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494 grants worth $407,364,463 have been awarded to organisations matching THE UNIVERSITY OF SYDNEY or ABN 15211513464 since January 2018

UNIVERSITY OF SYDNEY
Grayndler  $120,000
Address Sydney 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency Cancer Australia
Program Cancer Australia
Component Supporting people with cancer Grant initiative
CategoryCancer Open Competitive
PurposeAboriginal people with cancer to access evidence based care: developing a manual and training package in use for workers in primary care to support cancer care
ActivityAboriginal people with cancer to access evidence based care: developing a manual and training package in use for workers in primary care to support cancer care.
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
31 May 201904 Jun 201931 May 201930 May 2022 2018-19
THE UNIVERSITY OF SYDNEY
Grayndler  $38,012,536
Address SYDNEY 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency Department of Health
Program Health Workforce
Component Rural Health Multidisciplinary Training Programme
CategoryPublic Health Services Closed Non-Competitive
PurposeThe Rural Health Multidisciplinary Training Programme aims to increase the rural health workforce by supporting universities to deliver quality medical, multidisciplinary and dental training in rural communities and promote/encourage rural careers
ActivityRural Health Multidisciplinary Training Programme
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
31 May 201829 Mar 201901 Mar 201931 Dec 2020 2018-19
THE UNIVERSITY OF SYDNEY
Grayndler  $1,512,808
Address SYDNEY 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency Department of Health
Program Health policy Research and Analysis
Component CT Grant Activity - Low Survival Cancers
CategoryMedical Research Targeted or Restricted Competitive
PurposeCT Grant Activity - Low Survival Cancers
ActivityCT Grant Activity - Low Survival Cancers
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
31 Aug 201820 Jun 201901 Feb 201915 Feb 2024 2018-19
THE UNIVERSITY OF SYDNEY
Grayndler  $20,037
Address SYDNEY 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Agriculture and Water Resources
Agency Department of Agriculture
Program Dept Agricultural Resources
Component Science and Innovation Awards for Young People in Agriculture, Fisheries and Forestry
CategoryRural Development Open Competitive
PurposeSupport Science and Innovation Awards for Young People in Agriculture, Fisheries and Forestry
ActivityRe-use of aquaculture wastewater for the production of high-value compounds using microalgae.
Delivery Area Multiple National AUSTRALIA
ApprovedPublishedStartEndBudget
30 Nov 201703 Jul 201827 Apr 201827 Apr 2019 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $380,000
Address UNIVERSITY OF SYDNEY 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency Department of Health
Program Preventive Health and Chronic Disease Support
Component Drug and Alcohol Prevention and Early Intervention
CategoryAddiction and Substance Abuse Open Competitive
PurposeDrug and Alcohol Prevention and Early Intervention
ActivityDrug and Alcohol - Prevention and Early Intervention
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
30 May 201804 Jul 201820 Jun 201831 Dec 2019 2017-18
THE UNIVERSITY OF SYDNEY / CENTRE FOR ROBOTICS AND INTELLIGENT SYSTEMS
Grayndler  $33,000
Address University of Sydney 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Foreign Affairs and Trade
Agency Department of Foreign Affairs and Trade
Program Public Diplomacy including IRGP grants
Component Australia-Korea Foundation
CategoryPublic Diplomacy Open Competitive
PurposeAustralia-Korea Partnership on Mobile Robot Development in Public Space aims to establish a relationship among experts in innovation and technology to develop a long-term collaboration between two countries regarding the deployment of mobile robots and smart technologies in public space.
ActivityAustralia-Korea Partnership on Mobile Robot Development in Public Space
Delivery Area 2006 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
30 Jul 201907 Aug 201901 Aug 201930 Jun 2020 2019-20
UNIVERSITY OF SYDNEY
Grayndler  $81,108
Address Camperdown 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Foreign Affairs and Trade
Agency Department of Foreign Affairs and Trade
Program Public diplomacy including IRGP payments
Component 2018-19 Australia-India Council
CategoryTrade and Tourism Open Competitive
PurposeAustralian consumer affairs agencies will collaborate with the Department of Consumer Affairs, India and its partners through workshops for a new consumer agency. Australia and India view consumer welfare and law as central to economic transformation and trade.
ActivityAustralia-India Collaborative Consumer Protection Project for Improved Business Relations
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
30 Jul 201804 Sep 201801 Nov 201801 Sep 2019 2018-19
UNIVERSITY OF SYDNEY
Grayndler  $600,000
Address Sydney 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency Cancer Australia
Program Improved cancer control
Component 2018 Priority-driven Collaborative Cancer Research Scheme
CategoryCancer Targeted or Restricted Competitive
PurposeThe success of modern lung cancer radiotherapy relies on four-dimensional computed tomography (4DCT) scans to account for breathing-induced tumour motion. Currently, 90% of 4DCT scans suffer severe image errors that limit the treatment accuracy and reduce the chance of tumour control by up to one third. This project will translate high accuracy, real-time adaptive 4DCT from a software prototype to clinical reality, enabling more accurate treatments and better outcomes for up to 5,000 Australians/year.
ActivityImproving tumour targeting and delineation in lung cancer radiotherapy
Delivery Area Multiple National AUSTRALIA
ApprovedPublishedStartEndBudget
29 May 201903 Jul 201930 Jun 201929 Jun 2022 2018-19
UNIVERSITY OF SYDNEY
Grayndler  $1,391,472
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency Department of Health
Program Health and Medical Research
Component 2018 MRFF Rare Cancers Rare Diseases, Unmet Need commencing 2018
CategoryMedical Research Targeted or Restricted Competitive
PurposeThere are no effective treatments for patients with relapsed glioma. In the subset of patients with isocitrate dehydrogenase (IDH)-mutant glioma, there is promising biologic rationale for, and potential synergy, combining rucaparib (which inhibits DNA repair) and nivolumab (which augments the anti-cancer immune response). This combination has been previously reported to be safe. This study will test the effectiveness of rucaparib and nivolumab against relapsed IDH-mutant glioma.
ActivityMRF1170139 | PICCOG: PARP and Immune Checkpoint inhibitor COmbination for relapsed IDH-mutant high-grade Glioma
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
29 Mar 201926 Apr 201901 Apr 201931 Mar 2024 2018-19
UNIVERSITY OF SYDNEY
Grayndler  $1,704,432
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency Department of Health
Program Health and Medical Research
Component 2018 MRFF Rare Cancers Rare Diseases, Unmet Need commencing 2018
CategoryMedical Research Targeted or Restricted Competitive
PurposeALS is a neurodegenerative disorder where rapidly progressive motor weakness leads to death, usually within 3 years. This proposal unites the Australian ALS clinical community to present a coordinated multisite trial network - Amyotrophic Lateral Sclerosis Trials Australia (ALSTA). This proposal describes a clinical trial that may suggest a new therapy for ALS. Whole genome sequencing will be undertaken, to delineate subgroups to allow for targeted treatment approaches.
ActivityMRF1170223 | ALS Trials Australia (ALSTA) - to develop precision medicine
Delivery Area Multiple NSW, VIC, SA, WA, QLD AUSTRALIA
ApprovedPublishedStartEndBudget
29 Mar 201926 Apr 201901 Apr 201931 Mar 2022 2018-19
UNIVERSITY OF SYDNEY
Grayndler  $1,093,681
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency Department of Health
Program Health and Medical Research
Component 2018 MRFF Rare Cancers Rare Diseases, Unmet Need commencing 2018
CategoryMedical Research Targeted or Restricted Competitive
PurposeChildren with chronic kidney disease (CKD) suffers from reduced quality of life and premature death. More importantly, a strong social health gradient exists in children with CKD, with more deprived groups having a higher prevalence of poorer health outcomes. This program of work aims to compare the health benefits and costs of a patient navigator program with standard care in the context of a dynamic, waitlist, randomised controlled trial.
ActivityMRF1170021 | NAVMAN TRIAL: A multi-centre, dynamic, waitlist randomised controlled trial of patient naviagtors in children with chronic kidney disease
Delivery Area Multiple NSW, VIC, QLD AUSTRALIA
ApprovedPublishedStartEndBudget
29 Mar 201926 Apr 201901 Apr 201931 Mar 2022 2018-19
UNIVERSITY OF SYDNEY
Grayndler  $787,069
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency Department of Health
Program Health and Medical Research
Component 2018 MRFF Rare Cancers Rare Diseases, Unmet Need commencing 2018
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe phase 3 randomised controlled trial aims to improve the outcome of Follicular Lymphoma patients who remain PET positive after initial immunochemotherapy (who have demonstrated to have a poor outcome), and minimise further treatment for good prognosis patients who become PET negative. If the study can confirm the benefit of a PET response adapted approach, it will establish a new standard of care for follicular lymphoma globally.
ActivityMRF1170260 | PETReA: Phase 3 evaluation of PET-guided, Response-Adapted therapy in patients with previously untreated, high tumour burden follicular lymphoma.
Delivery Area Multiple ACT, NSW, VIC, WA, QLD, TAS AUSTRALIA
ApprovedPublishedStartEndBudget
29 Mar 201926 Apr 201901 Apr 201931 Mar 2024 2018-19
UNIVERSITY OF SYDNEY
Grayndler  $1,273,632
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency Department of Health
Program Health and Medical Research
Component 2018 MRFF Rare Cancers Rare Diseases, Unmet Need commencing 2018
CategoryMedical Research Targeted or Restricted Competitive
PurposeGlioblastoma (GBM) is the most deadly type of brain cancer. Around 1000 Australians die from GBM each year. Treatment hasn-t improved for many years because trials in this rare cancer are difficult. We will use a unique design to more rapidly test different treatments at the same time. By sharing credit and effort, we will enlist doctors nationwide to allow more Australian patients with GBM the chance to test better treatments faster than traditional clinical trials.
ActivityMRF1170193 | MAGMA: Multi-Arm GlioblastoMa Australasia Trial
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
29 Mar 201926 Apr 201901 Apr 201931 Mar 2024 2018-19
THE UNIVERSITY OF SYDNEY ACTING FOR THE AUSTRALASIAN GASTRO-INTESTINAL TRIALS GROUP
Grayndler  $1,500,000
Address The University of Sydney 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency Cancer Australia
Program Improved cancer control
Component Support for Cancer Clinical Trials Program
CategoryCancer Targeted or Restricted Competitive
PurposeClinical trials benefit the community by improving the survival of people affected by cancer, and contribute to a reduction in premature death and disability. Clinical trials are fundamental to establishing if new cancer treatments, diagnostic tests or preventive interventions are effective and they help generate evidence for best-practice cancer care.
ActivityThe development of industry-independent cancer clinical trial protocols.
Delivery Area Multiple National AUSTRALIA
ApprovedPublishedStartEndBudget
29 Jun 201805 Jul 201801 Jul 201801 Sep 2021 2018-19
THE UNIVERSITY OF SYDNEY ACTING FOR THE PSYCHO-ONCOLOGY CO-OPERATIVE RESEARCH GROUP
Grayndler  $1,477,995
Address The University of Sydney 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency Cancer Australia
Program Improved cancer control
Component Support for Cancer Clinical Trials Program
CategoryCancer Targeted or Restricted Competitive
PurposeClinical trials benefit the community by improving the survival of people affected by cancer, and contribute to a reduction in premature death and disability. Clinical trials are fundamental to establishing if new cancer treatments, diagnostic tests or preventive interventions are effective and they help generate evidence for best-practice cancer care.
ActivityThe development of industry-independent cancer clinical trial protocols.
Delivery Area Multiple National AUSTRALIA
ApprovedPublishedStartEndBudget
29 Jun 201805 Jul 201801 Jul 201801 Sep 2021 2018-19
THE UNIVERSITY OF SYDNEY ACTING FOR THE AUSTRALIA AND NEW ZEALAND MELANOMA TRIALS GROUP
Grayndler  $1,500,000
Address The University of Sydney 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency Cancer Australia
Program Improved cancer control
Component Support for Cancer Clinical Trials Program
CategoryCancer Targeted or Restricted Competitive
PurposeClinical trials benefit the community by improving the survival of people affected by cancer, and contribute to a reduction in premature death and disability. Clinical trials are fundamental to establishing if new cancer treatments, diagnostic tests or preventive interventions are effective and they help generate evidence for best-practice cancer care.
ActivityThe development of industry-independent cancer clinical trial protocols.
Delivery Area Multiple National AUSTRALIA
ApprovedPublishedStartEndBudget
29 Jun 201805 Jul 201801 Jul 201801 Sep 2021 2018-19
THE UNIVERSITY OF SYDNEY ACTING FOR THE AUSTRALIA NEW ZEALAND GYNAECOLOGICAL ONCOLOGY GROUP
Grayndler  $1,500,000
Address The University of Sydney 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency Cancer Australia
Program Improved cancer control
Component The Support for Cancer Clinical Trials Program
CategoryCancer Targeted or Restricted Competitive
PurposeClinical trials benefit the community by improving the survival of people affected by cancer, and contribute to a reduction in premature death and disability. Clinical trials are fundamental to establishing if new cancer treatments, diagnostic tests or preventive interventions are effective and they help generate evidence for best-practice cancer care.
ActivityThe development of industry-independent cancer clinical trial protocols.
Delivery Area Multiple National AUSTRALIA
ApprovedPublishedStartEndBudget
29 Jun 201805 Jul 201801 Jul 201801 Sep 2021 2018-19
THE UNIVERSITY OF SYDNEY ACTING FOR THE AUSTRALASIAN LUNG CANCER TRIALS GROUP
Grayndler  $1,500,000
Address The University of Sydney 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency Cancer Australia
Program Improved cancer control
Component Support for Cancer Clinical Trials Program
CategoryCancer Targeted or Restricted Competitive
PurposeClinical trials benefit the community by improving the survival of people affected by cancer, and contribute to a reduction in premature death and disability. Clinical trials are fundamental to establishing if new cancer treatments, diagnostic tests or preventive interventions are effective and they help generate evidence for best-practice cancer care.
ActivityThe development of industry-independent cancer clinical trial protocols.
Delivery Area Multiple National AUSTRALIA
ApprovedPublishedStartEndBudget
29 Jun 201805 Jul 201801 Jul 201801 Sep 2021 2018-19
THE UNIVERSITY OF SYDNEY ACTING FOR THE AUSTRALIAN AND NEW ZEALAND UROGENITAL AND PROSTATE CANCER TRIALS GROUP
Grayndler  $1,500,000
Address The University of Sydney 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency Cancer Australia
Program Improved cancer control
Component Support for Cancer Clinical Trials Program
CategoryCancer Targeted or Restricted Competitive
PurposeClinical trials benefit the community by improving the survival of people affected by cancer, and contribute to a reduction in premature death and disability. Clinical trials are fundamental to establishing if new cancer treatments, diagnostic tests or preventive interventions are effective and they help generate evidence for best-practice cancer care.
ActivityThe development of industry-independent cancer clinical trial protocols.
Delivery Area Multiple National AUSTRALIA
ApprovedPublishedStartEndBudget
29 Jun 201805 Jul 201801 Jul 201801 Sep 2021 2018-19
THE UNIVERSITY OF SYDNEY ACTING FOR THE COOPERATIVE TRIALS GROUP FOR NEURO-ONCOLOGY
Grayndler  $1,500,000
Address The University of Sydney 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency Cancer Australia
Program Improved cancer control
Component Support for Cancer Clinical Trials Program
CategoryCancer Targeted or Restricted Competitive
PurposeClinical trials benefit the community by improving the survival of people affected by cancer, and contribute to a reduction in premature death and disability. Clinical trials are fundamental to establishing if new cancer treatments, diagnostic tests or preventive interventions are effective and they help generate evidence for best-practice cancer care.
ActivityThe development of industry-independent cancer clinical trial protocols.
Delivery Area Multiple National AUSTRALIA
ApprovedPublishedStartEndBudget
29 Jun 201805 Jul 201801 Jul 201801 Sep 2021 2018-19
THE UNIVERSITY OF SYDNEY
Grayndler  $2,500,000
Address Camperdown 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency Cancer Australia
Program Health System Policy, Design and Innovation
Component Medical Research Future Fund: Australian Brain Cancer Mission
CategoryMedical Research
PurposeThe purpose is to improve treatments and outcomes for adults with brain cancer through increasing access to high quality international cancer clinical trials.
ActivityExpand the capacity of the Cooperative Trials Group for Neuro-Oncology
Delivery Area Multiple National AUSTRALIA
ApprovedPublishedStartEndBudget
28 Sep 201826 Oct 201828 Sep 201828 Sep 2023 2018-19
UNIVERSITY OF SYDNEY
Grayndler  $939,630
Address CAMPERDOWN 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Supporting Science and Commercialisation
Component Australia-China Science and Research Fund
CategoryScientific Research Open Competitive
PurposeUnder the Australian China Science and Research Fund, through the Joint Reserach Centre, Researchers from the University of Sydney and Tianjin University and their partners will collaborate on energy informatics and demand response technologies to supply green energy resources to the Australian and Chinese markets that is more efficient, reliable and affordable. Our research will benefit both consumers and providers of energy and improve the flexibility and reliability of the energy system as a whole. Consumers will receive lower energy bills, energy providers will experience reduced capital cost investments and need for network upgrades, and the reliability of system operations and expansion will be improved. Results from our research will be used by our industry partners to enable next generation energy services.
ActivityCentre for Energy Informatics and Demand Response Technologies
Delivery Area 2006 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
28 Mar 201915 Jul 201928 Jun 201908 Oct 2022 2018-19
THE UNIVERSITY OF SYDNEY
Grayndler  $50,000
Address SYDNEY 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Growing Business Investment and Improving Business Capability
Component Entrepreneurs' Programme - Innovation Connections
CategoryIndustry Innovation Demand Driven
PurposeInnovation Connections promotes collaboration between small and medium sized Australian businesses and the research sector to develop new ideas with commercial potential.
ActivityInnovation Connections
Delivery Area 2028 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
28 Aug 201810 Oct 201804 Oct 201830 Dec 2019 2018-19
THE UNIVERSITY OF SYDNEY
Grayndler  $50,000
Address SYDNEY 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Growing Business Investment and Improving Business Capability
Component Entrepreneurs' Programme - Innovation Connections
CategoryIndustry Innovation Demand Driven
PurposeInnovation Connections promotes collaboration between small and medium sized Australian businesses and the research sector to develop new ideas with commercial potential.
ActivityInnovation Connections
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Sep 201826 Nov 201823 Nov 201825 Dec 2019 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $470,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to explore how cells physically sense and respond to the surrounding environment on a molecular level. Physical distortion of erythrocytes doubles their glucose consumption and increases cation membrane flux five-fold. This mechanism involves opening of the mechanosenstive ion channel Piezo1. This project will include a kinetic description of these phenomena, with a goal to establish a predictive mathematical model of the regulation of cell'shape and volume. The project will provide an understanding of mechanisms operating when cells and tissues are succumbing to trauma and invasion, and how to control these processes on a molecular level.
ActivityMolecular mechanisms of mechanosensation and shape regulation in cells
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $378,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate well-known behavioural -biases- in probability and value perception through the lens of neurobiology. This project will generate new knowledge on how the value of rewards, and the likelihood of receiving them, are incorporated in the decision-making process. Using an interdisciplinary approach, this project will be of interest to researchers from several domains of social science, which focus on how and why people make their decisions and how we could improve people's wellbeing by improving their choices. The findings will provide insights into effective, behaviour-related policy design that aims to improve peoples- well-being.
ActivityNeuroeconomic foundations of probability and value perception
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Apr 201931 Mar 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $349,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to reveal how mammalian herbivores exploit leaf odour to detect plants while foraging. Insects track plant odour to find host plants, yet how mammalian herbivores use olfaction to forage and how this can be harnessed is unknown. This project will provide new perspectives on foraging ecology, and will pioneer novel ways to help protect plants using chemical camouflage, and to help protect animals from road collisions by attracting them to safety.
ActivityManipulating foraging by mammalian herbivores with plant odours
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201815 Feb 201914 Feb 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $410,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeFerroelectric materials have extensive applications in electromechanical devices and memories and in service are often subjected to repeat mechanical and/or electrical loading, leading to cyclic fatigue and failure. This project aims to apply in'situ electron microscopy techniques and computational modelling to explore cyclic ferroelectric fatigue behaviour and to understand the relationships between local atomic scale structure and fatigue. The structural origin of ferroelectric fatigue has not been clear because of the limitations of previous measurement capabilities. This project will provide guidance in materials design to increase ferroelectric fatigue lifetime for more reliable ferroelectric-based electronic devices.
ActivityUnravelling the structural origin of cyclic fatigue in ferroelectrics
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $660,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to develop consumer-centred approaches to reducing the harmful effects of confusion in financial decisions by studying superannuation investment and home loan decisions where confused choices are individually and collectively costly. The project intends to develop comprehensive models to capture the full complexity of financial products and the diverse preferences and capability of consumers, then to use advanced statistical methods to estimate the benefits of clearer decision-making. The outcomes of this project includes new models of complex financial decisions, and a better understanding of where confusion arises and the effects it may have. Decreased confusion will raise financial well-being and help communities become more resilient to financial shocks.
ActivityUnderstanding and overcoming confusion in consumer financial decisions
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Feb 201931 Jan 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $390,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to gain a better understanding of digital nomadism. Digital nomads use IT platforms to work remotely over the Internet while perpetually travelling. The project will develop new knowledge by better understanding of how IT transforms work and enable digital nomadism, the motivations and values of workers and their clients/organisations engaged in digital nomadism and the implications and consequences of digital nomadism for workers and clients/organisations. The project is expected to have a significant impact on policy and public discourse by providing an in-depth explanation and understanding of digital nomadism based on rigorous research.
ActivityDigital nomadism: How IT enables new forms of working and organising
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $172,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to produce a cultural history of Holocaust memory in Australia. Contemporary appeals to the memory of the Holocaust in the Australian setting are typically understood to illuminate the injustice of other instances of racial persecution. This project aims to uncover this memory's far more complex and politically potent history. Through detailed archival and cultural analysis of key moments in the development of Australian Holocaust memory, this project will probe the various political and social ends to which this memory has been applied. The project expects to generate a deep and nuanced understanding of the role Holocaust memory has played in shaping some of our most important, and enduring, national conversations.
ActivityThe memory of the Holocaust in Australia
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Mar 201928 Feb 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $569,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to increase knowledge of the way in which cells maintain their genomes, including the ends of their chromosomes, to enable their own survival. The ends of chromosomes (telomeres) are essential for survival and proliferation of the cells of most organisms. This project aims to determine the molecular details of a recently discovered link between telomere maintenance and the way cells maintain the integrity of their genome. This is likely to lead to increased understanding of the fundamental biological process of genome maintenance, representing a significant scientific advance. The project expects to have far-reaching implications for biotechnology applications that require the survival of cells.
ActivityLinks between DNA replication and chromosome end maintenance
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $420,256
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to solve fundamental problems in representation theory by combining cutting-edge techniques and developing novel higher level structures. Representation theory is the mathematical study of symmetry, an essential concept in science. Since the 1990s, mathematicians have been observing shadows of a more general notion of symmetry but so far have failed to explain it. Expected outcomes include a structural explanation of these shadows, new mathematical software to understand them and solutions to important conjectures. This project will make a significant contribution to the field of representation theory, with ramifications in mathematical physics and computer science.
ActivityRepresentation theory: studies of symmetry shadows
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Apr 201931 Mar 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $422,574
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to characterise and manipulate a novel oxygen sensing system, the cysteamine dioxygenases, to help understand how mammalian cells respond to low oxygen concentrations, a condition known as hypoxia. A number of the world's most destructive diseases can impair oxygen delivery, altering biochemical landscapes. By understanding how cells respond to fluctuations in oxygen, the project expects to develop effective methods to treat these detrimental conditions. Characterisation of the cysteamine dioxygenases could establish a novel mechanism by which cells monitor changes in oxygen, assisting in understanding hypoxia and disease. The project will also enable new cysteine initiating substrates to be identified, allowing the full impact of this regulatory process to be appreciated in mammals.
ActivityCysteamine dioxygenases: novel oxygen sensors implicated in hypoxia-
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 May 201930 Apr 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $211,100
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to examine the notion of the couple in the era of marriage equality. It is generally thought that couple longevity is an incontestable good socially, psychologically, and economically. The advent of same'sex marriage in Australia provides the occasion to reconsider why it is that general cultural benefits are thought to devolve from coupled intimacy alone. Rather than dismiss the value of marriage, either straight or gay, this project looks at an archive of contemporary representations in which the couple form presents as a public good, not a private good. This anthropological study tests the supposed connection between intimate companionship and collective thriving.
ActivityThe couple: commitment and durability in the era of marriage equality
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Mar 201928 Feb 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $420,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to deliver new models, metrics and algorithms for Faithful Visual Analytics of complex data. For a purported visual representation of some data, "faithfulness" measures how accurately the visual representation describes the data. This project will develop new models for Faithful Visual Analytics, design new faithfulness metrics for faithful visual analytics of complex networks, design new algorithms to compute faithful visualisations, and evaluate using real world social network and biological network data sets. The new models, metrics and algorithms produced by this project will be used in the next generation Visual Analytic tools to enable analysts develop accurate insights and new knowledge of complex data.
ActivityFaithful Visual Analytics: models, metrics and algorithms
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201819 Jun 201918 Jun 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $360,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to resolve the role of super-massive black holes in the life-cycles of galaxies.-Accretion of matter onto super-massive black holes should profoundly change their host galaxies, heating gas and shutting down star formation, particularly when the black hole is accreting at its highest rate. It has been difficult to find clear evidence of the impact of such feedback due to lack of knowledge concerning the time'scales for star formation shut-down and accretion triggering. This project will combine data from the world's premier imaging spectrograph with multi-wavelength imaging and numerical simulations to discover whether black holes influence galaxies, and position Australian researchers to exploit next generation technologies.
ActivitySetting the quasar feedback clock
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201815 Jun 201914 Jun 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $450,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate how much carbon plants need to invest belowground in return for water and nutrients. By using economic principles of supply and demand the project will quantify carbon expenditure for water and nutrients in grasslands and crops under different climate and land management scenarios. This project will use triple and quadruple isotope labelling techniques and explore the dependency of carbon investment on plant-microbial interactions and availability of belowground resources. Expected outcomes include new knowledge to build a universal framework about plant carbon-water-nutrient economics. This will benefit global carbon cycling models and efforts to increase nutrient and water use efficiencies in agricultural crops.
ActivityCarbon costs of plant nutrient and water uptake
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $346,500
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component Linkage Infrastructure, Equipment and Facilities
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to acquire an advanced mechanical testing facility for small'sized structural materials in the temperature range from -100-C to +350 -C. This state-of-the-art instrument for mechanical testing of advanced materials at a wide temperature range and dynamic conditions will develop Australia's research infrastructure for solving real-world problems. The facility will significantly broaden our capability in materials research and provide critical insights for engineering materials design with applications in infrastructures, aerospace, transportation, and medical devices. This will provide economic benefits to Australian industries, contribute significantly to the advancement of scientific knowledge in Australia and further enhance research collaborations.
ActivityAdvanced mechanical property testing suite
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2019 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $0
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to lay down a rigorous mathematical foundation of the gauged linear sigma model and seek its mathematical applications. The gauged linear sigma model is an important theory introduced by the great physicist Edward Witten. It is a fundamental framework in studying superstring theory, which is one of the most promising candidates for the unification of all aspects of physics. This project will generate new and significant results in geometry, with many benefits, providing solid mathematical foundations of the gauged linear sigma model, deepening the understanding of this theory, and providing new methods for solving classical problems.
ActivityGauged sigma model, mirror symmetry, and related topics
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201901 Jan 2019 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $368,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to address a fundamental question in mechanobiology on how integrin receptor coordinates with force to mediate cell spreading, migration, growth and survival. With an observation that membrane deformation enhances integrin binding, the project expects to establish a new model of integrin activation by membrane tension. It will develop an integrated approach combining single-molecule force probes, super resolution microscopy, microfluidics and molecular dynamics simulations. It is expected that the role of membrane tension in promoting cell adhesion will be defined at molecular scale, and the link between integrin activation and Piezo calcium channel mediated membrane tension sensing will be delineated.
ActivityMechanobiology: a new model of integrin activation by membrane tension
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jul 201930 Jun 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $330,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop proposals for the next generation of solid state quantum bits, enabling quantum computers that can solve real world problems. The project will address the lack of sufficiently good physical quantum bits, one of the most important bottlenecks for the realisation of a quantum computer. Key expected outcomes include new proposals for quantum computing architectures that can be implemented with current technology, and a deepened understanding of the interplay between noise, quantum hardware design and error correction. Benefits include enabling new milestone experiments in quantum computing, insight into the potential for near-term quantum computers, and accelerating the development of useful quantum computers.
ActivityNext generation solid state qubits
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Feb 201931 Jan 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $405,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop and validate fundamental theories and techniques for a novel intelligent wireless access paradigm to enhance the efficiency in frequency usage. This innovative approach will be one of the critical enablers for massive device access necessary for future wireless network evolution to support the growing Internet-of-Things. It will enable co-working devices to autonomously sense the local radio frequency landscape, determining how to avoid interference, and exploiting opportunities to intelligently and efficiently access the available radio resources. This will lead to enhanced efficiency in radio resource usage. The project will significantly improve the efficiency of current radio resource utilisation and offer solutions to a challenge of national significance.
ActivityIntelligent wireless access for Internet of Things
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Apr 201931 Mar 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $381,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to use three Australian radio telescopes to search for and monitor radio waves from future gravitational wave events.-The detection of gravitational waves and electromagnetic radiation from a neutron star merger was a scientific breakthrough, with important implications for physics and astronomy. The observations from this project will provide key information to reveal what causes some of the most energetic events in the Universe, their environment and how they evolve. The outcomes of this project include increased international collaboration with this global effort, and new techniques for automatic data processing and analysis, as well as engaging future students as we build Australian expertise in a new area of research.
ActivityRadio follow-up of gravitational wave events
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201804 Mar 201903 Mar 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $375,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims at practical representations of 3-dimensional and 4-dimensional spaces as needed in applications. Topology is the mathematical study of the shapes of spaces. Geometry endows spaces with additional structure such as distance, angle and curvature. Special combinatorial structures, such as minimal triangulations, are often closely connected to geometric structures or topological properties. This project aims to construct computable invariants, connectivity results for triangulations, and algorithms to recognise fundamental topological properties and structures such as trisections and bundles.
ActivityTrisections, triangulations and the complexity of manifolds
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jul 201930 Jun 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $360,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to explore the mechanisms of how heterogeneous structures have superior mechanical properties relative to homogenous structures by investigating how stacking fault energy affects the mechanical properties of materials. Materials with heterogeneous structures demonstrate superior mechanical properties, partly due to the simultaneous activation of multiple deformation mechanisms. Stacking fault energy plays a critical role in determining deformation mechanisms, yet the mechanism of this effect on the mechanical properties of materials with heterogeneous structures is not understood. This project is expected to provide guidance in structural and compositional design of heterogeneous metallic structures with optimum mechanical properties, which will significantly benefit Australian metallurgical and related industries.
ActivityImproving mechanical properties through heterogeneous structures
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $541,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to use complex systems science to detect and prevent colony collapse in honey bees while advancing knowledge of tipping points in complex social systems. Understanding the mathematics of colony collapse can help us develop strategies for safeguarding managed bee populations and the valuable pollination services they provide. Expected outcomes include methods for the early detection of stress in colonies, methods for reversing declines, and new mathematical techniques for studying tipping points in complex social systems. This will provide significant benefits for Australian agriculture, much of which depends on bee pollination, while building scientific capacity in complex systems science.
ActivityA complex systems approach to preventing colony failure in honey bees
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201815 Jun 201914 Jun 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $425,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project will investigate the crumbling of geomaterials such as soil and rock by analysing the microscopic mechanisms controlling their deterioration in acidic water. The project will help predict weathering processes using an experimentally validated theory and innovative pore'scale numerical simulations. Expected outcomes include a detailed knowledge of the multi'scale interactions between brittle geomaterials and acidic water, leading to accurate forecasts of the long-term response of large'scale geotechnical structures. This project should provide significant benefits by improving soil management for mining remediation, increasing carbon dioxide storage efficiency, and preventing the deterioration of tailings dams.
ActivityLong-term chemically induced crumbling of unsaturated brittle geomaterials
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $420,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to use mathematics, in particular the theory of micro-local analysis, to determine the amount of measurements one needs in order to reconstruct an image by some of the tomography methods commonly used in medical imaging. Expected outcomes of this project include showing that an arbitrarily small set of boundary measurements is sufficient to reconstruct the coefficients of various important partial differential equations such as Schrodinger equation, Dirac operators, and Maxwell equations. In addition to providing a theoretical foundation upon which one can build numerical algorithms, this project will also provide the missing link between inverse problems and unique continuation theory. The downstream impact of this research will lead to more efficient and accurate tomography methods which can be implemented in a range of imaging applications.
ActivityInverse problems with partial data
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201820 May 201919 May 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $365,709
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to understand the conditions that cause humans to misperceive the shape and surface properties of real-world materials. Most natural materials are translucent to varying degrees, but little is known about how light is transported through them or how such materials are perceived or misperceived. This project will determine the conditions and causes responsible for the misperception of material properties and shape, and will offer practical information about what can be done to minimise such misperceptions. The outcomes of the project are expected to lead to new techniques for depicting and manipulating real-world translucent materials in computer graphics, virtual reality, and gaming industries.
ActivityPerceiving and misperceiving the causes of optical structure
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $375,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to generate new classes of advanced materials that possess multiple high-order properties.-The project targets the strategic incorporation of three high-order functionalities into molecular materials. These are anomalous mechanical response to changes in temperature, pressure and included guests, electronic and magnetic function, involving the transport and alignment of electrons, and nanoporosity, involving the reversible inclusion of molecules and ions. Examination of the dynamic interplay between these properties will address key questions in the science of nanoscale systems. This will underpin the development of advanced new technologies spanning high precision device componentry, molecular electronic devices and gas separations.
ActivityEmergent function in coordination framework materials
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $505,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeRobots and other autonomous machines use models of the real world to predict the result of their actions and make decisions, but existing methods used for machine-learning are unreliable in many cases and can be easily fooled. This project aims to make machine-learning of dynamic system models reliable, accurate, and secure. The outcomes of this project will be new models and algorithms that ensure safety and increase accuracy of models learned from data. This project will benefit robotics, control engineering, infrastructure automation, and other fields that demand the capability to model physical systems from limited data. It will also improve cybersecurity by making learning algorithms resilient to deliberate attacks with false data.
ActivityRobust learning of dynamic systems
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $540,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component Linkage Infrastructure, Equipment and Facilities
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to leverage substantial existing investment in microscopy infrastructure to create a unique and comprehensive cryo-microscopy laboratory which is available to all Australian researchers in an open-access user environment. This project will use cryogenic transfer solutions to connect a suite of advanced microscopy platforms, opening up these techniques to new research areas. The facility will support research projects across disciplines such as materials science, nanotechnology, chemistry and biological science. It will provide research infrastructure to projects ranging from the prevention of corrosion in alloys for new energy technologies to the improvement of the biocompatibility of biomedical devices.
ActivityA comprehensive correlative cryo microscopy laboratory
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2019 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $471,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Indigenous
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop evidence-based retention strategies for the Indigenous frontline health and disability workforces. Indigenous people in these roles are critical to improving access to culturally safe and effective services and support for Indigenous Australians. The availability of culturally safe services, interventions and support will assist in closing the gap in health, education and socio-economic outcomes between Indigenous and non-Indigenous Australians. This project aims to uncover the factors that influence Indigenous front line workers to stay in their crucial roles. The findings will be translated into culturally-appropriate workforce retention strategies.
ActivityRetention of the Aboriginal health and disability workforce
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201804 Apr 201903 Apr 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $411,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop shape'shifting polymer nanomaterials that can adapt to changes in their environments by undergoing nanoscale morphology transformations. Shape'shifting polymer nanostructures are exciting new building blocks for designing the cutting-edge materials and biomedical therapies of tomorrow. This project will use shape'shifting polymer nanostructures to develop innovative tools for building technologies that can detect environmental pollutants, accelerate tissue regeneration and deliver drugs to diseased tissue with unparalleled specificity. These technologies have high commercial potential with benefits to the Australian economy and the potential to contribute powerful technological impacts across Australia's biomedical, agricultural and environmental industries.
ActivityShape-shifting polymer assemblies as stimuli-adaptive nanomaterials
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jun 201931 May 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $372,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to provide a theoretical, methodological and policy framework that can be used to resolve the practice in Australian cities of private car dependency. Taking the way we travel as parents as an example of a particularly complex expression of private car use, this project will combine theories of practice, policy and process to understand transport behaviour. The project seeks to establish an evidence base to inform potential, effective policy change to lessen the social, environmental, and economic impacts of private car use. This project expects to provide interdisciplinary and multifaceted understandings of car dependency, and ways to transition towards more sustainable and healthier modes of travel.
ActivityParenting and private car use in Australian cities
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201813 Jan 202031 Mar 2023 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $314,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop a state-of-the-art computational tool for modelling the coupled fluid transport'solid deformation behaviour in micro- and nano-porous media. A significant portion of the world's water and energy resources are stored in fractured rocks, many of which contain characteristic pores with size ranging from nanometres to micrometres. The pore'scale particle-based modelling method will provide for better understanding and opportunities for manipulating fluid flow through fractured micro- and nano-porous media. Successful application of the model will improve the performance of diverse energy and environmental systems including carbon geo'sequestration, unconventional oil and gas recovery, enhanced geothermal energy generation and groundwater contamination.
ActivityModelling fluid-solid interaction in micro- and nano-porous media
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201815 Jan 201914 Jan 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $398,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to discover the strategies honey bees use when choosing between multiple flowers. The choices that honey bees make about which flowers to visit and which to avoid has significant impacts on crop yields, the spread of invasive weeds, and the conservation of native plants. This project expects to generate new knowledge in the fields of behavioural and pollination ecology through a combination of field experiments and modelling. Expected outcomes of this project include enhanced capacity in the field of pollination ecology, and new insight into flower preferences in the world's most important commercial pollinator. This should provide significant benefits to food production and security as one third of the world's crops benefit from insect pollination.
ActivityContext dependent flower choice in honey bees
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $460,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop the fundamental science to enable transmission and channel coding technologies, which will be essential for building and rolling out of future ultra reliable and low latency wireless networks. Reliable and low latency communications are central to the development of the next generation mobile communications and many emerging critical applications. The project is expected to provide the foundations and tools for transforming, modernising and safeguarding Australia's national critical infrastructure. The project is expected to provide novel applications such as smart grids, telemedicine, intelligent transportations and industry automation.
ActivityShort code design for mission critical communications
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 May 201930 Apr 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $440,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate the evolutionary conundrum of how and why organelles remain asexual. The widespread occurrence of sexual reproduction suggests that sex is beneficial to organisms. Yet we all carry an ancient genome that never had sex, the mitochondrial genome (mtDNA). Theory predicts that mtDNA should no longer exist, because without sex it accumulates deleterious mutations and cannot accumulate beneficial ones. Yet mtDNA does not suffer mutational meltdown and is shown to adapt. This project will explain how, proposing that the combination of two traits, uniparental inheritance and multiple genomes per cell, make up for the lack of sex. This project expects to provide an explanation for the evolutionary question of what keeps mitochondria healthy, important as mitochondria affect ageing and health.
ActivityMultilevel selection and the integrity of mitochondrial DNA
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $484,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to determine the fundamental mechanisms that drive particle transport in physiologically realistic human airways. Through use of novel magnetic resonance imaging and laser diagnostic techniques, the project expects to transform our ability to develop effective and validated predictive capabilities for particle transport in physiologically accurate geometries. The project outcomes are expected to enable unprecedented definition of how particles are transported in human airways as a function of breathing profiles, particle properties and morphology.
ActivityParticle transport in the human upper airway
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $470,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop processes that can successfully functionalise the inner surfaces of high surface area to volume structures with interconnected porosity. These structures underpin many processes in modern manufacturing. Examples include columns and fluidised beds for purification, materials for energy storage and conversion, biomedical scaffolds and structures for high sensitivity sensing. The efficacy of these materials is strongly affected by the condition of the surfaces, but modifying the surfaces of internal pores deep within such structures presents major challenges. This project will provide environmental friendly, dry plasma processes to tailor surface functionality, improving the efficacy of existing processes and opening up new far reaching applications for such materials.
ActivityA new dimension of functionality for high surface-area-to volume materials
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201810 Jun 201909 Jun 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $300,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop a novel and principled approach for building correlation networks. Correlation networks aim to identify the most significant associations present in modern massive datasets, and have numerous applications, ranging from the biomedical and environmental sciences to the social sciences. Nodes of such networks represent features, and edges represent associations, or the lack thereof. Current methods are not readily scalable to modern ultra-high dimensional settings, and do not account for uncertainty in the estimated associations. This project will develop a principled, highly scalable methodology for building such networks, which incorporates uncertainty quantification. Emphasis is placed on modern ultra-high dimensional settings in which differentiating a true correlation from a spurious one is a notoriously difficult task.
ActivityPrincipled statistical methods for high-dimensional correlation networks
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201815 Apr 201914 Apr 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $1,058,374
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Indigenous
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to analyse and define the experiences and expectations of people with disability in rural and remote regions. People accessing the National Disability Insurance Scheme (NDIS) are required to complete a personalised service plan, however despite these reforms, people in rural and remote communities currently experience many challenges with the scheme. Using qualitative research methods, the project will investigate people's experiences engaging with Local Area Coordinators and Planners under the Rural and Remote Strategy 2016-2019 and Aboriginal and Torres Strait Islander Engagement Strategy. The project will provide significant outcomes for Aboriginal and non-Aboriginal people with disability in rural and remote areas, disability service providers, and government and non-government policy makers.
ActivityPlanning for a better life under the National Disability Insurance Scheme (NDIS)
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201822 Apr 201921 Apr 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $422,556
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to use Nature's compartments (encapsulins) for use in synthetic chemistry. Controlling selectivity is a major challenge for synthetic chemists. In contrast, Nature has mastered the art of selectivity by using self-assembled compartments for important biochemical processes such as carbon fixation. The encapsulin-based platform technology resulting from this project will help address the problem of poor selectivity in synthetic chemistry, leading to more energy efficient chemical processes. Adoption of these processes by industry is expected to translate into significant benefits for the economy and the environment.
ActivityBio-compartmentalised chemistry: controlling selectivity using encapsulins
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $553,306
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to test the link between behavioural inhibition, an essential psychological ability, and neural inhibition, by using a combination of new neurophysiological techniques and innovative experimental design. The project intends to generate insight into the neural and psychological mechanisms involved in deliberately inhibiting planned responses and learned inhibitory reflexes. Expected outcomes include a strong understanding of how inhibition in the brain contributes to control of behaviour and why some individuals are more efficient than others at inhibiting undesirable actions. The project carries health and societal benefits by identifying how individuals with poor inhibitory control can benefit from interventions.
ActivityLearning to stop: linking intra-cortical inhibition to response control
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $550,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to identify meaningful and specific indicators for predicting particle formation and alteration during thunderstorms. How thunderstorms develop is well-understood. However, identifying meaningful and specific indicators for predicting particle alteration during a thunderstorm is still not clear. This project will practically contribute to the evidence of the impact of air particulates, thereby having direct implications for meteorological, and air pollution policy in Australia and worldwide. This project will allow researchers to understand the impact of these factors on the escalation of the causative effects, and to find a way to prevent unnecessary fatal outcomes.
ActivityCause and effect: new mechanisms of particles formation in thunderstorms
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Feb 201931 Jan 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $225,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to reconstruct the liturgical life of one of the most diverse and influential religious traditions across Eurasia, from Roman Egypt to early modern China: the Manichaeans. It investigates cultural adaptation, chronological development and unity of practice in a deeper manner that helps support the discipline of religious studies more generally. It expects to generate new knowledge through the critical editing of complex texts and the employment of emergent methodologies for an integrated, holistic understanding of community literatures in terms of lived religion. Expected outcomes are advances to methodology and the profiling of one aspect of the ancient world.
ActivityLiturgical texts and practices in the ancient world
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Apr 201931 Mar 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $452,593
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to uncover how the brain uses knowledge and predictions about the world to interpret incoming sensory input. The project intends to study how recent sensory history influences current perception (serial dependence) and how rhythmic neural oscillations modulate perception. Project outcomes include a major advance in theories of how the brain achieves optimal predictive perception, and a model that can guide new applications in intelligent machines and sensing robots. Understanding predictive perception has a clinical benefit, as it is prone to dysfunction (as in autism), and an applied benefit, as it will generate a predictive model to guide new practical applications in sensing robots.
ActivityTemporal context in perception: serial dependence and rhythmic oscillations
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $475,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to determine how bisphenol A (BPA), which now represents a novel environmental driver, alters physiological responses of animals, and how-it-interacts with other environmental variables to alter ecological and evolutionary trajectories. Plastic pollution is a monumental global environmental and health problem, and Australia has one of the world's highest exposures to BPA, a plastics leachate. This project will use a new zebrafish gene knock-out model to show whether the effects of BPA are transferred between generations, and will establish an international collaboration, thereby increasing Australia's research capacity. Outcomes from the project are expected to benefit environmental management.
ActivityPlastic pollution: new driver altering responses to variable environments
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $450,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to understand the coupling between soil physical, chemical and biological diversity at a range of scales and land uses across New South Wales and its relationship with soil functioning. Soil diversity with its coupled biodiversity is crucial for conservation of sustainable ecosystems. Soil diversity varies on a continuum from microbial habitats to elds, catchments and regions. This project will enhance our ability to understand the drivers of soil change through time, critical for minimising loss of biodiversity, achieving food and soil security and inferring effects of climate change.
ActivitySynergising pedodiversity and biodiversity to secure soil functionality
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Feb 201931 Jan 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $422,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate the role of law, policy, and regulation in enabling local governments and communities to contribute to healthy, sustainable, and equitable food systems. The project will analyse policies and initiatives developed by local governments and communities in New South Wales and Victoria, including how law assists or prevents local-level action. The knowledge created by this project will inform recommendations for policy and legislative reforms that will empower local governments and communities to respond to food system challenges.
ActivityStrengthening food systems governance at the local level
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $450,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to design and manufacture meta-composites of high level thermal dimensional stability for future space-based imagery applications. The project will develop the fundamentals of novel enabling technologies including: meta-composite material design, miniature fibre tow placement, optimal processing window and the high precision net'shape additive manufacturing of continuous fibre laminated composites without needs of follow-up machining. This is expected to eliminate or minimise the current need to use a motorised adjustment system for space-based imagery applications. This project will develop the know-how for design and technology to manufacture meta-composites of high level thermal dimensional stability.
ActivityMeta-composites of high level thermal dimensional stability
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $399,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to produce a design-by-analysis method for steel frameworks that explicitly models the complete set of failure modes including fracture of connections. The project will develop models that can accurately predict the fracture behaviour of welded and bolted connections, and system reliability calibrations that account for random variations in the parameters controlling the strength of steel frameworks including fracture. The outcomes of this project will advance the design of steel structures, as it will become possible to analyse any type of structure for any type of failure including fracture. The design method will enable Australian structural engineers to enhance their competitive edge internationally, and maintain their preeminent record of producing innovative structural solutions.
ActivityComplete limit state analysis of steel structural framework
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $321,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to develop a legal and governance framework to enhance the resilience of Australia's electricity infrastructure in a changing climate. Building resilience reduces the total cost of disasters in Australia, a major share of which will come from replacing damaged critical infrastructure, without accounting for climate change impacts. This project aims to develop the legal and governance framework by addressing both the integration of smart technologies and disaster risk reduction measures in the electricity system. This is expected to provide significant economic, social and environmental benefits to Australia.
ActivityA legal framework for resilient electricity infrastructure in Australia
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $420,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis research project will lead to the development of new molecular agents containing the element gadolinium which can selectively accumulate within cell mitochondria, with a long-term application in cutting-edge therapies involving X-rays or neutrons. The lanthanoid element gadolinium offers many unique opportunities for medicinal chemistry and this project will generate new knowledge in bioinorganic chemistry and synchrotron science. The expected outcomes of this research will address many of the unresolved questions regarding mitochondrially-targeted gadolinium complexes, the first such agents specifically designed for potential long-term application in binary therapies and imaging.
ActivityMitochondrial targeting by a new class of gadolinium agents
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Apr 201931 Mar 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $315,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to measure the stellar populations of nearby galaxies that are apparently similar to the Milky Way. The stellar population of a galaxy provides a fossil record of its entire history and is a key window into galaxy evolution. The project will use the well'studied stellar population of our own galaxy as a galactic Rosetta Stone to interpret the light from nearby galaxies, revealing their chemical compositions and star formation histories. This project will advance understanding of galaxy evolution and reveal the evolutionary history of galaxies that are similar to our own Milky Way. The highly novel approach used will enable Australia to capitalise on its investment in optical astronomy, provide training and inspiration for the next generation of scientists, and maintain Australia's international reputation for cutting-edge optical astronomy research.
ActivityExtragalactic archaeology: our galaxy as a rosetta stone of galaxy evolution
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $366,513
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to promote the development of the first complete computational model of reading comprehension. Many computational models of sub-components of reading have been developed, but none fully explain the complex co-ordination of perceptual, attentional and cognitive processes required for successful comprehension. The project intends to use eye tracking studies to test and refine -ber-Reader, a new computational model that aims to provide a complete account of the memory systems and cognitive processes involved in reading comprehension and how they differ with reading skill. The outcomes will advance understanding of the causes of success and failure in reading and contribute to diagnosing and remediating reading difficulties.
ActivityTracking towards a complete model of skilled reading comprehension
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Feb 201931 Jan 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $350,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to describe, quantify and analyse the impact of workspace design on workers- satisfaction, productivity and health. The Australian market is the fastest adopter of Activity-Based Working (ABW) in the world and impacts arising from this workspace typology on workers will be significant now and in the next decade. This project will develop benchmarking for ABW offices, techniques for monitoring cognitive performance in situ, and design guidelines for health promotion. By shifting attention to design features that actually perform well, this project will provide the empirical basis needed to transform the way workspaces are designed now and in the future. It will therefore lead to greater productivity in and among workplaces.
ActivityDesigning offices well
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Apr 201931 Mar 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $317,610
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to examine why long-run projections of output, inflation, and interest rates have become lower for many economies in recent years resulting in a phenomenon often referred to as secular stagnation. The project intends to develop new econometric tools to account for sources of structural breaks and stochastic trends in order to quantify the roles of productivity growth, financial shocks, demographics, and inflation expectations in driving secular stagnation. Expected outcomes include findings that will help guide macroeconomic policy responses to stagnation and new econometric tools that will support future applied research on changes in the behaviour of macroeconomic variables.
ActivityUnderstanding the sources of secular stagnation
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $321,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to determine how introduced Asian honey bee populations in Australia and the Pacific managed to overcome severe genetic bottlenecks to become invasive pests. The project will use advanced molecular techniques to understand rapid evolution at a focal gene that determines fitness in these populations, and to see evolution in action across the genome using a twelve-year timeline of samples. The outcome will be an enhanced capacity to manage new outbreaks of invasive social insects of all kinds via a better understanding of how invasions establish and spread. This should provide significant benefits in the form of protecting Australian agriculture and pollination services from social insect pests.
ActivityRapid evolution via genetic novelty in an invasive social insect
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $495,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeNew technologies such as online recommendations, smart grids, and cyber-physical systems are becoming backbone infrastructure. Such systems are operated as network systems with interconnected functioning units (agents) where cooperative and adversarial agent relations often coexist. This project aims to develop the theories and tools for designing and building dynamic networks with signed interactions that arise from a variety of applications where both cooperative and adversarial agent interactions coexist. By developing theories and algorithms for control and identification over such systems, this project will contribute directly to their safe and robust operation. The resulting theories will provide deeper understanding of network control systems and the resulting algorithms will enable the elimination of attackers and malicious users for online review systems and smart grids. This project will contribute to increased cybersecurity for all Australians.
ActivityControl of network systems with signed dynamical interconnections
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 May 201930 Apr 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $440,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to use the theory of microlocal analysis to determine the amount of information one can recover about the earth and the universe by making observations on wave propagation. In addition to applications to seismic imaging and cosmology, this project will generate new knowledge in the field of differential geometry and dynamical systems. This will be accomplished by formulating the tomography problem in the language of differential geometry and introduce new analysis techniques to study them. Expected outcome of this project will be new rigidity type results in Lorentzian and Riemannian geometry. There is also the potential for downstream impacts in seismic and cosmological imaging.
ActivityProbing the earth and the universe with microlocal analysis
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Mar 201928 Feb 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $656,639
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component Linkage Infrastructure, Equipment and Facilities
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to complete a revolutionary new instrument, Hector-1 to be installed on the Anglo-Australian Telescope. Hector-1 builds on the highly successful SAMI instrument with new, larger, 3-D spectroscopic-imaging optical fibre bundles and the highest resolution spectrographs of any instrument of its type in the world. Hector-1 will enable the largest ever survey of nearby galaxies in 3-D. The Hector-1 data will be able to trace the kinematics of gas and stars as well as mapping ionisation mechanisms across 15,000 galaxies. Major breakthroughs are expected in understanding how the environment affects how galaxies evolve to have the broad-ranging physical properties seen in the local Universe.
ActivityHector-1: completing the revolutionary multi integral field spectrograph
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2019 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $422,460
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to generate advanced knowledge in amino acid metabolism in poultry in order to reduce soybean inclusion in broiler diets. Chicken-meat is the dominant animal protein source in human diets in Australia. However, Australia chicken-meat industry will need to increase production by more than 40 per cent to meet population growth by 2050. Soybean meal is the major protein source in poultry diets but the sustainability of increased soy production is problematic. The expected outcomes of this project will be an increase in our future capacity to produce affordable, healthy chicken-meat with humane animal welfare by novel dietary formulations. Chicken-meat production generates less greenhouse gases than its competitors but this project will contribute to the reduction of harmful environmental outputs and ensure food security for Australia.
ActivitySecuring future supplies of chicken-meat protein
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jun 201931 May 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $670,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to prepare new photocatalysts that capture and convert solar energy to stored energy by directly splitting water into oxygen and hydrogen, a perfectly clean and renewable fuel. The project will use a "bottom-up" nanoscale approach, in which compounds with different chemical and electronic properties, but with compatible crystal structures in at least one dimension, are assembled in a single synthetic step to form a well-ordered composite. By making composites of compounds the band gaps - crucial to capturing light - and surfaces -crucial to evolving hydrogen and oxygen gas- of which complement each other, the project can deliver higher performing materials at a lower cost than can be achieved by conventional top-down modification. The project will deliver new and improved photocatalysts that will hasten progress towards commercially viable systems, helping to establish a new technology and putting pressure on competing technologies such as photovoltaics and wind to drive the renewables sector forward.
ActivityComposite oxides as next-generation photocatalysts for solar energy capture
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $450,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to analyse mathematical billiards within domains bounded by confocal conics.-Mathematical billiards have applications in any situation that involves collisions and reflections, and any phenomenon that includes reflections and collisions can be modelled using mathematical billiards. This project aims to revolutionise the analysis of billiards within domains bounded by several confocal conics by exploring the relations of such billiards with polygonal billiards, and making research advances with the higher-dimensional generalisations within confocal quadrics and their relations with billiards within polyhedra. The project will link several significant areas of scientific work including polygonal billiards, classical integrable systems, Teichmuller spaces, and relativity theory. The project outcomes will have impact across areas of mathematics such as geometry, algebraic geometry, and dynamical systems.
ActivityBilliards within confocal quadrics and beyond
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Feb 201931 Jan 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $550,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to address a lack of knowledge about how post-translational sulfation of tyrosine residues influences protein function. The project will develop a synthetic platform for the rapid and efficient generation of libraries of site'selectively sulfated proteins. The new methods will be used to study bioactive sulfated proteins secreted by ticks that dampen the inflammatory response and prevent blood from clotting. Underpinned by the ability to access synthetic sulfoproteins, expected outcomes include a detailed understanding of how tyrosine sulfation can modulate function and stability of antibodies and proteins with anticoagulant and anti-inflammatory activities. Significant benefits of the project will include breakthrough technologies for the preparation of homogeneously modified proteins, which will strengthen Australia's growing biotechnology sector.
ActivityFunctional studies of tyrosine sulfation using synthetic sulfoproteins
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $420,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to deliver cost-effective techniques to explore and monitor marine environments. The project will develop novel methods for classification of large extent, multimodality seafloor surveys consisting of high-resolution visual 3D gigamosaics made of tens of thousands of images coregistered with broad'scale, lower resolution remote sensing data. This knowledge is essential for designing cost-effective, scalable systems to explore, map and monitor Australia's marine environments. At a broader level, the approach and the techniques developed in this project have the potential to have applications in other areas such as terrestrial and intertidal ecology, extending positive impacts beyond benthic environments.
ActivityAutomated benthic understanding with multimodal observations
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Mar 201928 Feb 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $425,134
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate and provide solutions for the realisation of a seemingly integrated Fog Computing (FC) paradigm with cloud environments, networking devices and Internet of Things devices. Fog Computing (FC) is an emerging paradigm with great promises for advancing Information and Communications Technologies. Using interdisciplinary approaches, the project expects to generate new knowledge for optimising both hardware and software resources of a FC system. Outcomes of this project include practical solutions through building novel mathematical frameworks and optimisation objectives. The project is expected to provide efficient monitoring and control of intelligent spaces, management of urban and rural environments and will have applications in the areas of energy, security, transport and public health.
ActivitySoftware-defined provisioning of Internet of Things applications in fog computing systems
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Feb 201931 Jan 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $233,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to analyse recent developments in Australian psychiatry by considering their broader social, cultural, and political contexts. In the 1970s, Australian psychiatry, primarily based in mental hospital care, came under sustained critique by psychologists, psychiatrists interested in developing alternative treatment methods, and broader social movements. This project will investigate how psychiatrists, psychologists, and other mental health professionals aimed to change mental hospital care and develop community psychiatry to provide alternatives. The project will examine the initiatives of the pioneers in Australian community psychiatry and its relationship to the broader deinstitutionalisation movement. The project will also analyse the resulting changes in research and practice.
ActivityThe development of Australian community psychiatry
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Mar 201928 Feb 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $360,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to predict the settlement and strength of the upper, partially saturated layer of the ground when it is subjected to cyclic loading. Most of our critical infrastructure is built on or in this layer, but currently we cannot reliably predict the ground response of partially saturated soils to the cyclic loads that arise from earthquakes, traffic and construction processes. The project is expected to develop a new numerical model that can predict the effects of cyclic loads, and provide updated engineering guidance to ensure the integrity of infrastructure dependent on partially'saturated soils. Improved predictions of the processes involved resulting from this project will have significant economic benefits, as well as ensuring the safety and security of infrastructure and reduced maintenance costs.
ActivityThe effects of cyclic loading on partially saturated soils
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201815 Jun 201914 Jun 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $370,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to apply Brillouin processing to the development of an innovative, self-tracking optical filter for isolating optical carriers in the coherent receiver of future ultrahigh bit-rate optical communication systems. By recovering a needle-like optical carrier with great precision from a drifting sea of wide-band noise and data channels, the project expects to minimise the effect of optical carrier distortions on the data-carrying signals. The project should advance knowledge in optical signal processing and communications technologies, with outcomes that increase the data-carrying capacity of optical networks. Future telecommunication networks should benefit through improved transmission rates and extended fibre links.
ActivityBrillouin processing for carrier recovery in optical communications
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $336,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop a suite of analytical methods to understand animals' behaviour through their movement patterns. Animal movement patterns encode detailed information about their behavioural state. Collecting and analysing animal movement trajectories can provide us with completely new insights to behaviour. Recent developments in bio-logging technologies have provided an incredible amount of rich data on free-ranging animals. This project will develop a suite of analytical techniques to interrogate this data through a combination of approaches, from fine scale experiments in the laboratory to tracking animal trajectories from the International Space Station. The findings will deliver major benefits to the broader community by transforming our ability to manage and conserve animal stocks.
ActivityUnderstanding animals through their movement
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $349,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to improve our understanding of the impact of commodity price changes. Over the past two decades, Australia has experienced unprecedented fluctuations in commodity prices. The fiscal position and potential of the economy depends on the extent to which commodity price changes are temporary or permanent. This project will uncover empirical regularities between commodity prices, unemployment across sectors and measures of fiscal policy. The project will build structural models of unemployment which will be estimated and used to assess implications for unemployment and budget deficits of commodity price shocks and to study the optimal design of fiscal policy. The project will benefit the conduct of economic policy in Australia.
ActivityFiscal policy and unemployment in an open economy
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jul 201930 Jun 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $601,647
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to reveal how Australians, over several generations, have sought to make sense of society in an organised way. The project intends to draw from interviews with key scholars, archival and citation data to ascertain how sociological knowledge has been shaped by a context of post-colonialism, multiculturalism and global capitalism as well as the extent to which these ideas have contributed to, and been influenced by, policy, legislation and public debate. Expected outcomes include new evidence about the role of disciplines and contribute to the international research effort in this emerging field.
ActivityKnowledge-making in Australian society: sociology and its social impact
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $419,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop new methods in the study of several classes of nonlinear partial differential equations featuring singularities and nonstandard growth conditions. The understanding of countless phenomena in physical and biological sciences is impaired by singularities arising naturally in the models of nonlinear partial differential equations. In a systematic study of singularities on important problems, this project aims to advance new analytical methods and settle fundamental questions that remain open. Outcomes include a more inclusive singularity theory, which fully describes all the singularities that can occur. More immediate applications are in core areas of mathematics, which bear significance to quantum mechanics and image processing in particular.
ActivityNonlinear partial differential equations with anisotropy and singularities
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $540,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to define mechanisms of chromatin looping and gene activation by a widely expressed mammalian protein. The project will establish if the functions of this protein are modulated by the binding of small molecules, whether it can act in conjunction with closely related proteins, and if post-translational modifications regulate looping and gene activation. Using protein engineering the project will develop synthetic looping factors that can switch on a wide array of target genes. The project aims to answer fundamental questions about how proteins can establish and maintain physical loops in DNA to modulate gene expression. The project will also develop research tools that might ultimately correct diseases caused by the faulty expression of genes.
ActivityEngineering a chromatin looping factor for artificial gene regulation
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $486,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop new brain imaging technology that adapts to and corrects for the motion of a responsive, freely moving mouse. Current technology requires the subject to be unconscious, precluding the use of imaging to study signalling pathways activated by external stimuli during cognitive and behavioural tasks. By harnessing new radiation detector, motion tracking and computational technologies, the project expects to bridge this technology gap and provide significant technical and conceptual advances in the field. This will provide important benefits, such as equipping neuroscientists with new tools to answer fundamental questions about how the mammalian brain regulates behavioural adaptation to a changing environment.
ActivityMotion-adaptive PET technology for brain imaging of freely moving mice
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $345,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate the central problem of singularity analysis in manifolds by profiling their topological structures and analysing their geometric structure. Understanding the geometric structure of manifolds is at the forefront of research in geometry and topology, with applications in disciplines such as physics and medical imaging. The project will undertake pressing research in this active and dynamic field and expects to generate greater understanding of limit spaces, deepening the theory of geometric measure theory, and enhancing their applications in mathematics and science.
ActivitySingularity analysis for manifolds with Ricci curvature bounds
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201815 Feb 201914 Feb 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $420,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to investigate the correlation between structural and electronic drivers of behaviour in complex metal oxides. Transition metal oxides are critical for modern electronics and discovering new materials and determining their physical properties is essential for the introduction of new technologies. This project will synthesis and characterise thermally novel oxides containing 4d and 5d transition metals to establish the relationships between the chemistry, crystal structure and physical properties of such oxides. The unusual hierarchy of interactions in such oxides, and high sensitivity to crystal fields and subtle structural distortions, makes such oxides candidate materials for the realisation of various emergent quantum phases that may be used in the next generation of electronics. The proposal has the potential to significantly advance Australian research and development capacity in advanced materials and the associated high-tech industries.
ActivityUnderstanding novel electronic and magnetic states in 4d and 5d oxides
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $580,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to delineate the precursor cells in the embryo that give rise specifically to major cell types in the body. The project will use genetic analysis to elucidate the critical genetic activity that underpins the genesis of these precursor cells and to track the trajectory and the scope of cell differentiation. The embryological knowledge will provide insights into the fundamentals of developmental process for generating cellular diversity and enable identifying unique precursors and the evaluation of the efficacy of deriving the biological relevant cell types from the stem cells. This project expects to have a significant impact on the translation to cell production methodology for tissue engineering and bioreactor technology.
ActivityCapturing tissue-specific progenitors from embryos and stem cells
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jan 201931 Dec 2021 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $450,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop a new generation of interfacial diffusion membranes for industrial gas separations including carbon dioxide removal, nitrogen gas enrichment, methane purification and air separation. The project focuses on advancing separation technologies for the petrochemical, natural gas, and clean energy industries in the mining sector. The project is expected to reveal new separation properties and performance based on highly selective interfacial diffusion membranes. The project will also create new scientific knowledge about the role of functional surfaces and nanostructures that will not only facilitate new membrane designs but also offer new, more cost-effective devices for solar conversion, energy storage and harvesting, biomedical applications, sensing and information technology.
ActivityDesigning high performance gas separation by interfacial diffusion membrane
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Apr 201931 Mar 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $387,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to equip machines with the ability to robustly harness feature-dependent label noise from big data. The project expects to produce the potential to explore and exploit the weakly supervised information to better understand, interpret, and infer big data. Expected outcomes of this project include theoretical foundations for learning with label noise in the real-world scenarios and the next generation of intelligent systems to accommodate noisily annotated big data. This project should benefit science, society, and the economy nationally and internationally through the applications in the areas of artificial intelligence, cybersecurity, and big data analytics.
ActivityFeature-dependent label noise learning for big data analytics
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jun 201931 May 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $345,000
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop new detection and control techniques to study interacting many-body quantum systems in an ion trap. The understanding of quantum correlations is essential for many of the future applications in quantum technology, such as quantum scale materials, quantum sensing and quantum computation. In particular, understanding quantum magnetism is on the forefront of modern physics. The project is expected to advance the extraction of time-domain information about the generation and spread of quantum correlations. This project should provide significant benefits in the understanding of exotic condensed matter phenomena such as high-temperature superconductivity or spin liquids. The knowledge and techniques developed in this project will also be valuable for other research areas from material science and atomic physics to quantum science.
ActivityCorrelation dynamics in a many-body quantum system using trapped ions
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201818 Dec 201801 Jun 201931 May 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $1,046,628
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component Linkage Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to measure the long-term genetic impacts of the Save the Tasmanian Devil Program's -Wild Devil Recovery- initiative. The project will determine whether supplementing small populations with individuals that are genetically diverse reduces inbreeding depression. The project will also monitor the impact of supplementation on the evolutionary trajectory of Devil Facial Tumour Disease. The project will train a cohort of conservation scientists to translate genetic data into management actions. The outputs will directly inform the management actions of the Tasmanian Department of Primary Industries Parks, Water and the Environment and will help shape other species recovery programs.
ActivityWill genetic rescue save the Tasmanian devil-
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
27 Nov 201830 Apr 201901 Apr 201931 Mar 2024 2018-19
THE UNIVERSITY OF SYDNEY
Grayndler  $161,151
Address Camperdown 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Blood Authority
Program National Blood Agreement Management
Component National Blood Sector Research and Development Program
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis study aims to utilise the existing Australian Placental Transfusion Study (APTS) dataset and collect additional data from all APTS sites to determine whether, after adjustment for prior risk factors (gestation, birth weight, etc), the: 1) timing of cord clamping, and APTS group allocation predicts the number of blood tests and calculated cumulative sample volume throughout hospital stay; 2) average haemoglobin in the first week and each subsequent week predicts calculated cumulative sample volume throughout the hospital stay; and 3) cumulative sample volume (independent of APTS group allocation and time to cord clamping) predicts the likelihood of an infant receiving a red cell transfusion and the time to first transfusion (if given).
ActivityPatient Blood Management Project Grant:Deferred Cord Clamping to Reduce Need for Neonatal Blood Transfusion
Delivery Area Multiple National AUSTRALIA
ApprovedPublishedStartEndBudget
26 Oct 201820 Feb 201924 Dec 201831 Mar 2020 2018-19
UNIVERSITY OF SYDNEY
Grayndler  $164,125
Address UNIVERSITY OF SYDNEY 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency Department of Health
Program Preventive Health and Chronic Disease Support
Component Fetal Alcohol Spectrum Disorder
CategoryAddiction and Substance Abuse Closed Non-Competitive
PurposeFetal Alcohol Spectrum Disorder
ActivityFetal Alcohol Spectrum Disorder
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
26 Mar 201912 Jul 201926 Jun 201930 Jun 2019 2018-19
UNIVERSITY OF SYDNEY
Grayndler  $167,169
Address Sydney 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency Cancer Australia
Program Improved cancer control
Component 2018 Priority-driven Collaborative Cancer Research Scheme
CategoryCancer Targeted or Restricted Competitive
PurposeMedulloblastoma is the most common malignant brain tumour of childhood but can also occur in older adolescents and young adults (AYA). The best treatment for these older patients is unknown, and until now their treatment has been suboptimal. This study will be the first of its kind in this patient group. This trial will give these patients access to state-of-the-art tumour profiling and targeted therapies in order to ensure optimal treatments to both improve cure rates, reduce therapy-related toxicities.
ActivityPersonalised targeted therapy for adolescent and young adult medulloblastoma patients
Delivery Area Multiple National AUSTRALIA
ApprovedPublishedStartEndBudget
26 Jun 201902 Jul 201930 Jun 201929 Jun 2022 2018-19
UNIVERSITY OF SYDNEY
Grayndler  $496,103
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component International Joint Calls
CategoryMedical Research Targeted or Restricted Competitive
PurposeMultidrug-resistant tuberculosis is a global public health emergency. Vietnam is a high-burden setting for the disease. Standard therapies frequently cause side effects, which can prevent patients from completing their treatment. We will conduct a randomised trial to evaluate the effect of new digital mobile health (mHealth) technologies upon patient treatment outcomes. The study will provide the evidence required to harness the power of rapidly-advancing technologies for improved patient care.
ActivityGNT1157643 | Harnessing new mHealth technologies to Strengthen the Management of Multidrug-Resistant Tuberculosis in Vietnam: The V-SMART Trial
Delivery Area Multiple NSW, Overseas AUSTRALIA, VIET NAM
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $66,502
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeIt is widely advocated to include patients and their families in their medical care and in research, yet there is limited evidence on how to do this well. This thesis will aim to provide a summary of the current state of patient involvement in research in chronic kidney disease, and work towards developing an evidence-based framework for involving patients and their families in research in future.
ActivityGNT1169149 | Establishing an evidence-based framework for involving patients in research about chronic kidney disease
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Mar 2021 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $78,554
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeFrontotemporal dementia (FTD), characterised by behavioural and language disturbance, affects over 6000 Australians. It is characterised by changes in behaviour, language skills and eating behaviour. There is evidence that sleep is also altered in FTD, which significantly increases carer burden. I propose to characterise the sleep disturbance in FTD, which may open an avenue for interventions that improve the lives of FTD patients and their carers.
ActivityGNT1169331 | Characterisation of sleep disturbance and assessing its impact on patients with frontotemporal dementia
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Oct 2020 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $84,106
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeImmunotherapy is commonly used in the treatment of melanoma. The side-effects of these therapies can be substantial, with health system costs associated with managing these side-effects and patient out-of-pocket costs are uncertain. This research will calculate the costs and benefits of these therapies and determine melanoma patient and clinician treatment preferences and factors that influence treatment choice.
ActivityGNT1168194 | The costs, benefits and patient and clinician preferences of adjuvant immunotherapy in melanoma (Health Economics)
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Mar 2021 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $88,502
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeDementia patients have difficulty interpreting internal body cues and experience behaviour and social impairments, which cause significant distress for their families. This project will explore the relationship between these abilities using novel virtual reality techniques and assess how they relate to dementia's effect on the brain. Potential interventions to improve sensitivity to the body will be explored. Outcomes will inform future behaviour management strategies and reduce carer distress.
ActivityGNT1168597 | The Role of Interoceptive Processing in Frontotemporal Dementia
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $96,294
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeGlomerulonephritis is common cause of kidney failure. Standardised Outcomes in Nephrology: Glomerulonephritis (SONG-GN) will determine which consequences of the disease and its treatment that people need more information about when making decisions. SONG-GN will gather evidence from patients, caregivers, care providers, researchers, industry and policymakers. We will provide a set of outcomes that researchers should measure when comparing treatments in glomerulonephritis.
ActivityGNT1168994 | Standardised Outcomes in Nephrology - Glomerulonephritis (SONG-GN): establishing core outcomes for trials in patients with glomerulonephritis
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Mar 2021 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $128,225
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeAcute kidney injury (AKI) has both important short and long term clinical implications, particularly with regards to the risk of developing chronic kidney disease; and reduced survival time of a renal transplant. There are no established interventions to treat or reverse AKI other than supportive therapy at this current time. Dendritic cells orchestrate the acute inflammatory response in AKI, and area promising therapeutic target in the future.
ActivityGNT1168776 | DENDRITIC CELL PATHOPHYSIOLOGY AND CELLULAR THERAPY IN ACUTE KIDNEY INJURY AND TRANSPLANTION
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $64,057
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis project aims to develop a tool to inform decisions about where best to allocate resources to combat the childhood obesity problem in Australia most effectively, equitably and sustainably. Nationally representative cost, health, and demographic information will be used to construct this tool. The results from obesity treatment and prevention trials will then be applied to predict what the impact of rolling out these interventions will be on health outcomes, inequalities and the economy.
ActivityGNT1169039 | Tackling the inequality and economic burden of obesity in Australian children
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201928 Feb 2021 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $34,723
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeDeveloping a novel approach to assess the benefits and harms of techonological changes in screening programs: example of transition from film to digital mammography for breast cancer screening
ActivityGNT1168688 | Examination of the impact of shifting practice from plain film mammography to digital mammography
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201929 Feb 2020 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $111,974
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeEarly, accurate diagnosis of cerebral palsy is possible, as published in a clinical practice guideline (CPG). Implementation barriers and behaviour change techniques are identifiable. Education of physicians is needed. A randomised control trial and multi-level evaluation will measure the effectiveness of a multi-faceted eLearning intervention on improving physician diagnostic behaviour and patient outcomes. A comparison of interactive eLearning design features and costs will be evaluated.
ActivityGNT1169076 | Implementation of the early diagnosis of cerebral palsy guidelines in the Australian context: exploring the impact of online educational interventions on physician behaviour and patient outcomes.
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $128,225
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeDifferent people can eat the same diet and do similar physical exercise but some will develop diabetes and others will not. Currently, we do not understand reason for these differences and we also do not understand why certain drugs used to treat diabetes work better in some individuals compared to others. By examining the effects of same diet on different mouse strains, we aim to better understand the cause of these differences.
ActivityGNT1168607 | Mouse Model of Personalised Medicine in Diabetes and Insulin Resistance
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $64,057
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeRandomised trials provide best evidence of treatment effects due to unbiased allocation of treatments to each patient group but post hoc analysis of these trials can still lead to substantial bias of estimates of treatment effect. The extent to which this occurs is not fully appreciated by the reader. This research will examine strategies for adjusting pre'specified analyses which are free from bias and provide a clear framework, in the form of a checklist to guide future trial analyses.
ActivityGNT1168666 | Changes to design aspects of ongoing randomised controlled trials (RCT)
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201928 Feb 2021 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $85,650
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposePeople with chronic kidney disease (CKD) have higher rates of cancer than the general population. This program of research will investigate the burden and risk factors for cancer in patients with CKD and develop a risk prediction model to predict the chances of patients with CKD developing or dying from cancer. Cancer screening strategies in patients with CKD will be assessed to determine if these strategies are effective in reducing the risk of cancer death in these high-risk patients.
ActivityGNT1168606 | Reducing the burden of cancer in patients with chronic kidney disease
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2020 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $50,171
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeOrgan transplantation can save lives, but there aren-t as many donor organs as people who need them. One limitation to organ donation is safety of the organs. We minimise risks to the recipient, including that of infection transmission, such as the viruses HIV, hepatitis B and C. This project wonders if clinicians have the balance right when rejecting organs on these grounds. We investigate the actual risk of blood borne virus transmission in transplantation, to see if we can increase donation.
ActivityGNT1168202 | Infectious diseases in solid organ transplantation
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201929 Feb 2020 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $92,746
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeSudden death or cardiac arrest occurs due to fatal heart rhythms. Narrowed heart arteries, heart muscle disease, or problems with electrical signalling in the heart are usual causes. Identifying at-risk patients is critical, but current methods are suboptimal. We propose that ultrasound technology called 'strain echocardiography- will allow early detection of various heart diseases that increase the vulnerability to sudden death or cardiac arrest, before overt disease develops.
ActivityGNT1168854 | Speckle Tracking Strain Echocardiography in the detection of Arrhythmogenic Substrates that lead to Sudden Cardiac Death
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201928 Feb 2021 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $51,835
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeKidney transplantation is the best treatment for people with kidney failure. But transplantation has risks. Risk of losing the transplant must be balanced with and a higher chance of potentially life-threatening infections and cancers. To improve long term outcomes, we need to look at the mechanisms of these diseases and how they affect what happens to transplant recipients.
ActivityGNT1168672 | Improving long-term outcomes in kidney transplant recipients: towards tailored treatment
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201930 Sep 2020 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $181,066
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component TRIP Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposePhysical inactivity is a global crisis, causing 5.3 million deaths each year and costing public healthcare $31.2 billion annually. Physical activity counselling has demonstrated efficacy for increasing physical activity; however implementation efforts within healthcare have been sub-optimal. This project will assist physiotherapists, an ideal health profession both in skill and pattern of practice, to deliver physical activity counselling within routine care to efficiently address this problem.
ActivityGNT1168274 | Implementation of physical activity counselling within NSW Health physiotherapy services: a cluster randomised controlled trial.
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2020 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $568,193
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeCurrent synthetic graft materials for revascularisation are incompatible with the body and have high rates of vessel occlusion. We have engineered a new synthetic silk conduit with a bioactive surface which uniquely suppress graft occlusion, potentially improving outcomes for many patients with cardiovascular disease.
ActivityGNT1162969 | New Synthetic Conduits for Arterial Revascularisation
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $744,920
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeTelomeres are DNA and protein structures at the ends of chromosome that function to maintain genome stability. Telomeres shorten with each cell division, until they become critically short. At this point the cell stops dividing. Telomere length is therefore an important indicator of cellular health. However, other factors also contribute to telomere integrity, and have been largely overlooked. We aim to investigate these factors and how they contribute to overall telomere function.
ActivityGNT1162886 | Telomere integrity in human health and disease
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $807,284
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis proposal will pioneer the development of a new class of molecules that will block the activity of proteins that regulate gene expression and have been shown to be promising targets for a range of diseases, predominantly cancer. These molecules have the potential to be much more selective and potent than existing molecules that are being trialled, and will also be valuable tools in our efforts to understand the basic mechanisms by which gene expression is regulated.
ActivityGNT1161623 | New approaches to BET-family bromodomain inhibitors
Delivery Area Multiple NSW, Overseas AUSTRALIA, UNITED KINGDOM, UNITED STATES
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $930,103
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis trial will determine the effectiveness, cost-effectiveness and implementation potential of yoga-based exercise for preventing falls in people aged 65+. This project addresses the urgent public health challenge of population ageing and is aligned with the World Health Organization's Global Strategy and Action Plan on Ageing and Health 2016-2020. Results have the potential to change policy and practice, improve quality of life and reduce the economic cost of an ageing population.
ActivityGNT1163067 | Preventing falls in older age with yoga-based exercise: effectiveness, cost-effectiveness and implementation
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $877,848
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeOver half of the children who develop end stage renal failure have an underlying genetic cause. In a number of the diseases normal kidney function is gradually injured by the pathway involved. In some disorders a defective gene in the liver leads to kidney damage through vascular or biochemical problems. We aim to deliver replacements or corrections of these genetic defects to the liver as a single dose to cure the disease using specialised gene constructs that specifically targets the liver.
ActivityGNT1161554 | Developing Single Dose Genetic Treatments to Cure Rare Kidney Disorders by Liver-Specific Targeting and Developing Kidney Targeting Strategies
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $676,653
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis project will provide important new insights into both varicella zoster virus (VZV) and herpes simplex virus (HSV) infection of sensory neurons, including how they differentially affect tthis key cell type that is their natural target of latency and reactivated infection.
ActivityGNT1164776 | Neuropathogenesis of herpes zoster and post-herpetic neuralgia
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $1,416,383
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeExtraordinarily high rates of dementia are evident in survivors of intracerebral haemorrhage (ICH), the most serious form of stroke. This project will determine in 400 subjects from the TRIDENT trial, whether over a 2-year period, the -triple pill- for intense blood pressure lowering, can reduce memory and cognitive decline in comparison to standard care. A secondary aim will be to examine the key mediators of cognitive decline using brain scanning markers of small vessel disease.
ActivityGNT1159055 | Triple therapy prevention of Recurrent Intracerebral Disease EveNts Trial (TRIDENT) - Cognitive sub-study
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2023 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $199,684
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe stromal tissue surrounding pancreatic cancer is a major driver of metastasis and therapeutic resistance. This proposal will examine a breakthrough drug in clinical trials that up-regulates the potent metastasis suppressor, NDRG1, and its role in inhibiting the oncogenic cross-talk between pancreatic cancer cells and the surrounding stroma.
ActivityGNT1160968 | Inhibiting the oncogenic cross-talk between cancer cells and surrounding stroma by targeting the metastasis suppressor NDRG1 in pancreatic cancer
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2020 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $967,915
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeMembrane proteins are pumps that control the movement of nutrients, waste products and chemical messengers in and out of cells. These pumps break down in a wide range of diseases including neurological disorders and cancer. This project is focused on a unique type of transporter/channel hybrid protein that uses a -twisting elevator- mechanism. We will uncover how they work and what goes wrong in disease. This information can then be used to develop new drugs to improve transporter function.
ActivityGNT1164494 | The spilt personality of glutamate transporters: the structural basis and physiological role of a dual function transporter/channel
Delivery Area Multiple NSW, Overseas AUSTRALIA, CANADA, UNITED STATES
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $354,872
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeFor very preterm births, we do not know when the best time to clamp the cord is, and we do not know the comparative effects of alternative policies for cord clamping. In order to resolve this uncertainty, several trials are currently being planned, or are underway. We have formed a prospectively planned collaboration which will synthesise data from individual participants in these trials.
ActivityGNT1163585 | Cord Clamping and Placental Transfusion at Preterm Birth: an individual participant data and network meta-analysis
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2023 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $492,192
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeTwo thousand Australians suffer from kidney failure requiring dialysis due to a genetic condition called autosomal dominant polycystic kidney disease (ADPKD). Finding a cure for ADPKD will depend on understanding why kidney cysts form in this disease. Our research has discovered that DNA damage is increased in kidney cysts, and in this project we the role of reducing DNA damage as a way to stop the formation of the kidney cysts.
ActivityGNT1164128 | Role of DNA damage signalling in Autosomal Dominant Polycystic Kidney Disease
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $1,121,891
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThere is evidence physical activity (PA) can reduce bowel cancer risk and suggesting it may decrease recurrence of bowel cancer. This randomised controlled trial will provide reliable evidence as to whether those completing a 3 year structured PA program after treatment for early colon cancer reduce the risk of disease recurrence compared to standard follow-up.
ActivityGNT1160385 | CHALLENGE: Colon Health And Life Long Exercise ChaNGE
Delivery Area Multiple NSW, QLD AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2023 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $782,521
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeGene therapy offers the possibility of new treatments for patients with genetic and acquired diseases. Modified non-pathogenic viruses can safely and efficiently deliver therapeutic DNA to affected cells inside a patient's body, but manufacturing of these vectors is inefficient and expensive, hampering clinical development. This project focuses on further developing this technology to dramatically enhance manufacturing efficiency and build the foundations for an Australian production capacity.
ActivityGNT1161583 | Strategies for development of novel adeno-associated viral vectors and production technology: towards national clinical-grade manufacturing capacity
Delivery Area Multiple ACT, NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $1,061,015
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeRisk-taking is part of normal adolescent development, but much illness and social adversity arises from risky behaviour in adolescence. No systematic way exists to distinguish those likely to have poor outcomes, limiting our capacity to screen and intervene. By linking the Raine cohort study to routinely collected health and welfare data, we will identify pathways to such outcomes, estimate associated health and productivity costs, and quantify savings achievable with effective intervention.
ActivityGNT1161445 | The health, social and economic implications of risk-taking in adolescence over the life-course: a data linkage study of the Raine cohort
Delivery Area Multiple NSW, VIC, WA AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2023 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $1,732,011
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe Symptom monitoring WIth Feedback Trial (SWIFT) is an Australia and New Zealand Dialysis and Transplant Association (ANZDATA) registry-based randomised trial to improve the lives of people on kidney dialysis. The trial will enrol 160 dialysis units (greater than3,000 people) to determine whether routine monitoring of symptoms such as pain and nausea, with feedback to clinicians, can improve health-related quality of life. An economic evaluation will determine the intervention's cost-effectiveness.
ActivityGNT1159051 | Can Symptom monitoring With Feedback to clinicians improve the lives of people on dialysis- (SWIFT)
Delivery Area Multiple NSW, SA AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2023 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $667,029
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeGlioblastoma is a form of brain cancer that is currently incurable. We have discovered that switching-off an enzyme called MK2 (using -MK2 inhibitors-) improves chemotherapy outcomes. This project will examine a novel drug combination treatment for glioblastoma patients and generate evidence for initiation of clinical trials. This could initiate a novel therapy that could significantly extend patients- lives.
ActivityGNT1163484 | Targeting MK2 to overcome glioblastoma resistance to therapy
Delivery Area Multiple NSW, VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $1,015,028
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeNeuropathic pain is difficult to treat, with front line anti-neuropathic drugs only providing adequate pain relief for a minority of patients. We have found that inhibitory neurons are compromised after nerve injury, and by restoring these natural pain killers we can 'cure' neuropathic pain. Here we will define the cellular identity of these pain killing neurons and identify new drug targets that can promote inhibitory neuron function, information that will help us treat this devastating illness
ActivityGNT1158165 | Defining the cellular and molecular factors that control central inhibition and neuropathic pain
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $863,035
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeWhen herpes simplex virus infects genital skin, it spreads down to infect nerves, ultimately resulting in lifelong infection, or to immune cells to initiate a controlling immune response. Elucidation of these pathways will help determine the targeting of an effective preventative vaccine. Furthermore these studies will also determine how HIV infection and spread is enhanced by prior herpes co-infection, guiding methods to prevent HIV acquisition through herpes lesions.
ActivityGNT1163748 | Defining pathways of epithelial spread of Herpes simplex virus after genital infection
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $980,028
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeChronic pain is regulated by transcriptional and epigenetic mechanisms that are not well understood. We have identified a novel epigenetic regulator that controls human pain perception. In this study we will characterize the molecular mechanisms for how this factor controls pain. These efforts will help us better understand the transcriptional and epigenetic regulation of pain, and may lead to new pain killers that can specifically turn off chronic pain in humans.
ActivityGNT1158164 | Histone methyltransferases control pain perception
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $1,093,596
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeHigh-risk prostate cancer (HRPCa) is a deadly. Driven by genomic alterations, the aim of this study is to establish a genomic signature for HRPCa to facilitate diagnosis, predict patient outcomes and treatment strategies. Our approach includes two distinct HRPCa population resources for comparative analyses. Australian men without treatment at surgery and extensive clinical follow-up, and African men with 2.4 times increased risk for untreated HRPCa at diagnosis and greater genomic diversity.
ActivityGNT1165762 | Establishing a Genomic Signature for High-Risk Prostate Cancer
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2020 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $634,841
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeOur recent pilot data provides the first solid evidence that -GABAARs are involved in social behaviour and we have effectively targeted them pharmacologically to reduce social deficits in a rodent autism model. This project will: (1) thoroughly define the role of --GABAARs in social behaviour; (2) assess abnormal functioning of --GABAARs in a rodent model of autism; and (3) discover and develop new drugs targeting --GABAARs, potentially providing much needed drug candidates for social disorders.
ActivityGNT1166044 | Characterising and exploiting - subunit-containing GABA-A receptors as novel targets for treating social disorders
Delivery Area Multiple NSW, Overseas AUSTRALIA, NEW ZEALAND
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $1,828,232
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeFalls after stroke place an enormous economic and personal cost on society. Stroke survivors are twice as likely to fall as the general older population and more likely to fall repeatedly. Our Falls After Stroke Trial (FAST) will establish the effectiveness of home-based, tailored intervention (habit-forming exercise and safety training), delivered by allied health professionals, in reducing falls after stroke, thereby potentially reducing the economic and social burden.
ActivityGNT1157739 | Tailored intervention for reducing falls after stroke trial (FAST)
Delivery Area Multiple ACT, NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $75,000
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeAustralian teens have high salt and low fruit and vegetable intake. This poor dietary pattern can raise the sodium to potassium ratio (Na:K) in urine which is a marker that predicts high blood pressure (BP) and heart disease. At puberty, teens show a natural rise in BP which may be exacerbated by a high urinary Na:K. As no data directly support this hypothesis, this study will explore the impact the urinary Na:K has upon BP and heart disease risk in a cohort of Australian adolescents.
ActivityGNT1165070 | Exploring the impact of the sodium-to-potassium ratio on longitudinal adolescent trajectories of blood pressure and cardiovascular risk
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2020 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $1,142,038
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeSciatica is a debilitating pain condition characterised by pain radiating to the leg from the lower back. But there is currently no simple solution to relieve this pain. In this clinical trial, we will investigate whether oral steroids, a simple, low-cost treatment, taken over a 5-week period can indeed reduce leg pain, improve other important outcomes and be reasonably tolerated in patients with acute sciatica.
ActivityGNT1157835 | Trial of glucocorticoids in acute sciatica
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $354,526
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeSuicide in Australia is the leading cause of death for young people. Optimising suicide prevention lies in delivering the right interventions to the right people. Yet currently we lack crucial information - we do not know which individuals are likely to receive some of our most promising suicide interventions and therefore where to deliver them in the future. To gain this knowledge we will examine the medicines dispensed and healthcare utilised prior to previous suicides in Australia.
ActivityGNT1157757 | Health service and medicine utilisation before suicide: optimising suicide prevention using population-based linkage of routinely collected data
Delivery Area Multiple NSW, VIC AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $995,411
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeWe will determine whether dietary manipulation of the chemicals and bacteria within the gut, known as the microbiome, can prevent mice from rejecting a kidney transplant. We will also study the microbiome in kidney transplant recipients to explore whether differences exist between those with versus without rejection. Ultimately, we aim to devise dietary strategies to prevent transplant rejection, reduce dependence on immunosuppressive drugs and improve outcomes for transplant recipients.
ActivityGNT1162764 | Manipulating the Microbiome by Diet to Prevent Kidney Transplantation Rejection
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $600,357
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeWe have discovered a major cause of frontotemporal dementias in genes that cause white matter disease and dysregulate lipid metabolism. We aim to understand how the mutations in these genes give rise to disease via perturbations of lipid metabolism, and their correlation with brain imaging information and blood based biological markers. This may allow us to identify novel therapeutic targets and to improve diagnostic accuracy.
ActivityGNT1163249 | Mutations in genes causal of white matter disease and dysregulation of lipid metabolism in frontotemporal dementias
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $1,982,802
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeKnee osteoarthritis (OA) is a major source of disability with no known cure. In order to address this gap, safe and effective treatments that reduce symptoms AND slow structural disease progression are needed. Whilst no disease-modifying agent has been approved to date, stem cells have biologic potential in this context. This trial will evaluate the efficacy of stem cell injections for reducing pain and slowing disease progression in knee OA compared to placebo.
ActivityGNT1162874 | Stem Cells as a symptom- and strUcture-modifying Treatment for knee OsteoaRthritis- the SCUlpTOR trial.
Delivery Area Multiple NSW, TAS AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2023 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $839,351
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeDespite Australia having one of the highest rates of melanoma in the world, there is currently no structured screening program for melanoma like there is for some other cancers. Our project will evaluate the benefits, harms, cost-effectiveness and resource implications of implementing a national risk'stratified melanoma screening program that aims to more accurately identify personal melanoma risk and tailor the screening strategy according to risk level.
ActivityGNT1165936 | A national risk-stratified melanoma screening program in Australia: a modelling study of the benefits, harms, cost-effectiveness and resource implications
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $747,389
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeIntractable childhood epilepsies have a large seizure burden and are associated with reduced lifespan and developmental delays. Recent successful human trials using cannabidiol (CBD) herald great promise for the future development of cannabinoids as novel anticonvulsants. We have discovered four cannabinoids that are more potent than CBD. In this project we aim to further develop these cannabinoids, and better understand the role of the natural cannabis system in childhood epilepsy.
ActivityGNT1161571 | PRECLINICAL DEVELOPMENT OF CANNABIS-DERIVED MEDICINES FOR DRUG-RESISTANT EPILEPSY
Delivery Area Multiple NSW, Overseas AUSTRALIA, UNITED STATES
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $659,057
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeMore than two-thirds of Australian children play organised sport. Yet exercising in hot weather can lead to overheating and other serious health problems. Doctors warn that children may be at more risk of heat illness, but most sport heat policies treat children and adults the same. Our study will develop a new Australian heat policy by identifying for the first time the temperature and humidity at which different sports should be cancelled for boys and girls of different age groups.
ActivityGNT1162371 | An Evidence-Based Extreme Heat Policy for Child and Youth Sport
Delivery Area Multiple ACT, NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $691,653
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeGenetically engineered viruses based on Adeno-Associated Virus (AAV) show immense promise in the treatment of genetic diseases of the liver and other organs. At present AAV-based gene transfer is sufficiently powerful to treat conditions such as haemophilia B, but the majority of potentially treatable conditions of the liver lie beyond reach. This grant focuses on engineering the outer shell of AAV to dramatically improve the efficiency with which human liver cells can be genetically repaired.
ActivityGNT1156431 | Unlocking the inherent power of adeno-associated virus vectors for liver-targeted gene therapy
Delivery Area Multiple NSW, Overseas AUSTRALIA, UNITED STATES
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $404,228
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeMore than 10 million people worldwide suffer from Parkinson's disease, with up to one third of patients also suffering from deficits in cognition. We think that we may know what may be causing the problem -- dysfunctional activity in the brain's noradrenergic system. In this proposal, we will use novel brain imaging techniques to prove this hypothesis, and thus provide new inroads into this troubling disorder.
ActivityGNT1156536 | Noradrenaline and Cognitive Dysfunction - Interrogating the Neglected Symptoms of Parkinson-s disease
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $1,587,164
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeNon-muscle invasive bladder cancer is common, causes substantial suffering and requires radical removal or irradiation of the bladder within 5 years in over 30 percent of people with high risk tumours despite best current treatment. Preliminary studies show exciting results from adding mitomycin (a chemotherapy drug) to best current treatment with BCG (an immunotherapy). This large randomized trial will determine the effects of adding mitomycin on cure rates, survival, side effects and quality of life.
ActivityGNT1159787 | BCG+MM Trial: Adding mitomycin to BCG as adjuvant intravesical therapy for high-risk, non-muscle-invasive bladder cancer: a 2-stage, randomised phase 3 trial.
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2023 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $814,170
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis work will provide a novel and highly precise method of identifying women at high risk of breast cancer by combining the radiologists- initial impression of a mammographic image with image feature analysis and deep learning algorithms. It will only use information already contained within each mammographic examination so no added inconvenience to the woman. This completely unique approach will be significantly more accurate than any of the risk prediction approaches currently employed.
ActivityGNT1162872 | MY RISC (MammographY: Robust InterrogationS and Calculations): Breast Cancer Prediction Transformed
Delivery Area Multiple NSW, VIC, Overseas AUSTRALIA, UNITED KINGDOM, UNITED STATES
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2021 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $1,229,190
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeMelanoma survivors need lifelong skin checks for new melanomas and other skin cancers. Technology now provides smartphone Apps which guide patients- own skin checking and allow photography of areas of possible concern. The results are sent for a dermatologist's review, which may prompt a clinic visit for further investigation. However the effectiveness and safety of using new technologies for skin checks are unknown, and our trial seeks to generate the evidence needed to assess this.
ActivityGNT1163054 | Can patient-led surveillance detect recurrent or new primary melanoma andamp; reduce need for routinely scheduled follow-up- A Randomised Controlled Trial.
Delivery Area Multiple NSW, VIC, QLD, Overseas AUSTRALIA, NEW ZEALAND
ApprovedPublishedStartEndBudget
25 Oct 201821 Dec 201801 Jan 201931 Dec 2022 2017-18
UNIVERSITY OF SYDNEY
Grayndler  $12,981,420
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Program
CategoryMedical Research Targeted or Restricted Competitive
PurposeNutrition shapes the relationship between genes and health, and failure to attain dietary balance has profound biological consequences leading to disease. This Application proposes an integrated program that harnesses advances in nutritional theory, systems metabolism, and data modelling that evaluates the effects of macro- and micro-nutrients on mice, cells and humans. This will provide the scientific foundations necessary for the development of evidence-based precision nutrition.
ActivityGNT1149976 | Nutrition and Complexity
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
24 Oct 201730 Jan 201801 Jan 201931 Dec 2023 2016-17
UNIVERSITY OF SYDNEY
Grayndler  $12,215,475
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Program
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis program aims to develop better health care though advances in clinical trials research and better methods for integrating trial evidence. The team comprises clinician researchers and trialists, biostatisticians, health economists and collaborative networks of clinical investigators. It aims to tackle major health care questions in priority health areas, in cancer, cardiovascular disease, and diabetes, where advances will have substantial impact on reducing death and serious disability.
ActivityGNT1150467 | Better Outcomes through Innovations in Clinical Trials: from Personalised Medicine to Population Health
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
24 Oct 201730 Jan 201801 Jan 201931 Dec 2023 2016-17
UNIVERSITY OF SYDNEY
Grayndler  $181,066
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component TRIP Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeNew high quality evidence has recently shown that targeting the oxygen saturation of very preterm babies at a level used routinely for many years causes an increase in their risk of death. Targeting a higher range reduces this risk but practitioners have been slow to change their practice. A program will be introduced at several newborn intensive care units which will ensure that those caring for these sick babies will be supported to move safely to a policy of higher saturation targeting.
ActivityGNT1151460 | Resolving 60 years of uncertainty: oxygen saturation targets in preterm infants
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
24 Oct 201730 Jan 201801 Jan 201831 Dec 2019 2016-17
UNIVERSITY OF SYDNEY
Grayndler  $181,066
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component TRIP Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposeThe goal of this work is to provide a quantitative objective measure of HINTS for developing an automatic diagnostic decision tool to differentiate vestibular neuritis (peripheral) and stroke (central) in patients presenting in emergency department for acute vestibular syndrome. Video oculography makes interpretation of the results more reliable. Video oculography goggles will be used as part of a systematic training program to enhance frontline clinician skills in eye movement examination.
ActivityGNT1150295 | Acute vertigo in emergency departments: distinguishing between central and peripheral causes by objective measure of oculomotor examination (HINTS)
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
24 Oct 201730 Jan 201801 Jan 201831 Dec 2019 2016-17
UNIVERSITY OF SYDNEY
Grayndler  $181,066
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component TRIP Fellowships
CategoryMedical Research Targeted or Restricted Competitive
PurposePatient Reported Outcome Measures (PROMs) are questionnaires that measure a person's physical symptoms such as pain or nausea, quality of life, and well-being. Traditionally these measures have not been used to assess the quality of medical treatments in routine care. This project seeks to implement PROMs alongside biological outcomes into the national kidney dialysis (ANZDATA) registry, and evaluate the feasibility and acceptability by patients, clinicians and policy makers
ActivityGNT1150898 | Incorporating patient reported outcome measures (PROMs) into clinical registries
Delivery Area Multiple NSW, SA AUSTRALIA
ApprovedPublishedStartEndBudget
24 Oct 201730 Jan 201801 Jan 201831 Dec 2019 2016-17
UNIVERSITY OF SYDNEY
Grayndler  $1,390,381
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposePeople with impaired mobility can achieve substantial benefits from appropriate physical activities but face many barriers to being active so require targeted interventions and health professional support. This trial (n=600) will test the effectiveness and cost-effectiveness of an enhanced physical activity coaching intervention (home-visit from a physiotherapist, phone coaching, technology) with phone coaching alone and with no intervention.
ActivityGNT1145739 | Physical activity coaching for adults with physical disabilities: a pragmatic randomised controlled trial.
Delivery Area Multiple NSW, VIC, SA, QLD AUSTRALIA
ApprovedPublishedStartEndBudget
24 Oct 201730 Jan 201801 Jan 201831 Dec 2021 2016-17
UNIVERSITY OF SYDNEY
Grayndler  $1,014,791
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeWe discovered, characterised and commercialised Macrophage inhibitory cytokine-1 (MIC-1/GDF15) for human therapy. Its blood level predicts death from cancer, heart attack/stroke and other diseases. This study will add important information for understandg the actions of this important protein
ActivityGNT1146312 | MIC-1/GDF15 in CNS disease
Delivery Area Multiple NSW, WA AUSTRALIA
ApprovedPublishedStartEndBudget
24 Oct 201730 Jan 201801 Jan 201831 Dec 2021 2016-17
UNIVERSITY OF SYDNEY
Grayndler  $1,265,463
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeAn Australian family with a rare myopathy has led to the discovery of a new gene called PYROXD1; a gene that all cells need to survive. PYROXD1 plays a critical role in protecting cells from oxidative stress. We are using patient samples and mouse models to find out what PYROXD1 does that is vital for cell and animal life. We will test whether redox therapies developed for neurodegenerative disorders might help patients with rare neuromuscular disorders, for whom there are no treatment options.
ActivityGNT1143901 | PYROXD1 - A novel myopathy disease gene identifies a redox pathway essential for life
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
24 Oct 201730 Jan 201801 Jan 201831 Dec 2022 2016-17
UNIVERSITY OF SYDNEY
Grayndler  $924,146
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Project
CategoryMedical Research Targeted or Restricted Competitive
PurposeWe have developed a new drug (CD5-2) that targets the junctions of endothelial cells, the cell that lines all vessels. CD5-2 reduces oedema in diseases such as diabetic retinopathy and tumours. Thus it has potential as a new therapeutic in chronic inflammatory diseases where leaky blood vessels are central to the pathology. This grant will provide fundamental understanding of how CD5-2 induces such profound effects to alter the levels of oedema and alter inflammatory cell infiltrates in tissues.
ActivityGNT1143230 | Modulation of endothelial junctions as selective immunotherapy
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
24 Oct 201730 Jan 201801 Jan 201831 Dec 2020 2016-17
UNIVERSITY OF SYDNEY
Grayndler  $128,225
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposeOlder adults use more medications than ever before, yet these medications can be harmful in old age causing dangerous drug interactions, falls, confusion and death. -Deprescribing- involves slowly stopping medicines that are not needed or may be harmful. This study explores how the use of multiple medications and stopping them affects how older people function. By studying mice and humans, we also explore the intriguing possibility that use of too many medications drives the ageing process.
ActivityGNT1151308 | Impact of polypharmacy and deprescribing on measures of function and biomarkers of ageing biology in mice and humans
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
24 Oct 201703 Apr 201801 Jan 201831 Dec 2020 2016-17
UNIVERSITY OF SYDNEY
Grayndler  $40,754
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Postgraduate Scholarships
CategoryMedical Research Targeted or Restricted Competitive
PurposePsychological interventions for people with MS may help to reduce commonly experienced psychosocial symptoms including depression, anxiety, pain and fatigue. The aim of this research project is to develop and evaluate an Internet-delivered mindfulness-based intervention for people with MS. It is hypothesized that this program will improve depressive symptoms health-related quality of life, disability and other aspects of psychological well-being in people with MS compared with waitlist controls.
ActivityGNT1150801 | Online Mindfulness Intervention for People with Multiple Sclerosis
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
24 Oct 201703 Apr 201801 Jan 201831 Jan 2019 2016-17
UNIVERSITY OF SYDNEY
Grayndler  $825
Address Sydney 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Environment and Energy
Agency Department of the Environment and Energy
Program Environmental Information and Research
Component 2018-19 National Taxonomy Research Grant Program
CategoryNatural Resources - Conservation and Protection Open Competitive
PurposeGenomic analysis reveals strong population structure in the Giant Sydney Crayfish (Euastacus spinifer).
ActivityGenomic analysis reveals strong population structure in the Giant Sydney Crayfish (Euastacus spinifer)
Delivery Area 2006 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
24 May 201917 Jun 201913 Jun 201903 Sep 2019 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $502,558
Address The University of Sydney 2007 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency Cancer Australia
Program ABCM Innovative Clinical Trials Grant Opportunity
Component Australian Brain Cancer Mission - Innovative Clinical Trials
CategoryMedical Research
PurposeThe Medical Research Future Fund (MRFF) provides grants of financial assistance to support health and medical research and innovation in improving the health and wellbeing of Australians. It operates as an endowment fund with the capital preserved in perpetuity. The MRFF aims to transform health and medical research and innovation to improve lives, build the economy and contribute to health system sustainability through targeted strategic investment across the research pipeline. The independent and expert Australian Medical Research Advisory Board's Australian Medical Research and Innovation Strategy 2016-2021 and related Australian Medical Research and Innovation Priorities 2016-2018 were developed following extensive stakeholder consultation. The priorities identified by the Advisory Board were utilised to make decisions on the provision of financial assistance from the MRFF. Brain cancer is the sixth leading cause of cancer burden and there are more than 100 types of brain cancer and other central nervous system cancers. These cancers carry high rates of morbidity and mortality. The five-year relative survival rate for brain cancer is low, at around 22 per cent and this rate has not improved for the past 30 years. The young are disproportionately affected by brain cancer, being the leading cause of cancer-related deaths for those under 25 years of age. Every year in Australia the equivalent of a classroom of children die from brain cancer. The Australian Government is committed to improving survival rates and outcomes for both children and adults with brain cancer through ongoing investment in cancer control. In October 2017, the Government established the Australian Brain Cancer Mission (the Mission). The aim of the Mission is to double survival rates and improve the quality of life of patients with brain cancer over 10 years to 2027, with the longer term aim of defeating brain cancer. Total funding for the Mission as at May 2019 stands at $124.65 million including $58.35 million in Australian Government funding under the MRFF. The remaining funds are being provided by philanthropy, other governments, industry and the private sector. Cancer Australia manages the implementation of the Mission, supported by a Strategic Advisory Group. The Mission is underpinned by the Brain Cancer Research Roadmap, developed by Australian and international experts in brain cancer treatment and research, and those affected by brain cancer, their advocates and philanthropic interests. One of the priorities under the investment strategy of Increased and Equitable Access and Participation in Clinical Trials, is to invest in, and expand, the capacity of innovative brain cancer research clinical trials of great potential. Clinical trials are fundamental to establishing whether new cancer treatments or new ways of using existing therapies, diagnostic tests, preventative or supportive interventions are effective, and whether they help generate the evidence for best-practice cancer care.
ActivityThe Innovative Clinical Trials Grant Opportunity's purpose is to increase brain cancer clinical trial activity in Australia by supporting new, high quality research. Novel and innovative clinical trial methodologies are encouraged.
Delivery Area Multiple National AUSTRALIA
ApprovedPublishedStartEndBudget
24 Jun 201912 Jul 201926 Jun 201931 Jul 2020 2018-19
THE UNIVERSITY OF SYDNEY
Grayndler  $502,558
Address SYDNEY 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency Department of Health
Program Health policy Research and Analysis
Component Brain Cancer Research
CategoryMedical Research Open Competitive
PurposeBrain Cancer Research
ActivityBrain Cancer Research
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
24 Jun 201909 Jul 201926 Jun 201930 Oct 2020 2018-19
UNIVERSITY OF SYDNEY
Grayndler  $771,042
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Partnership Projects
CategoryMedical Research Targeted or Restricted Competitive
PurposeMotor neurone diseases (MNDs) are adult-onset neurodegenerative disorders where progressive motor weakness leads to death, usually from respiratory failure within 2-3 years. The aim of this project is to create a national data capture app that collects health information from patients that can be used by them and their healthcare providers to manage their own health needs and furthermore can be collated to inform research and in turn direct national policy.
ActivityGNT1153439 | Motor Neurone Disease: Patient centred care for a progressive neurological disease - evidence driving policy.
Delivery Area Multiple NSW, VIC, SA, WA, QLD AUSTRALIA
ApprovedPublishedStartEndBudget
24 Apr 201805 Jun 201801 Jun 201831 May 2023 2017-18
UNIVERSITY OF SYDNEY
Sydney  $218,253
Address University of Sydney 2008 NSW AUSTRALIA ABN: 15211513464
Portfolio Communications and the Arts
Agency Department of Communications and the Arts
Program Arts and Cultural Development
Component Indigenous Languages and Arts Program
CategoryHumanities Open Competitive
PurposeTo preserve highly endangered Warlpiri and Yuendumu song traditions, and associated dancing and painting, through sourcing and creating video and photographic documentation of the traditions, that will be presented on an interactive website and made accessible to community on iPads.
ActivityDigital Space for Warlpiri Songs
Delivery Area Multiple NSW, NT AUSTRALIA
ApprovedPublishedStartEndBudget
23 Jul 201802 Nov 201817 Oct 201830 Jun 2020 2018-19
UNIVERSITY OF SYDNEY
Grayndler  $585,270
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency Department of Health
Program Health policy Research and Analysis
Component MRFF Next Generation Clinical Researchers Program Practitioner Fellowship
CategoryMedical Research Targeted or Restricted Competitive
PurposeAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease killing 2 Australians every day. The disease starts in one arm or leg, and then progresses rapidly to result in global weakness. Patients describe as being trapped in their bodies. We don't understand the reasons underlying the development of ALS or why the disease spreads very rapidly. This research will attempt to identify factors driving the rapid spread of disease, in the hope of developing effective therapies.
ActivityGNT1154676 - The role of cortical dysfunction in ALS pathophysiology
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
23 Aug 201831 Aug 201801 Jan 201931 Dec 2023 2018-19
UNIVERSITY OF SYDNEY
Grayndler  $418,050
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency Department of Health
Program Health policy Research and Analysis
Component MRFF Next Generation Clinical Researchers Program Practitioner Fellowship
CategoryMedical Research Targeted or Restricted Competitive
PurposeAlcohol use disorder (AUD) is a leading health problem in Australia with 5500 deaths annually. Current treatments are unsatisfactory and few people receive evidence based care. This Fellowship will develop better treatment and services to tackle this highly stigmatised disorder. I will conduct clinical trials of medications including as topiramate, oxytocin and cannabidiol. I will work to overcome barriers to receiving effective care, aiming to increase the number of people receiving treatment.
ActivityGNT1155320 - New approaches for treatment of alcohol use disorder
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
23 Aug 201831 Aug 201801 Jan 201931 Dec 2023 2018-19
THE UNIVERSITY OF SYDNEY
Grayndler  $50,000
Address SYDNEY 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Industry, Innovation and Science
Agency Department of Industry, Innovation and Science
Program Growing Business Investment and Improving Business Capability
Component Entrepreneurs' Programme - Innovation Connections
CategoryIndustry Innovation Demand Driven
PurposeInnovation Connections promotes collaboration between small and medium sized Australian businesses and the research sector to develop new ideas with commercial potential.
ActivityInnovation Connections
Delivery Area 6000 WA AUSTRALIA
ApprovedPublishedStartEndBudget
22 Aug 201910 Oct 201908 Oct 201908 Jan 2020 2019-20
THE UNIVERSITY OF SYDNEY
Grayndler  $2,500,000
Address SYDNEY 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency Department of Health
Program Health policy Research and Analysis
Component Brain Cancer Research
CategoryMedical Research Open Competitive
PurposeBrain Cancer Research
ActivityBrain Cancer Research
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
20 Sep 201817 Oct 201828 Sep 201829 Feb 2024 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $432,000
Address FOREST LODGE 2037 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project uses computational modelling and optimisation methods to the design of battery compartments for electric vehicles. As the use of electric vehicles becomes more extensive, awareness of the consequences of catastrophic failure of high energy battery in a crash has increased. This project will develop novel design methodologies, using multi-disciplinary techniques for battery compartment structure. The methodology will expand conventional crashworthiness design to the coupled mechanical-electrochemical-thermal problems. The proposed crashworthiness optimisation of battery compartment structure will enhance safety and reliability of electric vehicles, potentially benefiting consumers and manufacturers.
ActivityCrashworthiness topology optimisation for light-weight battery compartments
Delivery Area 2037 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
20 Dec 201818 Dec 201830 Sep 201929 Sep 2022 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $48,615
Address FOREST LODGE 2037 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Early Career Researcher Award
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to systematically study the fundamental theory and practical methods for supporting unmanned aerial vehicles (UAV) utilising both existing 4G cellular systems and future 5G-and-beyond cellular systems. Supporting UAV communications in cellular systems is a promising technology to unlock numerous UAV applications without the need to establish control infrastructure. This project will develop new channel models, analyse the fundamental performance limits, and propose key enabling techniques. A proof-of-concept experiment will be performed to evaluate the proposed designs. The outcomes of this project are expected to fundamentally advance the knowledge of cellular-connected UAV communications and create new business opportunities for both cellular and UAV industries.
ActivitySupporting unmanned aerial vehicle communications in cellular systems
Delivery Area 2037 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
20 Dec 201818 Dec 201801 Jan 201907 Jun 2019 2018-19
THE UNIVERSITY OF SYDNEY
Grayndler  $303,982
Address SYDNEY 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Prime Minister and Cabinet
Agency Department of the Prime Minister and Cabinet
Program Children and Schooling
Component Children and Schooling
CategoryIndigenous Education Closed Non-Competitive
PurposeStrategic activities that focus on getting children to school, improving education outcomes and improving access to further education as well as supporting families to give children a good start in life.
ActivityAWAY FROM BASE
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
20 Dec 201812 Mar 201901 Jan 201931 Dec 2019 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $227,772
Address Camperdown 2008 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Blood Authority
Program Program National Blood Agreement Management
Component National Blood Sector Research and Development Program
CategoryMedical Research Targeted or Restricted Competitive
PurposeThis research project aims to: Reduce the burden on blood supply and improve patient outcomes in maternity and obstetrics through: a) Objective 1: providing data on the use and safety of interventional radiology (IR) in obstetric conditions (such as morbidly adherent placenta) with a high risk of massive haemorrhage to guide its appropriate use; b) Objective 2: providing evidence of platelet levels associated with increased risk of bleeding, and whether this differs according to the planned mode of birth; and c) Objective 3: comparing outcomes of the use of red blood cells and intravenous (IV) iron in the treatment of anaemia following delivery.
ActivityPatient Blood Management Project Grant:Prevention and management of bleeding in maternity patients to optimise patient outcomes
Delivery Area Multiple National AUSTRALIA
ApprovedPublishedStartEndBudget
19 Sep 201904 Dec 201901 Jul 202031 Jul 2022 2019-20
UNIVERSITY OF SYDNEY
Grayndler  $22,000
Address SYDNEY 2006 NSW AUSTRALIA ABN: 15211513464
Portfolio Agriculture and Water Resources
Agency Department of Agriculture
Program Dept Agricultural Resources
Component Science and Innovation Awards for Young People in Agriculture, Fisheries and Forestry
CategoryFarming
PurposeSupport Science and Innovation Awards for Young People in Agriculture, Fisheries and Forestry
ActivityThe community within: unlocking the oyster microbiome to improve aquaculture in a rapidly changing climate
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
19 Nov 201813 May 201902 May 201930 Jun 2020 2018-19
THE UNIVERSITY OF SYDNEY
Sydney  $321,269
Address SYDNEY 2000 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Linkage
Component Linkage Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeHydrogen wreaks havoc in many alloys, leading to embrittlement that can cause catastrophic failure. This is a very serious issue for any industry in which structures are exposed to hydrogen and is a limiting factor for the production, transport, storage and use of hydrogen in a potential hydrogen economy. However, understanding the behaviour of hydrogen in alloys is restricted by the difficulty of observing it. In this project we will obtain accurate 3D maps showing the position of hydrogen atoms in steel by combining deuteration with cryogenic atom probe microscopy. In this way we will will elucidate how a proposed solution, hydrogen trapping, reduces hydrogen embrittlement, contributing to design criteria for hydrogen-resistant steels.
ActivityMitigating hydrogen embrittlement in high-strength steels
Delivery Area 2000 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
19 Mar 201930 Apr 201901 Jun 201931 May 2022 2018-19
UNIVERSITY OF SYDNEY
Grayndler  $1,468,685
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency National Health and Medical Research Council
Program Health and Medical Research
Component Boosting Dementia Research Grants
CategoryMedical Research Targeted or Restricted Competitive
PurposeChanges in overnight blood oxygen levels due to sleep apnoea are associated with increased risk for dementia. This feasibility study will screen older individuals with cognitive concerns for changes in blood oxygen due to sleep apnoea. We will determine if a personalised intervention targeting sleep apnoea is feasible and acceptable to older adults with memory complaints and how treatment correlates with memory outcomes at 6-mths and 2-years.
ActivityGNT1171479 | REducing Sleep Apnoea for the PrEvention of Dementia (REShAPED): a multi-site feasibility RCT
Delivery Area Multiple NSW, VIC, WA, QLD AUSTRALIA
ApprovedPublishedStartEndBudget
19 Jun 201908 Aug 201901 Aug 201931 Jul 2023 2018-19
UNIVERSITY OF SYDNEY
Grayndler  $4,118,000
Address Camperdown 2050 NSW AUSTRALIA ABN: 15211513464
Portfolio Health
Agency Department of Health
Program Health Policy Research and Analysis
Component 2019 MRFF Rapid Applied Research Translation (RART) funding commencing in 2019
CategoryMedical Research Targeted or Restricted Competitive
PurposeHealth and medical research
ActivitySydney Health Partners - MRFF Rapid Applied Research Translation, Stage Two
Delivery Area NSW AUSTRALIA
ApprovedPublishedStartEndBudget
19 Jul 201922 Oct 201919 Jul 201930 Jun 2021 2019-20
THE UNIVERSITY OF SYDNEY
Sydney  $480,000
Address FOREST LODGE 2037 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThe project aim is to derive a technology platform comprising new image processing and machine learning algorithms to integrate imaging and biological data across multiple body sites. The relationships between image features and biological data across multiple sites has not been discovered before. We propose the use of biological information from one sampled site to investigate other unsampled sites based on imaging-omics correspondences. We will use a data-driven, searchable graph model approach for knowledge discovery within the population data. The project will provide new insights into systems biology and bioinformatics that will then inform and promote benefits in life sciences, with potential future benefits in healthcare.
ActivityA technology platform for multiple body site image-omics
Delivery Area 2037 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
19 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF SYDNEY
Sydney  $390,000
Address FOREST LODGE 2037 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeImplementing deep learning (DL) applications usually requires a large amount of collected data and powerful computing resources in the cloud. However, this centralised approach has issues of high latency, large bandwidth usage, and possible privacy violation for many practical applications. Without properly addressing these issues, the wider application of DL in practice will seriously be hindered. This project aims to solve several key challenging problems in effective deployment and efficient execution of DL applications in a distributed edge-computing environment. Several innovative edge-computing methods will be developed for DL training, inference and implementation to achieve high performance with low latency and enhanced privacy.
ActivityEdge-Accelerated Deep Learning
Delivery Area 2037 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
19 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF SYDNEY
Sydney  $360,000
Address FOREST LODGE 2037 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to transform our understanding of the dynamics of fires and smoke in enclosures and their interaction with water sprays and mists carrying chemical suppressants. Fires in buildings remain very difficult to contain and continue to cause extensive loss of lives and property. The proposed research will exploit advances in laser diagnostics and computer power to determine and quantify the complex interactions between droplets, turbulent flames, smoke formation and chemical suppression processes. Outcomes include novel experimental databases for turbulent buoyant flames and chemical suppression effectiveness, thus laying the foundation for enhancing our predictive capabilities and improving fire control methodologies.
ActivityDynamics and Enhanced Suppression of Fires
Delivery Area 2037 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
19 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF SYDNEY
Sydney  $305,400
Address FOREST LODGE 2037 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThe project aims to develop new statistical tools, applicable when the conventional paradigm that diversification reduces risk fails and when textbook approaches to risk quantification severely under-report risk. The new tools enhance our capacity to build and manage natural, social and human-made systems in uncertain environments. Our effective response to many threats including financial crises and natural events, depends on this capacity. Thus, the expected benefits in the form of more reliable and robust risk analytics will accrue when they are most needed.
ActivityDiversification failures and improved measures of uncertainty
Delivery Area 2037 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
19 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF SYDNEY
Sydney  $437,420
Address FOREST LODGE 2037 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeBasic biochemistry and the metabolic regulation of proliferation remain as the fundamental building blocks of knowledge in cell biology that have enabled breakthrough advances in biology and medicine. Polyamines are unique and ubiquitous low-Mr amines that play vital roles in many biological processes, including proliferation, DNA/RNA synthesis, etc. This proposal will mechanistically dissect the "new" biochemistry of polyamines, as we have discovered that polyamines are regulated by iron at 2-major levels, involving >10-key polyamine pathway proteins. This proposal represents first-in-field studies specifically designed to dissect mechanisms involved in this relationship. Our Central Hypothesis is that iron regulates polyamine metabolism.
ActivityThe “New” Biochemistry of Polyamines: When Metabolic Pathways Collide
Delivery Area 2037 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
19 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF SYDNEY
Sydney  $510,000
Address FOREST LODGE 2037 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeEdge Computing (EC) is an emerging paradigm with a great promise for advancing Information and Communications Technologies. This project aims to investigate and provide solutions for the realization of a seemingly integrated Edge Data Centres (EDCs) with cloud environments. Using theoretical and system development approaches, the project expects to generate new knowledge for managing the resources of an EDC ecosystem. Outcome of this project includes practical solutions through building novel mathematical frameworks and resource management objectives accompanied by system implementations. These outcomes will benefit both scientific and industrial communities, and mark Australian scientists as pioneers in this emerging area of research.
ActivityA Unified Framework for Resource Management in Edge-Cloud Data Centres
Delivery Area 2037 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
19 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF SYDNEY
Sydney  $220,000
Address FOREST LODGE 2037 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThe project aims to give a first-time analysis of visual culture at the Strait of Gibraltar. It asks how painting, photography, film, and maps relate to colonial expansion, with a focus on Australian, French and Spanish involvement in the Western Mediterranean. The British fortress-colony of Gibraltar and the international Moroccan port of Tangier have never before been subject to comparative analysis. Key outcomes include two major exhibitions, one on Australian Orientalism at the National Gallery and the second on historical art in the region. By shedding historical light on people smuggling, contraband and post-Brexit identity at the Strait, the project aims to generate cultural knowledge pertinent to international co-operation.
ActivityArt and Cultural Exchange at the Strait of Gibraltar
Delivery Area 2037 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
19 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF SYDNEY
Sydney  $396,000
Address FOREST LODGE 2037 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeAI-assisted image segmentation & synthesis are very challenging and usually require pixel-level labelling (per-pixel prediction) that is costly to obtain. The small amount of labels makes it difficult to train an “optimal” unified model for varied data as conventional methods did. This project aims to develop a new paradigm “personalised learning” to tackle this problem, where each image could be dealt with a model tailored to individual characteristics. The success of this project could significantly advance the fundamental research in image analysis. Expected outcomes include new knowledge and algorithms for image analysis, which could benefit fields like biology and archaeology, where labeled images are hard to attain and scarce.
ActivityPersonalised Learning for Per-pixel Prediction Tasks in Image Analysis
Delivery Area 2037 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
19 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF SYDNEY
Sydney  $505,792
Address FOREST LODGE 2037 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeAffordability pressures are increasingly forcing low income renters into substandard or ‘informal' housing arrangements ranging from share accommodation through to backyard ‘granny flats' and unauthorised dwelling units. This project aims to uncover how this ‘hidden' housing is produced within formal systems of urban regulation, and risks or benefits for residents. By exposing the significant but often ignored role of informality within housing systems, the project expects to advance the fields of housing and urban studies; lead international scholarly collaboration; and build research capacity. Project outcomes are intended to enhance local planning practice and improve housing standards and choice, particularly for low income renters.
ActivityHidden housing crisis? Urban planning and informal housing supply
Delivery Area 2037 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
19 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF SYDNEY
Sydney  $342,120
Address FOREST LODGE 2037 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to develop new approaches to improve wildlife management by showing how deceit and misinformation can alter decision-making in pest animals. Using wild house mice as a model, it will test new theory on how animals decide whether or not to interact with wildlife control devices, like traps and baits, which is critical to all pest control efforts. The expected outcomes include new pest control tools that make strategic use of misinformation to alter decision making, to reduce a pest's ability to damage important agricultural crops such as wheat, boost the attraction of lures to traps, and improve bait uptake. These outcomes should provide significant new options for vertebrate pest control in Australia and globally.
ActivityMessing with their minds: using deception to improve pest management
Delivery Area 2037 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
19 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF SYDNEY
Sydney  $280,000
Address FOREST LODGE 2037 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project pursues breakthroughs in time series modelling and develops novel statistical models and inference techniques, with a focus on modelling of financial time series data. The advances will be achieved through interdisciplinary research, combining recent advances in machine learning, Bayesian computation, financial econometrics and the increasing availability of Big Data. The outcomes will provide a new range of proven and powerful approaches for analysing time series and understanding time effects. The methodologies developed will lead to a greater accuracy in financial forecasting and risk management, and open up new horizons for the wider scientific community to analyse time series data.
ActivityDeep learning based time series modeling and financial forecasting
Delivery Area 2037 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
19 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF SYDNEY
Sydney  $527,000
Address FOREST LODGE 2037 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThe project aims to greatly improve the accuracy and scope of computational epidemiological models predicting emergence and evolution of foodborne diseases in Australia. It expects to reveal key pathways for both biological evolution of microorganisms, and their spread though food supply chains and human interactions. The intended outcomes include discovering how the most dominant strains of foodborne infection emerge and self-organise in complex networks, how to predict and contain the epidemics closer to their source, and which are the most vulnerable groups and communities. This should make a significant economic and social impact, improving health of the population, while also safeguarding national and international supply chains.
ActivityQuantifying emergence and dynamics of foodborne epidemics in Australia
Delivery Area 2037 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
19 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF SYDNEY
Sydney  $334,154
Address FOREST LODGE 2037 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeMultinationals (MNCs) tax avoidance has become a national blight and a global problem impacting tax fairness, transparency and economic efficiency. This project aims to find the optimal solution for the tax avoidance problem for both MNCs and governments via effective cost-benefit analysis through the design of a cutting-edge interdisciplinary machine-learning technique. Expected outcomes will include profound breakthroughs for enhancing economic growth via tax policy reform in Australia but also globally through cross-country tax avoidance comparison. The benefits will be instrumental in reforming fiscal and investment policies that are highly critical for improving economic welfare and capital inflows in Australia.
ActivityInnovative approach to a fair tax system for Multinationals and Governments
Delivery Area 2037 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
19 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF SYDNEY
Sydney  $648,925
Address FOREST LODGE 2037 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to determine the mechanisms responsible for the inheritance of acquired traits. Sometimes the environment can have effects on the phenotype of not only the exposed individual, but also their children and grandchildren. While it is clear that this can occur, what is not clear is the mechanism by which this happens and the frequency at which it happens. This project will combine use of the model organism Caenorhabditis elegans with biochemistry and structural biology to determine what the molecular mechanism is by which this "transgenerational epigenetic inheritance" occurs.
ActivityHow is molecular information passed between generations?
Delivery Area 2037 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
19 Dec 201906 Jan 202001 Jan 202031 Dec 2023 2019-20
THE UNIVERSITY OF SYDNEY
Sydney  $504,000
Address FOREST LODGE 2037 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to apply principles of community ecology to the gut microbiome of an urban exploiter – the common brushtail possum - to reveal how animal traits influence individual variation in the load of gut parasites that cause disease in both humans and wildlife. By combining assays defining the behavioural and physiological states of individuals with sophisticated analyses of their gut microbiome, our project will provide a new, yet crucial, perspective on how and why diseases spread. Our discoveries will help understand and manage the burden of infectious diseases from parasites in and beyond our cities and across the human-wildlife interface; essential for improving human and wildlife health in an increasingly urbanised Australia.
ActivityLinking individual traits, the gut microbiome and parasite load in wildlife
Delivery Area 2037 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
19 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF SYDNEY
Sydney  $440,000
Address FOREST LODGE 2037 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to understand the link between trust, safety, and the public acceptance of driverless cars. The uptake of autonomous mobility systems relies upon public trust. Recent injuries, and even a fatality, have highlighted the risks they pose to pedestrians in particular. The project investigates new interfaces for improving public trust and pedestrial safety by allowing vehicles to communicate with the people around them. Along the way, it develops a validated approach for simulating real interactions with autonomous vehicles in a virtual-reality environment. Benefits include strategies for making driverless cars safer for pedestrians and a new approach for testing solutions to this emerging problem in a low-cost, low-risk way.
ActivityTrust and Safety in Autonomous Mobility Systems: A Human-centred Approach
Delivery Area 2037 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
19 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF SYDNEY
Sydney  $340,212
Address FOREST LODGE 2037 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryHumanities, Arts and Social Sciences (HASS) Research Targeted or Restricted Competitive
PurposeThis project aims to improve two key areas of environmental policy by investigating the meaning of environmental justice and how it is best implemented. It will generate a significant new framework of the idea of environmental justice and offer innovative research that demonstrates what hinders and enables just policies in practice. Expected outcomes of this project include an updated and enhanced theory of environmental justice, a new understanding of the enablers and barriers to its implementation in practice, and recommendations to make policies on urban food security and energy transition more just. Overall, the project should provide the benefit of the development of more just policies on two key environmental issues facing Australia.
ActivityEnvironmental Justice and the Making of Just Food and Energy Policy
Delivery Area 2037 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
19 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF SYDNEY
Sydney  $380,000
Address FOREST LODGE 2037 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims at exploring future pathways for the Australian food system to remain secure under future disruptive changes, environmentally and socially sustainable, and able to offer healthy food choices. It will reveal the connections among food supply chains, diets and human health, and portray a food system that achieves public health and sustainability goals while positioning Australia securely into the global supply chain network. These goals will be achieved by creating the Australian Food Lab, which will provide a collaborative research platform for environmental scientists, economists, public health experts, and food industry representatives for investigating issues pertaining to the future of our food system.
ActivitySustainable Australian food production within secure global supply chains
Delivery Area 2037 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
19 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20
THE UNIVERSITY OF SYDNEY
Sydney  $463,896
Address FOREST LODGE 2037 NSW AUSTRALIA ABN: 15211513464
Portfolio Education and Training
Agency Australian Research Council
Program ARC Discovery
Component Discovery Projects
CategoryScience, Technology, Engineering and Mathematics (STEM) Research Targeted or Restricted Competitive
PurposeThis project aims to determine how soil microbial communities adapt to phosphorus availability, and how the breakdown of microbial biomass sustains phosphorus demand. Using some of the most globally P-impoverished soils, the project expects to uncover how cellular composition of microbial populations is shaped by phosphorus availability, and feedbacks between cellular composition of microbes and phosphorus availability. Expected outcomes include better understanding of factors determining phosphorus availability, and a new analytical toolkit for tracing pools and fluxes of organic P in soils. Overall, these should provide significant benefit to the global effort in understanding how phosphorus shapes soil function.
ActivityPhosphorus cycling and adaptation of soil microbes to P availability
Delivery Area 2037 NSW AUSTRALIA
ApprovedPublishedStartEndBudget
19 Dec 201906 Jan 202001 Jan 202031 Dec 2022 2019-20