PurposeInnovation Connections promotes collaboration between small and medium sized Australian businesses and the research sector to develop new ideas with commercial potential.
ActivityInnovation Connections
Delivery Area 3043 VIC AUSTRALIA
ApprovedPublishedStartEndBudget
29 May 201905 Aug 201902 Aug 201903 Sep 2020 2019-20
UNIVERSITY OF QUEENSLAND
Ryan  $1,632,096
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency Department of Health
Program Health and Medical Research
Component 2018 MRFF Rare Cancers Rare Diseases, Unmet Need commencing 2018
CategoryMedical Research Targeted or Restricted Competitive
PurposeMerkel cell carcinoma (MCC) is a rare but highly aggressive type of skin cancer that has a much worse survival than melanoma. MCC mainly affects the elderly and those with weak immune systems and extensive sun exposure. Most patients present with early stage MCC, usually treated with surgery +/- radiotherapy (RT). This study will investigate whether the use of immunotherapy, shown to be effective in advanced MCC, can prevent the cancer returning after surgery, when given with RT.
ActivityMRF1169955 | A Randomised Phase II Trial of Adjuvant Avelumab in Patients with Early Stage Merkel Cell Carcinoma
Delivery Area Multiple NSW, VIC, SA, WA, QLD AUSTRALIA
ApprovedPublishedStartEndBudget
29 Mar 201926 Apr 201901 Apr 201931 Mar 2024 2018-19
UNIVERSITY OF QUEENSLAND
Ryan  $3,596,967
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency Department of Health
Program Health and Medical Research
Component 2018 MRFF Rare Cancers Rare Diseases, Unmet Need commencing 2018
CategoryMedical Research Targeted or Restricted Competitive
PurposeIn this ground-breaking Australian led phase-1 study, we will use an innovative trial design for the early identification of patients with highly aggressive B-cell lymphomas destined to fail conventional therapy. In these patients we will train the patient's own immune system to serve as a novel and highly targeted anti-tumour vaccine to eradicate the disease.
ActivityMRF1170278 | An Open Label, Multicentre, Phase One Study Incorporating Early Application of CAR T cells for Primary Refractory Aggressive Lymphoma
Delivery Area Multiple NSW, VIC, QLD AUSTRALIA
ApprovedPublishedStartEndBudget
29 Mar 201926 Apr 201901 Apr 201931 Mar 2024 2018-19
UNIVERSITY OF QUEENSLAND
Ryan  $2,383,207
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency Department of Health
Program Health and Medical Research
Component 2018 MRFF Rare Cancers Rare Diseases, Unmet Need commencing 2018
CategoryMedical Research Targeted or Restricted Competitive
PurposeEnd'stage kidney disease is a major health problem worldwide. Peritoneal dialysis (PD) is a home-based treatment which offers better survival and satisfaction. However, its utilisation has been decreasing due to high infection burden. The TEACH-PD study will determine whether delivery of a standardised training curriculum designed for PD nurse trainers and patients reduces patients- PD-related infection risk and improves their capacity to participate in usual activities.
ActivityMRF1170238 | The TEACH-PD study: a Targeted Education ApproaCH to improve Peritoneal Dialysis outcomes
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
29 Mar 201926 Apr 201901 Apr 201931 Mar 2024 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $196,206
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency Cancer Australia
Program Improved cancer control
Component 2018 Priority-driven Collaborative Cancer Research Scheme
CategoryCancer Targeted or Restricted Competitive
PurposeMedulloblastoma is the most frequent malignant brain tumour in children and is associated with a very poor survival. The investigators have identified a very promising new drug and this research will test this new drug in mice carrying human tumours, in combination with standard chemotherapy and radiotherapy. If successful this will improve survival but also in the longer term may also be able to reduce the dose of toxic chemo- and radio-therapy and therefore significantly improve quality of life for survivors.
ActivityExploiting CDK4/6 inhibition to treat medulloblastoma
Delivery Area Multiple National AUSTRALIA
ApprovedPublishedStartEndBudget
28 May 201903 Jul 201930 Jun 201929 Jun 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $3,000,000
Address BRISBANE 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency Department of Health
Program Health Policy Research and Analysis
Component Medical Research Future Fund
CategoryMedical Research
PurposeMedical Research Future Fund (MRFF) Accelerated Research - Stillbirth Research Project - Centre of Research Excellence in Stillbirth (The University of Queensland)
ActivityMedical Research Future Fund (MRFF)Accelerated Research Program
Delivery Area 4101 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
28 Mar 201904 Apr 201928 Mar 201930 Sep 2021 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $180,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to identify when and how stereotype threat leads to disengagement among older workers and consequences for their wellbeing. Expected outcomes include a better understanding of the factors that predict who will experience disengagement at work, withdrawal of effort, reduced job satisfaction, and increased likelihood of quitting as a result of demeaning age-related stereotypes. The project's results should provide a clearer theoretical understanding of stereotype threat and can be used to inform strategies for enhancing engagement at work. This project should benefit and improve the working lives of older employees.
ActivityStereotype threat, disengagement, and wellbeing among older employees
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201815 Feb 201914 Feb 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $520,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to identify and understand the factors that influence the useful function of key residues (parts of larger compounds) in Australian snake venom coagulotoxins, which alter blood-clotting ability.-In recent years, snake venom compounds have been demonstrated as useful models from which to synthesise therapeutic drugs to improve health and well-being. This project will test these important toxins on model systems that represent natural prey items in order to determine the molecular and functional evolution of blood-clot forming enzymes. Expected outcomes include substantial contributions to the body of evolutionary biology knowledge, as well as narrowing the search for the ultimate drug candidates.
ActivityFunctional evolution and therapeutic potential of snake venom coagulotoxins
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201822 Feb 201921 Feb 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $174,435
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to clarify the ways in which online speech can inflict harm. It is accepted in speech-act theory that speech is conduct that is capable of inflicting harm. This project aims to map and compare legal cases in which there was disagreement over the nature of the speech at issue because it occurred online. It will assess the harms of that speech from the perspective of speech-act theory, and the findings will be applied to the democratic argument in favour of free speech. This project should lead to societal benefits in reducing expressive harms, and cultural benefits in enhancing all users' ability to participate in important, legitimating deliberation online.
ActivityAssessing the harms of online speech
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201830 Jun 201929 Jun 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $538,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to understand dendritic cell recirculation. It will use virological tools to track dendritic cell migration, and identify key decision points. Expected outcomes include enhanced capacity in basic research and greater interdisciplinary collaboration between virology and immunology research groups. Significant benefits will include a new understanding of how G protein coupled receptor signalling and other tissue cues guide dendritic cell recirculation, and what consequences the recirculation has for immune cell function. This understanding will significantly advance our basic understanding of the immune system.
ActivityThe recirculation of myeloid dendritic cells
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201830 Jun 201929 Jun 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $414,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to describe a new class of naturally occurring multivalent molecules termed secreted cysteine-rich repeat proteins (SCREPs). Multivalency is a key feature of molecular interaction in biology, underlying the high specificity and potency found in many proteins. Focusing on bivalent peptides, the project will generate a database of bioactive SCREPs with similarity to known bioactive peptides, and develop new recombinant methods for their production. The project will use advanced nuclear magnetic resonance spectroscopy to characterise members of this new class, providing new insights into the design of bivalent and multivalent peptides and establishing a new source of molecules with applications in the rapidly growing biotechnology sector.
ActivityA new source of bivalent molecules from nature
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201810 Jan 201909 Jan 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $295,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate the largely invisible history of sport for Aboriginal people who were institutionalised during the 19th and 20th centuries. Sport is central to Indigenous communities, identities and cultures. This project aims to engage Australian Aboriginal communities in the history-making process by combining the passion for sport with culturally appropriate digital technologies. The project will expand our understanding of the complexity of Aboriginal existence during their institutionalisation under the State Protection Acts. Using innovative digital technologies, this project will generate a comprehensive body of scholarship and an archive of artefacts about Aboriginal sport, developing capacities in Aboriginal communities to reclaim their history and enhance their cultural identities through digital storytelling.
ActivityPride, resilience and identity: reimagining Aboriginal sport history
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201802 Jan 202001 Jan 2023 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $160,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to increase knowledge of how judicious disclosure of information facilitates economic exchange and social interactions and to shed light on how mediation can be an effective mode of dispute resolution. The project seeks to uncover how analogical arguments can be persuasive and determine social outcomes as well as provide guidance for advocates and decision makers on the best way to persuade and counteract misleading persuasion practices. Besides producing significant new knowledge, the project promises to inform future innovative economic, social and cultural developments of benefit to the Australian and international community.
ActivityInformation and market design: mediation and analogical argumentation
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Mar 201928 Feb 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $294,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to gain in-depth knowledge of how entrepreneurs create high impact ventures through the adoption of a practice-based approach. The project intends to uncover how routines are formed and developed to establish and sustain the creation of high-impact new ventures. The project expects to make significant contributions to core areas of management and entrepreneurship research, while providing beneficial insights on the impact of government support programs for facilitating high-impact entrepreneurship to ensure policy is effectively designed to foster the success of high-impact new ventures. An in-depth understanding of high-impact entrepreneurship will also help foster innovation-led growth in Australia's economic development.
ActivityHigh-impact entrepreneurship: routine formation, process and outcomes
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jun 201931 May 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $538,287
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to understand how resistance proteins function and to find new sources of these proteins. Plant diseases account for 15% loss of global crop production, representing a threat to food security. Fungicides, one key form of protection, represent environmental concerns. The other key form of protection corresponds to resistance gene breeding, which is limited by lengthy breeding processes, restricted choice of genes from sexually compatible species and short effective time spans in the field. Building on previous research, this project aims to characterise the molecular basis of the Toll/interleukin-1 receptor domain-mediated nicotinamide adenine dinucleotide (NAD+) cleavage and the structural architecture of plant NLR complexes. This knowledge will support the long-term objective of protecting crops from pathogens.
ActivityMolecular mechanisms of signalling by plant immune receptors
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201814 Mar 201913 Mar 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $355,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to determine and quantify key mechanisms governing chemical transport and transformation in a tidally dominated subterranean estuary. The project will be the first attempt worldwide to measure simultaneously the temporal and spatial variability of coupled physical and geochemical processes in the intertidal zone of a subterranean estuary. The project will generate much-needed understanding of the role of subterranean estuaries in controlling fluxes of land-derived chemicals to the ocean via submarine groundwater discharge. The outcomes will have important implications for assessing and minimising the impact of groundwater contamination on the coastal zone.-It will provide better understanding of the pathway of land-derived nutrients and contaminants entering coastal waters, leading to improvement of strategies for sustainable coastal resources management and development, and integration of upland and lowland catchments management.
ActivityPhysical and geochemical coupling in a subterranean estuary
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201803 Jun 201902 Jun 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $406,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to rationally design new perovskite quantum dots featuring prominent phase and thermal stability in humid air and remarkable optoelectronic properties. These will be crucial for the development of next-generation flexible, lightweight solar energy conversion devices. This project expects to generate new knowledge in the fundamental mechanism of functional materials for more efficient solar energy conversion. Expected outcomes include new advanced materials and commercially compelling technology for sustainable and decentralised energy utilisation. This project will position Australia at the frontier of clean energy, flexible optoelectronics and related research areas.
ActivityDesigning new perovskite quantum dots for efficient solar energy conversion
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201809 Jul 201908 Jul 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $387,574
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate how community food networks address inequalities in food access by advancing understandings of food justice and governance. Identifying transformative pathways to sustainable and just food systems is a challenge for research and policy. This project expects to generate new knowledge on community food networks' visions for sustainable food production and consumption in Australia. Expected outcomes include improved dialogue between food system actors and lessons for governance. This project should provide significant benefits for those seeking to enhance implementation of the Sustainable Development Goals.
ActivityFair food futures, civil society and the sustainable development goals
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201820 May 201914 Apr 2023 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $418,956
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to mitigate energy and environmental problems by fusing the fields of membrane separation, biocatalysis and electrochemistry. The novel single-enzyme biofuel cells can generate electrical power from processes like wastewater micropollutant degradation and flue gas carbon dioxide conversion. However, the bottleneck is the lifetime of enzymes and the lack of efficient reactor design. This project expects to overcome these challenges by developing metal-organic framework-based bioelectrode materials, and integrating them with separation membranes and single-enzyme fuel cells for energy generation. This project is expected to transform the current biocatalytic process for wastewater treatment and gas separation.
ActivitySingle-enzyme membrane biofuel cells for wastewater and flue gas treatment
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201804 Apr 201903 Apr 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $445,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate how local tissue renin-angiotensin systems operate. A blood-borne renin-angiotensin system (RAS) produces a peptide (AngII) to control blood pressure, and fluid/salt balance. Many tissues, such as the brain and heart, also possess an independent, tissue RAS, but how these function is not well understood. The project will use a model whereby infiltrating macrophages (following damage to the heart) drive the activation of this system to trigger the local generation of AngII. This project addresses the question of where exactly in the heart the RAS components are turned on, how they interact to generate AngII and whether the activation of the local RAS is beneficial or not to cardiac function. The findings should provide critical insights into an important hormonal system.
ActivityHow tissues generate the peptide hormone angiotensin II
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201810 Jan 201909 Jan 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $291,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to provide new knowledge about the relationships between energy, entropy and information in the quantum realm of nanoscale machines and few-atoms systems.-The Second Quantum Revolution is currently underway, and represents the merging of thermodynamic concepts of heat and work, with quantum concepts of information processing and entanglement. The project intends to shed light on how classical ideas on the nature of heat and work translate to quantum devices. The knowledge arising from the project is expected to underpin experimental breakthroughs in the field and aid the development of new quantum technologies. The benefits lie in informing the design of new energy-efficient quantum materials, making future quantum technologies thermodynamically viable, and strengthening Australia's capacity to develop a modern, knowledge-based economy.
ActivityQuantum thermodynamics of ultra-cold atoms
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201810 Jan 201909 Jan 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $180,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop a method for the direct detection of biomarkers based on a new class of highly porous superparamagnetic nanoparticles with peroxidase-like activity. The particles will be used as dispersible capture agents for isolating specific targets in biological samples, and electrocatalytic nanozymes for naked-eye evaluation and electrochemical detection. The project is expected to develop simple, low-cost, portable devices for the analysis of exosomes and exosomal miRNA in biological samples. The future development of this technology into diagnostic devices will improve patient outcomes by enabling earlier disease diagnosis and improved monitoring of treatment.
ActivityNanoarchitectured multifunctional porous superparamagnetic nanoparticles
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201827 Jun 201926 Jun 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $180,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to understand how endogenous network formations affect financial crisis and how such situations can be made into a coherent microeconomic model of financial network formations using modern tools in economics. The project intends to study the properties of financial systems in the presence of possible financial crisis, conduct applied economic policy analysis and provide policy implications for lifting productivity and economic growth. The projects expected outcomes would contribute to the theoretical understanding of financial crisis and consequences in financial markets as well as the economy and public policy. In the longer term, the project should benefit the health of the financial system.
ActivityBanks, endogenous network formations and financial crisis
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201810 Jan 201909 Jan 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $262,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to enable individuals, industries and governments, to freely access vital and linked information carried in different media types from different sources by developing a deep attribute-aware framework that embeds heterogeneous features into a shared data space to achieve effective and efficient cross system information retrieval. With the proliferation of heterogeneous data sources, there is an urgent need to enable search and retrieval across different media types and domains. The framework developed by the project uses deep learning methods to develop meaningful image attributes to positively bridge the modality gap and the domain gap when hash functions are affixed to data. This project will significantly advance the research of multimedia retrieval, and benefit a series of related research problems whenever heterogeneous multimedia data are involved in their applications.
ActivityDeep attribute-aware hashing for cross retrieval
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201810 Jan 201909 Jan 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $396,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate and develop a novel air flow enhancement concept, induced plume swirl, and its engineering approaches to boost the cooling capacity of natural draft cooling towers (NDCTs). These towers are widely used in thermal power plants due to their low operating costs. The project will explore why and how the artificial natural convective air swirls (vortices) significantly increase the updraft inside NDCTs and identify effective, low-energy cost swirl inducement methods to increase the efficiency of operation. A wide application of this technology will result in economic and environmental benefits, including increases in overall energy conversion efficiencies, cuts in operational costs in the order of billions, and reductions in carbon emissions in the thermal power sector.
ActivityArtificial tornados enhance updraft in natural draft cooling towers
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201826 Sep 201925 Sep 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $395,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to implement a quantum computer memory module which can be integrated in a future hybrid quantum computer, where the advantages of different quantum platforms are combined. The memory module will be achieved by coupling a superconducting qubit to the surface vibrations of superfluid helium and exchanging quantum information between the qubit and helium. By simulating chemical reactions, the project expects to find cleaner alternatives of current industrial processes, reducing environmental impact. The outcomes should provide significant benefits for testing the validity of quantum mechanics, and by contributing to the realisation of a quantum computer, contribute to broad socio-economic benefits.
ActivityBuilding a mechanical quantum memory from superfluid helium
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201809 Jul 201908 Jul 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $319,474
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to carry out analysis for the Ricci flow and a number of recent flows in complex geometry. Geometric evolution equations are a trending topic in modern mathematics, with successful applications such as the celebrated proof of the century-old Poincar- Conjecture in 2002-03 by means of the Ricci flow. An analysis of the behaviour of solutions with symmetry is an essential component in any mature theory on the subject. The project will use the novel tools and ideas resulting from this analysis to address the Alekseevskii Conjecture, a 40-year old fundamental open question in the field with major ramifications in mathematics and beyond. This project will further reinforce Australia's leading role in geometric analysis.
ActivityGeometric flows and distinguished geometric structures with symmetry
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $405,004
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to ascertain how stimulation affects the brain, and establishes key factors that predict individual subjects- responsiveness. Electrical brain stimulation techniques have shown promise as tools for studying the brain and behaviour. However, the physiological mechanisms through which stimulation alters neural activity, and thus behaviour, are unclear, and there is substantial variability in stimulation efficacy across individuals. By combining stimulation and structural, functional, and neurochemical imaging, this project will uncover key predictors of stimulation efficacy in modulating behaviour in individuals. This project will allow the development of protocols to increase stimulation efficacy, and advance understanding as to how the brain and behaviour are influenced by stimulation interventions.
ActivityHow brain stimulation modulates cortical processing and cognition
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201809 Jul 201908 Jul 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $403,232
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeAbattoir workers and butchers kill animals to prepare food, farmers to cull stock, and veterinarians to alleviate suffering. Soldiers kill other humans in war, police or security guards to protect the public, and doctors to enact legal euthanasia. Research shows that these tasks can be confronting, and even traumatic. This project aims to test the processes through which people learn socially supported palliative killing to avert suffering and their neural underpinnings, with a focus on norms and empathic distress. It will focus on two core samples: veterinarians, who must euthanize animals, and health practitioners in Victoria, where legal changes will introduce -voluntary assisted dying- in mid-2019. It will investigate how practitioners learn palliative killing, and what the impact is on psychological variables such as empathy and identity. It will generate new understandings of social influence around life and death decisions, provide an evidence basis to inform policy makers, and help institutions and practitioners seeking to manage distress and respond to fast-moving, controversial policy changes.
ActivityKilling which averts suffering: the role of norms and empathy
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201803 Jun 201902 Jun 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $98,671
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to give a systematic account of how states facing different dynamics of threats associated with climate change have gone about developing distinct institutional responses, policy settings and practices. Climate change is increasingly recognised as a national security threat. A range of states have developed climate security strategies to address climate change that threaten defence infrastructure and contribute to population movements, regional instability and even conflict. The findings from this project will inform recommendations for Australian policy-makers in addressing the climate change'security relationship that can be communicated to practitioners, and tailored to the needs of Australia's security and defence establishment. This project will help Australia respond effectively to pressing impacts of environmental change.
ActivityClimate change and national security: international responses
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201830 Jun 201929 Jun 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $515,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop an automated early warning social network to systematically detect newly identified emerging chemical threats.-Rapid identification of chemical exposures is key to managing chemical threats and associated risks. Global collaboration and sharing of archived, high-resolution mass spectrometry data through open/social platforms will revolutionise data processing and chemical threat identification. This project will result in a new and cost-effective approach for the identification, tracking and prioritisation of emerging chemical threats and address key national and global health risks. The outcomes include the first spatial and temporal distribution of new emerging chemical threats in Australia.
ActivityA global platform for identifying emerging chemical threats
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201817 Apr 201916 Apr 2023 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $477,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to address roadblocks in perivascular stem cell manufacturing by discovering novel mechanisms and materials that improve cell quality outcomes during extended culture. An innovative, interdisciplinary approach to biomaterials discovery, combining live cell-based screening of cell surface glycans, bio-inspired materials design and synthesis, and niche mimicry, will enable the discovery of cell surface glycan-mediated interactions that support long-term expansion and potency maintenance, and synthetic biomaterials that can mimic them. Significant benefits for stem cell researchers, manufacturers and end users are expected from the project and the application of this scalable biomaterial platform.
ActivityMimicking the perivascular niche with boronolectin-based biomaterials
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201827 Mar 201926 Mar 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $390,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop high performance composite oxygen electrodes by using both negative thermal expansion materials and electrolyte materials to tailor the thermal expansion and activities of the perovskite-based electrodes for use in reduced temperature solid oxide cells. Such composite electrodes will show highly matched thermal expansion with electrolyte without sacrificing high activity at reduced temperatures. This project seeks to address an important practical issue in the operation of solid oxide power cells - thermal expansion compatibility, which causes poor efficiency outside a narrow temperature band.
ActivityComposites for thermal expansion matched oxygen electrodes
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jul 201930 Jun 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $351,142
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to understand the activity of three novel, but related, molybdenum enzymes, human mARC and its bacterial homologs YcbX and YiiM. The role of mARC in humans remains unknown twelve years after its discovery. All three enzymes catalyse the reduction of potentially harmful N-hydroxylated compounds and there is interest in this area from the perspective of drug design. This project will apply an electrochemical methodology to rapidly identify enzyme substrates and inhibitors. Molybdenum enzymes pervade all life forms and the outcomes of this research include a unified understanding of an emerging enzyme class involved in drug metabolism.
ActivityMolybdenum enzyme electrochemical communication
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Feb 201931 Jan 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $575,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to evaluate how genomes become different during the origin of species by utilising an innovative system where multiple replicates of the speciation process exist. This project expects to generate knowledge in the area of speciation genetics by exploring the effects of sex, migration and selection on the diversity of hundreds of genomes from an Australian wildflower. Expected outcomes of this project include a deeper understanding of the maintenance of genetic diversity in natural populations, and development of a model organism for studying the genetics and ecology of speciation. This project should provide significant benefits including enhanced capacity in evolutionary genetics in Australia.
ActivityRecombination and the genomic landscape of speciation
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201812 Mar 201911 Mar 2023 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $375,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to discover and characterise critical new factors that control legume nodule numbers. Legume plants can increase crop productivity and improve agricultural sustainability by forming specialised root nodules that house nitrogen-fixing rhizobia bacteria. The project will use a multidisciplinary approach to identify the elusive Shoot Derived Inhibitor molecule and define its interaction with novel genes, microRNAs and phytohormones in nodulation control. Findings will considerably enhance the current nodulation models and will benefit strategies to generate new compounds and crop varieties that mitigate fertiliser requirements, improve soil conditions and increase food security.
ActivityMolecular dissection of systemic regulation of nodulation in legumes
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201826 Apr 201925 Apr 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $746,400
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to elucidate a new paradigm for regulating cell signals at the nanoscale level. Cell signalling involves the coordination of multi-molecular networks at the plasma membrane, the interface between the cell and its external environment. These are often thought to involve the assembly of multimolecular complexes through the action of protein scaffolds. This project will focus on how the contractile regulator, anillin, controls RhoA signalling by kinetic regulation. In particular, how nanoscale clustering of anillin by the dynamic actomyosin cytoskeleton modulates RhoA signalling for contractility and tissue homeostasis. The outcomes of this project are first and foremost fundamental understanding of how cells communicate with one another.
ActivityRhoA signaling: the nanoscale mechanisms of mechanochemical regulation
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201810 Jan 201909 Jan 2023 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $213,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to understand citizens- decisions to acquire information about different policy proposals within a democracy and how such information affects their voting behaviour. Proper democracies rely on the informed participation of their citizens in the political debate and political institutions. The project intends to provide formal theories of information acquisition together with empirical evidence on how voting decisions are shaped by the quantity and quality of information. Understanding how citizens decide to acquire information would help devise policies to reduce polarisation and improve the quality of the political debate and the democracy.
ActivityInformation acquisition and voting behaviour
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201825 Jan 201924 Jan 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $334,425
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component Linkage Infrastructure, Equipment and Facilities
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to establish a state-of-the-art gas chromatograph-based, high-resolution and high-accuracy mass spectrometer facility. The ability to effectively identify small molecules of natural or synthetic origin is essential in supporting the sustainable use of chemicals in society. A dedicated facility for gas chromatography-based high resolution mass spectrometry will facilitate significant improvements in the identification of small molecules that interact with biological systems and lead to improved characterisation of beneficial and harmful chemicals. Expected outcomes include the discovery of new chemical products, assuring the availability of safe food and water, protecting the environment and informing future developments in global health care.
ActivityA gas chromatography-high resolution accurate mass spectrometry facility
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2019 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $329,538
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to quantify the benefits of using dynamic multi'species models for harvest decisions in the fishing industry. More than 99.8 per cent of fisheries are assessed using single'species models. Since fishers harvest multiple interacting species, not considering these interactions can lead to negative outcomes that reduce food security, eliminate human livelihoods, decrease economic production, and harm the environment. The project is expected to provide guidance for fisheries scientists on when to use multi'species models for management, improved decision making capacity to reduce the risk of fishery collapse, a new method for dynamic model validation in the face of limited data, and enhanced collaboration between modellers and applied agencies. By reducing the risk of ecosystem collapse through better use of complex and simple models. The project will provide major benefits for the environment, humans, and the economy, at national and global scales.
ActivityThe value of model complexity for fisheries management
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201803 Jul 201902 Jul 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $422,107
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to characterise the novel role of the phospholipase A1 pathway in neurotransmission, generating new knowledge on how the saturated fatty acid changes in neurons affect the mobility of neurotransmitter receptors and synaptic vesicles. Learning and memory are thought to result from long-lasting changes in synaptic strength. Whereas the role of polyunsaturated fatty acids in these functions is well known, recent findings suggest an unprecedented role for the generation of saturated free fatty acids by phospholipase A1-enzyme. Expected outcomes of this project will be to provide novel conceptual insights into learning, memory and brain capacity.
ActivityA novel role for saturated fatty acids in learning and memory
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201809 Jul 201908 Jul 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $349,345
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate the impact of non-visual sensory information on what we see and how we move. The project intends to enhance understandings of how information from our senses is combined and how this might inform the development of simulators which are increasingly used as tools for training. Expected outcomes include methods for optimising the design of simulator technologies used in a wide range of medical, military and industrial training applications.
ActivityThe role of non-visual cues in regulating perception and skilled movement
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201808 Feb 201907 Feb 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $484,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop a new integrated photoelectrochemical (PEC) system for converting solar energy into hydrogen and electricity simultaneously. The key concept is to design innovative advanced materials which will be integrated into PEC devices with capacitor function for both solar fuel production and electricity storage. This project expects to generate new knowledge in understanding the fundamental mechanism of developing functional materials for more efficient solar energy conversion and storage. Expected outcomes include prototypes of the next generation advanced materials and technologies for sustainable energy utilisation systems for converting solar energy into hydrogen and electricity.
ActivityA new photoelectrochemical system for solar hydrogen and electricity
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201806 Feb 201905 Feb 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $276,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims is to develop the scientific and engineering basis for a new Australian inorganic membrane technology for the crystallisation of metal compounds. Inorganic membrane percrystallisation is a recent breakthrough promising improved productivity, energy savings and the ability to tailor particle properties. This project will develop a mechanistic model encompassing solution transport phenomena, crystal nucleation-growth-agglomeration and engineering process parameters affecting single and binary salt systems. This model will provide a basis for technology development benefiting Australia, such as the improvement of the production of nickel sulphate for the growing battery materials market.
ActivityInorganic membrane percrystallisation in hydrometallurgy
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Feb 201931 Jan 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $495,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeMost processes fundamental to life rely on the timely, and regulated, execution of cellular functions. The innate immune system, in which both timing and regulation is paramount, rapidly detects invading microbes and induces a measured and timely antimicrobial response to clear infection. This project aims to address a key knowledge gap by characterising a mechanism for timely and controlled immune system activation and immune cell death via the non-canonical inflammasome. We do not currently understand how some immune pathways are turned on or off. This project will yield fundamental insight into mechanisms of mammalian inflammasome, inflammation and anti-microbial responses.
ActivityMolecular determinants of inflammatory caspase activity upon inflammasomes
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201810 Jan 201909 Jan 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $550,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate how ultraviolet B radiation and temperature interact during early development to influence amphibian physiology.-The environment can shape ecological processes through effects on an individuals' physiology. The project will combine genetic, biochemical and physiological approaches to investigate the effects of ultraviolet B and temperature on a key fitness determinant - immune system function. The project expects to provide information on how environmental conditions experienced during development influence the growth and fitness of frogs. This will improve our capacity to forecast potential ecological-level effects of environmental change on amphibians.
ActivityEnvironmental and physiological drivers of immune function in frogs
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201810 Jan 201909 Jan 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $400,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop mathematical techniques to resolve longstanding problems in the area of integrability and exact solvability.-Quantum integrable systems and exact solvable models are of central importance for understanding the correct behaviours of complex quantum problems without approximation. This project aims to construct sophisticated mathematical tools to settle key questions across a variety of models such as superintegrable systems, quantum spin chains, and spin-boson models. Anticipated applications of the proposed research include the accurate prediction of physical phenomena, from energy spectra to quantum correlations. Such advances should have significant ramifications, and provide benefits, well beyond the mathematical discipline itself.
ActivityFrom superintegrability to quasi-exact solvability: theory and application
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Apr 201931 Mar 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $844,947
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component Linkage Infrastructure, Equipment and Facilities
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to establish a state-of-the-art surface analysis facility that combines electron spectroscopy with dedicated sample preparation stations and transfer systems to optimise sample operating conditions. The facility will support leading-edge research on a range of functional materials by allowing detailed examination of the chemistry occurring at the material's surface. This understanding is critical in the design of advanced materials impacting technologies such as the efficient production of clean and renewable energies, removal of wastes, chemical and bio'sensors, semiconductor production, information storage and electronic devices. Expected outcomes include new understandings of materials surfaces and new devices, with wide-ranging socioeconomic benefits as well as growth in new industry sectors, both in Australia and internationally.
ActivityAn integrated materials surface analytical facility
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2019 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $385,085
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to develop a low-cost, data-driven framework that builds a traffic simulation model automatically and directly from vehicle trajectory data to enable rapid and reliable analysis of large'scale traffic networks. The project expects to generate new knowledge in the area of transport engineering using an innovative approach to inferring travel behaviours, movement patterns and traffic dynamics from increasingly available urban trajectory data. Expected outcomes include improved decision support for urban planners and traffic operators and enhanced traffic management and incident response capabilities, providing significant social, economic and environment benefits through optimised road use and urban flow.
ActivityData-driven simulation of large traffic networks using trajectory data
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jun 201929 Nov 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $422,079
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to improve the sensitivity and speed of Brillouin microscopes. Brillouin microscopes use light to measure the stiffness of samples in 3D without requiring physical access, allowing their use in inaccessible locations such as the interior of cells or within intact tissue. However, Brillouin microscopes are too slow to be used in most research. This project introduces a new approach based on different optical physics that is expected to enable faster and more precise imaging. The microscope will be used to study the movement of amoeba, where it is expected to reveal the controlled stiffening and fluidising of the different regions of protoplasm believed to underlie the cell mobility.
ActivityBrillouin microscopy for high-speed imaging of rigidity within cells
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Apr 201931 Mar 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $368,554
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop new technologies to probe and control the flow of superfluid helium at size'scales never before possible. Superfluid helium is the only quantum liquid, characterised by flow without dissipation and quantised vortices. Leveraging the techniques of cavity optomechanics, this project aims to demonstrate control of superfluid helium properties at the quantum level, including the first demonstration of laser-cooling of a liquid into its quantum ground'state. The devices developed in this project will also serve as probes of unprecedented sensitivity for the study of 2D superfluid helium. The new technologies developed will have potential for broad uptake in the scientific community and generation of intellectual property and patents for quantum technology and inertial sensors.
ActivitySuperfluid optomechanics with quantised vortices
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201809 Jul 201908 Jul 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $385,288
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to understand visual short-term memory in natural visual environments using a combination of behavioural and brain data. Visual short-term memory is thought to be critical to complex cognitive tasks such as learning and problem solving, but how low-level image context and high-level semantic information influence short-term memory is poorly understood. This project will use advanced computational image processing tools, neuro-imaging, and psychophysical experiments to provide a comprehensive analysis of short-term memory in naturalistic images. The expected outcome is a better understanding of the neural bottlenecks that limit short-term memory, and a model that predicts memory constraints in natural visual environments.
ActivityThe influence of naturalistic context on visual short-term memory
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201809 Jul 201908 Jul 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $415,737
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to use single-cell gene regulation networks to predict cell types. Computational approaches are needed to recapitulate how the over 37 trillion cells program the shared genome sequence in a human body to create astoundingly diverse forms and functions. This project integrates millions of high-resolution single-cell gene expression profiles with large'scale population regulatory data to systematically reconstruct gene regulatory networks. These networks are the molecular basis for understanding human cells. This projects outcomes intend to include the first reference single-cell regulatory database and novel methods and software to predict individual cells. This project will contribute to advancing Australia's capabilities in single-cell, precision medicine, and big biological data analysis leading to significant scientific, societal and commercial benefits.
ActivityCell types and cell states revealed by single-cell regulatory networks
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $387,103
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to contribute and expand our rudimentary understanding of non-photosynthetic Cyanobacteria by obtaining representative genome sequences using metagenomics. The dogma that all Cyanobacteria are photosynthetic has recently been challenged by the discovery of non-photosynthetic lineages. This project expects to obtain representative genome sequences using metagenomics to predict surface structures. The expected outcomes from this project includes providing insights into the function and evolution of non-photosynthetic Cyanobacteria and their viruses, and pure or enriched cultures to enable future studies.
ActivityExploring the evolution and ecology of non-photosynthetic Cyanobacteria
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201809 Jul 201908 Jul 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $668,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to uncover the role of key molecules in allowing brain cells to actively communicate with each other. Communication between neurons relies on the fusion of synaptic vesicles containing neurotransmitters with the presynaptic plasma membrane. The addition of vesicular membrane is transient as the vesicles quickly reform from the plasma membrane and refill with neurotransmitter ready for subsequent rounds of fusion. This recycling process ensures that neurons communicate efficiently, however the underpinning mechanism is unknown. This project aims to use a recently developed single synaptic vesicle super-resolution tracking method to establish how Myosin-VI and Synapsin-IIa orchestrate this recycling in central and peripheral neurons. It will explain how neurons manage to preserve their ability to communicate.
ActivityUnveiling the nanoscale organisation and dynamics of synaptic vesicle pools
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201810 Jan 201909 Jan 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $433,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThe project aims to develop innovative technologies for the next generation of blue water aquaculture, focusing on developing novel floating concrete platforms, cages and anti-biofouling systems. Increasing global demand for high quality protein means offshore marine aquaculture is the only realistic environmentally sustainable alternative to conventional livestock farming and depleted wild fisheries. This project will provide significant benefits by addressing significant community objections to nearshore fish farms, including severe environmental pollution, disease and pathogens, over use of antibiotics and economic impacts on tourism.
ActivityNext generation offshore blue water aquaculture
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201816 Jul 201915 Jul 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $423,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to advance understanding of species coexistence and diversity maintenance in complex natural environments. Though diversity varies across patchy natural and human-created environments, the mechanistic drivers of these patterns remain poorly understood. This knowledge gap limits our ability to predict and manage responses of natural communities to environmental changes. Using data from threatened Western Australian wildflower communities and novel ecological models of species coexistence, the project aims to deliver a mechanistic understanding of biological diversity, and provide fundamental knowledge needed to improve ecosystem management and restoration outcomes across Australia and globally.
ActivityDiversity maintenance in patchy environments
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 May 201930 Apr 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $466,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to understand more deeply the symbiosis between coral and the alga Symbiodinium that underpins the primary productivity, biodiversity and economic impacts of Australia's iconic Great Barrier Reef. Reef-building corals are sustained by symbiosis between the coral and the alga Symbiodinium, and breakdown of symbiosis under environmental stress leads to coral bleaching and death. This project aims to understand how genomes of differently acquired Symbiodinium have evolved to support symbiosis with corals, through sequencing of algal genomes of Symbiodinium. This knowledge will improve the precision in predicting change to inform decision-making strategies in the conservation and restoration of coral reefs.
ActivityGenomics and evolution of symbiont transmission in coral reefs
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201806 Feb 201905 Feb 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $590,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to demonstrate that key developmental genes in cereals can be manipulated to design plant architecture for specific resource-limited environments. Producing more food with less water is one of the greatest challenges facing humanity today. This project expects to increase understanding of how shoot and root systems can be uncoupled to enhance crop adaptation in water-limited environments using an accelerated genome editing approach. An expected outcome of the project is enhanced drought adaptation for cereals in a dry world. This should provide significant benefits to farmers and consumers in Australia and worldwide.
ActivityCereal blueprints for a water-limited world
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201827 Mar 201926 Mar 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $440,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to tackle the growing problem of data curation. The capacity to effectively utilise the increasing number of datasets available to organisations for timely decision making is diminishing, due to onerous data preparation and curation tasks that have to be performed before the data can be consumed by analytics platforms. The project will be a first attempt at using a novel process-oriented approach in micro-task crowdsourcing, and will create new knowledge to harness the full potential of crowd sourced data curation. This is expected to make a significant benefit towards enhanced organisational capacity to accelerate the time-to-value from data analytics projects.
ActivityBuilding crowd sourced data curation processes
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201815 Jan 201914 Jan 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $450,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to thoroughly quantify the elastic flexibility of a suite of metal-organic molecular crystals. Since antiquity, crystalline materials have been thought to be brittle and inflexible. Crystals can, in fact, display appreciable, even remarkable, elasticity. Some crystals can bend, stretch and twist. The influence that the molecules, and their arrangements in crystals, have on the extent of elasticity will be determined along with molecular'scale mechanisms for contortion. This information will be used to design new crystals with predictable and tunable elasticity for potential applications previously considered impossible for crystalline materials.
ActivityFlexible molecular crystals: single crystals that bend, stretch and twist
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201810 Jan 201909 Jan 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $390,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to test theories of dark matter and dark energy with the ultimate goal of understanding the properties of the dark components of the universe and how those properties can be explained by new fundamental physics. The project will use two astronomical datasets, the Dark Energy Survey, with measurements of approximately 3000 supernovae, and the Dark Energy Spectroscopic Instrument, with measurements of 30 million galaxies. By comparing theoretical models to this combination of data the project will help to determine whether dark energy changes with time, measure detailed clustering properties of dark matter, and test advanced theories of gravity.
ActivityUnderstanding the dynamics of the dark universe
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $350,574
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to bridge the study of early Jewish-Christian relations during late antiquity by focusing on the analysis of objects, such as amulets. Many of the narratives around surviving artefacts from antiquity conflict with inherited ideas about the boundaries between early Judaism and Christianity and raise questions that challenge assumptions about religious interaction. This project expects to generate new knowledge in the study of religion as it was practiced historically. Bringing together modern theories of comparison and social exchange, the project will offer unique insight into how religious interactions between people of different faiths actually unfold in everyday situations. It will also contribute to the implementation of primary'school curricula on religion in antiquity.
ActivityEarly Jewish and Christian religious traditions
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Oct 201930 Sep 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $310,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate whether the discovery of diamonds in oceanic rocks, known as ophiolites, is a global phenomenon. Even half a century after the introduction of plate tectonic theory, significant knowledge gaps remain regarding the fate of subducted lithosphere and Earth processes deep within the mantle. This project will use Australasian examples to test the hypothesis that diamonds are ubiquitous in the mantle and occur widely in ophiolites. Results will have major implications for our understanding of how ocean crust grows and how rocks in the upper mantle form, as well as providing insight into how organic carbon is cycled from the seabed deep into the mantle before being returned back to Earth's surface.
ActivityDiamonds in ophiolite: recycling deep mantle into supra-subduction zones
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201830 Jun 201929 Jun 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $380,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop a fundamental molecular level understanding of flow-induced physical and chemical reactions in liquids. Nonequilibrium molecular dynamics simulations will be used to gain insight into the mechanisms that promote reactions under shear, and how these are related to molecular structure and fluid composition. New relationships for determination of rate constants of reactions in nonequilibrium systems will also be developed and tested. It is expected that this knowledge will enhance the capacity to control and promote reactions. This is significant for advancement of many technologies, from development of new synthetic pathways and products, to design of lubricants that can withstand extreme strain rates.
ActivityPromoting new reaction pathways with nonequilibrium flow
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201810 Jan 201909 Jan 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $430,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to better understand the functional relationship between epigenetic mechanisms and regulatory RNAs in the brain and how they influence learning and the formation of memory. Activity-induced gene expression is central to neural plasticity, learning, and memory. However, efforts to elucidate the underlying mechanisms in the brain have not been fully resolved. By elucidating the full repertoire of epigenetic mechanisms in the brain during learning and memory formation, the findings of the project will be broadly applicable and create new opportunities for understanding the true nature of brain adaptation.
ActivityDefining novel neuroepigenetic pathways that influence learning and memory
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201810 Jan 201909 Jan 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $435,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to address the question of how we can predict adaptive evolution. The project aims to probe the limits of evolutionary predictions by using a model system of bacterial populations that adapt to the presence of multiple stressors. This will be combined with high-throughput fitness measurements, whole genome sequencing and computer simulations. Anticipated outcomes include novel insights into deep questions regarding the structure of fitness landscapes and the repeatability, predictability and contingency of adaptive evolution. The project is expected to provide significant benefits, informing the development of improved strategies for managing pathogen resistance to antimicrobial drugs.
ActivityPredicting the evolutionary dynamics of adaptation
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jun 201931 May 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $367,412
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate how children deploy digital devices to interact with the "natural" world and how this influences their literate practices, emotional engagement and identities. The project intends to examine these issues longitudinally across Australia and Finland, and in relation to key contextual issues of social class, material conditions, and pedagogical approach. Expected outcomes include identifying ways of educating students through mobile digital technologies that connect them in emotional, creative and engaging ways with the "natural" world. This should provide significant benefits as children contribute as co-researchers in establishing a set of protocols for using digital technologies to both maximise learning in "nature" and mitigate harm to the environment.
ActivityDigital mediation of children-s interactions with the more than human world
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201809 May 201908 May 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $490,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate peptides that modulate prey behaviour. Chemical signalling constitutes much of the language of life underwater. Certain cone snails evolved a hunting strategy, where they release potent peptides to modulate fish behaviour through yet unknown mechanisms. The snail then expands its mouth and eats the fish without resistance. This project will investigate the mechanisms at play using transcriptomics, proteomics, peptide synthesis, behavioural pharmacology and nuclear magnetic resonance. This will advance the knowledge of aquatic chemo-modulators on a functional, structural and evolutionary level, and provide a source of molecular probes with unique pharmacology and applications in human physiology, developmental biology and aquacultures.
ActivityAquatic chemo-modulators: a novel source for potent molecular probes
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201809 Jul 201908 Jul 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $469,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to expand understanding of the genetic variation underlying phenotypic differences among individuals. The nature of genetic variation has broad consequences across biology, from the detection of causal genetic variants to the adaptation of natural populations. This project will take a novel experimental approach to test several long'standing assumptions about the effects of new mutations on individual traits and their joint pleiotropic effect on fitness. By expanding our understanding of how mutation, selection and drift interact, this project could provide significant improvements in our understanding of the genetic basis of phenotypes, and our ability to predict phenotypic evolution.
ActivityThe nature of standing genetic variation
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Mar 201928 Feb 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $508,397
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis proposal aims to understand the molecular mechanisms of neuronal communication and how neurons modify their synaptic strength. Although these processes are essential for normal brain function, the precise underlying mechanisms are still not well understood. This project will combine biochemical, molecular and cell biological assays, as well as electrophysiological measurements, to provide mechanistic insights into the molecular processes that control glutamate receptor trafficking in the postsynaptic compartment. This will elucidate how neural plasticity is generated and maintained, information that is critical for our understanding of sensory processing, learning and memory throughout life.
ActivityRegulation of glutamate receptor dynamics in mammalian central neurons
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201821 May 201920 May 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $350,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to characterise a new stem cell population that can maintain both blood vessels and contribute to a variety of tissues whether fibrous, bone, fat or cartilage. Blood vessels comprise an inner endothelial layer and surrounding mesenchyme, are integral to many organs and constitute a unique system connecting different parts of the body. Despite their importance little is known about how they are maintained and how they contribute to the response to injury. Previous work has described several populations of stem cell capable of self renewal and repletion of the endothelium or the mesenchyme. This project will examine the potency of these different progenitors to give rise to each of these fates in homeostasis but also during sounding and bone formation. This will help define a unique population of stem cells capable of both vascular and mesenchymal repair.
ActivityPotency and activity of Meso-Endothelial bipotent progenitors in vivo
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201814 Feb 201913 Feb 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $401,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to enhance the understanding and evaluate the impact of China's expanding role in international peacebuilding. Over the past decade, China has assumed a more proactive role in international peacebuilding. This project will generate new data to assess China as an emerging peacebuilding actor, and offer the first systematic cross-regional analysis that evaluates the impact of China's new peacebuilding activism using case studies on Myanmar, Afghanistan and South Sudan. The expected outcome is an evidence-based policy analysis that can help policymakers and peacebuilding practitioners respond to China's expanding peacebuilding presence in order support sustainable peace.
ActivityChina and the future of international peacebuilding
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201815 Mar 201914 Mar 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $364,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to advance the modelling of spacecraft heat shield performance to enable future returns to Earth from Mars, where vehicles will encounter heating loads an order of magnitude higher than Lunar returns. Survival depends on sacrificial heat shields which intentionally lose mass through ablation to form a protective layer. Currently, this process cannot be predicted accurately leading to compromised safety, excessive weight, and increased mission cost. The expected outcome is an ablation model for vehicle design which, for the first time, is based on experiments with a realistic aerodynamic flow. The significance and benefit of this project is its potential to make ambitious missions such as a Mars return feasible.
ActivityAdvanced thermal protection systems to enable Mars return missions
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $460,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to understand the origins of sex differences by dissecting heritable variation in sexually dimorphic gene expression. Sexual dimorphism constitutes a large fraction of phenotypic diversity and arises mainly from sex differences in gene expression that permit males and females of a species to escape sexual conflict caused by a shared genome. The project uses multi-population quantitative genetics and allele'specific expression assays to merge the studies of sex'specific local adaptation and sexually dimorphic regulatory variation. The project will help to understand how cis- and trans- regulatory factors can affect natural variation differently in males and females, shaping their phenotypic similarities and differences.
ActivityDissecting natural variation in sexually dimorphic gene expression
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Apr 201931 Mar 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $419,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to explore the role of microRNAs in regulation of the synthesis of a key hormone, juvenile hormone, involved in mosquito development and reproductive maturation. The development of novel approaches in mosquito control or inhibition of transmission are urgently required to combat against mosquito-borne pathogens. One such approach is to interrupt the reproduction or reduce the fitness of mosquitoes. This project will increase our understanding of the regulation of mosquito reproduction and development, but also lead to the discovery of potential target molecules to interfere with mosquito reproduction/development.
ActivityA novel approach in understanding regulation of development in mosquitoes
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201822 Mar 201921 Mar 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $416,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis proposal aims to uncover the source reefs for Crown-of-Thorns Seastars (CoTS) outbreaks and the main routes of spread through the Great Barrier Reef. Coral eating CoTS pose a significant threat to the Great Barrier Reef. Using population genomics, invasive species genetics, and epidemiology and drawing upon extensive collections of adults and larvae dating from the 1980's onwards, this project will test prominent hypotheses about outbreak origins and subsequent spatial spread of CoTS via larval dispersal. The project expects to clarify the locations and timing of long distance dispersal pathways and to test whether larval detection near reefs can provide an early warning for local outbreaks on these same reefs.
ActivityTracking origins and spread of Crown-of-Thorns Seastars on the Great Barrier Reef
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201817 Apr 201916 Apr 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $117,582
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to examine legal and policy challenges, together with expert opinion, to generate a legal framework that recognises and protects the multiple ecosystem services provided by mangroves. Global rates of mangrove loss are of great concern because of the significant ecosystem services they provide in coastal environments. In the Australian context it is important that national and state legal frameworks operate efficiently to manage and protect these valuable resources. The framework developed in this project will be adaptable to provide significant benefits to other fragile ecosystems in Australia.
ActivityA legal framework for managing mangrove ecosystem services
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Feb 201931 Jan 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $450,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to define the most effective spray formulations, consisting of clay nanoparticles and induced RNA interference (RNAi) to manipulate gene expression in plants. Topical application of double'stranded RNA (dsRNA) for RNAi represents an attractive alternative to genetically engineered crops. However, naked dsRNA is unstable and is not efficiently taken up by plants. For these reasons, topical application of dsRNA has thus far produced only modest induction of RNAi in plants. Nanoparticle-facilitated manipulation of gene expression in plants will enable sustainable clean green strategies for protecting crops from diseases. This project will result in improved crop protection and productivity and boost the export potential of Australian crops.
ActivityClay nanoparticle-facilitated RNAi for non-transgenic modification of crops
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201810 Jan 201909 Jan 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $490,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop a novel zebrafish platform for elucidating the circuits that mediate lateral line perception.-The sensory modality by which fish detect and respond to water flow is poorly understood. This project proposes a novel preparation in the zebrafish model for applying controlled water flow using microfluidics, thereby stimulating the lateral line. Because the animal remains stationary, it is possible to perform whole-brain calcium imaging of cells and circuits that respond to water flow, and to use optogenetics to stimulate or silence these neurons. This will reveal the circuitry mediating flow perception, and its relationship with other senses, in a way that has been previously impossible.
ActivityNeural mechanisms of water flow perception and spatial integration
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201831 Aug 201930 Aug 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $434,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate noncoding RNAs (sfRNAs) of insect'specific flaviruses (ISFs). These RNAs are produced from viral RNA by host ribonuclease and play important role in pathogenesis and transmission of vertebrate-infecting flaviviruses (VIFs). The team has shown that ISFs also produce sfRNAs although likely employing a different mechanism. The project expects to generate new knowledge on ISF sfRNA biogenesis and functions using combination of modern structural, biochemical, and innovative molecular virology methods. The outcome will be a clearer understanding of processes governing flavivirus host restriction and evolution. This will improve understanding of virus-host interactions and train students in cutting edge techniques.
ActivityNoncoding RNAs of insect-specific flaviviruses: biogenesis and functions
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201814 May 201913 May 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $705,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to advance understanding of sleep functioning as children transition from many naps, to one nap, then none. Through an intense, objective longitudinal study of sleep from age one to five years, the project seeks to examine the interplay of sleep, care environment and ongoing child development. The project is expected to deliver much needed evidence to address the controversy surrounding care practice in family and early childhood education and care contexts. The expected benefit for parents and educators is improved knowledge and confidence in supporting children's sleep. The expected benefit for children is positive development, given the known impacts of sleep on ongoing learning, behaviour and health.
ActivityThe developmental significance of sleep transition in early childhood
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201809 Jan 202008 Jan 2024 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $408,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to deliver efficient processes for the large'scale production of biopolymers from low cost inputs, using phototrophic bacteria. Feedstocks include syngas from solid wastes and carbon-dioxide-hydrogen mixes from fossil and renewable sources. The choice of phototrophic bacteria avoids the energy losses associated with existing technologies, since photons are used instead of chemical energy for metabolic needs. This project enables the production and optimisation of biopolymers through collaborations between engineers, polymer scientists and molecular biologists. The project will deliver technologies to produce tough, flexible and affordable biopolymers, converting wastes and greenhouse gases to a valuable product.
ActivityEfficient CO and CO2 conversion to biopolymers using phototrophic bacteria
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201808 Feb 201907 Feb 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $464,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to understand the molecular processes in a cell type and subcellular compartment that underlies learning and memory formation. Fundamental neuronal functions such as synaptic strengthening and memory formation are dependent on the tightly regulated process of protein translation. The kinase Fyn (which is localised to dendritic spines where memories are formed) activates the ERK/S6 pathway leading to massive translation of the scaffolding protein Tau. More importantly, the activation of this cascade is Tau-dependent. This project aims to determine how Tau activates this pathway, and to decipher the physiological role of the Tau/Fyn/Tau feedback loop. This will inform our understanding of the molecular regulation of learning and memory.
ActivityRegulation of mRNA translation by the microtubule-associated protein Tau
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201810 Jan 201909 Jan 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $564,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to address how the animal innate immune system evolved to discriminate between potential pathogens versus beneficial symbionts by studying a marine sponge holobiont. Using advanced genomic and cellular approaches, the project will uncover deeply conserved regulatory pathways used by the cells of sponges, humans and other animals, and thereby identify cardinal rules governing animal innate immunity and its evolutionary origin. The project will provide an understanding of how beneficial microbial symbionts are recruited and maintained by animals, and are instrumental to the health of our environment and all its inhabitants.
ActivityMarine sponge-microbe interactions and the origin of animal innate immunity
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jul 201930 Jun 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $460,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to provide methods for the design and verification of correct, secure and efficient concurrent software that are scalable and mechanised. Computers with multiple processors are now the norm and are used in a wide range of safety, security and mission critical software applications such as transport, health and infrastructure. These multi-core architectures have the potential to lead to important efficiency gains, but can introduce complex and error-prone behaviours that cannot be managed using traditional software development approaches. This project will produce better, scalable and mechanised methods for the design and verification of such software which is expected to reduce the prevalence of failures in efficient, modern software.
ActivityDesign and verification of correct, efficient and secure concurrent systems
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201830 Jun 201930 Jun 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $390,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop a remote sensing approach for more accurate monitoring of vegetation growth rate and productivity, and the fast-changing vegetation stress dynamics across agricultural and natural landscapes. Algorithms and methods will be developed to use and analyse newly available Earth Observation satellite data to map and monitor plant primary productivity. This project will combine direct plant function measurements, at leaf and canopy scales, with imaging and ranging data in 3D computer modelling techniques. This will address the need to optimise food production and to sustainably manage ecosystem services in a changing climate, with preferential benefits for extensive and inaccessible Australian landscapes.
ActivityLeaf to landscape: near-instant vegetation growth and productivity rates
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Oct 201929 Jan 2023 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $404,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop reliable approaches for measuring the toughness of a variety of metal/polymer interfaces integral to contemporary flexible devices. Adhesion between metal thin film conductors and polymer substrates is a critical factor influencing the reliability of the emerging polymer-based flexible electronics. This project will develop new methodologies for understanding the behaviour of these metal/polymer interfaces. This project will be a crucial enabler to accelerating the development of new flexible microelectronic technologies, from solar panels to electronic skin. This innovation will enable Australia to maintain an important connection to the rapidly-evolving international microelectronic industry and add significant value to Australian manufacturing industries.
ActivityMicro/nano-mechanical testing methodologies for interfacial adhesion
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jun 201931 May 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $0
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to improve our understanding of the cause of evolutionary limits. It will test the prediction that trait combinations with high genetic variation are highly correlated with other traits, and therefore are more evolutionary limited than they appear. This project will develop and implement novel evolutionary and statistical manipulations and methods to test this prediction, and is expected to provide new methods for the study of selection. A better understanding of evolutionary limits will provide a significant benefit, enabling better predictions of how natural populations will evolve over short and long time'scales, and their risks of extinction.
ActivityThe effect of apparent stabilising selection on genetic architecture
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201809 Jul 201909 Jul 2019 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $405,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to explore animal venoms for new pain-causing toxins, to determine their structure and mechanism of action. Many venomous animals use their venom defensively and envenomation is frequently associated with rapid and often excruciating pain. In most cases the molecular mechanisms by which they achieve this is unknown. Using biochemical, pharmacological and biophysical techniques, this project expects to uncover toxins that employ new mechanisms of pain signalling, leading to new insights into pain physiology.
ActivityGain from pain: new tools from venomous animals for exploring pain pathways
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201810 Jan 201909 Jan 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $420,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThe project aims to create new precision-built polymer vesicles with controlled size, stability, functionality and environmental responsiveness to mimic some of the key dynamic functions of the cell. The project expects to generate new knowledge on the dynamic interplay between the polymer and its bilayer including on-demand activated polymerisations and reactions, logic gates and in situ sensors. Expected outcomes of this project include new synthetic polymer techniques and new quantitative insights into the role of compartmentalisation on chemical reactions and polymerisations. This project will provide fundamental knowledge on bio/polymer vesicles with great potential to advance the polymer industry in Australia.
ActivityPrecision-built dynamic and functional polymer vesicles
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201809 May 201908 May 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $493,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop the first global ecosystem model with a more realistic representation of zooplankton. Fish are the main source of protein for 3 billion people, yet fish catches are declining. Current models of future fish biomass under climate change do not consider the complex role that zooplankton play in transferring energy from phytoplankton to fish. By resolving the link between phytoplankton and fish, this project will vastly improve estimates of future global fisheries production and regional variation. Such knowledge is vital for future food security in Australia and globally, and also to understand the role of zooplankton in carbon export in the ocean.
ActivityFuture fisheries under climate change: the missing role of zooplankton
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201828 May 201927 May 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $580,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to provide a fundamental understanding of how biomechanics influences stem cells under normal and microgravity conditions. This will be achieved by developing and validating simulated microgravity conditions on earth and establishing a valid system that mimics the extracellular matrix of living tissue in low gravity. The materials and technology generated will allow detailed insight into how force influences focal adhesion between cells and how this force is transferred from cell-to-cell in tissue. The findings from this project are expected to have significant benefit in controlling cell fate in space and on earth.
ActivityCellular mechanics in unusual systems
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Mar 201928 Feb 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $350,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeWith the advent of big data era, recommender systems are facing unprecedented challenges with respect to the four dimensions of big data: big volume, low veracity, high velocity and high variety. This project aims to develop a new generation of cost-effective techniques for scalable, robust and real-time recommendations utilising big data. This project aims to address these challenges to achieve scalable, robust and real-time recommendations. This project will devise a series of cost-effective machine learning methods and schemes to deliver an end-to-end recommender framework. This project has the potential to significantly reduce the energy consumption of large'scale recommender systems as well as facilitating an increase in the use of recommendation applications for big data.
ActivityChallenging big data for scalable, robust and real-time recommendations
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201808 Mar 201907 Mar 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $390,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate the cyclic-di-AMP signalling system in industrially important bacteria. The recently discovered cyclic-di-AMP is essential for normal bacterial growth and plays key roles in heat and antibiotic resistance, metabolism and virulence. This project will develop new biological assays to shed light on how bacteria sense and respond to environmental stress. Expected outcomes include a much deeper understanding of signalling inputs and outputs. This should lead to benefits such as guiding the improvement of bacterial strains used in food and biochemical biotechnological applications, and may provide the foundation for the development of novel antibiotics.
ActivityUnravelling a novel stress-signalling system in bacteria
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201808 Apr 201907 Apr 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $393,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop highly effective carbon-based electro-catalysts for oxygen reduction by using elaborately designed metal-organic framework precursors. Oxygen reduction is a key cathodic reaction in clean energy technologies such as metal-air batteries and fuel cells. Expected outcomes of this project include carbon-based nanomaterials with optimised topological and compositional features. This project will broaden the knowledge of designed synthesis of carbon-based nanocatalysts for oxygen reduction and provide a conceptual nanofabrication framework for preparing functional nanomaterials.
ActivityStructural and compositional controlled nanocarbon-based electrocatalyst
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201820 May 201919 May 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $398,700
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to understand environmental attitudes and behaviours that emerge through participation in recreational lifestyle sports. Linking the growth of lifestyle sports in Australia and the significance of oceans in humanities and social sciences research, the project will highlight how surfers and ocean swimmers develop relationships to, and produce knowledge about, Australian oceans and coasts. The project will consider everyday cultural practices relating to ethical consumption and will provide key insights for surfing and ocean swimming communities to enable them to make better choices about their attitudes and practices relating to sustainable oceans and coasts.
ActivityUnderstanding ecological sensibilities in recreational lifestyle sport
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201809 Jul 201908 Jul 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $374,433
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to understand how neuronal DNA is modified upon learning and how this impacts memory formation. The project will investigate the combination of different genome-wide sequencing approaches and molecular and cell biological assays to provide new insight into the functional role of a novel DNA modification, N6-methyl-2'-deoxyadenosine in the adult brain. This projects expects to have a major impact on many fields, including neuroscience, evolutionary biology, and genetics, by helping to shape a new way of thinking about gene-environment interactions
ActivityFunctional role of a novel DNA modification in the adult brain
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $411,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to solve the most pressing problem in organic light emitting diodes - the lack of highly efficient, phosphorescent blue emitters. The project expects to generate new understanding of energy loss mechanisms in such devices from multiscale quantum mechanical models, which describe the interaction of the emitter with its environment, and to design new materials via big data approaches. Expected outcomes include a fundamental understanding of non-radiative decay processes in organometallic complexes and more efficient lighting and display technologies. This project should provide significant benefits in reducing energy use, as lighting and displays consume around a quarter of the energy generated in developed countries.
ActivityRational design of light-emitting materials for lighting and displays
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201809 Jul 201908 Jul 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $236,852
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component Linkage Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to improve management of invasive species by assisting pest mitigation agencies to work together. This is expected to result in more efficient and effective strategies, with the potential to dramatically improve local and global agricultural and environmental outcomes. An interdisciplinary approach using game theory, spatial modelling, and ecology is expected to create a novel framework to identify how and when agencies might collaborate, and how collaboration might impact on costs and benefits of pest control strategies. The project will provide significant benefits by improving management of invasive species across Queensland, one of Australia's largest agricultural producing states and home to a vast number of Australia's threatened species.
ActivityTackling pests using game theory to support cooperative management
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201830 Apr 201930 Sep 201930 Sep 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $10,000,000
Address BRISBANE 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency Department of Health
Program Health Policy Research and Analysis
Component Medical Research Future Fund
CategoryMedical Research
PurposeMedical Research Future Fund (MRFF) Accelerated Research - Clem Jones Centre for Ageing Dementia Research (The University of Queensland)
ActivityMedical Research Future Fund (MRFF)Accelerated Research Program
Delivery Area 4072 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
27 Mar 201904 Apr 201927 Mar 201930 Sep 2023 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $491,346
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Blood Authority
Program National Blood Agreement Management
Component National Blood Sector Research and Development Program
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis study aims to 1) compare clinical endpoints in a non-inferiority trial of Fibrinogen Concentrate vs cryoprecipitate in critical bleeding trauma patients with low fibrinogen levels; 2) expand the FEISTY Pilot Trial to other Australian Major Trauma Centres; 3) build on the success of the original FEISTY Pilot Trial to perform a large multi-centre study with patient centred clinically relevant endpoints; and 4) consolidate the multi-disciplinary research group established in the four Queensland Trauma Centres, and expand this to include the other Major Trauma Centres in Australia and ultimately overseas.
ActivityPatient Blood Management Project Grant:Fibrinogen Replacement in Severe Traumatic Haemorrhage (FEISTY II)
Delivery Area Multiple National AUSTRALIA
ApprovedPublishedStartEndBudget
26 Oct 201820 Feb 201918 Jan 201931 May 2022 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $131,247
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Blood Authority
Program National Blood Agreement Management
Component National Blood Sector Research and Development Program
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis study aims to 1) use a sheep model of acute hypovolaemic shock to determine whether novel perfusion fluids are suitable alternatives to red blood cell (RBC) transfusion for delivering oxygen to vital tissues; and 2) determine whether measures of microvascular blood flow and tissue oxygenation are superior patient-relevant outcome measures compared to haemoglobin levels.
ActivityPatient Blood Management Project Grant:Novel fluid alternatives to blood transfusion to treat acute and chronic blood loss
Delivery Area Multiple National AUSTRALIA
ApprovedPublishedStartEndBudget
26 Oct 201812 Mar 201925 Feb 201914 Jun 2021 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $13,817
Address BRISBANE 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Growing Business Investment and Improving Business Capability
Component Entrepreneurs' Programme - Innovation Connections
CategoryIndustry Innovation Demand Driven
PurposeInnovation Connections promotes collaboration between small and medium sized Australian businesses and the research sector to develop new ideas with commercial potential.
ActivityInnovation Connections
Delivery Area 4006 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
26 Mar 201814 May 201810 May 201801 Dec 2018 2017-18
THE UNIVERSITY OF QUEENSLAND
Ryan  $17,037
Address BRISBANE 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Supporting Science and Commercialisation
Component Science for Australia's Future - Inspiring Australia
CategoryScientific Research Open Competitive
PurposeReefs are in trouble and again coral bleaching is lurking around the corner. In 2016-17, the GBR lost 50% coral cover and what will happen next- Many people aren't aware of the magnitude of this problem and that they can help save reefs from home. CoralWatch, a global citizen science program, will engage with communities near the QLD coast presenting the latest reef science, creating reef awareness and provide suggestions on how to help using Virtual Reality technology with up-to-date content and games, public displays and field science activities. New VR content will provide a real-life reef experience connecting participants with the reef and motivate them to move towards a more sustainable future to help save reefs for future generations.
ActivityCoral Reefs - Immerse, Learn and Act
Delivery Area 4072 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
26 Feb 201927 Mar 201921 Mar 201927 Feb 2020 2018-19
UNIVERSITY OF QUEENSLAND
Ryan  $415,807
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component International Joint Calls
CategoryMedical Research Targeted or Restricted Competitive
PurposeVietnamese children are heavily exposed to traffic-related air pollution(TRAP), especially when travelling to and from school. Such exposure increases the risk of acute and chronic respiratory diseases, such as pneumonia and asthma, and of hospitalization. We aim to develop the capacity of Vietnamese researchers to measure exposure to TRAP, assess the effect of TRAP exposure on respiratory health and to undertake a randomized control trial of wearing a mask to reduce TRAP exposure.
ActivityGNT1155241 | Wearing masks to reduce traffic-related air pollution exposure and improve children-s respiratory health
Delivery Area Multiple VIC, QLD, Overseas AUSTRALIA, VIET NAM
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $114,033
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeKidney transplant recipients are at increased risk of infections, particularly within their first year of having a transplant. There is increasing evidence suggesting kidney transplant recipients have a distinctly abnormal intestinal bacterial community, termed the gut microbiota. The aim of this study is to examine the predictors and pathogenesis of infections following kidney transplantation and to explore the benefit of manipulating the gut microbiota on patient related outcomes.
ActivityGNT1168186 | Infectious complications following kidney transplantation
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Aug 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $93,395
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe PEERS- social skill program aims to help teenagers develop the social skills needed to make and maintain friends. The program reduces the complexity of social behavior and teaches simple rules, using modeling and practice. Parents participate in separate concurrent sessions to help them support their teenager with real world practice. The program has not been tested with teenagers with CP/ABI and needs to be tailored for this population and the Australian context.
ActivityGNT1168214 | Social skills training for teenagers with brain injuries. Randomised controlled trial investigating a parent assisted social skills group program.
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201930 Jun 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $181,066
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component TRIP Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeIt is estimated that there are approximately 232,500 medication related admissions to hospital per year. There have been a number of interventions targeted towards improving medicine use at the point of hospital discharge however they have not been routinely implemented into practice. The integration of pharmacists into medical centres, collaborating with general practitioners, can assist patients during transition from hospital and will be an effective strategy to reducing readmissions.
ActivityGNT1167992 | Translating Medication Optimisation Evidence into Practice to Reduce Hospital Readmissions
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2020 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $525,157
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeMitochondria are the cells powerhouses. They convert the food and oxygen we consume into the critical chemical energy needed for our organs to function. Mitochondria have their own DNA genome, and mutations in this genome can cause severe diseases. This project will reveal the mechanism of action of a newly discovered molecule that protects organs from mtDNA lesions, and therefore uncover novel ways of treating mitochondrial disease.
ActivityGNT1162553 | Molecular protection against mitochondrial DNA damage
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $662,389
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeAntibody is a vital defence mechanism of the host immune system and protects against infection. Recently however, we identified a specific type of antibody that actually protects bacteria from immune killing. Presence of this -inhibitory antibody- correlated with worse disease and two patients have been successfully treated by removal of antibody. Here we explore the mechanism behind the inhibition to guide new therapies to target removal or inactivation of this inhibitory antibody.
ActivityGNT1162522 | Paradoxical antibody: the role of antibody in exacerbating Pseudomonas lung infection
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $772,521
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeA protein domain called TIR domain plays key roles in signalling in innate immunity pathways, associated with chronic inflammatory diseases, and the axon degeneration pathway, a pathway central to neurodegenerative disorders. We found that TIR domains form large assemblies and at least in some cases possess enzymatic activity. Through characterizing the molecular details of these functions, we will uncover ways to inhibit them and provide a foundation for developing a range of therapeutics.
ActivityGNT1160570 | Molecular basis and inhibition of TIR-domain function in Toll-like receptor and neuronal cell-death pathways
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $691,261
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeFamily history is an important risk indicator for the development of breast cancer. Germline alterations in genes such as BRCA1 and BRCA2 account for some of this risk, but for the majority of families the genetic contribution to the risk is unclear. The clinical management of individuals in these families is therefore extremely challenging. Here we will use a combination of techniques to help determine the genetic factors that are causing the increased risk in these families.
ActivityGNT1164770 | Improving the clinical management of familial breast cancers with genomics.
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2020 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $435,793
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeSleep helps keep our brains healthy. This is believed to involve cells in the brain called glia, which optimise the communication between neurons during deep sleep. It is unknown how glial cells -know- how much optimisation is needed throughout the brain. We have discovered similar sleep mechanisms in the tiny fruit fly brain, and will use its powerful genetic resources and whole-brain imaging technology to understand how this newly discovered glial sleep function works.
ActivityGNT1164499 | Bridging the gap between electrical and molecular sleep functions in the brain
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $809,254
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeDespite its integral function in health and disease, little is known about the molecular basis that underpin a functional lymphatic vasculature. This research project will address this gap in our knowledge by exploring how protein known as transcription factors instruct a lymphatic specific genetic program. Discoveries from this research is expected to open up new therapeutic avenues for lymphatic vascular disorders which include tumour metastasis and lymphedema.
ActivityGNT1164000 | A single molecule resolution approach to decipher the transcriptional regulation of endothelial cell fate
Delivery Area Multiple VIC, QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $676,653
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeSpinal cord and brain injuries leave patients with permanent and often severe disabilities. The axon is the most vulnerable of the neuronal processes and it is almost always damaged when an injury strikes. Understanding the basic molecular mechanisms of axonal regeneration is therefore a key step to develop effective treatments for neuronal injuries. We have identified a new class of molecules that promote axonal regeneration, and that can potentially be employed to promote axonal repair.
ActivityGNT1164491 | Understanding the role of UNC-71 in axonal regeneration.
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $713,346
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeMosquito-borne dengue virus is a major health threat in tropical areas. We found that the virus causes pathology in a similar manner to some bacterial infections, via a cell surface receptor called TLR4. We have used drugs to block TLR4, and this greatly reduced disease severity in a mouse model of infection. Blocking TLR4 prevents leakiness of blood vessels and inflammatory damage in the gut and is promising as a treatment to reduce hospitalisation.
ActivityGNT1163313 | Intestinal barrier integrity in dengue virus infection
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $606,732
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeOne third of the world's population is latently infected with M. tuberculosis, the bacteria that cause TB. We have identified key processes in M. tuberculosis that enable the bacterium to become inactive within infected individuals. We believe that we can inhibit this TB latency and reduce antibiotic treatment times from 6 months (current) to just weeks. We will further investigate our discoveries to yield vital information for a new paradigm of drug and vaccine development.
ActivityGNT1164198 | Blocking TB Latency: The Key to Reducing Therapy Duration
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $932,998
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeOur vasculature is important in tissue homeostasis and the pathogenesis of many diseases. Abnormal cell signalling occurs in most known vascular diseases. We have identified a developmental function of a previously under'studied molecular regulator of signalling in vasculature. This project will investigate this factor, building on our recent discoveries with the goal to generate new knowledge that leads to approaches to manipulate vascular signalling in disease in the future.
ActivityGNT1164734 | Control of vascular development and signalling by a tissue specific, target selective, alternative splicing regulator
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $666,876
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe goal of this project is to test the hypothesis that a recently discovered chemical modification on DNA represents an important new mechanism for the control of gene expression underlying fear-related learning and memory. Specifically, we propose that the experience-dependent accumulation of m6dA, through direct effects on DNA structure, protein binding and epigenetic state, is necessary for activity- or learning-induced gene expression and required for fear extinction memory.
ActivityGNT1160823 | Toward a deeper understanding of new DNA modifications in fear-related learning.
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $878,595
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeKidney disease (DKD) affects about a third of individuals with diabetes. Kidneys rely on mitochondria, the cellular power stations, which are dysfunctional in DKD. This project will investigate the relationship between kidney disease and mitochondrial dysfunction as well as testing the ability of two medicines to improve mitochondrial function and prevent diabetic kidney disease.
ActivityGNT1160428 | Preventing progression of diabetic kidney disease by targeting mitochondrial function
Delivery Area Multiple NSW, QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $683,096
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeExisting drugs used to prevent blood clots have a range of side effects, including the risk of uncontrolled bleeding after an injury. This project will use naturally-occurring peptides found in plant seeds as a starting point for developing new drugs that only target blood clotting that causes disease. A series of peptides will be produced in our laboratory, then tested for their activity against an enzyme implicated in disease-related blood clotting and in several blood clotting assays.
ActivityGNT1164412 | Developing Factor XIIa inhibitors as new leads for preventing thrombosis
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $640,788
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeUncontrolled inflammation underlies chronic inflammatory and autoimmune diseases, like lupus. Macrophages are cells that control inflammation through their networks of molecular receptors, adaptors, signals and cytokine messengers. Our project will define new regulatory proteins and pathways within this network that control inflammation and are also associated with lupus. The outcomes will generate essential knowledge and expand therapeutic options for control of inflammation in disease.
ActivityGNT1159106 | A macrophage transmembrane adaptor: scaffolding and regulation in inflammation.
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $548,990
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeWe have developed a chimeric flavivirus technology that allows the production of virus particles that resemble the pathogenic viruses from which they were constructed, but are safe for human handling as we have replaced the replicative machinery with that of an insect-only virus. We will use these chimeras together with cutting edge electron microscopy to elucidate the atomic structure of important human viral pathogens that were previously too dangerous or difficult to prepare for analysis.
ActivityGNT1164216 | High resolution structural determination of pathogenic flaviviruses by cryo-EM using a chimeric platform
Delivery Area Multiple VIC, QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $695,788
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeDuring injury or infection, our body's immune system protects us by launching inflammation. But uncontrolled inflammation drives common human diseases such as cancer, diabetes, and Alzheimer's. This project will reveal new functions for inflammasomes - protein complexes at the heart of host defence, inflammation and disease - so we can design better drugs for treating patients with microbial infection or inflammation-driven disease.
ActivityGNT1163924 | PyroNETosis: a new mechanism of host defence
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $610,591
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeLung cancer is the biggest cause of cancer deaths in Australia, and has a low five year survival rate. The poor health outcomes are understood to be due to late presentation of symptoms when treatment options and our understanding of prognostic factors impacting on patient response are limited. In this project we wish to discover novel markers of lung cancer in blood samples of patients to enable early diagnosis and personalise lung cancer treatment.
ActivityGNT1164020 | Novel biomarkers for lung cancer
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $706,535
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeRoad crashes are a major cause of death and disability for young Australians. Fatigue is a major contributor to road crash, and is primarily due to insufficient sleep. Young adults frequently lose sleep due to developmental, social, work, and education demands. This project uses a brief but powerful behavioural program to extend habitual sleep, reduce sleepiness while driving, and reduce driving risk. The program could reduce the very high medical, social, and individual costs of road trauma.
ActivityGNT1163614 | Reducing Crash Risk For Young Drivers: A Randomized Control Trial To Improve Sleep
Delivery Area Multiple QLD, Overseas AUSTRALIA, UNITED STATES
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $514,350
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeIn this grant, we will investigate mechanisms used by two proteins (Mbl and Rbfox) to regulate alternative splicing. Alternative splicing can produce multiple proteins from the same gene and thereby contribute to the diversity of factors required for wiring-up the brain. Defects in Mbl and Rbfox have been reported in numerous neurological diseases and our goal is to understand how they work so that we can design therapeutic strategies that modulate their function.
ActivityGNT1164253 | Identifying conserved alternative splicing mechanisms in vivo
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $605,363
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeTraumatic spinal cord injury is an important and costly cause of disability in Australia. The body's immune system plays a key role in the recovery from such injuries, but treatments to effectively target post-traumatic inflammation are lacking. This grant will test a promising new therapy, intravenous immunoglobulin (IVIG), and in particular uncover what cells and molecules are targeted by it so that we can better treat individuals affected by these devastating injuries.
ActivityGNT1163835 | Understanding the mechanism of action for intravenous immunoglobulin (IVIG) therapy in spinal cord injury
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $270,906
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeOsteoporosis is a debilitating genetic bone disease that involves bone loss and increases fracture risk. This project aims to lead the largest ever genetic study of osteoporosis in half a million individuals, and in doing so, combine statistical and molecular approaches to identify genes that could in future serve as osteoporosis drug targets that restore lost bone.
ActivityGNT1158758 | Using large scale genome-wide association studies to identify pharmacological targets for osteoporosis intervention
Delivery Area Multiple QLD, Overseas AUSTRALIA, UNITED KINGDOM
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $642,949
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeDeep brain stimulation has immense potential to help patients with brain-based disorders that fail to benefit from all other treatments. To ensure this potential is realised, we must understand how it works. This project will determine how brain stimulation changes the way information is transmitted in a part of the brain that regulates responses to negative and positive events. This information is necessary to help improve brain stimulation treatments and clinical outcomes for patients.
ActivityGNT1160472 | Circuit, cellular and synaptic mechanisms of nucleus accumbens deep brain stimulation
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $810,745
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposePsychosis is a mental illness for which the cause is unknown. We reported 5 of 113 patients with psychosis had inflammation in their central nervous system. Treatment with immunotherapy resulted in full remission. Identifying patients with psychosis who have an autoimmune illness affecting their brain is critical to ensuring they receive appropriate treatment. This study will enable detection of autoimmune illness in patients with psychosis so as to ensure the best clinical outcomes.
ActivityGNT1161407 | Identifying and treating patients with psychosis who are positive to anti-neuronal antibodies
Delivery Area Multiple NSW, VIC, QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $827,521
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeWe have established that brains from mice with tau pathology produce tau seeds 'encapsulated' within extracellular vesicles known as exosomes. Furthermore, exosomes containing tau seeds can induce tau aggregation in recipient cells, and exosomes spread from neuron to neuron by hijacking endosomes. We aim to determine how exosomal tau seeds escape endosomes, and whether controlling the exosome production or traffic can halt or reduce tau pathology.
ActivityGNT1161133 | Unravelling how exosomes induce and propagate tau pathology
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $467,127
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeMicroglia are cells of the immune system that are abundant in the brain. They appear early in development of the embryo and are believed to be essential for brain development and health ageing. Human mutations that affect the function of microglia cause dementia and other neurodegenerative diseases. This project is concerned with analysing the precise function of a gene that controls the generation of microglia using novel animal models.
ActivityGNT1163981 | CSF1R and the control of microglial function
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $843,857
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeTo spread tumours need to create the blood vessels they will use at distant sites called metastatic niches. We have uncovered key molecular factors that allow tumours to develop these distant niches that will eventually be invaded and we will test new therapies for their inhibition to prevent metastatic spread of the disease.
ActivityGNT1163986 | Targeting the pre-metastatic vascular niche in melanoma using a novel molecular strategy
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $551,325
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposePeople with diabetes are at risk of severe flu infections. However, the mechanisms that drive this susceptibility are incompletely understood. This project will investigate whether variable blood sugar levels in patients with diabetes increase the severity of the flu and impair the immune response by causing oxidative stress. In doing so, this project aims to identify if reducing oxidative stress will reduce the severity of the flu in patients with diabetes.
ActivityGNT1159959 | The role of glycaemic variability in influenza virus pathogenesis and immunity
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $841,560
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeEndosomes are internal cellular compartments that control the cell's interactions with the outside world, and maintain the natural balance of the cell's essential components. Retromer is a large protein machine required for normal endosome function that is impaired in human neurodegenerative diseases. This proposal will examine in atomic detail how retromer works within the cell to control endosomal transport.
ActivityGNT1156493 | Retromer assembly and targeting in neurodegenerative disease
Delivery Area Multiple QLD, Overseas AUSTRALIA, UNITED KINGDOM
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $704,376
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeControlling the synthesis, recycling and degradation of receptors in the cell is absolutely essential for normal cellular function, regulating processes as diverse as the metabolism and synaptic communication. This project we will determine how Commander, a protein machine that controls retrieval, export and recycling of receptors is assembled as a large multi subunit assembly. This will provide insights into how Commander regulates complex pathways of cellular homeostasis in health and disease.
ActivityGNT1156732 | Understanding the assembly of the Commander complex.
Delivery Area Multiple VIC, QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $1,111,250
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeEpithelial tissues (e.g. gut, skin) are necessary barriers that protect the body from potential environmental toxins and infection. But epithelial barriers can be compromised when their constituent cells die, either during normal tissue turnover or upon noxious stress. This project investigates a novel protective mechanism, based on how cells detect changes in mechanical tension, that eliminates dead cells to preserve epithelial barriers during health and protects against inflammation.
ActivityGNT1163462 | The enemy within: epithelial defence against cell death.
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $786,568
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeWe have recently discovered a new mechanism for general anaesthesia. Sedatives such as propofol first put you to sleep, but then do something completely different: they impair communication between neurons across the brain. We need to better understand exactly how this happens, for the different drugs used during surgery. This understanding will allow us to design more targeted approaches for general anaesthesia, with better temporal control during surgery as well as minimal side effects.
ActivityGNT1164879 | Presynaptic control of general anaesthesia
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $324,914
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeGlobally Australian Aboriginal and Torres Strait Islanders have the highest recorded rate of Group A Streptococcus (GAS) infection, mainly rheumatic heart disease and rheumatic fever. GAS infection is endemic and often fatal due to post-infection problems.This project aims to develop a glycoconjugate vaccine to prevent GAS infection.We aim to avert these deaths by making a vaccine from small, specific parts of GAS proteins so the body makes safe antibodies that stop GAS and its related diseases.
ActivityGNT1158748 | Developing an effective glycoconjugate vaccine against Group A Streptococcus causing rheumatic fever/heart disease
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $477,192
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeGrowth and function of blood vessels is dependent on the coordination of movement and adhesion between individual cells in the vessel wall, however the signals controlling these actions remain unknown. This project will unravel the precise mechanisms by which cells interact during vessel growth induced by disease. A greater understanding of these cellular processes will allow for the development of novel targeted therapies for diseases including cancer and diabetes.
ActivityGNT1158002 | Mechanisms to promote vascular normalisation and barrier integrity
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $622,644
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeDuring infection, HOCl (bleach) is produced by host cells in high concentrations, and this project will characterize the currently unknown mechanism of HOCl resistance in the respiratory tract pathogen Haemophilus influenzae. We have already identified three HOCl-responsive protein in H. influenzae, all of which are required for its survival in the host and will now be characterized in detail, paving the way for future translation into clinically relevant practice and novel treatments.
ActivityGNT1158451 | Extracellular stress defence mechanisms in non-typeable Haemophilus influenzae
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $1,748,534
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeDuring end'stage kidney disease, clinical guidelines suggest reducing elevated phosphate levels in the blood. However, the effect of lowering blood phosphate levels on important patient-centred outcomes has never been tested. This trial will evaluate whether compared to high levels, lowering blood phosphate levels would reduce death or major events due to heart disease, improve physical health, and be cost-effective.
ActivityGNT1162410 | Pragmatic randomised trial of High Or Standard PHosphAte Targets in End-stage kidney disease (The PHOSPHATE Study)
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2023 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $815,403
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposePneumonia is the most frequent infection for intensive care unit (ICU) patients but failure of antibiotic therapy is common. We propose to use an innovative approach to develop antibiotic doses that achieve therapeutic concentrations at the site of infection in ICU patients with pneumonia. This novel approach to improving treatment has the potential to save many lives around the world.
ActivityGNT1162281 | Novel dosing regimens to maximise antibiotic effectiveness for treatment of pneumonia in the intensive care unit
Delivery Area Multiple VIC, QLD, Overseas AUSTRALIA, BELGIUM
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $481,890
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeSchizophrenia is a mental disorder affecting ~1 percent of the population. This disease has a high (~80 percent) genetic predisposition. Great progress has been made in identifying the genetic variants underlying this disorder. We have now reached the exciting step of validating these findings. We will take advantage of the fast-developing and optically accessible zebrafish brain to determine the normal and potential pathologic function of the most promising gene candidates.
ActivityGNT1165850 | Investigating the neuro-developmental role of schizophrenia-associated genes using the zebrafish.
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $709,254
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe simple act of perceiving an object in the world is thought to depend not only on incoming sensory information, but also on the brain's prediction about the object's likely identity. The aim of this project is to characterise the neural mechanisms responsible for predictive coding of visual stimuli. We will test humans and rodents using analogous visual tasks, and apply novel analytic methods to reveal a common code for perception in whole brain systems and individual neurons.
ActivityGNT1165337 | How do visual predictions affect neural coding- From whole brain systems to single neurons
Delivery Area Multiple ACT, QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $874,384
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe addition of new neurons is a major regulator of brain function and plasticity, and is well understood in the hippocampus. We have discovered that new neurons are also generated in the amygdala, a region that processes emotional memories. Using animal models in which we can identify and manipulate adult-born neurons in these two regions, we will assess their contribution to the neural circuitry of the brain and their role in the pathogenesis and treatment of anxiety-related disorders.
ActivityGNT1165060 | Unravelling amygdala-hippocampus neural circuitry of anxiety: Role of adult-born neurons
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $684,920
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeDuring the early stages of the disease, before major cell loss, Alzheimer's disease targets synapses, the points of communication between neurons. Importantly, the degree of synaptic loss strongly correlates with the memory deficits found in Alzheimer's disease patients. In this project, we will evaluate the role of calcium-dependent signalling in mediating synaptic loss and cognitive deficits in Alzheimer's disease models.
ActivityGNT1165504 | The role of calcium/calmodulin-dependent protein kinase II in synaptotoxicity in Alzheimer's disease models.
Delivery Area Multiple QLD, Overseas AUSTRALIA, FRANCE
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $593,191
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposePatients with psychiatric disorders often perceive sensory events abnormally, and the studies that are possible in humans and rodents have difficulty addressing why. Our project will develop a system in zebrafish for observing activity throughout the brain while we can still see each brain cell individually. This will allow us to see just how the brain encodes visual and auditory information, and how this activity changes when animals have mutations like those in human patients.
ActivityGNT1165173 | Brain-wide mapping of sensory perception and integration in a vertebrate model
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $367,992
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeChildren who are born of low birthweight are at increased risk of diseases like diabetes and high blood pressure in later life. This project aims to perform the world's largest genetic study of birthweight, determine whether the genes that affect birthweight arise from the influence of the mother's or offspring genome, and then use this information to investigate the relationship between birthweight and future risk of diseases like diabetes and high blood pressure.
ActivityGNT1157714 | Identifying maternal and fetal genetic determinants of infant birthweight and their relationship to offspring cardiometabolic risk
Delivery Area Multiple QLD, Overseas AUSTRALIA, UNITED KINGDOM
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $1,600,099
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe study attempts to improve oxygenation in infants and children undergoing emergency intubation. The results of this study are likely to change standard practice to improve outcome for these vulnerable patients.
ActivityGNT1157004 | Nasal High Flow Apnoeic Oxygenation during Pediatric Emergency Intubation: A Randomised Controlled Trial
Delivery Area Multiple NSW, VIC, SA, QLD, Overseas AUSTRALIA, NEW ZEALAND
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $624,722
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeRespiratory illnesses are responsible for 14 percent of deaths in Australia, although many are avoidable through better pharmaceutical management. To address this problem, a number of inhalable nanomedicines have been developed and are currently in clinical trials to improve the treatment of a range of respiratory illnesses. To date however, the pharmaceutical behaviour of these medications in the lungs have not been adequately assessed and will therefore be the focus of this project.
ActivityGNT1158026 | Understanding the kinetics of nanomedicine clearance from healthy and diseased lungs
Delivery Area Multiple VIC, QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $535,078
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeOvarian cancer is the most deadly type of gynaecologic disease with more than 1500 new cases being diagnosed each year in Australia. The goal of this research is to enhance the activity of immune cells such that they can start recognising and attacking ovarian tumour cells. Using naturally occurring vesicles, we have developed an effective strategy to switch off genes that prevent immune cells from entering ovarian tumour. Ultimately, our findings could significantly enhance patient survival.
ActivityGNT1162413 | Harnessing the immune system to battle ovarian cancer: A novel approach using naturally occurring exosomes
Delivery Area Multiple QLD, Overseas AUSTRALIA, UNITED STATES
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $497,127
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeChronic liver disease (CLD) is a major health burden. The defining feature of CLD is scarring of the liver (fibrosis), which can lead to loss of liver function and death. Macrophages are cells of the immune system that play critical roles in both fibrosis progression and fibrosis resolution. We have identified a growth factor that may switch pro-fibrotic macrophages to anti-fibrotic macrophages. In this Project we will investigate the therapeutic potential of this growth factor in CLD.
ActivityGNT1162171 | CSF1 Therapy for Chronic Liver Disease
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $480,591
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeSodium channels are critical in the sensation, amplification and transduction of pain. Inhibitors of sodium channels are therefore sought-after leads for the development of novel analgesics. Structure-based drug design (SBDD) is an important method for drug discovery rarely applied to sodium channels. In this proposal, we will address an important problem that has prevented the application of SBDD to these channels, paving the way for development of new analgesic drugs.
ActivityGNT1162597 | Accessing structurally elusive states of sodium channels as novel analgesic targets
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $497,836
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeEach year, 110,000 Australian have a stroke or heart attack, and 20,000 die as a result. Stroke and heart attack are ischemic injuries caused by reduced blood flow to the affected organ. Clot-busting drugs can be used to restore blood flow but they do not address the underlying tissue damage caused by the ischemic insult. We aim to develop a drug that protects the brain and heart after stroke and heart attack, respectively. This drug will save lives and improve quality-of-life for survivors.
ActivityGNT1165361 | Virtuous cycles: a novel cyclic peptide approach to develop neuroprotective and cardioprotective drugs
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $1,195,506
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeOur lymphatics control tissue homeostasis and the pathogenesis of many diseases. Tumours induce lymphatic vessel formation and then invade via lymphatics and lymph nodes. We have identified a key tissue growth pathway involved in the expansion of lymphatic vessel beds. This project will investigate control of lymphatic vascular expansion, building on recent findings. The ultimate goal is to generate knowledge leading to approaches to manipulate lymphatics in disease settings in the future.
ActivityGNT1165117 | Understanding the role of tissue growth pathways in expansion of the lymphatic vasculature
Delivery Area Multiple SA, QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $689,187
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeEating disorders and addictions are a major health problem worldwide. Relaxin-3 is a neuropeptide transmitter that acts via a single neural receptor to modulate arousal-, stress- and reward-related circuits and resultant behaviours, including feeding. We have produced novel compounds that can effectively inhibit the relaxin-3 receptor signalling and this project will further develop and utilise these in preclinical studies to demonstrate the potential of this receptor as a therapeutic target.
ActivityGNT1165801 | Pharmacological modulation of the relaxin-3/RXFP3 neuropeptide system for controlling feeding
Delivery Area Multiple VIC, QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $556,431
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe nervous system plays an important role in controlling the immune response. However, there is limited information available about how the nervous system senses and responds to a flu infection in the lungs. This application will address this significant gap in our knowledge and provide the first insight as to the role of the vagus nerve in severe flu infections. The outcomes of this project will pave the way for future studies to modulate the response of the vagal nerve to reduce flu severity.
ActivityGNT1161029 | Neuro-immune cross talk in influenza virus pathogenesis
Delivery Area Multiple VIC, QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $397,127
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeInvasive lobular breast cancer is the second most common type of breast cancer and although patients respond well to treatment initially, they often return years later with an untreatable spread of disease. We are unable to predict which patients this will be. This study will investigate whether a new genetic test called -LobSig- can identify which patients will do well, and be spared chemotherapy, while also identifying which patients would be better served by an aggressive treatment regime.
ActivityGNT1159902 | Lobular Breast Cancer - can we identify the patients likely to have a poor prognosis-
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $580,788
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeOur project will define mechanisms in the developing brain responsible for a birth defect known as microcephaly, a condition characterized by reduced head size, cognitive capacity and epilepsy that severely impact the quality of life of affected individuals, their families and communities. We will reveal how errors in protein function and defects in neural stem cell divisions cause disease. This information will help us better understand how microcephaly develops for disease management.
ActivityGNT1162652 | How defects in centrosome to microtubule attachment cause microcephaly.
Delivery Area Multiple QLD, Overseas AUSTRALIA, CHINA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $932,284
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis proposal aims to understand the aetiology by which obstructive sleep apnea (OSA) is associated with an increased risk of developing Alzheimer's disease. The outcomes of our experiments will provide a clear understanding of the development of disease characteristics, and our results will therefore be directly relevant to diagnose, designing effective strategies to prevent and/or treat the the large population of OSA sufferers who are known to be at increased risk of developing dementia.
ActivityGNT1162505 | Mechanisms and consequences of cholinergic neuron degeneration in sleep apnea
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $831,653
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeType 1 diabetes (T1D) afflicts more than 100,000 Australians and results from autoimmune destruction of insulin producing beta-cells. Insulin injections are required for survival, but T1D leads to substantial illness and reduced life expectancy. This project will test a newly-developed immunotherapeutic approach in a humanized mouse model of disease. Successful completion would accelerate the translation of this approach as a potential cure for T1D.
ActivityGNT1162066 | Engineering human dendritic cells for tolerogenic gene therapy of type 1 diabetes
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $831,700
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeInfants born preterm can have problems with their motor development, learning and behaviour as they grow up. We will evaluate if brain scans done shortly after preterm birth accurately predict later motor, learning and educational outcomes at 6 years of age. Identification of infants at risk of adverse outcomes at this earlier time point than has been possible before will enable treatments to be started earlier to support the family and help the child achieve the best possible outcome.
ActivityGNT1161998 | Prediction of childhood Brain Outcomes in infants born preterm using neonatal MRI and concurrent clinical biomarkers - PREBO-6
Delivery Area Multiple ACT, QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2023 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $667,521
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeMost brain tumours arise by spreading from cancer elsewhere in the body. This lethal complication has a devastating impact and new treatments are urgently needed. We will develop multifunctional nanomedicines that home to cancer deposits after injection, creating local reservoirs of high-dose chemo- and radiation therapy. They incorporate a tracer, so that deposits can be visualised with a PET scan before treatment, and only patients whose disease is likely to respond will be prescribed therapy.
ActivityGNT1162560 | Nanomedicine strategies for early detection and treatment of brain metastases
Delivery Area Multiple ACT, QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $676,653
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe ability to surgically repair an injured axon and restore function is still a significant challenge in neurosurgery. However, a spontaneous repair mechanism, axonal fusion, by which the two separated ends of a transected axon are fused back together, has been observed in invertebrates. We have identified a molecule that acts as a master regulator of axonal fusion in the nematode C. elegans. Here, we will study this molecule and its potential to control axonal repair in mammalian neurons.
ActivityGNT1162204 | Understanding the role of the metalloprotease ADM-4/ADAM17/TACE in promoting axonal repair
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $261,418
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis study will identify unique near infrared spectroscopy spectral fingerprints for Plasmodium species and their intraerythrocytic stages in vitro and in vivo, elucidate chemical compounds associated with the spectral fingerprints and test the application of NIRS in diagnosing malaria in human subjects in the field.
ActivityGNT1159384 | Development of instantaneous ultra-sensitive diagnostic tool to guide malaria elimination
Delivery Area Multiple QLD, Overseas AUSTRALIA, KENYA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2020 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $528,990
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeNeurons in the brain wire together to from circuits that underpin brain function. In order to wire correctly, cortical neurons rely on spontaneous activity, where ensembles of neurons fire in specific patterns, to find and form their correct cortical circuits. This project aims to understand how spontaneous cortical activity regulates brain wiring and cortical development. The work will inform our understanding of neurodevelopmental disorders and ways to optimise brain development.
ActivityGNT1159783 | Role of spontaneous activity in the formation of functional cortical circuits in vivo.
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $624,920
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeOur goal in this proposal is to rationally guide the generation of human antibodies with therapeutic potential for both dengue and Zika virus infections. The project will provide a comprehensive structural and functional analysis of the secreted form of the dengue and Zika virus NS1 (sNS1) proteins in complex with a panel of anti-NS1 antibodies to reveal the molecular details of key protective and cross-reactive sites within NS1.
ActivityGNT1162507 | Structural insights into the function and antigenicity of the flavivirus NS1 protein.
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
THE UNIVERSITY OF QUEENSLAND
Brisbane  $49,978
Address BRISBANE 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Growing Business Investment and Improving Business Capability
Component Entrepreneurs' Programme - Innovation Connections
CategoryIndustry Innovation Demand Driven
PurposeInnovation Connections promotes collaboration between small and medium sized Australian businesses and the research sector to develop new ideas with commercial potential.
ActivityInnovation Connections
Delivery Area 4212 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Nov 201910 Dec 201908 Dec 201917 Jan 2021 2019-20
THE UNIVERSITY OF QUEENSLAND
Ryan  $50,000
Address BRISBANE 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Growing Business Investment and Improving Business Capability
Component Entrepreneurs' Programme - Innovation Connections
CategoryIndustry Innovation Demand Driven
PurposeInnovation Connections promotes collaboration between small and medium sized Australian businesses and the research sector to develop new ideas with commercial potential.
ActivityInnovation Connections
Delivery Area 6157 WA AUSTRALIA
ApprovedPublishedStartEndBudget
24 Oct 201805 Nov 201831 Oct 201804 Dec 2019 2018-19
UNIVERSITY OF QUEENSLAND
Ryan  $657,897
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis project will investigate use of an imaging instrument to identify renal cancers that are potentially harmless from aggressive renal cancers. Currently, such differentiation requires biopsies, and the outcome is often unnecessary surgical removal of whole or part of the diseased kidney. Long term, this project will provide knowledge to determine aggressiveness of a renal cancer non-invasively, without having to perform an operation. The approach was previously successful for breast cancer.
ActivityGNT1147077 | Evaluation of Renal Masses Using Magnetic Resonance
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
24 Oct 201706 Feb 201801 Jan 201831 Dec 2020 2016-17
UNIVERSITY OF QUEENSLAND
Ryan  $68,947
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis project will develop best practice guidelines for burns care of Aboriginal and Torres Strait Islander children by consulting medical experts and parents/carers of Aboriginal and Torres Strait Islander children admitted to a public hospital due to burn injuries. These guidelines will be used to explore the care provided to Aboriginal and Torres Strait Islander children and barriers or enablers experienced by them and medical experts in receiving/providing high-quality, culturally safe care.
ActivityGNT1150245 | Provision of best practice care to Aboriginal and Torres Strait Islander children with burn injuries.
Delivery Area Multiple NSW, QLD AUSTRALIA
ApprovedPublishedStartEndBudget
24 Oct 201706 Feb 201801 Jan 201830 Apr 2020 2016-17
UNIVERSITY OF QUEENSLAND
Ryan  $825
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Environment and Energy
Agency Department of the Environment and Energy
Program Environmental Information and Research
Component 2018-19 National Taxonomy Research Grant Program
CategoryNatural Resources - Conservation and Protection Open Competitive
PurposeIntermediate host'switch events appear to underlie a new subfamily classification system for the largest family of trematodes.
ActivityIntermediate host-switch events appear to underlie a new subfamily classification system for the largest family of trematodes
Delivery Area 4072 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
24 May 201914 Jun 201911 Jun 201911 Sep 2019 2018-19
UNIVERSITY OF QUEENSLAND
Ryan  $1,195,649
Address St Lucia 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Partnership Projects
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis project aims to improve the early detection of melanoma for those at highest risk, using recent advances in imaging technology. We will also examine how telehealth approaches (eg. secure on-line transfer and assessment of images) can improve access to specialised monitoring of moles. Detecting melanoma as early as possible will result in improved treatment outcomes and reduce the burden melanoma places on individuals, their families and the health system.
ActivityGNT1153046 | Implementation of an innovative teledermatology network for the early detection of melanoma in high risk Australians
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
24 Apr 201805 Jun 201801 Jun 201831 May 2021 2017-18
THE UNIVERSITY OF QUEENSLAND
Ryan  $220,000
Address St Lucia 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Communications and the Arts
Agency Department of Communications and the Arts
Program Arts and Cultural Development
Component Indigenous Languages and Arts Program
CategoryHumanities Open Competitive
PurposeTo support language revival efforts through the development of Opie Robots for language activities in Queensland.
ActivityOpie: Indigenous Language Robots for community-led revitalisation
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
23 Jul 201812 Oct 201802 Oct 201830 Jun 2020 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $3,478,000
Address ST LUCIA, BRISBANE 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Health
Agency Department of Health
Program Preventive Health and Chronic Disease Support
Component Research Centres - ATODB
CategoryAddiction and Substance Abuse Closed Non-Competitive
PurposeResearch Centres - ATODB
ActivityResearch Centres - ATODB
Delivery Area QLD AUSTRALIA
ApprovedPublishedStartEndBudget
22 Mar 201929 Jul 201924 Jul 201930 Jun 2022 2019-20
THE UNIVERSITY OF QUEENSLAND
Ryan  $192,500
Address BRISBANE 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Supporting Science and Commercialisation
Component Global Innovation Strategy
CategoryScience
PurposeThe purpose of the Grant is to model predicted changes in environmental conditions of coastal ecosystems over the next 30 years. This risk model will identify locations at which future conservation and restoration efforts will be most effective.
ActivityModelling predicted changes in environme ntal conditions of coastal ecosystems
Delivery Area 4072 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
22 Jun 201827 Jun 201822 Jun 201830 Oct 2021 2017-18
UNIVERSITY OF QUEENSLAND
Ryan  $1,100
Address University of Queensland 4072 QLD AUSTRALIA ABN: 63942912684
Portfolio Environment and Energy
Agency Great Barrier Reef Marine Park Authority
Program Improving the Outlook for the Great Barrier Reef
Component Reef Guardian Research Grants - 2017/18
CategoryScientific Research Open Competitive
PurposeGBRMPA's Reef Guardians Research Grants (previously named Science for Management Awards) are intended to assist students working towards Doctorate or Masters degrees in the physical, biological and social science disciplines, which make a contribution to the management of the Great Barrier Reef Marine Park. Proposed research projects must address GBRMPA's scientific information needs. The awards, under different names, have been in existence for over thirty years.
ActivityReef Guardian Research Grants - 2017/18
Delivery Area 4072 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
21 Nov 201728 Aug 201821 Nov 201731 Jan 2019 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $650,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Growing Business Investment and Improving Business Capability
Component Industry 4.0 Testlabs for Australia
CategoryIndustry Innovation Closed Non-Competitive
PurposeThe project will establish an Energy Industry 4.0 Testlab to serve as a point of engagement with SMEs and enable knowledge transfer to support uptake of Industry 4.0 approaches to energy management.
ActivityUQ Energy Testlab: Collaborative research, teaching & learning space for 21st ce
Delivery Area 4072 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
21 Dec 201814 Feb 201924 Jan 201907 Dec 2019 2018-19
THE UNIVERSITY OF QUEENSLAND
Ryan  $405,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop new machine learning techniques based around the close correspondence betweenneural networks used in deep learning, and tensor networks used in quantum physics. Tensor networks are a form of information compression that is useful in machine learning to construct a compact representation of a large data set in a way that is more amenable to understanding the internal structure than a deep neural network. Expected outcomes of this project include more resilient algorithms for machine learning, and new ways to represent quantum states that will impact fundamental physics. The resulting benefits include enhanced capacity for cross-discipline collaboration, and improved methods for future industrial applications.
ActivityQuantum-Inspired Machine Learning
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
20 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF QUEENSLAND
Ryan  $400,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeWorldwide markets for biotechnology-derived products are projected to grow to at least $50 billion per year for the next 10 years. The cornerstone of biotechnology is the production of proteins. The applicant has discovered a new pathway for protein production in bacteria. The primary objective of this project is to use a diverse array of biochemical and biophysical techniques to understand how this new protein production platform works. We will also assess this new pathway for the production of proteins of interest to the biotechnology sector. This project expects to determine how this system can be exploited for use in the growing Australian bioeconomy.
ActivitySlipping out unnoticed: a new bacterial lipoprotein transport system
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
20 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF QUEENSLAND
Ryan  $493,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to establish a methodology for spatiotemporal entity linking by utilising object movement traces to support database integration and data quality management for the next-generation of data where spatiotemporal attributes are ubiquitous. It expects to develop a novel entity linking paradigm for automatic, efficient and reliable spatiotemporal data integration together with a new data privacy study in this context. Expected outcome include new database technologies for data signature generation and similarity-based search, and improved location data privacy protection methods. This project should provide significant benefits to all areas where high quality spatiotemporal data fusion is essential to meaningful data analysis.
ActivityMaking Spatiotemporal Data More Useful: An Entity Linking Approach
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
20 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF QUEENSLAND
Ryan  $512,774
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project will examine the structure and function of the sensory cortex of the human brain using ultra-high resolution functional magnetic resonance imaging (7 Tesla MRI). The project pushes new boundaries for resolution with ultra-high field MRI (7 Tesla) and, as such, will advance techniques for the acquisition, analysis, and computational modelling of high-resolution fMRI brain imaging, providing detail of the functional organisation of the sensory cortex at a level never previously possible in the living human brain. This will provide new understanding of the neural-level networks that underpin attention and touch perception in the human brain.
ActivityLinking human brain structure to function with ultra-high resolution fMRI
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
20 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF QUEENSLAND
Ryan  $449,250
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to generate fundamental knowledge on the origin of diversity in mammalian brain circuits by studying development of marsupials and rodents. The expected outcome is to elucidate how differences in the timing, rate and sequence of development of gene expression, cell differentiation and circuit formation can relate to the origin of key evolutionary innovations in the mammalian brain. The significance of understanding the dynamics of developmental systems that shape complex brain traits includes establishing new developmental paradigms in evolutionary theory, generating new tools to investigate and manipulate brain gene expression in vivo, and the potential discovery of the causes of neurodevelopmental dysfunction.
ActivityHow does timing affect mammalian brain development and evolution?
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
20 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF QUEENSLAND
Ryan  $540,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThe marine snails of the genus Conus have evolved one of the most complex venoms that has emerged as a rich source of novel bioactive peptides. However, < 0.1% of their true potential has been characterised to-date. Using advanced genomic, proteomic, structural and pharmacological approaches pioneered in our laboratory, this study will decipher how conotoxin diversification from ancestral worm hunters facilitated the shift in diet to modern fish and mollusc hunting species by determining the evolutionary trajectories of positively selected conotoxins. Investigation of the structure and function of these highly optimised venom peptides will provide new research tools and potential leads to new pharmaceuticals and agrochemicals.
ActivityConotoxin diversification and evolution of venom peptides in cone snails
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
20 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF QUEENSLAND
Ryan  $249,993
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to examine the early effects of two recent initiatives by the Australian government to improve children's dental health by providing funds to cover essential dental services for children from disadvantaged families. It explores the factors affecting eligible children's access to benefits from these initiatives and identifies the causal impacts of these changed health care financing arrangements on children's consumption of dental services, indicators of oral health and general health, and other indicators of cognitive and non-cognitive development. Using advanced econometric techniques and panel datasets, this project is expected to contribute to the development of effective policies for promoting health and wellbeing.
ActivityChild Dental Benefit Policies and the Health of Australian Children
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
20 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF QUEENSLAND
Ryan  $390,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThe proposal aims to apply new materials design theory to create new classes of highly efficient materials and overcome device efficiency roll-off issue for next-generation transparent electronics. The project expects to advance new see-through technology through new materials and device architectures innovations. Expected key outcomes include novel highly efficient multi-nuclear metal complexes generation, establishment of new knowledge of materials' structure-property relationship and fundamental understanding of device physics, creation of new transparent display pixels, new training of young scientists and new IPs generation, which will provide benefits to maximise Australia's competitive advantages and meet with global innovation need.
ActivityHigh-brightness, low-efficiency roll-off materials for augmented realities
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
20 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF QUEENSLAND
Ryan  $395,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to engineer a multifunctional nanoparticle platform tailored for mRNA delivery. An innovative assembly approach will be used to design nanoparticles with adjustable composition, asymmetry and surface topography. Uniquely, three functions will be integrated in one nanoparticle, with the goal to enhance transfection efficiency in target cells. This project expects to advance knowledge of mRNA transfection mechanisms, and determine how cell-type dependent particle-mRNA interactions correlate with the nanoparticle structure and delivery performance. Outcomes include a new family of functional materials with improved mRNA delivery performance over benchmark systems to facilitate and broaden the application of mRNA technology.
ActivityNext-Generation Multifunctional Nanoparticles for mRNA Transfection
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
20 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF QUEENSLAND
Ryan  $510,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims is to study the non-equilibrium aerodynamic processes involved in hypervelocity flight. The design of vehicles for high speed flight is critically dependent on modelling the interactions between the flow field and the airframe, and the current lack of understanding is restricting the scope and benefit of viable activities in space. The expected outcomes include the ability to design optimised heat shields and air-frames with minimum mass and maximum payload, precisely targeting specific flight conditions and vehicle shapes. The prospective benefits include increased productivity and reliability and reduced cost of missions to and from space, and a proliferation of new applications which this understanding will facilitate.
ActivityNon-equilibrium reacting shock layers
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
20 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF QUEENSLAND
Ryan  $546,992
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeGenetic diversity is the variation in DNA sequence among individuals. We now know that there are also differences in the DNA sequences of cells within the same individual, known as genetic mosaicism. The aims of this proposal are 1) to develop a system to visualise genetic mosaicism 2) arising during embryonic development and 3) in the brain, driven by mobile DNA activity. The expected outcome of this proposal is an unprecedented understanding of the scope and consequences of mobile DNA-driven mosaicism. This work will have significant impacts in developmental genetics and neurogenetics, and has the benefit of introducing an innovative experimental system with the potential to spark international scientific collaboration and recognition.
ActivityVisualising genetic mosaicism during development
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
20 Dec 201906 Jan 202001 Jan 202031 Dec 2023 2019-20
THE UNIVERSITY OF QUEENSLAND
Ryan  $204,046
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to address the question about which animals feel pain by framing multiple current debates into a single narrative focused on the fundamental principle in evolutionary biology that structure determines function. This project is significant because the question as to whether or not an animal (such as a fish or octopus) feels pain is highly contentious across both science and philosophy and arguments are plagued by simplistic anecdotes and poor analogies. The ramifications of this confusion for animal welfare and food security are considerable. Expected outcomes include the development of shared principles of reasoning and structural constraints on the attribution of pain that promise to move the debate towards consensus.
ActivityTowards Closure on the Animal Pain Debate
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
20 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF QUEENSLAND
Ryan  $505,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to determine how germ cells are regulated in the mammalian embryo. Germ cells go on to form the sperm and eggs and are, therefore, critical for reproduction. In particular, this project expects to generate new knowledge about the process of meiosis, a cellular process that is specific to the germ cells. Expected outcomes will inform efforts to control fertility and infertility in livestock, humans and other mammalian animals (e.g. pets and endangered species). They are also likely to inform the discipline of stem cell biology in general.
ActivityHow do mammalian germ cells transition from mitosis to meiosis?
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
20 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF QUEENSLAND
Ryan  $465,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeOur senses perceive the outside world and permit appropriate behaviours, but the underlying brain circuits are poorly understood. This project will use new technologies to observe all active brain cells in zebrafish during the important behaviour of visual predator avoidance and characterise the underlying circuits comprehensively. This approach's significance is in its breadth, spanning functional imaging, anatomy, computational modelling, and behaviour, with the major outcome of producing the first complete map of a visual behaviour at the level of brain circuits and the individual brain cells composing them. Benefits will include new insights into visual processing and the refinement of new genetic, optical, and informatics approaches.
ActivityMapping a complete visual circuit in zebrafish
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
20 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF QUEENSLAND
Ryan  $445,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate the structure, function and evolution of peptide toxins in venoms made by caterpillars in superfamily Zygaenoidea. Caterpillars in this group are covered in spines that inject pain-causing venoms, and this protects them from vertebrate and invertebrate predators. This project will test if peptides in this venom cause pain by pharmacological modulation of mammalian ion channels and signalling receptors, and if they have insecticidal properties. The first three-dimensional structures of caterpillar venom peptides will also be solved. Genomes of representatives of two different zygaenoid families will be produced, and genomic techniques will be used to elucidate how venom use evolved at the molecular level.
ActivityNettles & toxic toupees: the molecular weaponry of venomous caterpillars
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
20 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF QUEENSLAND
Ryan  $451,284
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop robust protein cages derived from the coats of viruses to contain heat'stable P450 enzymes, for use as specialised protein bio-catalysts in chemical industries. A valuable chemical precursor of renewable bio-plastics will be produced from seed oils by enzymes, reducing the use of fossil fuels. This synthetic biology approach combines biotechnology, nanotechnology and protein engineering to establish a plant-based platform biotechnology for using enzymes as catalysts to make high-value molecules. The project aims to show how to engineer clean, sustainable chemistry in designer nano-environments. This should make synthetic processes more sustainable and enhance advanced chemical manufacturing in Australia.
ActivityNano-reactors: Protein cages as reusable scaffolds for designer enzymes
Delivery Area 4067 QLD AUSTRALIA
ApprovedPublishedStartEndBudget
20 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF QUEENSLAND
Ryan  $414,000
Address ST LUCIA 4067 QLD AUSTRALIA ABN: 63942912684
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
Category